DK1892245T3 - Antineoplastiske forbindelser og farmaceutiske sammensætninger deraf - Google Patents

Antineoplastiske forbindelser og farmaceutiske sammensætninger deraf Download PDF

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DK1892245T3
DK1892245T3 DK06753157.4T DK06753157T DK1892245T3 DK 1892245 T3 DK1892245 T3 DK 1892245T3 DK 06753157 T DK06753157 T DK 06753157T DK 1892245 T3 DK1892245 T3 DK 1892245T3
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urea
chloroethyl
amino
dioxoimidazolidin
semicarbazone
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DK06753157.4T
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Fernandez Rolando Eduardo Rodriguez
Alvarez Roberto Vera
La Nuez Veulens Ania De
Reyes Yuliet Mazola
Rodríguez Silvio Ernesto Perea
Lasa Alexis Musacchio
Gómez Raimundo Ubieta
Castro Boris Ernesto Acevedo
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Ct Ingenieria Genetica Biotech
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    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
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    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
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    • C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
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Claims (3)

1. Kemisk forbindelse, der blokerer den kaseinkinase 2 (CK2)-medierede phosphorylering, til anvendelse som et medikament, hvor forbindelsen er udvalgt fra (lZ)-3,5,5-trimethylcyclohex-2-en-l-on-semicarbazon, ,V-(4-amino-2,6-dihydroxypyrimidin-5-yl)-V'-isopropylthiourea, V-butyl-V’-(2- furylmethyl)urea, 3-({[2-carboxyethyl)amino]carbonyl}amino)propansyre, 1 -(2- chlorethyl)-3-(cyanmethyl)urea, (2E)-1 - (1 H-indol-3-yl)acetone-thiosemicarbazon, (\E,AE)-\-phenylhex-4-en-1 -on-semicarbazon, l-(2,5-dioxoimidazolidin-4-yl)-3- (hydroxymethyl)urea, l-ter?-butyT3-(2-chlorcthyl)urca, l-(2-chlorethyl)- 3-(l-methyl- 1 -phenylethyl)urea, l-(2-chlorethyl)-3-[l, 1 -dimethyl-2-(methylsulfonyl)ethyl]urea, (IE, 1 £')-2,2’-(2,4-dioxopyrimidin-1,3(2/7,4//)-diyl)diacctaldchyd-dithiosemicarbazon og l-(2,5-dioxoimidazolidin- 4-yl)-iV-[3-(trifluormethyl)phenyl]methansulfonamid.
2. Farmaceutisk sammensætning til anvendelse i en fremgangsmåde til behandling af cancer, der omfatter en kemisk forbindelse, der blokerer den kaseinkinase 2 (CK2)-medierede phosphorylering udvalgt fra (lZ)-3,5,5-trimethylcyclohex-2-en-l-on-semicarbazon, V-(4-amino-2,6-dihydroxypyrimidin-5-yl)-iV’-isopropylthiourea, jV-butyl-V-(2- furylmethyl)urea, 3-({[2-carboxyethyl)amino]carbonyl}amino)propansyre, 1 -(2- chlorethyl)-3-(cyanmethyl)urea, (2E)-\-( 1 H-indol-3-yl)acetone-thiosemicarbazon, (IE,4E)-l-phenylhex-4-en-l-on-semicarbazon, 1-(2,5- dioxoimidazolidin-4-yl)-3- (hydroxymethyl)urea, l-tert-butyl-3-(2-chlorethyl)urea, l-(2-chlorethyl)-3-(l - methyl-1 -phenylethyl)urea, 1 -(2-chlorethyl)-3-[l, 1 -dimethyl-2- (methylsulfonyl)ethyl]urea, (2Z)-l-phenoxyacetone-thiosemicarbazon, (\E,\E)-2,2'-(2,4-dioxopyrimidin-l ,3(2//, 4//)-diyl)diacctaldehyd-dithioscmicarbazon og l-(2,5-dioxoimidazolidin-4-yl)- 7V-[3-(trifluormethyl)phenyl]methansulfonamid, og/eller et farmaceutisk acceptabelt salt deraf med andre farmaceutisk tilladte excipienser eller additiver.
3. Kemisk forbindelse, der blokerer den kaseinkinase 2 (CK2)-medierede phosphorylering, udvalgt fra (lZ)-3,5,5-trimethylcyclohex-2-en-l-on-semicarbazon, /V-(4-amino-2,6- dihydroxypyrimidin-5-yl)-V’-isopropylthiourea, /V-butyl-/V’-(2-furylmcthyl)urca, 3- ({[2-carboxyethyl)amino] carbonyl} amino)propansyre, 1 -(2-chlorethyl)-3 - (cyanmethyl)urea, (2E)-1 -(1 H-indol-3-yl)acetone-thiosemicarbazon, (\E,4E)-\- phcnylhcx-4-en-1 -on-semicarbazon, l-(2,5-dioxoimidazolidin-4-yl)-3- (hydroxymethyl)urea, l-tert-butyl-3-(2-chlorethyl)urea, 1 -(2-chlorethyl)-3- (1 -methyl-l-phenylethyl)urea, 1 -(2-chlorethyl)-3 -[ 1,1 -dimethyl-2- (methylsulfonyl) ethyl] urea, (2Z)-1 -phenoxyacetone-thiosemicarbazon, (\E,\E')-2,2'-(2,4-dioxopyrimidin-l ,3(2//,4//)-diyl)diacetaldehyd-dithiosemicarbazon og 1 -(2,5- dioxoimidazolidin-4-yl)-jV-[3-(trifluormethyl)phenyl]methansulfonamid, til anvendelse i en fremgangsmåde til behandling af cancer.
DK06753157.4T 2005-05-12 2006-05-05 Antineoplastiske forbindelser og farmaceutiske sammensætninger deraf DK1892245T3 (da)

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