DK1934207T3 - Substituerede 4-phenylpiperidiner til anvendelse som renininhibitorer - Google Patents

Substituerede 4-phenylpiperidiner til anvendelse som renininhibitorer

Info

Publication number
DK1934207T3
DK1934207T3 DK07820887T DK07820887T DK1934207T3 DK 1934207 T3 DK1934207 T3 DK 1934207T3 DK 07820887 T DK07820887 T DK 07820887T DK 07820887 T DK07820887 T DK 07820887T DK 1934207 T3 DK1934207 T3 DK 1934207T3
Authority
DK
Denmark
Prior art keywords
phenylpiperidines
substituted
renin inhibitors
renin
inhibitors
Prior art date
Application number
DK07820887T
Other languages
Danish (da)
English (en)
Inventor
Peter Herold
Robert Mah
Stefan Stutz
Vincenzo Tschinke
Aleksandar Stojanovic
Dirk Behnke
Nathalie Jotterand
Stjepan Jelakovic
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK1934207T3 publication Critical patent/DK1934207T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK07820887T 2006-10-04 2007-10-03 Substituerede 4-phenylpiperidiner til anvendelse som renininhibitorer DK1934207T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06121772A EP1911758A1 (en) 2006-10-04 2006-10-04 Phenyl piperidine derivatives for use as renin inhibitors
PCT/EP2007/060510 WO2008040764A1 (en) 2006-10-04 2007-10-03 Substituted 4-phenyl piperidines for use as renin inhibitors

Publications (1)

Publication Number Publication Date
DK1934207T3 true DK1934207T3 (da) 2009-06-02

Family

ID=37946086

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07820887T DK1934207T3 (da) 2006-10-04 2007-10-03 Substituerede 4-phenylpiperidiner til anvendelse som renininhibitorer

Country Status (18)

Country Link
US (1) US7625893B2 (pt)
EP (2) EP1911758A1 (pt)
JP (1) JP2009532443A (pt)
CN (1) CN101415703B (pt)
AR (1) AR063124A1 (pt)
AT (1) ATE425159T1 (pt)
BR (1) BRPI0716114A2 (pt)
CA (1) CA2642455A1 (pt)
DE (1) DE602007000679D1 (pt)
DK (1) DK1934207T3 (pt)
ES (1) ES2322629T3 (pt)
HK (1) HK1119678A1 (pt)
IL (1) IL193476A0 (pt)
PL (1) PL1934207T3 (pt)
PT (1) PT1934207E (pt)
SI (1) SI1934207T1 (pt)
TW (1) TW200831499A (pt)
WO (1) WO2008040764A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1863763A1 (en) * 2005-03-31 2007-12-12 Speedel Experimenta AG 3,4,5-substituted piperidines as renin inhibitors
TW200932241A (en) * 2007-12-05 2009-08-01 Speedel Experimenta Ag Organic compounds
TWI434690B (zh) 2007-12-19 2014-04-21 Dainippon Sumitomo Pharma Co 雜雙環衍生物
CN101970431A (zh) * 2008-04-02 2011-02-09 诺瓦提斯公司 用作治疗化合物的取代哌啶
WO2010150840A1 (ja) 2009-06-24 2010-12-29 大日本住友製薬株式会社 Ｎ－置換－環状アミノ誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2031745A1 (en) * 1989-12-08 1991-06-09 William J. Greenlee Cyclic renin inhibitors containing 2-substituted(3s, 4s)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3s, 4s)-5-cyclohexyl-3,4-dihydroxy-pentanoic acid or 2 -substituted (4s, 5s)-5-amino-6- yclohexyl-4-hydroxyhexanoic acid or its analogs
US5194605A (en) * 1989-12-08 1993-03-16 Merck & Co., Inc. Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
US20040204455A1 (en) * 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
AR053406A1 (es) * 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas

Also Published As

Publication number Publication date
HK1119678A1 (en) 2009-03-13
US20090088426A1 (en) 2009-04-02
EP1934207B1 (en) 2009-03-11
ATE425159T1 (de) 2009-03-15
CN101415703A (zh) 2009-04-22
BRPI0716114A2 (pt) 2013-09-24
EP1934207A1 (en) 2008-06-25
PT1934207E (pt) 2009-05-21
IL193476A0 (en) 2009-05-04
TW200831499A (en) 2008-08-01
CA2642455A1 (en) 2008-04-10
AR063124A1 (es) 2008-12-30
PL1934207T3 (pl) 2009-10-30
WO2008040764A1 (en) 2008-04-10
SI1934207T1 (sl) 2009-08-31
US7625893B2 (en) 2009-12-01
CN101415703B (zh) 2012-04-25
JP2009532443A (ja) 2009-09-10
DE602007000679D1 (de) 2009-04-23
EP1911758A1 (en) 2008-04-16
ES2322629T3 (es) 2009-06-23

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