DK173309B1 - Carboximidamidderivater, mellemprodukter til fremstilling af sådanne, midler med kaliumkanalaktiverende, hypotensiv, hjerte - Google Patents
Carboximidamidderivater, mellemprodukter til fremstilling af sådanne, midler med kaliumkanalaktiverende, hypotensiv, hjerte Download PDFInfo
- Publication number
- DK173309B1 DK173309B1 DK198906669A DK666989A DK173309B1 DK 173309 B1 DK173309 B1 DK 173309B1 DK 198906669 A DK198906669 A DK 198906669A DK 666989 A DK666989 A DK 666989A DK 173309 B1 DK173309 B1 DK 173309B1
- Authority
- DK
- Denmark
- Prior art keywords
- cyano
- pyridinecarboximidamide
- mmol
- formula
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33033688 | 1988-12-27 | ||
JP33033688 | 1988-12-27 | ||
JP20417689 | 1989-08-07 | ||
JP20417689 | 1989-08-07 | ||
JP29895089 | 1989-11-17 | ||
JP1298950A JPH0662567B2 (ja) | 1988-12-27 | 1989-11-17 | ピリジンカルボキシイミダミド誘導体、その製造中間体、製造法および用途 |
JP30989889 | 1989-11-29 | ||
JP30989889 | 1989-11-29 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK666989D0 DK666989D0 (da) | 1989-12-27 |
DK666989A DK666989A (da) | 1990-06-28 |
DK173309B1 true DK173309B1 (da) | 2000-07-10 |
Family
ID=27476180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198906669A DK173309B1 (da) | 1988-12-27 | 1989-12-27 | Carboximidamidderivater, mellemprodukter til fremstilling af sådanne, midler med kaliumkanalaktiverende, hypotensiv, hjerte |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0388528B1 (xx) |
AT (1) | ATE128464T1 (xx) |
AU (1) | AU628453B2 (xx) |
CA (1) | CA2006734C (xx) |
DE (1) | DE68924416T2 (xx) |
DK (1) | DK173309B1 (xx) |
ES (1) | ES2080062T3 (xx) |
FI (1) | FI95244C (xx) |
GR (1) | GR3017662T3 (xx) |
HK (1) | HK1000092A1 (xx) |
HU (1) | HU219337B (xx) |
NO (1) | NO178400C (xx) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6075024A (en) | 1991-11-27 | 2000-06-13 | Sepracor Inc. | Methods for treating infection using optically pure (S)-lomefloxacin |
MX9300433A (es) * | 1992-01-28 | 1994-07-29 | Kirin Brewery | Compuestos de piridincarboximidamina y composiciones farmaceuticas que los contienen. |
CN105017078B (zh) * | 2014-04-23 | 2017-02-15 | 中国科学院大连化学物理研究所 | 一种芳香醛催化转化制备亚胺酸酯的方法 |
CN117567338A (zh) | 2019-10-09 | 2024-02-20 | 拜耳公司 | 作为农药的新的杂芳基三唑化合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8000869A (nl) * | 1979-02-16 | 1980-08-19 | Eisai Co Ltd | Cyanoguanidine-derivaten en werkwijze voor de bereiding daarvan. |
DE2906489A1 (de) * | 1979-02-20 | 1980-09-04 | Bristol Myers Co | Neue n-cyan-n'-alkinyl-s-(subst.)- isothioharnstoffe |
GB8603780D0 (en) * | 1986-02-15 | 1986-03-19 | Smith Kline French Lab | Chemical compounds |
-
1989
- 1989-12-22 FI FI896228A patent/FI95244C/fi active IP Right Grant
- 1989-12-27 NO NO895252A patent/NO178400C/no not_active IP Right Cessation
- 1989-12-27 DE DE68924416T patent/DE68924416T2/de not_active Expired - Lifetime
- 1989-12-27 AT AT89124025T patent/ATE128464T1/de not_active IP Right Cessation
- 1989-12-27 HU HU786/89A patent/HU219337B/hu unknown
- 1989-12-27 DK DK198906669A patent/DK173309B1/da not_active IP Right Cessation
- 1989-12-27 CA CA002006734A patent/CA2006734C/en not_active Expired - Lifetime
- 1989-12-27 EP EP89124025A patent/EP0388528B1/en not_active Expired - Lifetime
- 1989-12-27 ES ES89124025T patent/ES2080062T3/es not_active Expired - Lifetime
- 1989-12-28 AU AU47308/89A patent/AU628453B2/en not_active Expired
-
1995
- 1995-10-05 GR GR950402767T patent/GR3017662T3/el unknown
-
1997
- 1997-07-08 HK HK97101517A patent/HK1000092A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2080062T3 (es) | 1996-02-01 |
EP0388528A2 (en) | 1990-09-26 |
DK666989D0 (da) | 1989-12-27 |
HU678689D0 (en) | 1990-03-28 |
CA2006734C (en) | 1996-07-09 |
NO178400B (no) | 1995-12-11 |
NO178400C (no) | 1996-03-20 |
AU4730889A (en) | 1990-07-05 |
EP0388528B1 (en) | 1995-09-27 |
NO895252D0 (no) | 1989-12-27 |
CA2006734A1 (en) | 1990-06-27 |
AU628453B2 (en) | 1992-09-17 |
FI95244B (fi) | 1995-09-29 |
DE68924416D1 (de) | 1995-11-02 |
HK1000092A1 (en) | 1997-11-21 |
NO895252L (no) | 1990-06-28 |
HU219337B (en) | 2001-03-28 |
EP0388528A3 (en) | 1991-06-05 |
DE68924416T2 (de) | 1996-06-13 |
ATE128464T1 (de) | 1995-10-15 |
DK666989A (da) | 1990-06-28 |
FI95244C (fi) | 1996-01-10 |
GR3017662T3 (en) | 1996-01-31 |
FI896228A0 (fi) | 1989-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |