DK2031063T3 - Modulatorer af duftreceptorer - Google Patents

Modulatorer af duftreceptorer

Info

Publication number
DK2031063T3
DK2031063T3 DK08013482.8T DK08013482T DK2031063T3 DK 2031063 T3 DK2031063 T3 DK 2031063T3 DK 08013482 T DK08013482 T DK 08013482T DK 2031063 T3 DK2031063 T3 DK 2031063T3
Authority
DK
Denmark
Prior art keywords
modulators
fragrance
receptors
fragrance receptors
Prior art date
Application number
DK08013482.8T
Other languages
Danish (da)
English (en)
Inventor
Hiroaki Matsunami
Momoka Matsunami
Harumi Saito
Hanyi Zhuang
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Application granted granted Critical
Publication of DK2031063T3 publication Critical patent/DK2031063T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
DK08013482.8T 2004-06-18 2005-06-20 Modulatorer af duftreceptorer DK2031063T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58108704P 2004-06-18 2004-06-18
US58201104P 2004-06-22 2004-06-22
US11/156,516 US7425445B2 (en) 2004-06-18 2005-06-20 Modulators that promote cell surface expression of odorant receptors
EP05792749A EP1771582A4 (en) 2004-06-18 2005-06-20 Modulators of odorant receptors

Publications (1)

Publication Number Publication Date
DK2031063T3 true DK2031063T3 (da) 2014-01-27

Family

ID=36034502

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08013482.8T DK2031063T3 (da) 2004-06-18 2005-06-20 Modulatorer af duftreceptorer

Country Status (9)

Country Link
US (6) US7425445B2 (enExample)
EP (2) EP2031063B1 (enExample)
JP (2) JP5022217B2 (enExample)
CN (1) CN101087879B (enExample)
AU (2) AU2005258061C1 (enExample)
CA (1) CA2571080C (enExample)
DK (1) DK2031063T3 (enExample)
PL (1) PL2031063T3 (enExample)
WO (1) WO2006002161A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7811762B2 (en) * 2006-03-30 2010-10-12 Duke University Identification of a novel gene underlying familial spastic paraplegia
WO2008137993A1 (en) * 2007-05-08 2008-11-13 Duke University Compositions and methods for characterizing and regulating olfactory sensation
JP5690467B2 (ja) 2008-04-11 2015-03-25 花王株式会社 嗅覚感度抑制剤のスクリーニング法
WO2011069156A2 (en) 2009-12-04 2011-06-09 Duke University Compositions and methods for enhancing odorant receptor activity
JP5520173B2 (ja) * 2010-09-16 2014-06-11 花王株式会社 ミューゲ香料素材の探索方法
WO2012056603A1 (ja) 2010-10-25 2012-05-03 パナソニック株式会社 キメラ嗅覚受容体を用いてｃＡＭＰを産生する方法
WO2012139526A1 (zh) * 2011-04-14 2012-10-18 上海交通大学医学院 一种配位金属的气味化合物的探测方法
JP5921226B2 (ja) * 2012-02-02 2016-05-24 花王株式会社 ミューゲ香料素材の探索方法
US20130210775A1 (en) 2012-02-09 2013-08-15 Kao Corporation Agent for inhibiting odor of pyrazine derivatives
AU2013311316A1 (en) * 2012-09-10 2015-03-26 The Johns Hopkins University Compositions and methods for increasing the expression and signalling of proteins on cell surfaces
JP2016523546A (ja) 2013-06-29 2016-08-12 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 匂い物質および香り受容体を特定、単離および使用する方法
EP2832347B1 (en) 2013-08-02 2018-01-31 Takasago International Corporation Method for identifying patchouli odorant materials
US10041935B2 (en) 2013-08-05 2018-08-07 New York University Identification of olfactory receptors sensitive to different odorants
WO2015095062A2 (en) 2013-12-16 2015-06-25 Monell Chemical Senses Center Methods of identifying modulators of olfactory receptors
WO2015116771A1 (en) 2014-01-29 2015-08-06 The Johns Hopkins University Compositions and methods for increasing the expression and signalling of proteins on cell surfaces
US11267852B2 (en) 2015-06-10 2022-03-08 Firmenich Sa Cell lines for screening odorant and aroma receptors
US10512253B2 (en) 2015-08-03 2019-12-24 Research Foundation Of The City University Of New York DNA sequence that increases odorant receptor representation in the olfactory system
EP4365591A3 (en) 2016-02-24 2024-08-07 Suntory Holdings Limited Biosensor detecting smell, scent and taste
MX2019003507A (es) * 2016-09-30 2019-08-01 Mars Inc Metodos de evaluacion usando receptores olfatorios y compuestos novedosos identificados usando los mismos.
US11029308B2 (en) 2016-10-27 2021-06-08 Duke University Methods for vapor detection and discrimination with mammalian odorant receptors expressed in heterologous cells
US11255830B2 (en) 2016-12-30 2022-02-22 Research Foundation Of The City University Of New York Biosensor exhibiting sensitivity to trinitrotoluene
PL3573944T3 (pl) 2017-01-30 2022-05-16 Chemcom S.A. Związki ograniczające postrzeganie nieprzyjemnego zapachu i ich zastosowanie
WO2018163800A1 (ja) * 2017-03-07 2018-09-13 高砂香料工業株式会社 マリンノートを呈する香料素材のスクリーニング方法
US10209239B1 (en) 2017-08-16 2019-02-19 Aromyx Corporation Method of making an aromagraph comprising ectopic olfactory receptors
US12163950B2 (en) 2018-06-26 2024-12-10 Duke University Synthetic odorant receptors
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US12269315B2 (en) 2020-08-20 2025-04-08 Denso International America, Inc. Systems and methods for measuring and managing odor brought into rental vehicles
GB202108867D0 (en) 2021-06-21 2021-08-04 Givaudan Sa Screening system
US20260210939A1 (en) 2022-12-15 2026-07-23 Givaudan Sa Modified olfactory receptors
JP2024132485A (ja) * 2023-03-17 2024-10-01 住友化学株式会社 ヒトリガ科の昆虫由来細胞
CN116200456B (zh) * 2023-04-27 2023-07-28 汉王科技股份有限公司 利用嗅觉受体检测食品变质的方法
EP4664463A1 (en) 2024-06-14 2025-12-17 Givaudan SA Computer-implemented method for olfactory property prediction
WO2025257381A1 (en) 2024-06-14 2025-12-18 Givaudan Sa Modified olfactory receptors
CN118501118B (zh) * 2024-07-16 2024-10-29 汉王科技股份有限公司 一种基于细胞的生物荧光能量共振转移检测系统及应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
AU3069189A (en) 1988-02-05 1989-08-25 Trustees Of Columbia University In The City Of New York, The Retroviral packaging cell lines and processes of using same
WO1990002806A1 (en) 1988-09-01 1990-03-22 Whitehead Institute For Biomedical Research Recombinant retroviruses with amphotropic and ecotropic host ranges
GB8901778D0 (en) 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
CA2144040A1 (fr) 1993-07-13 1995-01-26 Michel Perricaudet Vecteurs adenoviraux defectifs et utilisation en therapie genique
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US5993778A (en) * 1997-05-07 1999-11-30 Firestein; Stuart J. Functional expression of, and assay for, functional cellular receptors in vivo
WO2001051609A1 (en) * 2000-01-14 2001-07-19 The Johns Hopkins University Isolation and in vitro differentiation of conditionally immortalized murine olfactory receptor neurons
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
WO2003025130A2 (en) * 2001-09-14 2003-03-27 Incyte Genomics, Inc. Receptors and membrane-associated proteins
WO2003098221A1 (en) * 2002-05-02 2003-11-27 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of ensadin-0255 gene and protein for neurodegenerative diseases
EP1572921A2 (en) * 2002-05-07 2005-09-14 Immunex Corporation Cytokine polypeptides
CA2500521A1 (en) * 2002-10-02 2004-09-23 Nuvelo, Inc. Novel nucleic acids and polypeptides

Also Published As

Publication number Publication date
JP5340430B2 (ja) 2013-11-13
EP1771582A4 (en) 2008-04-16
US20060057640A1 (en) 2006-03-16
AU2005258061A1 (en) 2006-01-05
EP2031063A2 (en) 2009-03-04
AU2005258061B9 (en) 2009-12-17
CA2571080A1 (en) 2006-01-05
US7425445B2 (en) 2008-09-16
CN101087879B (zh) 2013-08-14
CN101087879A (zh) 2007-12-12
JP5022217B2 (ja) 2012-09-12
EP2031063B1 (en) 2013-11-06
AU2005258061B2 (en) 2009-07-16
US20090123997A1 (en) 2009-05-14
US20080124742A1 (en) 2008-05-29
US7691592B2 (en) 2010-04-06
EP2031063A3 (en) 2009-03-11
US20090092997A1 (en) 2009-04-09
US7838288B2 (en) 2010-11-23
AU2009227827A2 (en) 2010-03-11
PL2031063T3 (pl) 2014-04-30
US7879565B2 (en) 2011-02-01
JP2008503220A (ja) 2008-02-07
US20100222561A1 (en) 2010-09-02
JP2012105660A (ja) 2012-06-07
AU2005258061C1 (en) 2010-09-09
WO2006002161A3 (en) 2007-06-21
AU2009227827A1 (en) 2009-11-05
US20090124003A1 (en) 2009-05-14
EP1771582A2 (en) 2007-04-11
WO2006002161A2 (en) 2006-01-05
CA2571080C (en) 2013-05-28

Similar Documents

Publication Publication Date Title
DK1745062T3 (da) Forbedrede modulatorer af koagulationsfaktorer
DK1979314T3 (da) Indolsulfonamidmodulatorer af progesteronreceptorer
DK1802579T3 (da) Derivater af 3-arylaminopyridin
DK1778618T3 (da) Syntese af triethylentetraminer
DK1720866T3 (da) Fremgangsmåde
DE602007008222D1 (de) Diazepanderivate als modulatoren von chemokinrezeptoren
DK2038290T3 (da) Modulatorer af toll-lignende receptor 7
DK1992697T3 (da) Fremstilling af TNFR-Fc
PL2031063T3 (pl) Modulatory receptorów węchowych
DE602005012267D1 (de) N von geräten
DK2363414T3 (da) Stedstyret modifikation af FVIII
EP1735652A4 (en) LIGHT MODULATORS
DK1786472T3 (da) Antisense-modulering af apolipoprotein B-ekspression
DE602005011285D1 (de) Formmasse von polymer
DK1587542T3 (da) Anvendelse af anti-CD100-antistoffer
DK2060570T3 (da) Som modulatorer af dopamin-d3-receptorer anvendelige azabicyclo(3.1.0)hexanderivater
ATE540027T1 (de) Tetrahydroindazol-cannabinoidmodulatoren
DK1656345T3 (da) Cykliske derivater som modulatorer af chemokinreceptoraktivitet
DK1931315T3 (da) Depotformuleringer af nalbufin
DK1986622T3 (da) Små-molekyle-modulatorer af Trp-p8-aktivitet
DK1940465T3 (da) Ny anvendelse af anti-IL-1beta-antistoffer
EP1719409A4 (en) INSECTICIDE COMPOSITION
MA28580B1 (fr) 3-(4-hétéroarylcyclohexylamino) cyclopentanecarboxamides servant de modulateurs de récepteurs de chimiokines
NO20043305D0 (no) Preparation of lodixanol
DK2004815T3 (da) Funktional ekspression af triacylglycerol-lipaser