DK1945206T3 - Indolderivater som histamin 3-receptorinhibitorer til behandling af kognitive forstyrrelser og søvnforstyrrelser, obesitas og andre CNS-forstyrrelser - Google Patents
Indolderivater som histamin 3-receptorinhibitorer til behandling af kognitive forstyrrelser og søvnforstyrrelser, obesitas og andre CNS-forstyrrelserInfo
- Publication number
- DK1945206T3 DK1945206T3 DK06826203.9T DK06826203T DK1945206T3 DK 1945206 T3 DK1945206 T3 DK 1945206T3 DK 06826203 T DK06826203 T DK 06826203T DK 1945206 T3 DK1945206 T3 DK 1945206T3
- Authority
- DK
- Denmark
- Prior art keywords
- disorders
- histamine
- cognitive
- obesity
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72679305P | 2005-10-14 | 2005-10-14 | |
PCT/US2006/040744 WO2007047775A1 (en) | 2005-10-14 | 2006-10-16 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other cns disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1945206T3 true DK1945206T3 (da) | 2013-07-29 |
Family
ID=37962842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06826203.9T DK1945206T3 (da) | 2005-10-14 | 2006-10-16 | Indolderivater som histamin 3-receptorinhibitorer til behandling af kognitive forstyrrelser og søvnforstyrrelser, obesitas og andre CNS-forstyrrelser |
Country Status (13)
Country | Link |
---|---|
US (3) | US7528262B2 (da) |
EP (1) | EP1945206B1 (da) |
JP (1) | JP5250420B2 (da) |
AR (1) | AR056690A1 (da) |
AU (1) | AU2006304584B2 (da) |
CA (1) | CA2626028C (da) |
DK (1) | DK1945206T3 (da) |
ES (1) | ES2429940T3 (da) |
HK (1) | HK1122497A1 (da) |
IL (1) | IL190783A (da) |
RU (1) | RU2423360C2 (da) |
TW (1) | TWI378097B (da) |
WO (1) | WO2007047775A1 (da) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE466007T1 (de) * | 2005-11-30 | 2010-05-15 | Hoffmann La Roche | 5-substituierte indol-2-carbonsäureamidderivate |
HUE025471T2 (hu) | 2008-04-16 | 2016-03-29 | Karobio Ab | Új ösztrogén receptor ligandumok |
GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
WO2016090094A1 (en) * | 2014-12-03 | 2016-06-09 | Wisconsin Alumni Research Foundation | Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmeceutical compositions containing them, and methods and using them |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3799943A (en) * | 1971-06-23 | 1974-03-26 | Sterling Drug Inc | 1,2-diphenylindoles |
TW229140B (da) | 1992-06-05 | 1994-09-01 | Shell Internat Res Schappej B V | |
US5399599A (en) * | 1993-04-06 | 1995-03-21 | Thiokol Corporation | Thermoplastic elastomeric internal insulation for rocket motors for low temperature applications |
EP0738713B1 (en) | 1995-04-21 | 2000-02-09 | Rhone-Poulenc Agrochimie | Process for the preparation of pesticidal 1-(chloroaryl)heterocyclic compounds |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
IL137540A0 (en) | 1998-02-25 | 2001-07-24 | Genetics Inst | Inhibitors of phospholipase a2 |
ES2325477T3 (es) * | 2000-03-31 | 2009-09-07 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indoles sustituidos por fenilo como antagonistas del receptor de histamina h3. |
ES2286114T3 (es) * | 2000-03-31 | 2007-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Imidazopiridina fenil-substituidos. |
US6353007B1 (en) * | 2000-07-13 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents |
DE60126785T2 (de) * | 2000-08-08 | 2007-10-25 | Ortho-Mcneil Pharmaceutical, Inc. | Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden |
ES2201907B1 (es) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos. |
GB0224557D0 (en) * | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
JP2006525366A (ja) | 2003-04-30 | 2006-11-09 | ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー | 複素環式カルボン酸置換基 |
DE602005009209D1 (de) * | 2004-06-18 | 2008-10-02 | Biolipox Ab | Zur behandlung von entzündungen geeignete indole |
-
2006
- 2006-10-11 AR ARP060104464A patent/AR056690A1/es unknown
- 2006-10-12 TW TW095137574A patent/TWI378097B/zh not_active IP Right Cessation
- 2006-10-16 AU AU2006304584A patent/AU2006304584B2/en not_active Ceased
- 2006-10-16 JP JP2008535801A patent/JP5250420B2/ja not_active Expired - Fee Related
- 2006-10-16 DK DK06826203.9T patent/DK1945206T3/da active
- 2006-10-16 US US11/581,631 patent/US7528262B2/en not_active Expired - Fee Related
- 2006-10-16 CA CA2626028A patent/CA2626028C/en not_active Expired - Fee Related
- 2006-10-16 RU RU2008118904/04A patent/RU2423360C2/ru not_active IP Right Cessation
- 2006-10-16 EP EP06826203.9A patent/EP1945206B1/en not_active Not-in-force
- 2006-10-16 ES ES06826203T patent/ES2429940T3/es active Active
- 2006-10-16 WO PCT/US2006/040744 patent/WO2007047775A1/en active Application Filing
-
2008
- 2008-04-10 IL IL190783A patent/IL190783A/en not_active IP Right Cessation
- 2008-09-23 US US12/284,574 patent/US7855224B2/en not_active Expired - Fee Related
-
2009
- 2009-01-14 HK HK09100386.3A patent/HK1122497A1/xx not_active IP Right Cessation
-
2010
- 2010-11-10 US US12/943,659 patent/US8129424B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2626028C (en) | 2014-06-17 |
US8129424B2 (en) | 2012-03-06 |
US7855224B2 (en) | 2010-12-21 |
RU2423360C2 (ru) | 2011-07-10 |
ES2429940T3 (es) | 2013-11-18 |
JP5250420B2 (ja) | 2013-07-31 |
WO2007047775A1 (en) | 2007-04-26 |
JP2009511605A (ja) | 2009-03-19 |
AU2006304584B2 (en) | 2011-11-24 |
HK1122497A1 (en) | 2009-05-22 |
AU2006304584A1 (en) | 2007-04-26 |
AR056690A1 (es) | 2007-10-17 |
CA2626028A1 (en) | 2007-04-26 |
IL190783A0 (en) | 2008-11-03 |
TW200745091A (en) | 2007-12-16 |
TWI378097B (en) | 2012-12-01 |
EP1945206B1 (en) | 2013-04-24 |
EP1945206A1 (en) | 2008-07-23 |
US20070161676A1 (en) | 2007-07-12 |
IL190783A (en) | 2014-07-31 |
US20090036446A1 (en) | 2009-02-05 |
EP1945206A4 (en) | 2011-05-04 |
US7528262B2 (en) | 2009-05-05 |
US20110059966A1 (en) | 2011-03-10 |
RU2008118904A (ru) | 2009-11-20 |
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