DK171748B1 - Stabile opløsningsmiddeladdukter, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende addukterne samt anvendelse af addukterne - Google Patents

Stabile opløsningsmiddeladdukter, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende addukterne samt anvendelse af addukterne Download PDF

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Publication number
DK171748B1
DK171748B1 DK189888A DK189888A DK171748B1 DK 171748 B1 DK171748 B1 DK 171748B1 DK 189888 A DK189888 A DK 189888A DK 189888 A DK189888 A DK 189888A DK 171748 B1 DK171748 B1 DK 171748B1
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DK
Denmark
Prior art keywords
group
general formula
adducts
compound
straight
Prior art date
Application number
DK189888A
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Danish (da)
English (en)
Other versions
DK189888D0 (da
DK189888A (da
Inventor
Ingomar Grafe
Helmut Schickaneder
Peter W Jungblut
Kurt Henning Ahrens
Original Assignee
Heumann Pharma Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co
Publication of DK189888D0 publication Critical patent/DK189888D0/da
Publication of DK189888A publication Critical patent/DK189888A/da
Application granted granted Critical
Publication of DK171748B1 publication Critical patent/DK171748B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK189888A 1987-04-21 1988-04-07 Stabile opløsningsmiddeladdukter, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende addukterne samt anvendelse af addukterne DK171748B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87105803A EP0287690B1 (de) 1987-04-21 1987-04-21 Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en
EP87105803 1987-04-21

Publications (3)

Publication Number Publication Date
DK189888D0 DK189888D0 (da) 1988-04-07
DK189888A DK189888A (da) 1988-10-22
DK171748B1 true DK171748B1 (da) 1997-05-05

Family

ID=8196934

Family Applications (1)

Application Number Title Priority Date Filing Date
DK189888A DK171748B1 (da) 1987-04-21 1988-04-07 Stabile opløsningsmiddeladdukter, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende addukterne samt anvendelse af addukterne

Country Status (18)

Country Link
US (1) US4973755A (es)
EP (1) EP0287690B1 (es)
JP (1) JP2596446B2 (es)
KR (1) KR940010274B1 (es)
AR (1) AR243494A1 (es)
AT (1) ATE80152T1 (es)
AU (1) AU607198B2 (es)
CA (1) CA1305972C (es)
DE (1) DE3781546D1 (es)
DK (1) DK171748B1 (es)
ES (1) ES2044860T3 (es)
GR (1) GR3005582T3 (es)
HU (1) HU204501B (es)
IE (1) IE62488B1 (es)
IL (1) IL85804A (es)
NZ (1) NZ224296A (es)
PT (1) PT87268B (es)
ZA (1) ZA882016B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DE69435137D1 (de) * 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US6197789B1 (en) 1995-06-07 2001-03-06 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
CA2150230C (en) * 1993-10-25 1998-10-27 Fumihiko Shinozaki Process for producing acid-addition salt of z-isomer of triphenylethylene compound
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US5650425A (en) * 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists
GB9601167D0 (en) * 1996-01-20 1996-03-20 Univ Bradford Tamoxifen and analogues thereof
CA2243330A1 (en) 1996-01-20 1997-07-24 Ioana Popa Tamoxifen and analogues thereof
US6083990A (en) * 1997-04-02 2000-07-04 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
WO1998046588A2 (en) 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
GB9715479D0 (en) * 1997-07-23 1997-10-01 Univ Bradford Tamoxifen and analogues thereof
JP2001527037A (ja) * 1997-12-23 2001-12-25 ヘキサル アーゲー Ｚ−４−ヒドロキシタモキシフェン及びシクロデキストリンを含む混合物及び薬剤学的組成
AU2003296757A1 (en) * 2002-12-18 2004-07-09 Laboratoires Besins International Reduction of breast density with 4-hydroxy tamoxifen
DK1572178T3 (da) * 2002-12-18 2006-09-11 Besins Int Lab Behandling af mastalgi med 4-hydroxytamoxifen
EP1608353B1 (en) * 2003-04-01 2014-04-30 Besins Healthcare Luxembourg SARL Prevention and treatment of breast cancer with 4-hydroxy tamoxifen
NZ544031A (en) * 2003-06-09 2008-08-29 Univ Northwestern Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
CA2529852A1 (en) * 2003-06-20 2004-12-29 Viral Genomix, Inc. Compositions for and methods for treating hiv
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
RU2357726C2 (ru) * 2004-03-22 2009-06-10 Лаборатуар Безен Энтернасьональ Лечение и профилактика доброкачественной опухоли груди 4-гидрокситамоксифеном
EP1579856A1 (en) * 2004-03-22 2005-09-28 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637389A (es) * 1962-09-13
GB1099093A (en) * 1965-09-03 1968-01-17 Ici Ltd Alkene derivatives
GB1560274A (en) * 1977-02-28 1980-02-06 Ici Ltd Phenylbut 1-ene derivatives having antiostrogenicactivity
DE2860900D1 (en) * 1977-08-22 1981-11-05 Ici Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
DE3239610A1 (de) * 1982-10-26 1984-04-26 Klinge Pharma GmbH, 8000 München Neue 1,1,2-triphenyl-but-l-en-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
DE3781546D1 (de) 1992-10-08
KR940010274B1 (ko) 1994-10-22
AU1379888A (en) 1988-10-20
EP0287690A1 (de) 1988-10-26
AU607198B2 (en) 1991-02-28
EP0287690B1 (de) 1992-09-02
JP2596446B2 (ja) 1997-04-02
HUT50318A (en) 1990-01-29
AR243494A1 (es) 1993-08-31
DK189888D0 (da) 1988-04-07
GR3005582T3 (es) 1993-06-07
IE62488B1 (en) 1995-02-08
IL85804A0 (en) 1988-09-30
PT87268A (pt) 1988-05-01
PT87268B (pt) 1992-08-31
IL85804A (en) 1991-07-18
NZ224296A (en) 1990-02-26
HU204501B (en) 1992-01-28
US4973755A (en) 1990-11-27
ES2044860T3 (es) 1994-01-16
ATE80152T1 (de) 1992-09-15
KR880012528A (ko) 1988-11-28
ZA882016B (en) 1988-12-28
CA1305972C (en) 1992-08-04
JPS6445347A (en) 1989-02-17
DK189888A (da) 1988-10-22

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