DK1824980T3 - Rhamnosepromotor-ekspressionssystem - Google Patents

Rhamnosepromotor-ekspressionssystem

Info

Publication number
DK1824980T3
DK1824980T3 DK05815428.7T DK05815428T DK1824980T3 DK 1824980 T3 DK1824980 T3 DK 1824980T3 DK 05815428 T DK05815428 T DK 05815428T DK 1824980 T3 DK1824980 T3 DK 1824980T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
acid sequence
promoter region
pseudomonas
host
Prior art date
Application number
DK05815428.7T
Other languages
English (en)
Inventor
Johann Brass
Christoph Kiziak
Joachim Klein
Ralf Ostendorp
Armin Weidmann
Original Assignee
Lonza Ag
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag, Morphosys Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of DK1824980T3 publication Critical patent/DK1824980T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/78Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK05815428.7T 2004-12-07 2005-12-05 Rhamnosepromotor-ekspressionssystem DK1824980T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04028917 2004-12-07
PCT/EP2005/013013 WO2006061174A2 (en) 2004-12-07 2005-12-05 Rhamnose promoter expression system

Publications (1)

Publication Number Publication Date
DK1824980T3 true DK1824980T3 (da) 2010-08-16

Family

ID=36304177

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05815428.7T DK1824980T3 (da) 2004-12-07 2005-12-05 Rhamnosepromotor-ekspressionssystem

Country Status (14)

Country Link
US (3) US20080206817A1 (da)
EP (2) EP2123761A3 (da)
JP (1) JP5069124B2 (da)
CN (1) CN101090969B (da)
AT (1) ATE466090T1 (da)
AU (1) AU2005313531B2 (da)
CA (1) CA2589937C (da)
DE (1) DE602005020972D1 (da)
DK (1) DK1824980T3 (da)
ES (1) ES2346894T3 (da)
HK (1) HK1115156A1 (da)
IL (1) IL183608A (da)
SG (1) SG149071A1 (da)
WO (1) WO2006061174A2 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE555128T1 (de) * 2006-11-30 2012-05-15 Res Dev Foundation Verbesserte immunglobulin-bibliotheken
EP2150616A4 (en) 2007-05-10 2011-07-27 Univ Arizona REGULATED ANTIGEN SYNTHESIS AND / OR REGULATED ATTENUATION FOR IMPROVING VACCINATE IMMUNOGENICITY AND / OR SAFETY
ATE544860T1 (de) 2008-02-29 2012-02-15 Xbrane Bioscience Aktiebolag Expressionssystem für proteine
CN102978219B (zh) * 2012-11-09 2015-05-13 汕头大学 一种弧菌交叉保护性抗原及其制备方法和应用
US9911245B1 (en) * 2013-07-19 2018-03-06 Geotoll, Inc. Method and apparatus for using a vehicle license tag number for toll payment as a backup form of account authorization
CN106676125B (zh) * 2015-11-05 2020-08-14 中国科学院天津工业生物技术研究所 一种包含麦芽糖启动子的载体以及麦芽糖启动子突变体
CN109219662A (zh) 2016-03-02 2019-01-15 龙沙有限公司 改进的发酵工艺
EP3444269A1 (en) 2017-08-17 2019-02-20 National Research Council of Canada Systems and methods for the production of diphtheria toxin polypeptides
CN115698300A (zh) 2020-03-26 2023-02-03 阿斯克肋匹奥生物制药公司 佛司可林诱导型启动子和低氧诱导型启动子
WO2021209743A1 (en) 2020-04-15 2021-10-21 Synpromics Limited Forskolin-inducible promoters and hypoxia-inducible promoters
US20220031771A1 (en) * 2020-07-31 2022-02-03 Iowa State University Research Foundation, Inc. Microencapsulated and chromosome integrated compositions for l-dopa microbiome therapy
EP3981879A1 (en) * 2020-10-09 2022-04-13 Stada Arzneimittel Ag Method of producing a recombinant protein in a host cell which has a disabled rhamnose metabolism as well as expression vectors, host cells and recombinant proteins thereof
EP4405473A1 (en) * 2021-09-24 2024-07-31 Xbrane Biopharma AB Dna constructs and host cells for expressing recombinant protein

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3689598T2 (de) 1985-01-28 1994-06-30 Xoma Corp Arab-promoter und verfahren zur herstellung von polypeptiden einschliesslich cecropinen mittels mikrobiologischer verfahren.
ATE140731T1 (de) * 1988-01-11 1996-08-15 Xoma Corp Plasmidvektor mit pectatlyase-signalsequenz
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5240831A (en) * 1991-01-10 1993-08-31 Board Of Regents, The University Of Texas Methods and compositions for the expression of biologically active eukaryotic cytochrome p45os in bacteria
US5435128A (en) * 1993-11-15 1995-07-25 Thiokol Corporation Pyrotechnically driven nozzle restrictor
JP2000516452A (ja) 1996-07-16 2000-12-12 プリュックテュン,アンドレアス 可溶性が増大した免疫グロブリンスーパーファミリードメインおよびフラグメント
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
CN100445391C (zh) * 2002-12-02 2008-12-24 巴斯福股份公司 L-鼠李糖-诱导型表达系统
CA2513025A1 (en) * 2003-01-09 2004-07-29 Macrogenics, Inc. Dual expression vector system for antibody expression in bacterial and mammalian cells

Also Published As

Publication number Publication date
AU2005313531A1 (en) 2006-06-15
US20120135463A1 (en) 2012-05-31
CN101090969B (zh) 2013-01-16
ES2346894T3 (es) 2010-10-21
JP2008522599A (ja) 2008-07-03
EP1824980A2 (en) 2007-08-29
WO2006061174A3 (en) 2007-01-18
US20170107525A1 (en) 2017-04-20
EP2123761A2 (en) 2009-11-25
IL183608A (en) 2011-10-31
EP2123761A3 (en) 2009-12-16
WO2006061174A2 (en) 2006-06-15
CA2589937C (en) 2014-04-22
EP1824980B1 (en) 2010-04-28
CA2589937A1 (en) 2006-06-15
DE602005020972D1 (en) 2010-06-10
AU2005313531B2 (en) 2011-04-14
US9279128B2 (en) 2016-03-08
US20080206817A1 (en) 2008-08-28
HK1115156A1 (en) 2008-12-24
ATE466090T1 (de) 2010-05-15
SG149071A1 (en) 2009-01-29
IL183608A0 (en) 2007-09-20
JP5069124B2 (ja) 2012-11-07
CN101090969A (zh) 2007-12-19

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