DK195583A - Fremgangsmaade til fremstilling af benzoxazin-2-oner - Google Patents

Fremgangsmaade til fremstilling af benzoxazin-2-oner Download PDF

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Publication number
DK195583A
DK195583A DK195583A DK195583A DK195583A DK 195583 A DK195583 A DK 195583A DK 195583 A DK195583 A DK 195583A DK 195583 A DK195583 A DK 195583A DK 195583 A DK195583 A DK 195583A
Authority
DK
Denmark
Prior art keywords
group
hydrogen
benzoxazin
oner
preparing
Prior art date
Application number
DK195583A
Other languages
English (en)
Other versions
DK164860C (da
DK195583D0 (da
DK164860B (da
Inventor
Berthold Narr
Josef Nickl
Erich Mueller
Josef Roch
Walter Haarmann
Johannes-Maximili Weisenberger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK195583D0 publication Critical patent/DK195583D0/da
Publication of DK195583A publication Critical patent/DK195583A/da
Publication of DK164860B publication Critical patent/DK164860B/da
Application granted granted Critical
Publication of DK164860C publication Critical patent/DK164860C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/181,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Description

R4 er hydrogen eller akyl, R5 er hydrogen eller halogen, nitro eller alkyl, og *6 er hydrogen eller halogen eller alkyl fremstilles ved en række fremgangsmåder, der er kendte til fremstilling af analoge forbindelser.
Forbindelserne har værdifulde farmakologiske egenskaber især antithrombotiske virkninger.
DK195583A 1982-05-06 1983-05-03 Analogifremgangsmaade til fremstilling af benzoxazin-2-oner DK164860C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823217012 DE3217012A1 (de) 1982-05-06 1982-05-06 Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3217012 1982-05-06

Publications (4)

Publication Number Publication Date
DK195583D0 DK195583D0 (da) 1983-05-03
DK195583A true DK195583A (da) 1983-11-07
DK164860B DK164860B (da) 1992-08-31
DK164860C DK164860C (da) 1993-01-11

Family

ID=6162917

Family Applications (1)

Application Number Title Priority Date Filing Date
DK195583A DK164860C (da) 1982-05-06 1983-05-03 Analogifremgangsmaade til fremstilling af benzoxazin-2-oner

Country Status (25)

Country Link
US (1) US4518597A (da)
EP (1) EP0093922B1 (da)
JP (1) JPS58203979A (da)
KR (1) KR900006546B1 (da)
AT (1) ATE24501T1 (da)
AU (1) AU563453B2 (da)
CA (1) CA1204744A (da)
CS (1) CS236876B2 (da)
DD (1) DD210453A5 (da)
DE (2) DE3217012A1 (da)
DK (1) DK164860C (da)
ES (3) ES8402585A1 (da)
FI (1) FI79704C (da)
GB (1) GB2119382B (da)
GR (1) GR79255B (da)
HU (1) HU194842B (da)
IE (1) IE55481B1 (da)
IL (1) IL68573A (da)
NO (1) NO158738C (da)
NZ (1) NZ204143A (da)
PL (1) PL139119B1 (da)
PT (1) PT76627B (da)
SU (1) SU1138025A3 (da)
YU (1) YU42854B (da)
ZA (1) ZA833190B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3439281A1 (de) * 1984-10-26 1986-04-30 Bayer Ag, 5090 Leverkusen Chromogene 4,4-diaryl-2-oxo-benzo-3,1-oxazine, ihre herstellung und verwendung
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
US5519021A (en) * 1992-08-07 1996-05-21 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
US5874430A (en) 1996-10-02 1999-02-23 Dupont Pharmaceuticals Company 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
UA73119C2 (en) * 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
JP5529757B2 (ja) * 2008-01-17 2014-06-25 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 免疫調節薬としてのスルホキシミン置換キナゾリン誘導体、それらの調製及び医薬品としての使用
EP3102567B1 (en) * 2014-02-04 2019-07-17 University of Tennessee Research Foundation Inhibitors of paxillin function and related compositions and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3526621A (en) * 1966-08-03 1970-09-01 Farmaceutical Italia Soc Substituted 3,1-benzoxazin-2-one
US3542774A (en) * 1968-07-05 1970-11-24 Warner Lambert Pharmaceutical 3,4-dihydrobenzoxazinones
CH624395A5 (da) * 1976-01-08 1981-07-31 Ciba Geigy Ag
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2

Also Published As

Publication number Publication date
YU95783A (en) 1985-10-31
ES526724A0 (es) 1984-07-01
KR900006546B1 (ko) 1990-09-13
GB2119382B (en) 1985-09-18
EP0093922A3 (en) 1984-01-25
ES8406454A1 (es) 1984-07-01
YU42854B (en) 1988-12-31
ES522104A0 (es) 1984-02-01
FI831412A0 (fi) 1983-04-26
ES8402585A1 (es) 1984-02-01
NZ204143A (en) 1986-02-21
SU1138025A3 (ru) 1985-01-30
ZA833190B (en) 1985-01-30
IE55481B1 (en) 1990-09-26
ES526723A0 (es) 1984-07-01
DD210453A5 (de) 1984-06-13
NO158738B (no) 1988-07-18
PL139119B1 (en) 1986-12-31
EP0093922A2 (de) 1983-11-16
IL68573A (en) 1986-10-31
PT76627B (de) 1986-02-26
DK164860C (da) 1993-01-11
NO831599L (no) 1983-11-07
IL68573A0 (en) 1983-09-30
PT76627A (de) 1983-06-01
DK195583D0 (da) 1983-05-03
DK164860B (da) 1992-08-31
GB8312344D0 (en) 1983-06-08
GR79255B (da) 1984-10-22
FI79704B (fi) 1989-10-31
CA1204744A (en) 1986-05-20
KR840004736A (ko) 1984-10-24
AU1426583A (en) 1983-11-10
AU563453B2 (en) 1987-07-09
US4518597A (en) 1985-05-21
JPS58203979A (ja) 1983-11-28
ATE24501T1 (de) 1987-01-15
DE3217012A1 (de) 1983-11-10
FI79704C (fi) 1990-02-12
CS236876B2 (en) 1985-05-15
NO158738C (no) 1988-11-16
PL241806A1 (en) 1984-08-13
IE831032L (en) 1983-11-06
EP0093922B1 (de) 1986-12-30
ES8406453A1 (es) 1984-07-01
HU194842B (en) 1988-03-28
GB2119382A (en) 1983-11-16
FI831412L (fi) 1983-11-07
DE3368621D1 (en) 1987-02-05

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