DK171928B1 - Fastfasesystem til benyttelse i ligand-receptor analyser og anvendelse af fastfasesystemet som en første porøs del i et ligand-receptor analyseapparat samt i sådanne analysefremgangsmåder - Google Patents
Fastfasesystem til benyttelse i ligand-receptor analyser og anvendelse af fastfasesystemet som en første porøs del i et ligand-receptor analyseapparat samt i sådanne analysefremgangsmåder Download PDFInfo
- Publication number
- DK171928B1 DK171928B1 DK153886A DK153886A DK171928B1 DK 171928 B1 DK171928 B1 DK 171928B1 DK 153886 A DK153886 A DK 153886A DK 153886 A DK153886 A DK 153886A DK 171928 B1 DK171928 B1 DK 171928B1
- Authority
- DK
- Denmark
- Prior art keywords
- receptor
- microspheres
- ligand
- phase system
- solid phase
- Prior art date
Links
- 239000007790 solid phase Substances 0.000 title claims abstract description 108
- 238000003556 assay Methods 0.000 title claims abstract description 60
- 239000004005 microsphere Substances 0.000 claims abstract description 103
- 239000003446 ligand Substances 0.000 claims abstract description 73
- 239000012491 analyte Substances 0.000 claims abstract description 29
- 239000000126 substance Substances 0.000 claims abstract description 17
- 239000013642 negative control Substances 0.000 claims abstract description 10
- 238000001514 detection method Methods 0.000 claims abstract description 8
- 239000013641 positive control Substances 0.000 claims abstract description 8
- 239000012530 fluid Substances 0.000 claims abstract description 3
- 239000000523 sample Substances 0.000 claims description 47
- 239000000427 antigen Substances 0.000 claims description 45
- 102000036639 antigens Human genes 0.000 claims description 45
- 108091007433 antigens Proteins 0.000 claims description 45
- 239000007788 liquid Substances 0.000 claims description 33
- 239000000463 material Substances 0.000 claims description 32
- 239000012876 carrier material Substances 0.000 claims description 21
- 238000003018 immunoassay Methods 0.000 claims description 18
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 230000027455 binding Effects 0.000 claims description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 239000002250 absorbent Substances 0.000 claims description 10
- 230000002745 absorbent Effects 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 150000007523 nucleic acids Chemical group 0.000 claims description 10
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 9
- 239000002853 nucleic acid probe Substances 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 8
- 239000013566 allergen Substances 0.000 claims description 8
- 239000011148 porous material Substances 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 5
- 229920000126 latex Polymers 0.000 claims description 5
- 239000004816 latex Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- -1 polyethylene Polymers 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 208000006454 hepatitis Diseases 0.000 claims description 4
- 231100000283 hepatitis Toxicity 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 241000710799 Rubella virus Species 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 229940088597 hormone Drugs 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 244000045947 parasite Species 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 241000222122 Candida albicans Species 0.000 claims description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims description 2
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 claims description 2
- 241000606153 Chlamydia trachomatis Species 0.000 claims description 2
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims description 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims description 2
- 102000004420 Creatine Kinase Human genes 0.000 claims description 2
- 108010042126 Creatine kinase Proteins 0.000 claims description 2
- 241000701022 Cytomegalovirus Species 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 claims description 2
- 241000598436 Human T-cell lymphotropic virus Species 0.000 claims description 2
- 108010044467 Isoenzymes Proteins 0.000 claims description 2
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 102100035703 Prostatic acid phosphatase Human genes 0.000 claims description 2
- 241000702670 Rotavirus Species 0.000 claims description 2
- 241000224527 Trichomonas vaginalis Species 0.000 claims description 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims description 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 2
- 229940095731 candida albicans Drugs 0.000 claims description 2
- 229910010293 ceramic material Inorganic materials 0.000 claims description 2
- 229940038705 chlamydia trachomatis Drugs 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000003365 glass fiber Substances 0.000 claims description 2
- 208000010710 hepatitis C virus infection Diseases 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 230000029849 luteinization Effects 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 108010043671 prostatic acid phosphatase Proteins 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 241001529453 unidentified herpesvirus Species 0.000 claims description 2
- 241000712461 unidentified influenza virus Species 0.000 claims description 2
- 241000194017 Streptococcus Species 0.000 claims 1
- 102000005962 receptors Human genes 0.000 abstract description 57
- 102000016979 Other receptors Human genes 0.000 abstract description 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 238000011534 incubation Methods 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 230000009871 nonspecific binding Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 238000013198 immunometric assay Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000011152 fibreglass Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 201000005404 rubella Diseases 0.000 description 3
- 239000003656 tris buffered saline Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 210000004754 hybrid cell Anatomy 0.000 description 2
- PCKPVGOLPKLUHR-UHFFFAOYSA-N indoxyl Chemical group C1=CC=C2C(O)=CNC2=C1 PCKPVGOLPKLUHR-UHFFFAOYSA-N 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 229920002477 rna polymer Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 241001556449 Garrha rubella Species 0.000 description 1
- 229910004809 Na2 SO4 Inorganic materials 0.000 description 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 description 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000005080 phosphorescent agent Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72003685A | 1985-04-04 | 1985-04-04 | |
US72003685 | 1985-04-04 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK153886D0 DK153886D0 (da) | 1986-04-04 |
DK153886A DK153886A (da) | 1986-10-05 |
DK171928B1 true DK171928B1 (da) | 1997-08-11 |
Family
ID=24892389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK153886A DK171928B1 (da) | 1985-04-04 | 1986-04-04 | Fastfasesystem til benyttelse i ligand-receptor analyser og anvendelse af fastfasesystemet som en første porøs del i et ligand-receptor analyseapparat samt i sådanne analysefremgangsmåder |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP0437287B1 (fr) |
JP (1) | JPH07113636B2 (fr) |
AT (2) | ATE140539T1 (fr) |
AU (1) | AU605101B2 (fr) |
CA (1) | CA1272127A (fr) |
DE (2) | DE3687589T2 (fr) |
DK (1) | DK171928B1 (fr) |
ES (1) | ES8900176A1 (fr) |
FI (1) | FI92257C (fr) |
IE (2) | IE940276L (fr) |
NO (1) | NO170825C (fr) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
TW203120B (fr) * | 1985-10-04 | 1993-04-01 | Abbott Lab | |
US5160701A (en) * | 1986-02-18 | 1992-11-03 | Abbott Laboratories | Solid-phase analytical device and method for using same |
US4916056A (en) * | 1986-02-18 | 1990-04-10 | Abbott Laboratories | Solid-phase analytical device and method for using same |
JPS62231168A (ja) | 1986-03-21 | 1987-10-09 | ハイブリテツク・インコ−ポレイテツド | アナライト−レセプタ−分析用内部標準を設けるための改良法 |
CA1289876C (fr) * | 1986-07-15 | 1991-10-01 | Richard R. Anderson | Systeme en phase solide incorporant des sels de tetrazolium, destines a etre utilise pour des essais ligand-recepteur |
DE3786388T2 (de) * | 1986-10-16 | 1994-01-05 | Abbott Lab | Analytisches Gerät und Verfahren zum Nachweis von Chlamydia Trachomatis und Neisseria Gonorrhoeae. |
DE3786875D1 (de) * | 1986-10-23 | 1993-09-09 | Behringwerke Ag | Bioaffine poroese festphasen, ein verfahren zur herstellung von bioaffinen poroesen festphasen und ihre verwendung. |
EP0280560B1 (fr) * | 1987-02-27 | 1994-05-11 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Structure membraneuse enduite de protéine ayant un pI bas et méthodes pour sa fabrication et son utilisation |
WO1989001158A1 (fr) * | 1987-08-05 | 1989-02-09 | Calypte Biomedical Company | Systeme autonome de diagnostic par multi-immunodosage |
US5447837A (en) * | 1987-08-05 | 1995-09-05 | Calypte, Inc. | Multi-immunoassay diagnostic system for antigens or antibodies or both |
US5039604A (en) * | 1987-08-21 | 1991-08-13 | Cellular Products, Inc. | Test device and method of preparing same, assay kit and method for the simultaneous detection of two HTLV or HIV antibodies |
DE3740471A1 (de) * | 1987-11-28 | 1989-06-08 | Boehringer Mannheim Gmbh | Testtraeger zur analyse einer probenfluessigkeit und verfahren zu seiner herstellung |
US5198368A (en) * | 1988-04-22 | 1993-03-30 | Abbott Laboratories | Methods for performing a solid-phase immunoassay |
US5006309A (en) * | 1988-04-22 | 1991-04-09 | Abbott Laboratories | Immunoassay device with liquid transfer between wells by washing |
DE3814370A1 (de) * | 1988-04-28 | 1989-11-09 | Boehringer Mannheim Gmbh | Testtraeger fuer die analyse einer probenfluessigkeit, verfahren zur durchfuehrung einer solchen analyse und herstellungsverfahren |
US5374524A (en) * | 1988-05-10 | 1994-12-20 | E. I. Du Pont De Nemours And Company | Solution sandwich hybridization, capture and detection of amplified nucleic acids |
US5137804A (en) * | 1988-05-10 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Assay device and immunoassay |
US5573919A (en) * | 1988-06-02 | 1996-11-12 | Carter-Wallace | Assay using an absorbent material |
US5094962A (en) * | 1988-06-13 | 1992-03-10 | Eastman Kodak Company | Microporous article having a stabilized specific binding reagent, a method for its use and a diagnostic test kit |
US5089424A (en) * | 1988-06-14 | 1992-02-18 | Abbott Laboratories | Method and apparatus for heterogeneous chemiluminescence assay |
CA1335880C (fr) * | 1988-07-14 | 1995-06-13 | Thomas P. O'connor | Detection d'anticorps et d'antigenes dans le cadre d'un dosage immunologique |
US5028535A (en) * | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
US5939272A (en) * | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
US5514550A (en) * | 1989-02-03 | 1996-05-07 | Johnson & Johnson Clinical Diagnostics, Inc. | Nucleic acid test article and its use to detect a predetermined nucleic acid |
KR910700354A (ko) * | 1989-02-03 | 1991-03-14 | 존 디. 후써 | 핵산 테스트 제품 및 이것을 이용해 미리 알고있는 핵산을 검출하는 방법 |
US6352863B1 (en) | 1990-01-19 | 2002-03-05 | La Mina, Inc. | Assay device |
US5244815A (en) * | 1990-01-19 | 1993-09-14 | Lamina Ltd. | Fingerprint test pad and method for fingerprinting using particle based immunoassay |
BR9105168A (pt) * | 1990-03-28 | 1992-08-04 | Tenta Properties Nv | Processo para a coleta de anticorpos e deteccao de uma especie de anticorpo especifica em uma amostra fluida,complexo nao toxico,nao infeccioso,dispositivo compreendendo um veiculo que contem o complexo e kit para realizar dosagens imunodiagnosticas |
DE69117097T2 (de) * | 1990-05-11 | 1996-09-05 | Eastman Kodak Co | Testvorrichtungen |
US5143852A (en) * | 1990-09-14 | 1992-09-01 | Biosite Diagnostics, Inc. | Antibodies to ligand analogues and their utility in ligand-receptor assays |
CA2072758A1 (fr) * | 1990-09-14 | 1992-03-15 | Kenneth Francis Buechler | Anticorps liant aux complexes de recepteurs de ligands et de ligands et leur utilite dans les tests ligand-recepteur |
US5700636A (en) * | 1990-10-19 | 1997-12-23 | Becton Dickinson And Company | Methods for selectively detecting microorganisms associated with vaginal infections in complex biological samples |
EP0554355B1 (fr) * | 1990-10-19 | 1998-01-07 | Microprobe Corporation | Procedes et kits pharmaceutiques utiles pour la detection de microorganismes associes a des infections vaginales |
US5215102A (en) * | 1991-10-25 | 1993-06-01 | La Mina Ltd. | Capillary blood antigen testing apparatus |
NZ249579A (en) * | 1992-03-05 | 1997-01-29 | Edmund Bruce Mitchell | Apparatus for collecting and detecting antigens such as microorganisms and allergenic disease causing agents from an environment such as a household environment |
US5441894A (en) * | 1993-04-30 | 1995-08-15 | Abbott Laboratories | Device containing a light absorbing element for automated chemiluminescent immunoassays |
SE9301929D0 (sv) * | 1993-06-07 | 1993-06-07 | Kabi Pharmacia Ab | Foerfarande vid uppfaangning av partiklar |
US5491096A (en) * | 1993-12-27 | 1996-02-13 | Eli Lilly And Company | Antigen detection with affinity chromatography and parallel processing a control |
US5541059A (en) * | 1993-12-29 | 1996-07-30 | Chu; Albert E. | Immunoassay device having an internal control of protein A and methods of using same |
GB9417912D0 (en) * | 1994-09-06 | 1994-10-26 | Univ Leeds | Diagnostic apparatus |
AU3999995A (en) * | 1994-11-10 | 1996-06-06 | Minnesota Mining And Manufacturing Company | Solid phase extraction using composite sheet for direct measurement of radioactivity |
US5789261A (en) * | 1996-10-30 | 1998-08-04 | Temple University Of The Commonwealth System Of Higher Education | Solid phase immunoassay |
US6177282B1 (en) * | 1997-08-12 | 2001-01-23 | Mcintyre John A. | Antigens embedded in thermoplastic |
SE9704933D0 (sv) | 1997-12-30 | 1997-12-30 | Pharmacia & Upjohn Diag Ab | Metod som utnyttjar en ny kalibrator och test kit som innehåller kalibratorn |
SE9704935D0 (sv) | 1997-12-30 | 1997-12-30 | Pharmacia & Upjohn Diag Ab | Analysmetod med partiklar |
EP1090298B2 (fr) † | 1998-06-22 | 2015-06-24 | Roche Diagnostics GmbH | Essais de liaison ameliores par analyse d'epitopes multiples |
US6837171B1 (en) | 2002-04-29 | 2005-01-04 | Palmer/Snyder Furniture Company | Lightweight table with unitized table top |
US20030119203A1 (en) | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
US7011971B2 (en) * | 2002-06-03 | 2006-03-14 | Eastman Kodak Company | Method of making random array of microspheres using enzyme digestion |
US7285424B2 (en) | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
US7781172B2 (en) | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
US7247500B2 (en) | 2002-12-19 | 2007-07-24 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
US20040197819A1 (en) | 2003-04-03 | 2004-10-07 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
US7713748B2 (en) | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
US7943395B2 (en) | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
US7943089B2 (en) | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
US7521226B2 (en) | 2004-06-30 | 2009-04-21 | Kimberly-Clark Worldwide, Inc. | One-step enzymatic and amine detection technique |
US8940527B2 (en) | 2006-03-31 | 2015-01-27 | Lamina Equities Corp. | Integrated device for analyte testing, confirmation, and donor identity verification |
US7879623B2 (en) | 2006-03-31 | 2011-02-01 | Guirguis Raouf A | Integrated device for analyte, testing, confirmation, and donor identity verification |
US7741103B2 (en) | 2006-03-31 | 2010-06-22 | Guirguis Raouf A | Integrated screening and confirmation device |
US11906512B2 (en) | 2006-03-31 | 2024-02-20 | Zeus Diagnostics, LLC | Integrated device for analyte testing, confirmation, and donor identity verification |
WO2008092095A2 (fr) * | 2007-01-25 | 2008-07-31 | Madden Kathleen S | Protéine kinase c gamma utilisée comme biomarqueur pour des fonctions neuropsychologiques et cognitives dans le système nerveux central |
US10564155B2 (en) | 2017-01-27 | 2020-02-18 | Raouf A Guirguis | Dual swab fluid sample collection for split sample testing and fingerprint identification device |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1420916A (en) * | 1971-09-08 | 1976-01-14 | Bagshawe K D | Performance of chemical or biological reactions |
CA983358A (en) * | 1971-09-08 | 1976-02-10 | Kenneth D. Bagshawe | Performance of chemical or biological reactions |
US3951748A (en) * | 1974-11-11 | 1976-04-20 | Medical Products, Inc. | Sensitized matrix for detection of disease |
US4338094A (en) * | 1979-10-25 | 1982-07-06 | Nasik Elahi | Macroencapsulated immunosorbent assay technique |
US4486530A (en) * | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
US4517288A (en) * | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
JPS589070A (ja) * | 1981-04-29 | 1983-01-19 | チバ−ガイギ−・アクチエンゲゼルシヤフト | 免疫分析用装置及びキツト |
JPS59102388A (ja) * | 1982-12-03 | 1984-06-13 | Fuji Photo Film Co Ltd | 生物学的反応層およびその製造方法 |
JPS59170768A (ja) * | 1983-03-17 | 1984-09-27 | Fuji Photo Film Co Ltd | 非アイソト−プアツセイ用多層分析要素およびそれを用いるアツセイ方法 |
US4632901A (en) * | 1984-05-11 | 1986-12-30 | Hybritech Incorporated | Method and apparatus for immunoassays |
-
1986
- 1986-04-03 CA CA000505788A patent/CA1272127A/fr not_active Expired - Fee Related
- 1986-04-04 EP EP91103886A patent/EP0437287B1/fr not_active Expired - Lifetime
- 1986-04-04 ES ES553724A patent/ES8900176A1/es not_active Expired
- 1986-04-04 DE DE8686302521T patent/DE3687589T2/de not_active Expired - Fee Related
- 1986-04-04 EP EP86302521A patent/EP0200381B1/fr not_active Expired - Lifetime
- 1986-04-04 DE DE3650542T patent/DE3650542T2/de not_active Expired - Fee Related
- 1986-04-04 IE IE940276A patent/IE940276L/xx unknown
- 1986-04-04 NO NO861317A patent/NO170825C/no unknown
- 1986-04-04 IE IE89086A patent/IE61365B1/en not_active IP Right Cessation
- 1986-04-04 AT AT91103886T patent/ATE140539T1/de not_active IP Right Cessation
- 1986-04-04 FI FI861460A patent/FI92257C/fi not_active IP Right Cessation
- 1986-04-04 JP JP61078064A patent/JPH07113636B2/ja not_active Expired - Lifetime
- 1986-04-04 AT AT86302521T patent/ATE85129T1/de not_active IP Right Cessation
- 1986-04-04 AU AU55657/86A patent/AU605101B2/en not_active Ceased
- 1986-04-04 DK DK153886A patent/DK171928B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE940276L (en) | 1986-10-04 |
AU605101B2 (en) | 1991-01-10 |
IE860890L (en) | 1986-10-04 |
EP0437287A2 (fr) | 1991-07-17 |
DE3687589T2 (de) | 1993-05-19 |
ES8900176A1 (es) | 1989-02-01 |
NO170825B (no) | 1992-08-31 |
FI92257C (fi) | 1994-10-10 |
ATE85129T1 (de) | 1993-02-15 |
FI861460A (fi) | 1986-10-05 |
NO861317L (no) | 1986-10-06 |
ES553724A0 (es) | 1989-02-01 |
ATE140539T1 (de) | 1996-08-15 |
DE3650542D1 (de) | 1996-08-22 |
JPS61292059A (ja) | 1986-12-22 |
FI861460A0 (fi) | 1986-04-04 |
NO170825C (no) | 1992-12-09 |
DE3687589D1 (de) | 1993-03-11 |
CA1272127A (fr) | 1990-07-31 |
DK153886A (da) | 1986-10-05 |
DK153886D0 (da) | 1986-04-04 |
DE3650542T2 (de) | 1996-11-21 |
EP0200381B1 (fr) | 1993-01-27 |
JPH07113636B2 (ja) | 1995-12-06 |
EP0437287B1 (fr) | 1996-07-17 |
EP0437287A3 (fr) | 1991-07-24 |
EP0200381A1 (fr) | 1986-11-05 |
IE61365B1 (en) | 1994-11-02 |
AU5565786A (en) | 1986-10-16 |
FI92257B (fi) | 1994-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK171928B1 (da) | Fastfasesystem til benyttelse i ligand-receptor analyser og anvendelse af fastfasesystemet som en første porøs del i et ligand-receptor analyseapparat samt i sådanne analysefremgangsmåder | |
DK170353B1 (da) | Fremgangsmåde og apparat til immunanalyser | |
US5879881A (en) | Solid phase system for use in ligand-receptor assays | |
EP0643834B1 (fr) | Analyse simultanee de test anti-dopage et de prise d'empreinte digitale | |
JP5181058B2 (ja) | ヒトabo/rh/mn血液型を迅速に判定する方法及びキット | |
US4851210A (en) | Blood typing device | |
US8137985B2 (en) | Polyelectrolytic internal calibration system of a flow-through assay | |
US20040002121A1 (en) | High throughput methods and devices for assaying analytes in a fluid sample | |
EP1119770A1 (fr) | Procede et appareil destines a la detection in vitro de substances multiples | |
EP0248892A1 (fr) | Immunoanalyse de composants de liaison lies a des particules | |
JP3640278B2 (ja) | アッセイ装置およびそれを用いるアッセイ方法 | |
AU2004232218A1 (en) | Reduction of the hook effect in assay devices | |
US8664001B2 (en) | Immunochemical filter device and methods for use thereof | |
CA2570383C (fr) | Dispositif de filtre, procede, kit et utilisation de celui-ci | |
JPS63210664A (ja) | 酸素要求検出系を用いる装置のための乾燥試験片及び被検流体中の分析成分の検出方法 | |
JP3529096B2 (ja) | アッセイ装置 | |
KR910001313B1 (ko) | 면역 분석 방법 및 장치 | |
CA1245981A (fr) | Analyse de diagnostic biologique en phase solide | |
CA1292180C (fr) | Essai immunologique a l'aide d'un element de liaison fixe sur une particule |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed | ||
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |