DK175890B1 - Fremgangsmåde til fremstilling af bionedbrydelige mikrokugler - Google Patents

Fremgangsmåde til fremstilling af bionedbrydelige mikrokugler Download PDF

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Publication number
DK175890B1
DK175890B1 DK198702446A DK244687A DK175890B1 DK 175890 B1 DK175890 B1 DK 175890B1 DK 198702446 A DK198702446 A DK 198702446A DK 244687 A DK244687 A DK 244687A DK 175890 B1 DK175890 B1 DK 175890B1
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DK
Denmark
Prior art keywords
biodegradable
hydrophilic polymer
polymer
soluble
biologically active
Prior art date
Application number
DK198702446A
Other languages
Danish (da)
English (en)
Other versions
DK244687D0 (da
DK244687A (da
Inventor
Patrick P Deluca
Frantisek Rypacek
Original Assignee
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky Res Found filed Critical Univ Kentucky Res Found
Publication of DK244687D0 publication Critical patent/DK244687D0/da
Publication of DK244687A publication Critical patent/DK244687A/da
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Publication of DK175890B1 publication Critical patent/DK175890B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polymerisation Methods In General (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK198702446A 1986-05-16 1987-05-14 Fremgangsmåde til fremstilling af bionedbrydelige mikrokugler DK175890B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/864,147 US4741872A (en) 1986-05-16 1986-05-16 Preparation of biodegradable microspheres useful as carriers for macromolecules
US86414786 1986-05-16

Publications (3)

Publication Number Publication Date
DK244687D0 DK244687D0 (da) 1987-05-14
DK244687A DK244687A (da) 1987-11-17
DK175890B1 true DK175890B1 (da) 2005-05-30

Family

ID=25342631

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198702446A DK175890B1 (da) 1986-05-16 1987-05-14 Fremgangsmåde til fremstilling af bionedbrydelige mikrokugler

Country Status (11)

Country Link
US (1) US4741872A (fr)
EP (1) EP0245820B1 (fr)
JP (1) JP2634813B2 (fr)
AT (1) ATE132035T1 (fr)
AU (1) AU600723B2 (fr)
CA (1) CA1309657C (fr)
DE (1) DE3751647T2 (fr)
DK (1) DK175890B1 (fr)
ES (1) ES2080715T3 (fr)
GR (1) GR3018872T3 (fr)
NZ (1) NZ220323A (fr)

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DK244687D0 (da) 1987-05-14
AU7266887A (en) 1987-11-19
DE3751647D1 (de) 1996-02-08
US4741872A (en) 1988-05-03
CA1309657C (fr) 1992-11-03
ES2080715T3 (es) 1996-02-16
GR3018872T3 (en) 1996-05-31
EP0245820A3 (fr) 1991-01-30
EP0245820B1 (fr) 1995-12-27
ATE132035T1 (de) 1996-01-15
DK244687A (da) 1987-11-17
EP0245820A2 (fr) 1987-11-19
JPS6328445A (ja) 1988-02-06
JP2634813B2 (ja) 1997-07-30
AU600723B2 (en) 1990-08-23
NZ220323A (en) 1991-04-26
DE3751647T2 (de) 1996-06-20

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HYDROGELS Division of Bioengineering, Faculty of Engineering National University of Singapore, Lower Kent Ridge Road, Singapore 1 19260; Institute of Materials Research and Engineering, Singapore 117602 E-mail: bieljanus. edu. sg; jun-li (Qimre. a-star. edu. sg

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