DK172889A - Triaza makrocykliske forbindelser og metalkomplekser deraf - Google Patents

Triaza makrocykliske forbindelser og metalkomplekser deraf

Info

Publication number
DK172889A
DK172889A DK172889A DK172889A DK172889A DK 172889 A DK172889 A DK 172889A DK 172889 A DK172889 A DK 172889A DK 172889 A DK172889 A DK 172889A DK 172889 A DK172889 A DK 172889A
Authority
DK
Denmark
Prior art keywords
integer
zero
metal complexes
triaza
macrocyclic compounds
Prior art date
Application number
DK172889A
Other languages
Danish (da)
English (en)
Other versions
DK172889D0 (da
Inventor
David Parker
Thomas Andrew Millican
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Ltd filed Critical Celltech Ltd
Publication of DK172889D0 publication Critical patent/DK172889D0/da
Publication of DK172889A publication Critical patent/DK172889A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK172889A 1987-08-12 1989-04-11 Triaza makrocykliske forbindelser og metalkomplekser deraf DK172889A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719041A GB8719041D0 (en) 1987-08-12 1987-08-12 Conjugate compounds
PCT/GB1988/000672 WO1989001475A1 (en) 1987-08-12 1988-08-12 Tri-aza macrocycles and metal complexes thereof

Publications (2)

Publication Number Publication Date
DK172889D0 DK172889D0 (da) 1989-04-11
DK172889A true DK172889A (da) 1989-04-11

Family

ID=10622172

Family Applications (1)

Application Number Title Priority Date Filing Date
DK172889A DK172889A (da) 1987-08-12 1989-04-11 Triaza makrocykliske forbindelser og metalkomplekser deraf

Country Status (11)

Country Link
US (2) US5247075A (de)
EP (1) EP0329737B1 (de)
JP (1) JP2683080B2 (de)
KR (1) KR920700205A (de)
AT (1) ATE121082T1 (de)
AU (1) AU629178B2 (de)
CA (1) CA1340603C (de)
DE (1) DE3853579T2 (de)
DK (1) DK172889A (de)
GB (1) GB8719041D0 (de)
WO (1) WO1989001475A1 (de)

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FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
US5612016A (en) * 1988-04-01 1997-03-18 Immunomedics, Inc. Conjugates of antibodies and bifunctional ligands
US5756065A (en) * 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
NZ229700A (en) * 1988-06-24 1993-01-27 Dow Chemical Co Tetraazacyclododecane derivatives containing a linker/spacer moiety capable of forming antibody conjugates; complexes with radionuclides and conjugates of such compounds and complexes with antibodies or antibody fragments
CN1033030C (zh) * 1988-06-24 1996-10-16 唐化学原料公司 大环双官能螯合剂及其配合物和抗体共轭物的制备方法
WO1990009379A1 (en) * 1989-02-10 1990-08-23 Celltech Limited Aza-macrocycles and processes for their preparation
US6139603A (en) * 1989-02-22 2000-10-31 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for recovering oxygen
GB8914543D0 (en) * 1989-06-23 1989-08-09 Parker David Chemical compounds
ATE173336T1 (de) * 1989-08-28 1998-11-15 Gen Hospital Corp Hydroxy-aryl metallchelate für bildformung zur nmr diagnose
US6004951A (en) * 1989-11-22 1999-12-21 Bernstein; Lawrence Richard Administration of gallium complexes of 3-hydroxy-4-pyrones to provide physiologically active gallium levels in a mammalian individual
WO1991014458A1 (en) * 1990-03-26 1991-10-03 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce A fonctionalized complexand
GB9008724D0 (en) * 1990-04-18 1990-06-13 Celltech Ltd Chemical compounds
US5684135A (en) * 1990-04-18 1997-11-04 Celltech Therapeutics Limited Conjugate compounds containing aza-macro-cycles and processes for their preparation
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
PT590766E (pt) * 1992-07-31 2000-07-31 Australian Nuclear Science Tec Complexos metalicos de hidroxiarilo contendo agentes quelantes de acido aminocarboxilico
US5428156A (en) * 1993-04-02 1995-06-27 Associated Universities, Inc. Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging
US5554749A (en) * 1994-01-14 1996-09-10 Mallinckrodt Medical, Inc. Functionalized macrocyclic ligands for imaging applications
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
US5739022A (en) * 1994-08-18 1998-04-14 Wisconsin Alumni Research Foundation Copper(II) nuclease compounds, compositions, and kits
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US5663161A (en) * 1995-02-17 1997-09-02 The Research Foundation Of State University Of New York Anti-viral triaza compounds
US5612478A (en) * 1995-03-30 1997-03-18 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US5811524A (en) * 1995-06-07 1998-09-22 Idec Pharmaceuticals Corporation Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
DE19523891C1 (de) * 1995-06-30 1996-11-21 Hoechst Ag Chirale Mangan-triazanonankomplexe und Verfahren zu ihrer Herstellung
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US6051704A (en) * 1996-07-22 2000-04-18 Carnegie Mellon University Synthesis of macrocyclic tetraamido-N ligands
US6806363B1 (en) 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
US7591995B2 (en) 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
EP1239887A1 (de) 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin-konjugate geeignet zur verwendung wie bilderzeugungs- oder therapeutische mitteln
AU2001240020B9 (en) 2000-03-01 2008-12-04 Medimmune, Llc High potency recombinant antibodies and method for producing them
ATE474854T1 (de) * 2000-01-27 2010-08-15 Medimmune Llc Rsv neutralisierende antikörper mit sehr hohen affinität
GB0020846D0 (en) * 2000-08-23 2000-10-11 Unilever Plc Ligands for bleaching compositions and synthesis thereof
US7179900B2 (en) * 2000-11-28 2007-02-20 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US6855493B2 (en) 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
GB0118936D0 (en) * 2001-08-02 2001-09-26 Unilever Plc Improvements relating to colour-safe fabric treatment compositions
GB0205276D0 (en) * 2002-03-06 2002-04-17 Unilever Plc Bleaching composition
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US7060818B2 (en) 2003-02-21 2006-06-13 Carnegie Mellon University Synthesis of macrocyclic tetraamido compounds and new metal insertion process
US7161000B2 (en) * 2003-05-30 2007-01-09 Sumitomo Chemical Company, Limited Method for producing phenol condensate
EP1778699A4 (de) * 2004-08-10 2009-02-25 Dow Global Technologies Inc Targeting von chelanten und chelaten
AU2005302453A1 (en) * 2004-10-29 2006-05-11 Medimmune, Llc Methods of preventing and treating RSV infections and related conditions
WO2007128874A1 (en) * 2006-05-05 2007-11-15 Wallac Oy Biomolecule labeling reactants based on azacycloalkanes and conjugates derived thereof
EP2056887A2 (de) * 2006-08-29 2009-05-13 GE Healthcare Limited 68ga-markierung eines freien und grossmoleküligen konjugierten makrozyklischen chelators bei umgebungstemperatur
EP1997830A1 (de) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung
JP5690733B2 (ja) * 2009-08-20 2015-03-25 富士フイルムＲｉファーマ株式会社 ビスホスホン酸誘導体及びその放射性金属核種標識体
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
FR2978149B1 (fr) 2011-07-18 2014-01-10 Cisbio Bioassays Nouveaux agents complexants et complexes de lanthanide correspondant, et leur utilisation comme marqueurs luminescents
WO2013048832A1 (en) 2011-09-29 2013-04-04 Ge Healthcare Limited 18 f - labelled 6 - ( 2 - fluoroethoxy) - 2 - naphthaldehyde for detecting cancer stem cells
GB201201062D0 (en) 2012-01-23 2012-03-07 Ge Healthcare Ltd Radiofluorination method
FR3000960B1 (fr) 2013-01-16 2015-03-06 Cisbio Bioassays Nouveaux agents complexants hydrosolubles et complexes de lanthanide correspondants
WO2014165774A1 (en) 2013-04-05 2014-10-09 Lawson Martin E All wheel drive motorcycle with enhanced soft terrain capabilities
CN109369621B (zh) * 2018-10-19 2020-07-17 北京师范大学 基于TPA-BI的大环多胺[12]aneN3化合物及其制备方法和用途
CN113277989B (zh) * 2021-04-27 2022-05-31 中南大学湘雅医院 一种68Ga标记的分子探针、制备方法及其应用

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Also Published As

Publication number Publication date
AU629178B2 (en) 1992-10-01
JP2683080B2 (ja) 1997-11-26
DK172889D0 (da) 1989-04-11
ATE121082T1 (de) 1995-04-15
CA1340603C (en) 1999-06-22
EP0329737A1 (de) 1989-08-30
JPH02501069A (ja) 1990-04-12
DE3853579T2 (de) 1995-10-05
AU2252788A (en) 1989-03-09
GB8719041D0 (en) 1987-09-16
US5484893A (en) 1996-01-16
DE3853579D1 (de) 1995-05-18
US5247075A (en) 1993-09-21
WO1989001475A1 (en) 1989-02-23
KR920700205A (ko) 1992-02-19
EP0329737B1 (de) 1995-04-12

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)