DK200900369A - Solid dosage form of olmesartan medoxomil and amlodipine - Google Patents
Solid dosage form of olmesartan medoxomil and amlodipine Download PDFInfo
- Publication number
- DK200900369A DK200900369A DK200900369A DKPA200900369A DK200900369A DK 200900369 A DK200900369 A DK 200900369A DK 200900369 A DK200900369 A DK 200900369A DK PA200900369 A DKPA200900369 A DK PA200900369A DK 200900369 A DK200900369 A DK 200900369A
- Authority
- DK
- Denmark
- Prior art keywords
- dosage form
- solid dosage
- form according
- less
- concentration
- Prior art date
Links
- 239000007909 solid dosage form Substances 0.000 title claims 52
- 229940043092 olmesartan medoxomil and amlodipine Drugs 0.000 title claims 6
- 235000000346 sugar Nutrition 0.000 claims 9
- 150000008163 sugars Chemical class 0.000 claims 9
- 239000012535 impurity Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 claims 7
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims 4
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 4
- 229960000528 amlodipine Drugs 0.000 claims 4
- 229960002003 hydrochlorothiazide Drugs 0.000 claims 4
- AAEQXEDPVFIFDK-UHFFFAOYSA-N 3-(4-fluorobenzoyl)-2-(2-methylpropanoyl)-n,3-diphenyloxirane-2-carboxamide Chemical compound C=1C=CC=CC=1NC(=O)C1(C(=O)C(C)C)OC1(C=1C=CC=CC=1)C(=O)C1=CC=C(F)C=C1 AAEQXEDPVFIFDK-UHFFFAOYSA-N 0.000 claims 3
- 206010020772 Hypertension Diseases 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical group OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims 1
- APZSGEHAFPIYQZ-UHFFFAOYSA-N 3-o-ethyl 5-o-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methylpyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(COCCN)N=C(C)C(C(=O)OC)=C1C1=CC=CC=C1Cl APZSGEHAFPIYQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000002051 C09CA08 - Olmesartan medoxomil Substances 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- UQGKUQLKSCSZGY-UHFFFAOYSA-N Olmesartan medoxomil Chemical compound C=1C=C(C=2C(=CC=CC=2)C2=NNN=N2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C UQGKUQLKSCSZGY-UHFFFAOYSA-N 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical class [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000007907 direct compression Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 229960003511 macrogol Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960001199 olmesartan medoxomil Drugs 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84509006P | 2006-09-15 | 2006-09-15 | |
| US84509006 | 2006-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK200900369A true DK200900369A (en) | 2009-03-16 |
Family
ID=38754721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK200900369A DK200900369A (en) | 2006-09-15 | 2009-03-16 | Solid dosage form of olmesartan medoxomil and amlodipine |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20090175942A1 (sk) |
| JP (1) | JP5344620B2 (sk) |
| AT (1) | AT509493B1 (sk) |
| AU (1) | AU2007297333B2 (sk) |
| BR (1) | BRPI0716893A2 (sk) |
| CH (1) | CH703897B1 (sk) |
| DE (1) | DE212007000063U1 (sk) |
| DK (1) | DK200900369A (sk) |
| FI (1) | FI124122B (sk) |
| GB (1) | GB2454620B (sk) |
| HK (1) | HK1127282A1 (sk) |
| IL (1) | IL197518A0 (sk) |
| IS (1) | IS8808A (sk) |
| MY (1) | MY157716A (sk) |
| NZ (1) | NZ575422A (sk) |
| PT (1) | PT2008032107W (sk) |
| RU (1) | RU2423975C2 (sk) |
| SE (1) | SE0900332L (sk) |
| SK (1) | SK288460B6 (sk) |
| TR (1) | TR200901984T1 (sk) |
| TW (1) | TWI399223B (sk) |
| WO (1) | WO2008032107A1 (sk) |
| ZA (1) | ZA200810616B (sk) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2253318B1 (en) | 2008-03-13 | 2014-08-06 | Daiichi Sankyo Company, Limited | Improvement of dissolvability of preparation containing olmesartan medoxomil |
| TW201000097A (en) * | 2008-05-30 | 2010-01-01 | Daiichi Sankyo Co Ltd | Medicament for the prophylaxis or treament of hypertension |
| US20120115837A1 (en) * | 2009-04-30 | 2012-05-10 | Takeda Pharmaceutical Company Limited | Solid Preparation |
| CA2790817A1 (en) * | 2010-02-24 | 2011-09-01 | Sanofi-Aventis Deutschland Gmbh | Solid pharmaceutical formulations of ramipril and amlodipine besylate, and their preparation |
| EP2425859A1 (en) * | 2010-08-08 | 2012-03-07 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Olmesartan formulations |
| CN102028663B (zh) * | 2010-12-14 | 2011-11-30 | 北京万生药业有限责任公司 | 一种稳定的奥美沙坦酯固体制剂 |
| JP6018420B2 (ja) * | 2012-06-05 | 2016-11-02 | ニプロ株式会社 | アンジオテンシンｉｉ受容体拮抗薬およびサイアザイド系利尿薬を含む医薬組成物 |
| CN103565807B (zh) * | 2012-07-25 | 2015-11-04 | 天津市汉康医药生物技术有限公司 | 一种奥美沙坦酯氨氯地平药物组合物 |
| KR101778050B1 (ko) * | 2012-10-12 | 2017-09-13 | 이에이 파마 가부시키가이샤 | 칼슘 길항약／안지오텐신 ｉｉ 수용체 길항약 함유 의약 제제의 제조 방법 |
| JP5871984B2 (ja) * | 2013-04-15 | 2016-03-01 | 株式会社三和化学研究所 | オルメサルタンメドキソミルを含有する医薬組成物 |
| WO2014188729A1 (ja) * | 2013-05-24 | 2014-11-27 | 持田製薬株式会社 | 経口用組成物 |
| EP2883539A1 (en) | 2013-12-12 | 2015-06-17 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of olmesartan and amlodipine |
| CN104739799B (zh) * | 2013-12-27 | 2018-01-05 | 辰欣药业股份有限公司 | 一种用于直接压片的苯磺酸氨氯地平组合物及其片剂制备方法 |
| KR102222917B1 (ko) * | 2014-06-25 | 2021-03-05 | 한림제약(주) | 암로디핀 및 올메사탄 메독소밀을 포함하는 약학 조성물 |
| CN104997778A (zh) * | 2015-07-08 | 2015-10-28 | 南京正大天晴制药有限公司 | 一种奥美沙坦酯氨氯地平药物组合物 |
| CN105902510A (zh) * | 2015-12-24 | 2016-08-31 | 嘉实（湖南）医药科技有限公司 | 一种奥美沙坦酯氨氯地平复方制剂的制备工艺 |
| CN113811294B (zh) * | 2019-02-26 | 2023-05-12 | 株式会社大熊制药 | 用于治疗或预防高血压和高脂血症的单一剂型药物组合物 |
| CN115300476B (zh) * | 2022-09-01 | 2024-04-16 | 华润双鹤药业股份有限公司 | 一种药物组合物及其制备方法 |
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-
2007
- 2007-09-14 TW TW096134347A patent/TWI399223B/zh active
- 2007-10-12 BR BRPI0716893-4A2A patent/BRPI0716893A2/pt not_active Application Discontinuation
- 2007-10-12 GB GB0903844A patent/GB2454620B/en active Active
- 2007-10-12 RU RU2009114166/15A patent/RU2423975C2/ru active
- 2007-10-12 NZ NZ575422A patent/NZ575422A/en unknown
- 2007-10-12 WO PCT/GB2007/003933 patent/WO2008032107A1/en active Application Filing
- 2007-10-12 SK SK5021-2009A patent/SK288460B6/sk unknown
- 2007-10-12 AT AT0939307A patent/AT509493B1/de active
- 2007-10-12 PT PT2007003933A patent/PT2008032107W/pt unknown
- 2007-10-12 DE DE212007000063U patent/DE212007000063U1/de not_active Ceased
- 2007-10-12 MY MYPI20091051A patent/MY157716A/en unknown
- 2007-10-12 TR TR2009/01984T patent/TR200901984T1/xx unknown
- 2007-10-12 AU AU2007297333A patent/AU2007297333B2/en active Active
- 2007-10-12 CH CH00742/08A patent/CH703897B1/de unknown
- 2007-10-12 JP JP2009527899A patent/JP5344620B2/ja active Active
- 2007-10-12 SE SE0900332A patent/SE0900332L/sv unknown
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2008
- 2008-12-15 ZA ZA200810616A patent/ZA200810616B/xx unknown
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2009
- 2009-03-10 IL IL197518A patent/IL197518A0/en unknown
- 2009-03-11 US US12/401,748 patent/US20090175942A1/en not_active Abandoned
- 2009-03-12 IS IS8808A patent/IS8808A/is unknown
- 2009-03-13 FI FI20090094A patent/FI124122B/fi active IP Right Grant
- 2009-03-16 DK DK200900369A patent/DK200900369A/en not_active Application Discontinuation
- 2009-06-03 HK HK09104986.9A patent/HK1127282A1/xx unknown
-
2015
- 2015-06-09 US US14/734,893 patent/US20160129008A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007297333A1 (en) | 2008-03-20 |
| DE212007000063U1 (de) | 2009-05-14 |
| AT509493A5 (de) | 2011-09-15 |
| FI20090094A (fi) | 2009-03-13 |
| GB2454620B (en) | 2011-08-17 |
| MY157716A (en) | 2016-07-15 |
| ZA200810616B (en) | 2009-08-26 |
| AT509493B1 (de) | 2012-01-15 |
| IL197518A0 (en) | 2009-12-24 |
| GB2454620A (en) | 2009-05-13 |
| US20160129008A1 (en) | 2016-05-12 |
| RU2009114166A (ru) | 2010-10-20 |
| US20090175942A1 (en) | 2009-07-09 |
| TW200817052A (en) | 2008-04-16 |
| HK1127282A1 (en) | 2009-09-25 |
| JP5344620B2 (ja) | 2013-11-20 |
| BRPI0716893A2 (pt) | 2014-05-06 |
| IS8808A (is) | 2009-03-12 |
| NZ575422A (en) | 2011-01-28 |
| TWI399223B (zh) | 2013-06-21 |
| PT2008032107W (pt) | 2013-07-09 |
| CH703897B1 (de) | 2012-04-13 |
| AU2007297333B2 (en) | 2010-10-28 |
| SK50212009A3 (sk) | 2009-06-05 |
| FI124122B (fi) | 2014-03-31 |
| GB0903844D0 (en) | 2009-04-22 |
| WO2008032107A1 (en) | 2008-03-20 |
| RU2423975C2 (ru) | 2011-07-20 |
| JP2011500505A (ja) | 2011-01-06 |
| SK288460B6 (sk) | 2017-03-01 |
| SE0900332L (sv) | 2009-06-12 |
| TR200901984T1 (tr) | 2009-08-21 |
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