DK171299B1 - 4-Amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske præparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske lægemidler - Google Patents

4-Amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske præparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske lægemidler Download PDF

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Publication number
DK171299B1
DK171299B1 DK452088A DK452088A DK171299B1 DK 171299 B1 DK171299 B1 DK 171299B1 DK 452088 A DK452088 A DK 452088A DK 452088 A DK452088 A DK 452088A DK 171299 B1 DK171299 B1 DK 171299B1
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DK
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Prior art keywords
methoxy
tetrahydroisoquinolin
preparation
formula
amino
Prior art date
Application number
DK452088A
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Danish (da)
English (en)
Other versions
DK452088D0 (da
DK452088A (da
Inventor
Nigel John Cussans
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of DK452088D0 publication Critical patent/DK452088D0/da
Publication of DK452088A publication Critical patent/DK452088A/da
Application granted granted Critical
Publication of DK171299B1 publication Critical patent/DK171299B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK452088A 1987-08-15 1988-08-12 4-Amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske præparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske lægemidler DK171299B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719378A GB8719378D0 (en) 1987-08-15 1987-08-15 Antiarrythmic agents
GB8719378 1987-08-15

Publications (3)

Publication Number Publication Date
DK452088D0 DK452088D0 (da) 1988-08-12
DK452088A DK452088A (da) 1989-02-16
DK171299B1 true DK171299B1 (da) 1996-08-26

Family

ID=10622374

Family Applications (1)

Application Number Title Priority Date Filing Date
DK452088A DK171299B1 (da) 1987-08-15 1988-08-12 4-Amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske præparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske lægemidler

Country Status (13)

Country Link
US (1) US4965360A (fr)
EP (1) EP0308059B1 (fr)
JP (1) JP2800830B2 (fr)
AT (1) ATE80395T1 (fr)
CA (1) CA1332415C (fr)
DE (1) DE3874465T2 (fr)
DK (1) DK171299B1 (fr)
ES (1) ES2051856T3 (fr)
FI (1) FI90420C (fr)
GB (1) GB8719378D0 (fr)
GR (1) GR3005840T3 (fr)
IE (1) IE61749B1 (fr)
PT (1) PT88256B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711650D0 (en) * 1997-06-05 1997-07-30 Pfizer Ltd Compounds useful in therapy
GB0112061D0 (en) * 2001-05-18 2001-07-11 Pfizer Ltd Process for the production of quinazolines
GB0118752D0 (en) * 2001-08-01 2001-09-26 Pfizer Ltd Process for the production of quinazolines
KR100863692B1 (ko) * 2006-12-08 2008-10-15 울산대학교 산학협력단 퇴행성질환 및 염증질환에 대한 예방치료 효과를 갖는7-하이드록시-6-메톡시-1,2,3,4-테트라하이드로이소퀴놀린유도체
KR100870576B1 (ko) * 2008-08-27 2008-11-27 울산대학교 산학협력단 퇴행성질환 및 염증질환에 대한 예방치료 효과를 갖는 7-하이드록시-6-메톡시-1,2,3,4-테트라하이드로이소퀴놀린 유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855228A (en) * 1972-08-21 1974-12-17 Sterling Drug Inc 3,4-dihydro-1-or 3-(polyfluoroalkyl)-2(1h)-isoquinolinecarboxamidoximes
GR79603B (fr) * 1982-07-24 1984-10-31 Pfizer

Also Published As

Publication number Publication date
EP0308059B1 (fr) 1992-09-09
FI883760A (fi) 1989-02-16
ATE80395T1 (de) 1992-09-15
ES2051856T3 (es) 1994-07-01
FI90420B (fi) 1993-10-29
IE882474L (en) 1989-02-15
IE61749B1 (en) 1994-11-30
JP2800830B2 (ja) 1998-09-21
DE3874465T2 (de) 1993-02-25
PT88256B (pt) 1995-03-01
US4965360A (en) 1990-10-23
DK452088D0 (da) 1988-08-12
FI90420C (fi) 1994-02-10
JPH01110680A (ja) 1989-04-27
FI883760A0 (fi) 1988-08-12
DK452088A (da) 1989-02-16
PT88256A (pt) 1989-06-30
DE3874465D1 (de) 1992-10-15
GB8719378D0 (en) 1987-09-23
CA1332415C (fr) 1994-10-11
GR3005840T3 (fr) 1993-06-07
EP0308059A1 (fr) 1989-03-22

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed