DK173854B1 - 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater - Google Patents

7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater Download PDF

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Publication number
DK173854B1
DK173854B1 DK198502800A DK280085A DK173854B1 DK 173854 B1 DK173854 B1 DK 173854B1 DK 198502800 A DK198502800 A DK 198502800A DK 280085 A DK280085 A DK 280085A DK 173854 B1 DK173854 B1 DK 173854B1
Authority
DK
Denmark
Prior art keywords
mixture
epoxy
solution
dione
acid
Prior art date
Application number
DK198502800A
Other languages
Danish (da)
English (en)
Other versions
DK280085D0 (da
DK280085A (da
Inventor
Michel Biollaz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of DK280085D0 publication Critical patent/DK280085D0/da
Publication of DK280085A publication Critical patent/DK280085A/da
Application granted granted Critical
Publication of DK173854B1 publication Critical patent/DK173854B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198502800A 1984-06-21 1985-06-20 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater DK173854B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH300984 1984-06-21
CH300984 1984-06-21
CH464684 1984-09-28
CH464684 1984-09-28

Publications (3)

Publication Number Publication Date
DK280085D0 DK280085D0 (da) 1985-06-20
DK280085A DK280085A (da) 1985-12-22
DK173854B1 true DK173854B1 (da) 2001-12-27

Family

ID=25691934

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198502800A DK173854B1 (da) 1984-06-21 1985-06-20 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater

Country Status (16)

Country Link
US (1) US4670551A (sv)
EP (1) EP0165902B1 (sv)
AR (2) AR242036A1 (sv)
AU (1) AU582754B2 (sv)
CA (1) CA1239388A (sv)
DE (1) DE3569540D1 (sv)
DK (1) DK173854B1 (sv)
ES (2) ES8704967A1 (sv)
FI (1) FI83225C (sv)
GR (1) GR851499B (sv)
HU (1) HU192232B (sv)
IE (1) IE58050B1 (sv)
IL (1) IL75569A (sv)
NO (1) NO165496C (sv)
NZ (1) NZ212492A (sv)
PT (1) PT80663B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2287943T3 (es) 1995-12-11 2007-12-16 G.D. Searle Llc. Procedimiento para la preparacion de un compuesto epoxidado.
JP2001509792A (ja) * 1996-12-11 2001-07-24 ジー．ディー．サール アンド カンパニー ９，１１−エポキシステロイドの製造法ならびに該方法に有用な中間体
EP1223174A3 (en) * 1996-12-11 2005-03-16 G.D. Searle & Co. Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
EP1455795A1 (en) 2001-12-12 2004-09-15 Pharmacia Corporation Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
PL2398500T3 (pl) 2009-02-20 2019-09-30 2-Bbb Medicines B.V. System dostarczania leków na bazie glutationu
KR101741629B1 (ko) 2009-05-06 2017-05-31 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013012A (en) * 1960-12-22 1961-12-12 Searle & Co Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
FI77669C (sv) * 1983-04-13 1989-04-10 Ciba Geigy Ag 20-spiroxaner och analoger, som innehåller en öppen ring E, förfarand e för deras framställning samt dessa innehållande farmaceutiska prepar at.
EP0134529B1 (de) * 1983-08-17 1990-03-21 Schering Aktiengesellschaft 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
AR242036A1 (es) 1993-02-26
IE58050B1 (en) 1993-06-16
US4670551A (en) 1987-06-02
AR245731A1 (es) 1994-02-28
DE3569540D1 (en) 1989-05-24
IE851535L (en) 1985-12-21
HU192232B (en) 1987-05-28
IL75569A (en) 1989-03-31
FI83225B (fi) 1991-02-28
ES8707737A1 (es) 1987-08-16
HUT38367A (en) 1986-05-28
AU582754B2 (en) 1989-04-13
EP0165902A3 (en) 1986-10-22
GR851499B (sv) 1985-11-25
FI83225C (sv) 1991-06-10
ES544387A0 (es) 1987-04-16
PT80663A (en) 1985-07-01
ES8704967A1 (es) 1987-04-16
PT80663B (en) 1987-05-08
AU4397185A (en) 1986-01-02
FI852430L (fi) 1985-12-22
NO165496B (no) 1990-11-12
FI852430A0 (fi) 1985-06-19
DK280085D0 (da) 1985-06-20
NO165496C (no) 1991-02-20
EP0165902A2 (de) 1985-12-27
ES557112A0 (es) 1987-08-16
EP0165902B1 (de) 1989-04-19
DK280085A (da) 1985-12-22
NO852501L (no) 1985-12-23
CA1239388A (en) 1988-07-19
IL75569A0 (en) 1985-10-31
NZ212492A (en) 1989-02-24

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