FR2809733B1 - Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants - Google Patents

Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants

Info

Publication number
FR2809733B1
FR2809733B1 FR0007113A FR0007113A FR2809733B1 FR 2809733 B1 FR2809733 B1 FR 2809733B1 FR 0007113 A FR0007113 A FR 0007113A FR 0007113 A FR0007113 A FR 0007113A FR 2809733 B1 FR2809733 B1 FR 2809733B1
Authority
FR
France
Prior art keywords
toxin
bont
detecting
determining
peptide substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0007113A
Other languages
English (en)
Other versions
FR2809733A1 (fr
Inventor
Bernard Pierre Roques
Christine Anne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to FR0007113A priority Critical patent/FR2809733B1/fr
Priority to JP2002500923A priority patent/JP2003535103A/ja
Priority to EP01940658A priority patent/EP1290020A1/fr
Priority to PCT/FR2001/001698 priority patent/WO2001092312A1/fr
Priority to CA002409964A priority patent/CA2409964A1/fr
Priority to US10/296,396 priority patent/US7160982B2/en
Publication of FR2809733A1 publication Critical patent/FR2809733A1/fr
Application granted granted Critical
Publication of FR2809733B1 publication Critical patent/FR2809733B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
FR0007113A 2000-06-02 2000-06-02 Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants Expired - Lifetime FR2809733B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0007113A FR2809733B1 (fr) 2000-06-02 2000-06-02 Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants
JP2002500923A JP2003535103A (ja) 2000-06-02 2001-05-31 ＢｏＮＴ／Ｂ型のボツリヌス毒素により認識されるペプチド基質並びに前記毒素もしくは対応の阻害物質をアッセイ及び／もしくは検出する為のそれらの利用
EP01940658A EP1290020A1 (fr) 2000-06-02 2001-05-31 Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants
PCT/FR2001/001698 WO2001092312A1 (fr) 2000-06-02 2001-05-31 SUBSTRAT PEPTIDIQUE RECONNU PAR LA TOXINE BOTULIQUE DE TYPE BoNT/B ET SON UTILISATION POUR DOSER ET/OU DETECTER LADITE TOXINE OU DES INHIBITEURS CORRESPONDANTS
CA002409964A CA2409964A1 (fr) 2000-06-02 2001-05-31 Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants
US10/296,396 US7160982B2 (en) 2000-06-02 2001-05-31 Peptide substrate identified by type BoNT/B botulinus toxin and use thereof for assaying and/or detecting said toxin or corresponding inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0007113A FR2809733B1 (fr) 2000-06-02 2000-06-02 Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants

Publications (2)

Publication Number Publication Date
FR2809733A1 FR2809733A1 (fr) 2001-12-07
FR2809733B1 true FR2809733B1 (fr) 2004-04-30

Family

ID=8850925

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0007113A Expired - Lifetime FR2809733B1 (fr) 2000-06-02 2000-06-02 Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants

Country Status (6)

Country Link
US (1) US7160982B2 (fr)
EP (1) EP1290020A1 (fr)
JP (1) JP2003535103A (fr)
CA (1) CA2409964A1 (fr)
FR (1) FR2809733B1 (fr)
WO (1) WO2001092312A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762280B2 (en) 2000-09-25 2004-07-13 The United States Of America As Represented By The Secretary Of The Army High throughput assays for the proteotytic activities of clostridial neurotoxins
US7183066B2 (en) * 2002-09-27 2007-02-27 Allergan, Inc. Cell-based fluorescence resonance energy transfer (FRET) assays for clostridial toxins
FR2869908B1 (fr) * 2004-05-05 2006-07-28 Pharmaleads Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite
CA2565678C (fr) * 2004-05-05 2013-07-09 Pharmaleads Substrats peptidiques reconnus par la toxine botulique de type a, bont/a et leurs utilisations
AU2006231470B2 (en) 2005-04-05 2011-12-01 Allergan, Inc. Lipophilic dye-based FRET assays for Clostridial toxin activity
AU2006340711C1 (en) * 2005-04-05 2013-02-07 Allergan, Inc. Clostridial toxin activity assays
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
JP4864064B2 (ja) 2008-10-30 2012-01-25 エムジーファーマ株式会社 抗糖尿病作用を有するペプチドおよびその用途
WO2015088477A1 (fr) * 2013-12-09 2015-06-18 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Substrats peptidiques identifiables par la neurotoxine botulique de type e
EP3312290A1 (fr) 2016-10-18 2018-04-25 Ipsen Biopharm Limited Dosage de clivage d'empeigne cellulaire

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
GB9411138D0 (en) * 1994-06-03 1994-07-27 Microbiological Res Authority Toxin assay
US5962637A (en) * 1994-06-03 1999-10-05 Microbiological Research Authority Toxin assay
US7332567B2 (en) * 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins

Also Published As

Publication number Publication date
CA2409964A1 (fr) 2001-12-06
EP1290020A1 (fr) 2003-03-12
FR2809733A1 (fr) 2001-12-07
US20040126810A1 (en) 2004-07-01
US7160982B2 (en) 2007-01-09
JP2003535103A (ja) 2003-11-25
WO2001092312A1 (fr) 2001-12-06

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