DK174645B1 - Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf - Google Patents
Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf Download PDFInfo
- Publication number
- DK174645B1 DK174645B1 DK200000801A DKPA200000801A DK174645B1 DK 174645 B1 DK174645 B1 DK 174645B1 DK 200000801 A DK200000801 A DK 200000801A DK PA200000801 A DKPA200000801 A DK PA200000801A DK 174645 B1 DK174645 B1 DK 174645B1
- Authority
- DK
- Denmark
- Prior art keywords
- acid
- methoxy
- compound
- phenoxy
- addition salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK200000801A DK174645B1 (da) | 2000-05-18 | 2000-05-18 | Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
DK01929337T DK1282601T3 (da) | 2000-05-18 | 2001-05-03 | Fremgangsmåde og mellemprodukter til fremstilling af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
ES03077684T ES2268275T3 (es) | 2000-05-18 | 2001-05-03 | Intermedios para la preparacion de carvedilol. |
ES03077677T ES2260575T3 (es) | 2000-05-18 | 2001-05-03 | Intermedio para la preparacion de carvedilol. |
AT03077684T ATE332892T1 (de) | 2000-05-18 | 2001-05-03 | Zwischenverbindung für die herstellung von carvedilol |
EP03077677A EP1375474B1 (en) | 2000-05-18 | 2001-05-03 | Intermediate for the preparation of carvedilol |
PT01929337T PT1282601E (pt) | 2000-05-18 | 2001-05-03 | Processo e intermediarios para a preparacao de 1-(9h-carbazol-4-iloxi)-3-¬2-12(2-metoxi-fenoxi)-etilamino|-propan-2-ol carvedilol ou de um seu sal de adicao de acido |
AT01929337T ATE258165T1 (de) | 2000-05-18 | 2001-05-03 | Verfahren und zwischenverbindungen zur herstellung von 1-(9h-carbazol-4-yloxy)-3-(2-(2- methoxy-phenoxy)-ethylamino)-propan-2-ol, carvediol, oder ein säureadditionssalz davon |
PT03077677T PT1375474E (pt) | 2000-05-18 | 2001-05-03 | Intermediario para a preparacao de carvedilol. |
PCT/DK2001/000306 WO2001087837A1 (en) | 2000-05-18 | 2001-05-03 | Process and intermediates for the preparation of 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol or acid addition salts thereof |
ES01929337T ES2214414T3 (es) | 2000-05-18 | 2001-05-03 | Procedimiento e intermedios para la preparacion de 1-(9h-carbazol-4-iloxi)-3-(2-(2-metoxifenoxi)etilamino)propan-2-ol, carvedilol o sales de adicion acidas del mismo. |
AT03077677T ATE322481T1 (de) | 2000-05-18 | 2001-05-03 | Zwischenverbindung zur herstellung von carvedilol |
DK03077684T DK1367052T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
DK03077677T DK1375474T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
EP03077684A EP1367052B1 (en) | 2000-05-18 | 2001-05-03 | Intermediate for the preparation of carvedilol |
PT03077684T PT1367052E (pt) | 2000-05-18 | 2001-05-03 | Intermediario para a preparacao de carvedilol |
EP01929337A EP1282601B1 (en) | 2000-05-18 | 2001-05-03 | Process and intermediates for the preparation of 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol or acid addition salt thereof |
CA002407103A CA2407103A1 (en) | 2000-05-18 | 2001-05-03 | Process and intermediates for the preparation of 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol or acid addition salts thereof |
NO20025476A NO323828B1 (no) | 2000-05-18 | 2002-11-15 | Fremgangsmate og mellomprodukter for fremstilling av 1-(9H-karbazol-4-yloksy)-3-[2-(2-metoksyfenoksy)-etylamino]-propan-2-ol, karvedilol eller syreaddisjonssalter derav |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK200000801A DK174645B1 (da) | 2000-05-18 | 2000-05-18 | Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
DK200000801 | 2000-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK200000801A DK200000801A (da) | 2001-11-19 |
DK174645B1 true DK174645B1 (da) | 2003-08-04 |
Family
ID=8159503
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK200000801A DK174645B1 (da) | 2000-05-18 | 2000-05-18 | Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
DK03077677T DK1375474T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
DK01929337T DK1282601T3 (da) | 2000-05-18 | 2001-05-03 | Fremgangsmåde og mellemprodukter til fremstilling af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
DK03077684T DK1367052T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03077677T DK1375474T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
DK01929337T DK1282601T3 (da) | 2000-05-18 | 2001-05-03 | Fremgangsmåde og mellemprodukter til fremstilling af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
DK03077684T DK1367052T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
Country Status (8)
Country | Link |
---|---|
EP (3) | EP1375474B1 (no) |
AT (3) | ATE258165T1 (no) |
CA (1) | CA2407103A1 (no) |
DK (4) | DK174645B1 (no) |
ES (3) | ES2214414T3 (no) |
NO (1) | NO323828B1 (no) |
PT (3) | PT1375474E (no) |
WO (1) | WO2001087837A1 (no) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0312102A (pt) * | 2002-06-27 | 2007-05-29 | Sb Pharmco Inc | sais de fosfato de carvedilol e/ou seus solvatos, composições correspondentes, e/ou métodos de tratamento |
AU2003251627A1 (en) | 2002-06-27 | 2004-01-19 | Sb Pharmco Puerto Rico Inc. | Carvedilol hydrobromide |
EP1615888A1 (en) | 2003-04-21 | 2006-01-18 | Matrix Laboratories Ltd | Process for the preparation of carvedilol form-ii |
JP2007512372A (ja) * | 2003-11-25 | 2007-05-17 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール塩、対応する組成物、送達および/または治療方法 |
KR100746455B1 (ko) | 2006-02-23 | 2007-08-03 | 안국약품 주식회사 | 고광학순도의 키랄 카베딜롤의 제조방법 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0004920A1 (de) * | 1978-04-13 | 1979-10-31 | Roche Diagnostics GmbH | Carbazolyl-(4)-oxy-propanolamin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
FR2506769A2 (fr) * | 1978-06-09 | 1982-12-03 | Delalande Sa | Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique |
EP0918055A1 (en) * | 1997-11-24 | 1999-05-26 | Egis Gyogyszergyar Rt. | Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol] |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3152168A (en) * | 1961-09-05 | 1964-10-06 | Monsanto Co | Haloalkyl pentahalophenyl carbonates |
-
2000
- 2000-05-18 DK DK200000801A patent/DK174645B1/da not_active IP Right Cessation
-
2001
- 2001-05-03 DK DK03077677T patent/DK1375474T3/da active
- 2001-05-03 AT AT01929337T patent/ATE258165T1/de not_active IP Right Cessation
- 2001-05-03 ES ES01929337T patent/ES2214414T3/es not_active Expired - Lifetime
- 2001-05-03 DK DK01929337T patent/DK1282601T3/da active
- 2001-05-03 ES ES03077684T patent/ES2268275T3/es not_active Expired - Lifetime
- 2001-05-03 AT AT03077677T patent/ATE322481T1/de not_active IP Right Cessation
- 2001-05-03 PT PT03077677T patent/PT1375474E/pt unknown
- 2001-05-03 PT PT01929337T patent/PT1282601E/pt unknown
- 2001-05-03 EP EP03077677A patent/EP1375474B1/en not_active Expired - Lifetime
- 2001-05-03 EP EP01929337A patent/EP1282601B1/en not_active Expired - Lifetime
- 2001-05-03 CA CA002407103A patent/CA2407103A1/en not_active Abandoned
- 2001-05-03 DK DK03077684T patent/DK1367052T3/da active
- 2001-05-03 AT AT03077684T patent/ATE332892T1/de not_active IP Right Cessation
- 2001-05-03 EP EP03077684A patent/EP1367052B1/en not_active Expired - Lifetime
- 2001-05-03 PT PT03077684T patent/PT1367052E/pt unknown
- 2001-05-03 WO PCT/DK2001/000306 patent/WO2001087837A1/en active IP Right Grant
- 2001-05-03 ES ES03077677T patent/ES2260575T3/es not_active Expired - Lifetime
-
2002
- 2002-11-15 NO NO20025476A patent/NO323828B1/no unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0004920A1 (de) * | 1978-04-13 | 1979-10-31 | Roche Diagnostics GmbH | Carbazolyl-(4)-oxy-propanolamin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
FR2506769A2 (fr) * | 1978-06-09 | 1982-12-03 | Delalande Sa | Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique |
EP0918055A1 (en) * | 1997-11-24 | 1999-05-26 | Egis Gyogyszergyar Rt. | Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol] |
Also Published As
Publication number | Publication date |
---|---|
PT1282601E (pt) | 2004-06-30 |
WO2001087837A1 (en) | 2001-11-22 |
NO20025476D0 (no) | 2002-11-15 |
ATE332892T1 (de) | 2006-08-15 |
CA2407103A1 (en) | 2001-11-22 |
EP1282601B1 (en) | 2004-01-21 |
ATE322481T1 (de) | 2006-04-15 |
EP1367052B1 (en) | 2006-07-12 |
NO323828B1 (no) | 2007-07-09 |
EP1282601A1 (en) | 2003-02-12 |
PT1375474E (pt) | 2006-07-31 |
ES2214414T3 (es) | 2004-09-16 |
DK200000801A (da) | 2001-11-19 |
EP1375474B1 (en) | 2006-04-05 |
DK1282601T3 (da) | 2004-05-24 |
ES2260575T3 (es) | 2006-11-01 |
EP1375474A3 (en) | 2004-10-06 |
DK1367052T3 (da) | 2006-09-25 |
DK1375474T3 (da) | 2006-08-07 |
NO20025476L (no) | 2002-11-15 |
EP1367052A2 (en) | 2003-12-03 |
EP1375474A2 (en) | 2004-01-02 |
ES2268275T3 (es) | 2007-03-16 |
PT1367052E (pt) | 2006-10-31 |
ATE258165T1 (de) | 2004-02-15 |
EP1367052A3 (en) | 2003-12-10 |
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