DK1920248T3 - Clostridialt-toksin-aktivitetsassays - Google Patents
Clostridialt-toksin-aktivitetsassaysInfo
- Publication number
- DK1920248T3 DK1920248T3 DK06851224.3T DK06851224T DK1920248T3 DK 1920248 T3 DK1920248 T3 DK 1920248T3 DK 06851224 T DK06851224 T DK 06851224T DK 1920248 T3 DK1920248 T3 DK 1920248T3
- Authority
- DK
- Denmark
- Prior art keywords
- clostridial toxin
- toxin activity
- activity assays
- cleavage site
- fluorescent member
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Optical Filters (AREA)
- Led Devices (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66890905P | 2005-04-05 | 2005-04-05 | |
PCT/US2006/012825 WO2008036060A2 (en) | 2005-04-05 | 2006-04-04 | Clostridial toxin activity assays |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1920248T3 true DK1920248T3 (da) | 2010-12-13 |
Family
ID=38829390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06851224.3T DK1920248T3 (da) | 2005-04-05 | 2006-04-04 | Clostridialt-toksin-aktivitetsassays |
Country Status (9)
Country | Link |
---|---|
US (1) | US8067231B2 (da) |
EP (2) | EP2264458A1 (da) |
AT (1) | ATE483158T1 (da) |
AU (1) | AU2006340711C1 (da) |
CA (1) | CA2605160A1 (da) |
DE (1) | DE602006017237D1 (da) |
DK (1) | DK1920248T3 (da) |
ES (1) | ES2351942T3 (da) |
WO (1) | WO2008036060A2 (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7332567B2 (en) * | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
AU2003304419A1 (en) * | 2002-10-31 | 2005-03-07 | Wisconsin Alumni Research Foundation | Botulinum neurotoxin b receptors and use thereof |
KR101609894B1 (ko) | 2008-03-14 | 2016-04-08 | 알러간, 인코포레이티드 | 면역-기반 보툴리눔 독소 세로타입 a 활성 검정 |
KR101604515B1 (ko) * | 2008-03-14 | 2016-03-17 | 알러간, 인코포레이티드 | 면역-기반 보툴리눔 독소 세로타입 a 활성 검정 |
WO2010014608A1 (en) * | 2008-07-28 | 2010-02-04 | University Of Louisville Research Foundation, Inc. | Methods and compositions for inhibition of neutrophil exocytosis |
ES2689703T3 (es) | 2009-03-13 | 2018-11-15 | Allergan, Inc. | Células útiles para ensayos de actividad de serotipo A de toxina botulínica basados en la respuesta inmunológica |
US10908146B2 (en) | 2011-06-01 | 2021-02-02 | Biomadison, Inc. | Compositions and methods for improving sensitivity in cell based assays |
US9303285B2 (en) | 2012-01-04 | 2016-04-05 | Biomadison, Inc. | Methods and compounds for increasing sensitivity of botulinum assays |
US11325954B2 (en) | 2011-06-01 | 2022-05-10 | Biomadison, Inc. | Compositions and methods for stability testing of botulinum toxin |
CN107475293A (zh) | 2011-06-01 | 2017-12-15 | 拜奥麦迪逊公司 | 非‑fret肉毒梭菌测定法 |
CA2857998C (en) * | 2011-12-09 | 2021-01-19 | Institut Pasteur | Multiplex immuno screening assay |
EP3279335B1 (en) | 2011-12-31 | 2021-03-10 | Allergan, Inc. | Highly sensitive cell-based assay to detect the presence of active botulinum neurotoxin serotype-a |
KR102059091B1 (ko) | 2012-01-04 | 2019-12-24 | 바이오메디슨, 인코퍼레이티드 | 보툴리눔 분석 감도를 증진시키기 위한 방법 및 화합물 |
BR112015022176A8 (pt) | 2013-03-13 | 2019-11-26 | Tahoe Institute For Rural Health Res Llc | monitor de contagem de glóbulos sanguíneos portátil |
JP6636919B2 (ja) * | 2013-10-25 | 2020-01-29 | バイオマジソン・インコーポレイテッドBiomadison, Inc. | 二重蛍光体を用いた酵素アッセイ |
US10408837B2 (en) | 2013-12-09 | 2019-09-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Peptide substrates recognizable by type E botulinum neurotoxin |
CN105535975B (zh) * | 2015-12-21 | 2018-05-18 | 中国人民解放军第二军医大学 | 囊泡相关膜蛋白1在防治肠道病毒71型感染中的应用 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
AU2018389121A1 (en) | 2017-12-20 | 2020-07-30 | Allergan, Inc. | Botulinum toxin cell binding domain polypeptides and methods of use for treatments of fibrosis associated disorders |
CN116693638B (zh) * | 2023-05-15 | 2024-03-08 | 西北农林科技大学 | Pg1-lc蛋白作为snap-25的水解酶的应用 |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652122A (en) | 1989-12-21 | 1997-07-29 | Frankel; Alan | Nucleic acids encoding and methods of making tat-derived transport polypeptides |
US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
ATE220421T1 (de) | 1990-02-26 | 2002-07-15 | Univ Leland Stanford Junior | Identifizierung und expression von insekten- steroidrezeptor-dns-sequenzen |
DE69334150T2 (de) | 1992-05-14 | 2008-03-13 | Baylor College Of Medicine, Houston | Mutierte steroidhormonrezeptoren, methoden für ihre benutzung und molekularer schalter für gentherapie |
US5364791A (en) | 1992-05-14 | 1994-11-15 | Elisabetta Vegeto | Progesterone receptor having C. terminal hormone binding domain truncations |
ES2341140T3 (es) | 1993-06-10 | 2010-06-15 | Allergan, Inc. | Tratamiento de trastornos y afecciones neuromusculares con un seropositivo botulinico diferente. |
ES2194025T3 (es) | 1993-06-10 | 2003-11-16 | Allergan Inc | Toxinas botulinicas multiples para tratar trastornos y enfermedades neuromusculares. |
US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
US6974578B1 (en) | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
US5962637A (en) | 1994-06-03 | 1999-10-05 | Microbiological Research Authority | Toxin assay |
US6495518B1 (en) | 1994-06-13 | 2002-12-17 | Vanderbilt University | Method for importing biologically active molecules into cells |
US5807746A (en) | 1994-06-13 | 1998-09-15 | Vanderbilt University | Method for importing biologically active molecules into cells |
US5795737A (en) | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
US5625048A (en) | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
JPH11510386A (ja) | 1995-07-28 | 1999-09-14 | マリー キュリー キャンサー ケア | 輸送蛋白質およびそれらの使用 |
FR2739621B1 (fr) | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
US5804387A (en) | 1996-02-01 | 1998-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | FACS-optimized mutants of the green fluorescent protein (GFP) |
US6072041A (en) | 1996-06-03 | 2000-06-06 | Case Western Reserve University | Fusion proteins for protein delivery |
US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
US5965699A (en) * | 1996-11-06 | 1999-10-12 | The United States Of America As Represented By The Secretary Of The Army | Assay for the proteolytic activity of serotype a from clostridium botulinum |
US6017735A (en) | 1997-01-23 | 2000-01-25 | Marie Curie Cancer Care | Materials and methods for intracellular transport and their uses |
IL132941A0 (en) | 1997-05-21 | 2001-03-19 | Univ Leland Stanford Junior | Composition and method for enhancing transport across biological membranes |
US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
JP2002512808A (ja) | 1998-04-28 | 2002-05-08 | ワシントン ユニバーシティー | 融合タンパク質の形質導入法 |
US7090976B2 (en) * | 1999-11-10 | 2006-08-15 | Rigel Pharmaceuticals, Inc. | Methods and compositions comprising Renilla GFP |
US6140132A (en) | 1998-06-09 | 2000-10-31 | The Regents Of The University Of California | Fluorescent protein sensors for measuring the pH of a biological sample |
CA2354044A1 (en) | 1998-12-10 | 2000-06-15 | Washington University | Protein transduction system and methods of use thereof |
EP1157275A4 (en) | 1999-02-28 | 2003-01-15 | Univ Washington | NEW TRANSDUCTION MOLECULES AND METHOD FOR USING THE SAME |
US6767544B2 (en) | 2002-04-01 | 2004-07-27 | Allergan, Inc. | Methods for treating cardiovascular diseases with botulinum toxin |
GB9930519D0 (en) | 1999-12-24 | 2000-02-16 | Phogen Limited | Uses of transport proteins |
US6464986B1 (en) | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
FR2809733B1 (fr) | 2000-06-02 | 2004-04-30 | Inst Nat Sante Rech Med | Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants |
US20040219619A1 (en) | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
US6841535B2 (en) | 2000-07-31 | 2005-01-11 | Active Motif | Peptide-mediated transfection agents and methods of use |
DE60131468D1 (de) | 2000-09-25 | 2007-12-27 | U S Medical Res Inst Of Infect | Hoch-durchsatz assays für proteolytische aktivitäten von clostridium neurotoxinen |
US6423319B1 (en) | 2000-10-04 | 2002-07-23 | Allergan Sales, Inc. | Methods for treating muscle injuries |
US7349691B2 (en) | 2001-07-03 | 2008-03-25 | Microsoft Corporation | System and apparatus for performing broadcast and localcast communications |
US7208285B2 (en) | 2001-08-28 | 2007-04-24 | Allergan, Inc. | Fret protease assays for botulinum serotype A/E toxins |
US7332567B2 (en) | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
US7374896B2 (en) * | 2001-08-28 | 2008-05-20 | Allergan, Inc. | GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity |
US20060063221A1 (en) * | 2004-09-21 | 2006-03-23 | Williams Dudley J | Lanthanide-based substrates and methods for determining clostridial toxin activity |
JP4423851B2 (ja) | 2002-02-28 | 2010-03-03 | 日本精工株式会社 | 直動案内装置の製造方法 |
US6921538B2 (en) | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
WO2004033355A1 (de) * | 2002-09-13 | 2004-04-22 | Otis Elevator Company | Sicherheitsüberwachung für personenbeförderer |
US7183066B2 (en) | 2002-09-27 | 2007-02-27 | Allergan, Inc. | Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins |
AU2003272800A1 (en) * | 2002-10-01 | 2004-04-23 | University Of Maryland | Methods for identifying inhibitors of botulinum neurotoxins |
US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
EP1751284A4 (en) * | 2003-12-19 | 2010-01-13 | Wisconsin Alumni Res Found | METHOD AND COMPOSITIONS FOR DETECTING BOTULINUM NEUROTOXINE |
CA2565678C (fr) | 2004-05-05 | 2013-07-09 | Pharmaleads | Substrats peptidiques reconnus par la toxine botulique de type a, bont/a et leurs utilisations |
US7399607B2 (en) | 2004-09-22 | 2008-07-15 | Allergan, Inc. | Fluorescence polarization assays for determining clostridial toxin activity |
-
2006
- 2006-04-04 WO PCT/US2006/012825 patent/WO2008036060A2/en active Application Filing
- 2006-04-04 DK DK06851224.3T patent/DK1920248T3/da active
- 2006-04-04 ES ES06851224T patent/ES2351942T3/es active Active
- 2006-04-04 EP EP10167481A patent/EP2264458A1/en not_active Withdrawn
- 2006-04-04 US US11/908,451 patent/US8067231B2/en active Active
- 2006-04-04 EP EP06851224A patent/EP1920248B1/en not_active Revoked
- 2006-04-04 DE DE602006017237T patent/DE602006017237D1/de active Active
- 2006-04-04 CA CA002605160A patent/CA2605160A1/en not_active Abandoned
- 2006-04-04 AT AT06851224T patent/ATE483158T1/de not_active IP Right Cessation
- 2006-04-04 AU AU2006340711A patent/AU2006340711C1/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US20090191583A1 (en) | 2009-07-30 |
WO2008036060A2 (en) | 2008-03-27 |
EP1920248B1 (en) | 2010-09-29 |
US8067231B2 (en) | 2011-11-29 |
EP2264458A1 (en) | 2010-12-22 |
AU2006340711B2 (en) | 2012-02-23 |
WO2008036060A3 (en) | 2008-09-12 |
CA2605160A1 (en) | 2006-10-05 |
AU2006340711C1 (en) | 2013-02-07 |
EP1920248A2 (en) | 2008-05-14 |
AU2006340711A8 (en) | 2008-08-07 |
AU2006340711A1 (en) | 2007-11-15 |
ATE483158T1 (de) | 2010-10-15 |
ES2351942T3 (es) | 2011-02-14 |
DE602006017237D1 (en) | 2010-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1920248T3 (da) | Clostridialt-toksin-aktivitetsassays | |
DE602006014812D1 (de) | Lostridientoxinaktivität | |
EP1903478A3 (en) | Methods and systems for defining, identifying and learning geometric features | |
BRPI0510674A (pt) | variantes fc otimizadas | |
ITRM20040447A1 (it) | Sistema di fornitura di seminari interattivi, e relativo metodo. | |
BRPI0812878B8 (pt) | anticorpo isolado ou parte funcional do mesmo, vetor, método para produzir um anticorpo ou uma parte funcional do mesmo, para produzir uma célula produtora de anticorpo e para produzir um anticorpo capaz de se ligar especificamente a rsv, composição, e, uso de um anticorpo ou parte funcional do mesmo ou de uma composição ou de vetor | |
ATE462783T1 (de) | Variante foki-spaltungshälften-domänen | |
WO2006135904A3 (en) | Method for producing improved results for applications which directly or indirectly utilize gene expression assay results | |
NO20044051L (no) | Analyse for ACTRIIB-kinase aktivitet | |
EA200702193A1 (ru) | Гликозилирование белков | |
CY1113816T1 (el) | Μορια ταυτοποιησης τα οποια ρυθμιζουν τις αλληλεπιδρασεις πρωτεϊνης-πρωτεϊνης με τη χρηση ανταποκριτων που ενεργοποιουνται με μια πρωτεαση | |
NO20064715L (no) | Deteksjon, isolering og anvendelse av renalase (monoamin aksidase C) | |
WO2006107611A3 (en) | Detection of an immune response to gdf-8 modulating agents | |
WO2007094752A3 (en) | Biobriefcase | |
ATE460487T1 (de) | Screening-test für ribosomale antibiotika | |
WO2005103229A3 (en) | Transgenomic mitochondria, transmitochondrial cells and organisms, and methods of making and using | |
WO2006074464A3 (en) | Modulating toll-like receptor activity | |
NO20052553D0 (no) | Cobalaminanalyse. | |
WO2005094441A3 (en) | Split enzyme linked immunosorbent and nucleic acid assays | |
WO2006091672A3 (en) | Novel assays utilizing nicotinic acetylcholine receptor subunits | |
WO2008143702A3 (en) | Anti-mrp3 antibodies and methods of use | |
NO20090326L (no) | DNA fragmenteringsanalyse | |
DK1838851T3 (da) | Fremgangsmåde til polypeptidmutagenese | |
WO2007126415A3 (en) | Novel compositions and methods for promoting, inhibiting, and detecting protein entry into cells | |
WO2008149088A8 (en) | Melanoma assay and antigens |