DK1781789T3 - Thymidinkinase - Google Patents

Thymidinkinase

Info

Publication number
DK1781789T3
DK1781789T3 DK05766582.0T DK05766582T DK1781789T3 DK 1781789 T3 DK1781789 T3 DK 1781789T3 DK 05766582 T DK05766582 T DK 05766582T DK 1781789 T3 DK1781789 T3 DK 1781789T3
Authority
DK
Denmark
Prior art keywords
thymidine kinase
nucleotides
splice
polynucleotide
altered
Prior art date
Application number
DK05766582.0T
Other languages
English (en)
Inventor
Francesca Salvatori
Stefania Massa
Marina Radrizzani
Salvatore Toma
Original Assignee
Molmed Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molmed Spa filed Critical Molmed Spa
Application granted granted Critical
Publication of DK1781789T3 publication Critical patent/DK1781789T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C12N9/1211—Thymidine kinase (2.7.1.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
DK05766582.0T 2004-06-18 2005-06-17 Thymidinkinase DK1781789T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413702.2A GB0413702D0 (en) 2004-06-18 2004-06-18 Thymidine kinase
PCT/IB2005/002358 WO2005123912A2 (en) 2004-06-18 2005-06-17 Thymidine kinase

Publications (1)

Publication Number Publication Date
DK1781789T3 true DK1781789T3 (da) 2011-11-28

Family

ID=32750189

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05766582.0T DK1781789T3 (da) 2004-06-18 2005-06-17 Thymidinkinase

Country Status (21)

Country Link
US (5) US8357788B2 (da)
EP (1) EP1781789B1 (da)
JP (1) JP5091669B2 (da)
KR (1) KR101337210B1 (da)
CN (1) CN101010428B (da)
AT (1) ATE520779T1 (da)
AU (1) AU2005254807B2 (da)
CA (1) CA2569304C (da)
CY (2) CY1111925T1 (da)
DK (1) DK1781789T3 (da)
ES (1) ES2372022T3 (da)
GB (1) GB0413702D0 (da)
HK (1) HK1097881A1 (da)
HU (1) HUS1600064I1 (da)
IL (2) IL179660A (da)
LT (1) LTC1781789I2 (da)
NL (1) NL300856I2 (da)
PL (1) PL1781789T3 (da)
PT (1) PT1781789E (da)
SI (1) SI1781789T1 (da)
WO (1) WO2005123912A2 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0413702D0 (en) 2004-06-18 2004-07-21 Molmed Spa Thymidine kinase
JP2014528729A (ja) 2011-10-05 2014-10-30 モルメド エスピーエー ウイルスベクター精製システム
CA3087175A1 (en) 2017-12-28 2019-07-04 Bionoxx Inc. An oncolytic virus vector comprising c-terminally truncated herpes simplex virus-thymidine kinase (hsv-tk), compositions and methods of use thereof
US11157042B1 (en) 2018-03-28 2021-10-26 Douglas Patton Systems and methods for interaction of wearable communication devices
CN112204133B (zh) 2018-05-30 2024-04-19 格雷克斯迪姆医疗私人有限公司 Car nk细胞
WO2020263059A1 (ko) * 2019-06-27 2020-12-30 주식회사 바이오녹스 안전성 및 항암효과가 개선된 항암바이러스

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033975T2 (de) 1989-01-23 2002-10-02 Chiron Corp Rekombinanttherapien für Infektionen und hyperproliferative Störungen
EP0832980B1 (en) 1989-01-23 2002-06-19 Chiron Corporation Recombinant therapies for infection and hyperproliferative disorders
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
IT1261847B (it) 1993-09-01 1996-06-03 San Romanello Centro Fond Metodo per marcare cellule eucariote.
FR2712603B1 (fr) 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
ATE211174T1 (de) 1994-05-02 2002-01-15 Univ Washington Thymidin-kinase-mutanten
FR2744731B1 (fr) 1996-02-09 1998-05-22 Rhone Poulenc Rorer Sa Nouveaux variants de la thymidine kinase, sequences d'acides nucleiques correspondantes et leur utilisation en therapie genique
FR2751988B1 (fr) 1996-08-01 1998-09-11 Rhone Poulenc Rorer Sa Nouveaux variants de la thymidine kinase, sequences d'acides nucleiques correspondantes et leur utilisation en therapie genique
AU720936B2 (en) 1996-02-09 2000-06-15 Gencell S.A. Thymidine kinase variants, corresponding nucleic acid sequences and their use in gene therapy
EP0954222A4 (en) 1996-04-10 2003-01-15 Univ Southern California GENE THERAPY FOR PROLIFERATIVE VITREORETINOPATHY
EP1611885A1 (en) 1996-07-26 2006-01-04 Susan P. Perrine Use of an inducing agent for the treatment of blood, viral and cellular disorders
JP2002516061A (ja) 1997-10-14 2002-06-04 ダーウィン モレキュラー コーポレイション チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質
GB0008966D0 (en) * 2000-04-13 2000-05-31 Imp College Innovations Ltd Vectors for gene therapy
CN1273587C (zh) * 2002-06-05 2006-09-06 上海新世界基因技术开发有限公司 疱疹病毒胸苷激酶突变体及其应用
DE50213745D1 (de) 2002-12-09 2009-09-17 Celltech Gmbh Biotechnologie Verbesserte retrovirale Vektoren für die Gentherapie
GB0413702D0 (en) 2004-06-18 2004-07-21 Molmed Spa Thymidine kinase

Also Published As

Publication number Publication date
CN101010428B (zh) 2013-10-02
IL213084A0 (en) 2011-07-31
CY1111925T1 (el) 2015-11-04
SI1781789T1 (sl) 2012-03-30
CY2016054I2 (el) 2017-07-12
US20090130069A1 (en) 2009-05-21
US20190070312A1 (en) 2019-03-07
HK1097881A1 (en) 2007-07-06
US20130028876A1 (en) 2013-01-31
US20140178345A1 (en) 2014-06-26
AU2005254807A1 (en) 2005-12-29
KR101337210B1 (ko) 2013-12-06
JP5091669B2 (ja) 2012-12-05
US8642311B2 (en) 2014-02-04
CA2569304C (en) 2014-08-12
IL179660A (en) 2012-12-31
ES2372022T3 (es) 2012-01-13
US9005945B2 (en) 2015-04-14
AU2005254807B2 (en) 2011-08-18
CA2569304A1 (en) 2005-12-29
WO2005123912A3 (en) 2006-05-04
US10155052B2 (en) 2018-12-18
CN101010428A (zh) 2007-08-01
US10314925B2 (en) 2019-06-11
WO2005123912A2 (en) 2005-12-29
LTC1781789I2 (lt) 2018-10-10
PL1781789T3 (pl) 2011-12-30
IL179660A0 (en) 2007-05-15
EP1781789A2 (en) 2007-05-09
GB0413702D0 (en) 2004-07-21
US20150231275A1 (en) 2015-08-20
CY2016054I1 (el) 2017-07-12
ATE520779T1 (de) 2011-09-15
JP2008502342A (ja) 2008-01-31
EP1781789B1 (en) 2011-08-17
NL300856I2 (da) 2017-04-20
LTPA2016047I1 (lt) 2017-01-25
KR20070032786A (ko) 2007-03-22
HUS1600064I1 (hu) 2017-02-28
US8357788B2 (en) 2013-01-22
PT1781789E (pt) 2011-10-20

Similar Documents

Publication Publication Date Title
LTC1781789I2 (lt) Timidinkinazė
DE602006015405D1 (de) Inkrementelle Assoziation von Metadaten zu Produktionsdaten
DK1966195T3 (da) 5-arylisoxazoliner til bekæmpelse af hvirvelløse skadedyr
DE602005021040D1 (de) Elektrochirurgisches System mit Vielzahl von Elektroden
GT200500272A (es) 2-anilinopirimidinas sustituidas como inhibidores de la quinasa del ciclo celular o del receptor de la tirosina quinasa, su preparacion y su uso como medicamentos
DE60232245D1 (de) Wasserbehandlung zur kontrolle von biobewuchs mittels stabilisierter bromlösungen
FR2897069B1 (fr) Construction de nouveaux variants de l'enzyme dextrane-saccharase dsr-s par ingienerie moleculaire.
DK1749921T3 (da) Brandhæmmende, syntetisk læder
ATE315585T1 (de) Multispezifisches reagenz zur selektiven stimulierung von zelloberflächenrezeptoren
CY1111486T1 (el) Μιμητικα αντισωματα (mimetibodies) δεσμευμενα με υποδοχεα μελανοκορτινης, συνθεσεις, μεθοδοι και χρησεις
NO20100724L (no) Ledende sementformulering og anvendelse av denne i en bronn
DE502004009010D1 (de) Prozessor mit verschiedenartigen steuerwerken für gemeinsam genutzte ressourcen
ATE536360T1 (de) Neues nukleinsäuretransfersystem
ATE438726T1 (de) Modulation der anzahl von pflanzenzellen
BRPI0716763A2 (pt) grande de chapa delgada énica com bulbo reforÇado
EA200801927A1 (ru) Усовершенствованный грохот
ITTO20050108A1 (it) Trasmissione idrostatica a variazione continua.
DK2176466T3 (da) Byggesæt til fremstilling af brolægningsflader
ATE544599T1 (de) Fluidzufuhrsystem
ATE543828T1 (de) Heteropolynukleotid-duplexe mit purin-purin- paarung
ATE443929T1 (de) Enzymatische brennstoffzelle
FR2853906B1 (fr) N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
DK1478664T3 (da) Vævsspecifik ekspression
Mori Engineering Education
ITCR20030012A1 (it) Digestore anaerobico.