ES8900176A1 - Un procedimiento de ensayo ligando-receptor para detectar al menos un analito seleccionado en una muestra fluida mediante un sistema de fase solida - Google Patents

Un procedimiento de ensayo ligando-receptor para detectar al menos un analito seleccionado en una muestra fluida mediante un sistema de fase solida

Info

Publication number
ES8900176A1
ES8900176A1 ES553724A ES553724A ES8900176A1 ES 8900176 A1 ES8900176 A1 ES 8900176A1 ES 553724 A ES553724 A ES 553724A ES 553724 A ES553724 A ES 553724A ES 8900176 A1 ES8900176 A1 ES 8900176A1
Authority
ES
Spain
Prior art keywords
microspheres
ligand
bound
receptor
capturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553724A
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English (en)
Other versions
ES553724A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of ES8900176A1 publication Critical patent/ES8900176A1/es
Publication of ES553724A0 publication Critical patent/ES553724A0/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Abstract

COMPRENDE LAS OPERACIONES DE: A) INTRODUCCION DE LA MUESTRA FLUIDA SOSPECHOSA DE CONTENER UN LIGANDO OBJETICO EN UN PRIMER MIEMBRO POROSO FORMADO POR UN SISTEMA DE FASE SOLIDA QUE INCLUYE UNA MATRIZ POROSA DONDE SE ENCUENTRAN ATRAPADAS UNAS MICROESFERAS, FIJADAS A UN RECEPTOR CAPAZ DE CAPTAR EL LIGANDO OBJETIVO, Y UN SEGUNDO MIEMBRO QUE APORTA UN MEDIO APROPIADO Y ADECUADAMENTE ASOCIADO CON EL PRIMER MIEMBRO POROSO, DE FORMA QUE SE PERMITA EL FLUJO DE LA MUESTRA FLUIDA Y LOS REACTIVOS LIQUIDOS EMPLEADOS EN EL ENSAYO A TAVES DEL PRIMER MIEMBRO Y HASTA EL INTERIOR DEL SEGUNDO MIEMBRO; B) ADICION DE UNA SOLUCION DE UN CONJUGADO DEL RECEPTOR, CAPAZ DE FIJARSE AL LIGANDO OBJETIVO, PARA FORMAR UN COMPLEJO QUE SERA MARCADO CON EL FIN DE PERMITIR SU DETECCION. C) DETECCION DE DICHO CONJUGADO DEL RECEPTOR, SI LO HAY, QUE SE ENCUENTRE FIJADO AL MIEMBRO POROSO. EMPLEADO PARTICULARMENTE EN INMUNOENSAYOS QUE UTILIZAN ANTICUERPOS MONOCLONALES.
ES553724A 1985-04-04 1986-04-04 Un procedimiento de ensayo ligando-receptor para detectar al menos un analito seleccionado en una muestra fluida mediante un sistema de fase solida Expired ES8900176A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72003685A 1985-04-04 1985-04-04

Publications (2)

Publication Number Publication Date
ES8900176A1 true ES8900176A1 (es) 1989-02-01
ES553724A0 ES553724A0 (es) 1989-02-01

Family

ID=24892389

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553724A Expired ES8900176A1 (es) 1985-04-04 1986-04-04 Un procedimiento de ensayo ligando-receptor para detectar al menos un analito seleccionado en una muestra fluida mediante un sistema de fase solida

Country Status (11)

Country Link
EP (2) EP0200381B1 (es)
JP (1) JPH07113636B2 (es)
AT (2) ATE140539T1 (es)
AU (1) AU605101B2 (es)
CA (1) CA1272127A (es)
DE (2) DE3687589T2 (es)
DK (1) DK171928B1 (es)
ES (1) ES8900176A1 (es)
FI (1) FI92257C (es)
IE (2) IE61365B1 (es)
NO (1) NO170825C (es)

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Also Published As

Publication number Publication date
DK153886D0 (da) 1986-04-04
EP0437287B1 (en) 1996-07-17
AU5565786A (en) 1986-10-16
FI861460A0 (fi) 1986-04-04
ATE140539T1 (de) 1996-08-15
IE860890L (en) 1986-10-04
DK153886A (da) 1986-10-05
IE61365B1 (en) 1994-11-02
EP0437287A3 (en) 1991-07-24
DE3650542T2 (de) 1996-11-21
NO861317L (no) 1986-10-06
ES553724A0 (es) 1989-02-01
ATE85129T1 (de) 1993-02-15
FI92257B (fi) 1994-06-30
EP0200381A1 (en) 1986-11-05
DE3687589D1 (de) 1993-03-11
IE940276L (en) 1986-10-04
FI861460A (fi) 1986-10-05
EP0437287A2 (en) 1991-07-17
CA1272127A (en) 1990-07-31
NO170825B (no) 1992-08-31
NO170825C (no) 1992-12-09
AU605101B2 (en) 1991-01-10
EP0200381B1 (en) 1993-01-27
DE3687589T2 (de) 1993-05-19
DK171928B1 (da) 1997-08-11
JPH07113636B2 (ja) 1995-12-06
JPS61292059A (ja) 1986-12-22
FI92257C (fi) 1994-10-10
DE3650542D1 (de) 1996-08-22

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