CA2571080C - Modulators of odorant receptors - Google Patents

Modulators of odorant receptors Download PDF

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Publication number
CA2571080C
CA2571080C CA2571080A CA2571080A CA2571080C CA 2571080 C CA2571080 C CA 2571080C CA 2571080 A CA2571080 A CA 2571080A CA 2571080 A CA2571080 A CA 2571080A CA 2571080 C CA2571080 C CA 2571080C
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Prior art keywords
rtp
rtp1
reep
cell
cells
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Expired - Lifetime
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CA2571080A
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English (en)
French (fr)
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CA2571080A1 (en
Inventor
Hiroaki Matsunami
Momoka Matsunami
Harumi Saito
Hanyi Zhuang
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Duke University
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Duke University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
CA2571080A 2004-06-18 2005-06-20 Modulators of odorant receptors Expired - Lifetime CA2571080C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US58108704P 2004-06-18 2004-06-18
US60/581,087 2004-06-18
US58201104P 2004-06-22 2004-06-22
US60/582,011 2004-06-22
PCT/US2005/021921 WO2006002161A2 (en) 2004-06-18 2005-06-20 Modulators of odorant receptors
US11/156,516 US7425445B2 (en) 2004-06-18 2005-06-20 Modulators that promote cell surface expression of odorant receptors
US11/156,516 2005-06-20

Publications (2)

Publication Number Publication Date
CA2571080A1 CA2571080A1 (en) 2006-01-05
CA2571080C true CA2571080C (en) 2013-05-28

Family

ID=36034502

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2571080A Expired - Lifetime CA2571080C (en) 2004-06-18 2005-06-20 Modulators of odorant receptors

Country Status (9)

Country Link
US (6) US7425445B2 (enExample)
EP (2) EP2031063B1 (enExample)
JP (2) JP5022217B2 (enExample)
CN (1) CN101087879B (enExample)
AU (2) AU2005258061C1 (enExample)
CA (1) CA2571080C (enExample)
DK (1) DK2031063T3 (enExample)
PL (1) PL2031063T3 (enExample)
WO (1) WO2006002161A2 (enExample)

Cited By (11)

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US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
US12269315B2 (en) 2020-08-20 2025-04-08 Denso International America, Inc. Systems and methods for measuring and managing odor brought into rental vehicles
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking

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JP5690467B2 (ja) 2008-04-11 2015-03-25 花王株式会社 嗅覚感度抑制剤のスクリーニング法
WO2011069156A2 (en) 2009-12-04 2011-06-09 Duke University Compositions and methods for enhancing odorant receptor activity
JP5520173B2 (ja) * 2010-09-16 2014-06-11 花王株式会社 ミューゲ香料素材の探索方法
WO2012056603A1 (ja) 2010-10-25 2012-05-03 パナソニック株式会社 キメラ嗅覚受容体を用いてｃＡＭＰを産生する方法
WO2012139526A1 (zh) * 2011-04-14 2012-10-18 上海交通大学医学院 一种配位金属的气味化合物的探测方法
JP5921226B2 (ja) * 2012-02-02 2016-05-24 花王株式会社 ミューゲ香料素材の探索方法
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US10041935B2 (en) 2013-08-05 2018-08-07 New York University Identification of olfactory receptors sensitive to different odorants
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WO2015116771A1 (en) 2014-01-29 2015-08-06 The Johns Hopkins University Compositions and methods for increasing the expression and signalling of proteins on cell surfaces
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US10512253B2 (en) 2015-08-03 2019-12-24 Research Foundation Of The City University Of New York DNA sequence that increases odorant receptor representation in the olfactory system
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MX2019003507A (es) * 2016-09-30 2019-08-01 Mars Inc Metodos de evaluacion usando receptores olfatorios y compuestos novedosos identificados usando los mismos.
US11029308B2 (en) 2016-10-27 2021-06-08 Duke University Methods for vapor detection and discrimination with mammalian odorant receptors expressed in heterologous cells
US11255830B2 (en) 2016-12-30 2022-02-22 Research Foundation Of The City University Of New York Biosensor exhibiting sensitivity to trinitrotoluene
PL3573944T3 (pl) 2017-01-30 2022-05-16 Chemcom S.A. Związki ograniczające postrzeganie nieprzyjemnego zapachu i ich zastosowanie
WO2018163800A1 (ja) * 2017-03-07 2018-09-13 高砂香料工業株式会社 マリンノートを呈する香料素材のスクリーニング方法
US10209239B1 (en) 2017-08-16 2019-02-19 Aromyx Corporation Method of making an aromagraph comprising ectopic olfactory receptors
US12163950B2 (en) 2018-06-26 2024-12-10 Duke University Synthetic odorant receptors
GB202108867D0 (en) 2021-06-21 2021-08-04 Givaudan Sa Screening system
US20260210939A1 (en) 2022-12-15 2026-07-23 Givaudan Sa Modified olfactory receptors
JP2024132485A (ja) * 2023-03-17 2024-10-01 住友化学株式会社 ヒトリガ科の昆虫由来細胞
CN116200456B (zh) * 2023-04-27 2023-07-28 汉王科技股份有限公司 利用嗅觉受体检测食品变质的方法
EP4664463A1 (en) 2024-06-14 2025-12-17 Givaudan SA Computer-implemented method for olfactory property prediction
WO2025257381A1 (en) 2024-06-14 2025-12-18 Givaudan Sa Modified olfactory receptors
CN118501118B (zh) * 2024-07-16 2024-10-29 汉王科技股份有限公司 一种基于细胞的生物荧光能量共振转移检测系统及应用

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
US12269315B2 (en) 2020-08-20 2025-04-08 Denso International America, Inc. Systems and methods for measuring and managing odor brought into rental vehicles
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking

Also Published As

Publication number Publication date
JP5340430B2 (ja) 2013-11-13
EP1771582A4 (en) 2008-04-16
US20060057640A1 (en) 2006-03-16
DK2031063T3 (da) 2014-01-27
AU2005258061A1 (en) 2006-01-05
EP2031063A2 (en) 2009-03-04
AU2005258061B9 (en) 2009-12-17
CA2571080A1 (en) 2006-01-05
US7425445B2 (en) 2008-09-16
CN101087879B (zh) 2013-08-14
CN101087879A (zh) 2007-12-12
JP5022217B2 (ja) 2012-09-12
EP2031063B1 (en) 2013-11-06
AU2005258061B2 (en) 2009-07-16
US20090123997A1 (en) 2009-05-14
US20080124742A1 (en) 2008-05-29
US7691592B2 (en) 2010-04-06
EP2031063A3 (en) 2009-03-11
US20090092997A1 (en) 2009-04-09
US7838288B2 (en) 2010-11-23
AU2009227827A2 (en) 2010-03-11
PL2031063T3 (pl) 2014-04-30
US7879565B2 (en) 2011-02-01
JP2008503220A (ja) 2008-02-07
US20100222561A1 (en) 2010-09-02
JP2012105660A (ja) 2012-06-07
AU2005258061C1 (en) 2010-09-09
WO2006002161A3 (en) 2007-06-21
AU2009227827A1 (en) 2009-11-05
US20090124003A1 (en) 2009-05-14
EP1771582A2 (en) 2007-04-11
WO2006002161A2 (en) 2006-01-05

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