AU2005258061C1 - Modulators of odorant receptors - Google Patents

Modulators of odorant receptors Download PDF

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Publication number
AU2005258061C1
AU2005258061C1 AU2005258061A AU2005258061A AU2005258061C1 AU 2005258061 C1 AU2005258061 C1 AU 2005258061C1 AU 2005258061 A AU2005258061 A AU 2005258061A AU 2005258061 A AU2005258061 A AU 2005258061A AU 2005258061 C1 AU2005258061 C1 AU 2005258061C1
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AU
Australia
Prior art keywords
rtp
nucleic acid
rtp1
reep
cell
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Expired
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AU2005258061A
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English (en)
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AU2005258061B2 (en
AU2005258061B9 (en
AU2005258061A1 (en
Inventor
Hiroaki Matsunami
Momoka Matsunami
Harumi Saito
Hanyi Zhuang
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Duke University
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Duke University
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Publication of AU2005258061A1 publication Critical patent/AU2005258061A1/en
Publication of AU2005258061B2 publication Critical patent/AU2005258061B2/en
Priority to AU2009227827A priority Critical patent/AU2009227827A1/en
Publication of AU2005258061B9 publication Critical patent/AU2005258061B9/en
Application granted granted Critical
Publication of AU2005258061C1 publication Critical patent/AU2005258061C1/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
AU2005258061A 2004-06-18 2005-06-20 Modulators of odorant receptors Expired AU2005258061C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009227827A AU2009227827A1 (en) 2004-06-18 2009-10-16 Modulators of odorant receptors

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US58108704P 2004-06-18 2004-06-18
US60/581,087 2004-06-18
US58201104P 2004-06-22 2004-06-22
US60/582,011 2004-06-22
PCT/US2005/021921 WO2006002161A2 (en) 2004-06-18 2005-06-20 Modulators of odorant receptors
US11/156,516 US7425445B2 (en) 2004-06-18 2005-06-20 Modulators that promote cell surface expression of odorant receptors
USNONE 2005-10-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2009227827A Division AU2009227827A1 (en) 2004-06-18 2009-10-16 Modulators of odorant receptors

Publications (4)

Publication Number Publication Date
AU2005258061A1 AU2005258061A1 (en) 2006-01-05
AU2005258061B2 AU2005258061B2 (en) 2009-07-16
AU2005258061B9 AU2005258061B9 (en) 2009-12-17
AU2005258061C1 true AU2005258061C1 (en) 2010-09-09

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2005258061A Expired AU2005258061C1 (en) 2004-06-18 2005-06-20 Modulators of odorant receptors
AU2009227827A Ceased AU2009227827A1 (en) 2004-06-18 2009-10-16 Modulators of odorant receptors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2009227827A Ceased AU2009227827A1 (en) 2004-06-18 2009-10-16 Modulators of odorant receptors

Country Status (9)

Country Link
US (6) US7425445B2 (enExample)
EP (2) EP2031063B1 (enExample)
JP (2) JP5022217B2 (enExample)
CN (1) CN101087879B (enExample)
AU (2) AU2005258061C1 (enExample)
CA (1) CA2571080C (enExample)
DK (1) DK2031063T3 (enExample)
PL (1) PL2031063T3 (enExample)
WO (1) WO2006002161A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5312314B2 (ja) * 2006-03-30 2013-10-09 デューク ユニヴァーシティー 家族性痙性対麻痺の根底にある新規遺伝子の同定
US8298781B2 (en) * 2007-05-08 2012-10-30 Duke University Compositions and methods for characterizing and regulating olfactory sensation
JP5690467B2 (ja) * 2008-04-11 2015-03-25 花王株式会社 嗅覚感度抑制剤のスクリーニング法
US9068226B2 (en) 2009-12-04 2015-06-30 Duke University Compositions and methods for enhancing odorant receptor activity
JP5520173B2 (ja) * 2010-09-16 2014-06-11 花王株式会社 ミューゲ香料素材の探索方法
WO2012056603A1 (ja) 2010-10-25 2012-05-03 パナソニック株式会社 キメラ嗅覚受容体を用いてｃＡＭＰを産生する方法
CN103608674B (zh) * 2011-04-14 2015-04-22 上海交通大学医学院 一种配位金属的气味化合物的探测方法
JP5921226B2 (ja) * 2012-02-02 2016-05-24 花王株式会社 ミューゲ香料素材の探索方法
US20130210775A1 (en) 2012-02-09 2013-08-15 Kao Corporation Agent for inhibiting odor of pyrazine derivatives
AU2013311316A1 (en) * 2012-09-10 2015-03-26 The Johns Hopkins University Compositions and methods for increasing the expression and signalling of proteins on cell surfaces
MX371282B (es) 2013-06-29 2020-01-24 Firmenich & Cie Metodos para identificar, aislar y usar receptores de odorizantes y aroma.
ES2665906T3 (es) 2013-08-02 2018-04-30 Takasago International Corporation Método para identificar materiales odorantes de pachulí
US10041935B2 (en) 2013-08-05 2018-08-07 New York University Identification of olfactory receptors sensitive to different odorants
US10908147B2 (en) 2013-12-16 2021-02-02 Monell Chemical Senses Center Methods of identifying modulators of olfactory receptors
US10435456B2 (en) 2014-01-29 2019-10-08 The Johns Hopkins University Compositions and methods for increasing the expression and signalling of proteins on cell surfaces
EP3726218B1 (en) * 2015-06-10 2023-08-09 Firmenich Sa Cell lines for screening odorant and aroma receptors
EP3331990A4 (en) * 2015-08-03 2019-04-03 Research Foundation Of The City University Of New York THE ODOR RECEPTOR PRESENTATION IN THE OLFACTORY SYSTEM INCREASING DNA SEQUENCE
AU2017222572A1 (en) 2016-02-24 2018-08-23 Aromyx Corporation Biosensor for detecting smell, scent and taste
EP3519815A1 (en) * 2016-09-30 2019-08-07 Mars, Incorporated Screening methods using olfactory receptors and novel compounds identified using the same
US11029308B2 (en) 2016-10-27 2021-06-08 Duke University Methods for vapor detection and discrimination with mammalian odorant receptors expressed in heterologous cells
US11255830B2 (en) 2016-12-30 2022-02-22 Research Foundation Of The City University Of New York Biosensor exhibiting sensitivity to trinitrotoluene
ES2912621T3 (es) 2017-01-30 2022-05-26 Chemcom Sa Compuestos que reducen la percepción de mal olor y uso de los mismos
WO2018163800A1 (ja) * 2017-03-07 2018-09-13 高砂香料工業株式会社 マリンノートを呈する香料素材のスクリーニング方法
US10209239B1 (en) 2017-08-16 2019-02-19 Aromyx Corporation Method of making an aromagraph comprising ectopic olfactory receptors
US12163950B2 (en) 2018-06-26 2024-12-10 Duke University Synthetic odorant receptors
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US12269315B2 (en) 2020-08-20 2025-04-08 Denso International America, Inc. Systems and methods for measuring and managing odor brought into rental vehicles
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking
GB202108867D0 (en) 2021-06-21 2021-08-04 Givaudan Sa Screening system
WO2024126820A1 (en) 2022-12-15 2024-06-20 Givaudan Sa Modified olfactory receptors
JP2024132485A (ja) * 2023-03-17 2024-10-01 住友化学株式会社 ヒトリガ科の昆虫由来細胞
CN116200456B (zh) * 2023-04-27 2023-07-28 汉王科技股份有限公司 利用嗅觉受体检测食品变质的方法
EP4664463A1 (en) 2024-06-14 2025-12-17 Givaudan SA Computer-implemented method for olfactory property prediction
CN118501118B (zh) * 2024-07-16 2024-10-29 汉王科技股份有限公司 一种基于细胞的生物荧光能量共振转移检测系统及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993778A (en) * 1997-05-07 1999-11-30 Firestein; Stuart J. Functional expression of, and assay for, functional cellular receptors in vivo
US20020048812A1 (en) * 2000-01-14 2002-04-25 Ronnett Gabriele V. Isolation and in vitro differentiation of conditionally immortalized murine olfactory receptor neurons
WO2003098221A1 (en) * 2002-05-02 2003-11-27 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of ensadin-0255 gene and protein for neurodegenerative diseases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
AU3069189A (en) 1988-02-05 1989-08-25 Trustees Of Columbia University In The City Of New York, The Retroviral packaging cell lines and processes of using same
EP0432216A1 (en) 1988-09-01 1991-06-19 Whitehead Institute For Biomedical Research Recombinant retroviruses with amphotropic and ecotropic host ranges
GB8901778D0 (en) 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
ES2310924T3 (es) 1993-07-13 2009-01-16 Centelion Vectores adenovirales defectivos y utilizacion en terapia genica.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
CA2459137A1 (en) * 2001-09-14 2003-03-27 Incyte Genomics, Inc. Receptors and membrane-associated proteins
PL375202A1 (en) * 2002-05-07 2005-11-28 Immunex Corporation Cytokine polypeptides
AU2003303305A1 (en) * 2002-10-02 2004-09-30 Nuvelo,Inc. Novel nucleic acids and polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993778A (en) * 1997-05-07 1999-11-30 Firestein; Stuart J. Functional expression of, and assay for, functional cellular receptors in vivo
US20020048812A1 (en) * 2000-01-14 2002-04-25 Ronnett Gabriele V. Isolation and in vitro differentiation of conditionally immortalized murine olfactory receptor neurons
WO2003098221A1 (en) * 2002-05-02 2003-11-27 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of ensadin-0255 gene and protein for neurodegenerative diseases

Also Published As

Publication number Publication date
DK2031063T3 (da) 2014-01-27
US7691592B2 (en) 2010-04-06
US7425445B2 (en) 2008-09-16
JP2008503220A (ja) 2008-02-07
US20090124003A1 (en) 2009-05-14
CN101087879B (zh) 2013-08-14
US20100222561A1 (en) 2010-09-02
WO2006002161A2 (en) 2006-01-05
AU2005258061B2 (en) 2009-07-16
US20090092997A1 (en) 2009-04-09
AU2005258061B9 (en) 2009-12-17
EP2031063B1 (en) 2013-11-06
US20080124742A1 (en) 2008-05-29
EP2031063A3 (en) 2009-03-11
US20060057640A1 (en) 2006-03-16
EP1771582A4 (en) 2008-04-16
JP5022217B2 (ja) 2012-09-12
AU2009227827A2 (en) 2010-03-11
EP2031063A2 (en) 2009-03-04
CA2571080A1 (en) 2006-01-05
JP5340430B2 (ja) 2013-11-13
EP1771582A2 (en) 2007-04-11
JP2012105660A (ja) 2012-06-07
CN101087879A (zh) 2007-12-12
US7838288B2 (en) 2010-11-23
PL2031063T3 (pl) 2014-04-30
AU2005258061A1 (en) 2006-01-05
CA2571080C (en) 2013-05-28
US20090123997A1 (en) 2009-05-14
AU2009227827A1 (en) 2009-11-05
US7879565B2 (en) 2011-02-01
WO2006002161A3 (en) 2007-06-21

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