DK2046318T3 - Kombination af adapalen og benzoylperoxid til behandling af inflammatoriske acnelæsioner - Google Patents
Kombination af adapalen og benzoylperoxid til behandling af inflammatoriske acnelæsionerInfo
- Publication number
- DK2046318T3 DK2046318T3 DK07787478.2T DK07787478T DK2046318T3 DK 2046318 T3 DK2046318 T3 DK 2046318T3 DK 07787478 T DK07787478 T DK 07787478T DK 2046318 T3 DK2046318 T3 DK 2046318T3
- Authority
- DK
- Denmark
- Prior art keywords
- adapalene
- treatment
- combination
- benzoyl peroxide
- acne lesions
- Prior art date
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title 1
- 239000004342 Benzoyl peroxide Substances 0.000 title 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 title 1
- 206010000496 acne Diseases 0.000 title 1
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 title 1
- 229960002916 adapalene Drugs 0.000 title 1
- 235000019400 benzoyl peroxide Nutrition 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 230000003902 lesion Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0652968A FR2903603B1 (fr) | 2006-07-13 | 2006-07-13 | Combinaison d'adapalene et de peroxyde de benzole dans le traitement de l'acne |
| US83349106P | 2006-07-27 | 2006-07-27 | |
| PCT/EP2007/057207 WO2008006888A1 (en) | 2006-07-13 | 2007-07-12 | Combination of adapalene and benzoyl peroxide for treating acne lesions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2046318T3 true DK2046318T3 (da) | 2013-08-05 |
Family
ID=37763873
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07787478.2T DK2046318T3 (da) | 2006-07-13 | 2007-07-12 | Kombination af adapalen og benzoylperoxid til behandling af inflammatoriske acnelæsioner |
| DK12152317.9T DK2450035T3 (da) | 2006-07-13 | 2007-07-12 | Kombination af adapalen og benzoylperoxid til behandling af acne-læsioner |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12152317.9T DK2450035T3 (da) | 2006-07-13 | 2007-07-12 | Kombination af adapalen og benzoylperoxid til behandling af acne-læsioner |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US8129362B2 (da) |
| EP (2) | EP2046318B1 (da) |
| JP (3) | JP2009542779A (da) |
| KR (3) | KR20150003917A (da) |
| CN (1) | CN101541320B (da) |
| AR (1) | AR061989A1 (da) |
| AU (1) | AU2007274288B2 (da) |
| BR (1) | BRPI0713182A8 (da) |
| CA (1) | CA2656456A1 (da) |
| CO (1) | CO6150136A2 (da) |
| CY (1) | CY1121398T1 (da) |
| DK (2) | DK2046318T3 (da) |
| ES (2) | ES2423951T3 (da) |
| FR (1) | FR2903603B1 (da) |
| HU (1) | HUE043502T2 (da) |
| LT (1) | LT2450035T (da) |
| MX (1) | MX2009000319A (da) |
| PL (2) | PL2450035T3 (da) |
| PT (2) | PT2046318E (da) |
| RU (3) | RU2009104949A (da) |
| SI (2) | SI2450035T1 (da) |
| TR (1) | TR201819658T4 (da) |
| WO (1) | WO2008006888A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820186B2 (en) | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| FR2910320B1 (fr) | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
| SI2114392T1 (sl) * | 2007-01-30 | 2016-01-29 | Galderma Research & Development | Uporaba adapalena in benzoil peroksida za dolgotrajno zdravljenje navadnih aken |
| WO2009077693A2 (fr) | 2007-11-30 | 2009-06-25 | Galderma Research & Development | Compositions comprenant au moins un derive de l'acide naphtoïque, du peroxyde de benzoyle et au moins un agent filmogene, leurs procedes de preparation, et leurs utilisations |
| US8853275B2 (en) | 2008-05-16 | 2014-10-07 | Galderma Research & Development | Concurrent therapy regime/regimen for the treatment of acne related diseases |
| WO2011098391A1 (en) * | 2010-02-09 | 2011-08-18 | Galderma Research & Development | A dermatological composition comprising a combination of adapalene and benzoyl peroxide for the treatment of acne in non- caucasian population with decrease of post- inflammatory hyperpigmentation |
| EP2563357B1 (en) * | 2010-04-29 | 2018-10-17 | Galderma Research & Development | Adapalene 0.3% for use in a method for treating scars |
| FR2969491B1 (fr) * | 2010-12-23 | 2013-07-12 | Galderma Res & Dev | Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant une combinaison d'adapalene et de bpo |
| US8563535B2 (en) * | 2011-03-29 | 2013-10-22 | Kamal Mehta | Combination composition comprising benzoyl peroxide and adapalene |
| CA2870690A1 (en) * | 2012-05-25 | 2013-11-28 | Galderma Research & Development | Treatment of preadolescent moderate acne vulgaris |
| KR20150085069A (ko) * | 2012-11-20 | 2015-07-22 | 알레간 인코포레이티드 | 국소적 댑손 및 댑손/아다팔렌 조성물 및 이의 사용 방법 |
| WO2015150332A1 (en) * | 2014-04-01 | 2015-10-08 | Galderma Research & Development | Combination of adapalene and benzoyl peroxide for treating acne scars |
| CN107072939A (zh) | 2014-07-25 | 2017-08-18 | 盖尔德马研究及发展公司 | 用于治疗严重痤疮的阿达帕林和过氧化苯甲酰的组合 |
| MX2018002176A (es) * | 2015-08-20 | 2018-06-15 | Sol Gel Tech Ltd | Composiciones para aplicaciones topicas que comprenden peroxido de benzoilo y adapaleno. |
| JP6679299B2 (ja) * | 2015-12-21 | 2020-04-15 | 第一三共ヘルスケア株式会社 | ニキビ治療用外用医薬組成物 |
| KR101986177B1 (ko) * | 2016-10-31 | 2019-06-05 | (주)동구바이오제약 | 여드름 치료용 약물의 생체이용률을 증진시키는 약학적 조성물 |
| WO2018080284A1 (ko) * | 2016-10-31 | 2018-05-03 | (주)동구바이오제약 | 여드름 치료용 약물의 생체이용률을 증진시키는 약학적 조성물 |
| MX2017003003A (es) * | 2017-03-08 | 2018-09-07 | Centro Int De Cosmiatria S A P I De C V | Composición y método para el tratamiento tópico del acné severo. |
| WO2018183763A1 (en) * | 2017-03-30 | 2018-10-04 | Zubovskiy Konstantin | Method of treating and preventing infections |
| WO2023177625A1 (en) * | 2022-03-14 | 2023-09-21 | Blue Hill Technologies Llc | Shelf-stable formulations of benzoyl peroxide and methods of producing same |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW203552B (en) * | 1992-02-18 | 1993-04-11 | J Baroody Lloyd | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| FR2727609B1 (fr) | 1994-12-06 | 1997-01-10 | Oreal | Ensemble de distribution pour l'application d'un produit de consistance liquide a pateuse |
| FR2775566B1 (fr) | 1998-03-03 | 2000-05-12 | Oreal | Cupule porte raisin et ensemble de conditionnement pour un produit de maquillage la comportant |
| US6559189B2 (en) * | 1999-04-28 | 2003-05-06 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
| FR2806273B1 (fr) | 2000-03-16 | 2002-10-04 | Oreal | Dispositif de conditionnement et d'application d'un produit cosmetique ou de soin |
| US7820186B2 (en) * | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| FR2833841B1 (fr) * | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
| FR2837101B1 (fr) | 2002-03-12 | 2004-07-02 | Galderma Res & Dev | Utilisation de l'acide 6-[1-adamantyl)-4-methoxyphenyl]-2- naphthoique pour le traitement de desordres dermatologiques |
| GB0301577D0 (en) * | 2003-01-23 | 2003-02-26 | Edko Pazarlama Tanitim Ltd Sti | Topical pharmaceutical and/or cosmetic dispense systems |
| EP1648491A1 (en) * | 2003-07-23 | 2006-04-26 | XOMA Technology Ltd. | Use of xmp-629 for the treatment of acne |
| US20050239723A1 (en) * | 2004-04-27 | 2005-10-27 | Amin Avinash N | Compositions and methods useful for treatment of acne |
| US20060128808A1 (en) * | 2004-10-20 | 2006-06-15 | Galderma Research & Development, S.N.C. | Method of using adapalene in acne maintenance therapy |
| AR054805A1 (es) * | 2005-06-29 | 2007-07-18 | Stiefel Laboratories | Composiciones topicas para el tratamiento de la piel |
| FR2901139B1 (fr) | 2006-05-17 | 2009-03-20 | Galderma Res & Dev S N C Snc | Compositions comprenant au moins un derive de l'acide naphtoique et du peroxyde de benzoyle, leurs procedes de preparation, et leurs utilisations |
-
2006
- 2006-07-13 FR FR0652968A patent/FR2903603B1/fr not_active Expired - Fee Related
-
2007
- 2007-07-12 KR KR1020147034871A patent/KR20150003917A/ko not_active Application Discontinuation
- 2007-07-12 RU RU2009104949/15A patent/RU2009104949A/ru unknown
- 2007-07-12 EP EP07787478.2A patent/EP2046318B1/en active Active
- 2007-07-12 PT PT77874782T patent/PT2046318E/pt unknown
- 2007-07-12 JP JP2009518901A patent/JP2009542779A/ja active Pending
- 2007-07-12 DK DK07787478.2T patent/DK2046318T3/da active
- 2007-07-12 MX MX2009000319A patent/MX2009000319A/es active IP Right Grant
- 2007-07-12 SI SI200732094T patent/SI2450035T1/sl unknown
- 2007-07-12 KR KR1020167027364A patent/KR20160120352A/ko not_active Application Discontinuation
- 2007-07-12 DK DK12152317.9T patent/DK2450035T3/da active
- 2007-07-12 LT LTEP12152317.9T patent/LT2450035T/lt unknown
- 2007-07-12 TR TR2018/19658T patent/TR201819658T4/tr unknown
- 2007-07-12 CN CN200780026489.8A patent/CN101541320B/zh active Active
- 2007-07-12 HU HUE12152317A patent/HUE043502T2/hu unknown
- 2007-07-12 BR BRPI0713182A patent/BRPI0713182A8/pt not_active Application Discontinuation
- 2007-07-12 WO PCT/EP2007/057207 patent/WO2008006888A1/en active Application Filing
- 2007-07-12 SI SI200731283T patent/SI2046318T1/sl unknown
- 2007-07-12 ES ES07787478T patent/ES2423951T3/es active Active
- 2007-07-12 EP EP12152317.9A patent/EP2450035B1/en active Active
- 2007-07-12 AU AU2007274288A patent/AU2007274288B2/en active Active
- 2007-07-12 ES ES12152317T patent/ES2703505T3/es active Active
- 2007-07-12 PT PT12152317T patent/PT2450035T/pt unknown
- 2007-07-12 KR KR1020097000572A patent/KR20090028764A/ko not_active Application Discontinuation
- 2007-07-12 PL PL12152317T patent/PL2450035T3/pl unknown
- 2007-07-12 CA CA002656456A patent/CA2656456A1/en not_active Abandoned
- 2007-07-12 PL PL07787478T patent/PL2046318T3/pl unknown
- 2007-07-13 AR ARP070103115A patent/AR061989A1/es unknown
- 2007-07-13 US US11/826,364 patent/US8129362B2/en active Active
-
2009
- 2009-01-13 US US12/318,937 patent/US8071644B2/en active Active
- 2009-02-13 CO CO09014466A patent/CO6150136A2/es unknown
-
2011
- 2011-11-14 US US13/296,186 patent/US20120059063A1/en not_active Abandoned
-
2012
- 2012-01-17 US US13/351,986 patent/US8785420B2/en active Active
- 2012-08-29 RU RU2012136952/15A patent/RU2012136952A/ru not_active Application Discontinuation
- 2012-10-18 RU RU2012144414/15A patent/RU2012144414A/ru unknown
-
2013
- 2013-11-22 JP JP2013241729A patent/JP2014040481A/ja active Pending
-
2014
- 2014-06-11 US US14/301,816 patent/US20140296340A1/en not_active Abandoned
-
2015
- 2015-11-06 JP JP2015218597A patent/JP2016029094A/ja active Pending
-
2017
- 2017-03-31 US US15/476,241 patent/US20170202803A1/en not_active Abandoned
-
2019
- 2019-01-24 CY CY20191100091T patent/CY1121398T1/el unknown
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