DK1702073T3 - Produktion af høje niveauer af dha i mikroalger ved anvendelse af modificerede mængder af chlorid og kalium - Google Patents

Produktion af høje niveauer af dha i mikroalger ved anvendelse af modificerede mængder af chlorid og kalium

Info

Publication number
DK1702073T3
DK1702073T3 DK04785345.2T DK04785345T DK1702073T3 DK 1702073 T3 DK1702073 T3 DK 1702073T3 DK 04785345 T DK04785345 T DK 04785345T DK 1702073 T3 DK1702073 T3 DK 1702073T3
Authority
DK
Denmark
Prior art keywords
microalges
dha
potassium
chloride
production
Prior art date
Application number
DK04785345.2T
Other languages
Danish (da)
English (en)
Inventor
Paul W Behrens
John M Thompson
Kirk Apt
Joseph W Pfeifer Iii
James P Wynn
James Casey Lippmeier
Jaouad Fichtali
Jon Hansen
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of DK1702073T3 publication Critical patent/DK1702073T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK04785345.2T 2003-10-02 2004-10-01 Produktion af høje niveauer af dha i mikroalger ved anvendelse af modificerede mængder af chlorid og kalium DK1702073T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50850503P 2003-10-02 2003-10-02
PCT/US2004/032383 WO2005035775A1 (en) 2003-10-02 2004-10-01 Production of high levels of dha in microalgae using modified amounts of chloride and potassium

Publications (1)

Publication Number Publication Date
DK1702073T3 true DK1702073T3 (da) 2014-04-07

Family

ID=34434916

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04785345.2T DK1702073T3 (da) 2003-10-02 2004-10-01 Produktion af høje niveauer af dha i mikroalger ved anvendelse af modificerede mængder af chlorid og kalium

Country Status (13)

Country Link
US (17) US7163811B2 (enExample)
EP (2) EP1702073B1 (enExample)
JP (4) JP4733043B2 (enExample)
KR (6) KR101295390B1 (enExample)
CN (3) CN103834699A (enExample)
AU (2) AU2004280575B8 (enExample)
CA (2) CA2801065C (enExample)
DK (1) DK1702073T3 (enExample)
ES (1) ES2454196T3 (enExample)
HK (1) HK1199289A1 (enExample)
MX (4) MX338455B (enExample)
NO (1) NO20061916L (enExample)
WO (1) WO2005035775A1 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2352001T3 (es) 2000-01-19 2011-02-14 Martek Biosciences Corporation Procedimiento de extracción sin disolvente.
KR101295390B1 (ko) * 2003-10-02 2013-09-17 마텍 바이오싸이언스스 코포레이션 변형량의 염소 및 칼륨을 사용하는 미세조류 중에 고농도 디에치에이의 생산
WO2007120801A2 (en) * 2006-04-13 2007-10-25 Nereus Pharmaceuticals, Inc. Fermentation method
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
US20100086979A1 (en) * 2006-10-27 2010-04-08 Thomas Kiy Production of omega-3 fatty acids in microflora of thraustochytriales using modified media
CN104069112A (zh) * 2007-10-19 2014-10-01 贝林格尔.英格海姆国际有限公司 取代的哌啶子基-二氢噻吩并嘧啶
CA2702524A1 (en) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh Heterocycle-substituted piperazino-dihydrothienopyrimidines
CA2702518A1 (en) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh New piperazino-dihydrothienopyrimidine derivatives
BRPI0920280B8 (pt) 2008-10-14 2022-11-16 Corbion Biotech Inc Composição alimentícia, e, método para fabricar uma composição alimentícia
US8809037B2 (en) 2008-10-24 2014-08-19 Bioprocessh20 Llc Systems, apparatuses and methods for treating wastewater
EP2194138A1 (en) * 2008-12-08 2010-06-09 Marenutrica GmbH Compositions containing docosahexaenoic acid and method for its production
US20110306102A1 (en) 2009-02-25 2011-12-15 V. B. Medicare Pvt. Ltd. Improved methods for fermentative production of docosahexaenoic acid
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
KR101769121B1 (ko) 2009-04-14 2017-08-17 테라비아 홀딩스 인코포레이티드 신규의 미세 조류 식품 조성물
BR122015020119B8 (pt) 2010-01-19 2021-05-04 Dsm Ip Assets Bv óleo microbiano, produtos alimentícios para um animal não humano e biomassa isolada
JP5865894B2 (ja) 2010-04-14 2016-02-17 ソラザイム ロケット ニュートリショナルズ， エルエルシー 高脂質微細藻類粉末食品組成物
US8969067B2 (en) 2010-05-20 2015-03-03 Pond Biofuels Inc. Process for growing biomass by modulating supply of gas to reaction zone
US8889400B2 (en) 2010-05-20 2014-11-18 Pond Biofuels Inc. Diluting exhaust gas being supplied to bioreactor
US8940520B2 (en) 2010-05-20 2015-01-27 Pond Biofuels Inc. Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply
US11512278B2 (en) 2010-05-20 2022-11-29 Pond Technologies Inc. Biomass production
US20120156669A1 (en) 2010-05-20 2012-06-21 Pond Biofuels Inc. Biomass Production
CA2801011C (en) 2010-06-01 2019-02-26 Dsm Ip Assests B.V. Extraction of lipid from cells and products therefrom
MY163938A (en) 2010-06-14 2017-11-15 Io-Mega Holding Corp Method for the production of algae derived oils
US20120276633A1 (en) 2011-04-27 2012-11-01 Pond Biofuels Inc. Supplying treated exhaust gases for effecting growth of phototrophic biomass
US8795589B1 (en) 2011-04-29 2014-08-05 Cortec Corporation Bio-based volatile corrosion inhibitors
WO2013013211A1 (en) 2011-07-21 2013-01-24 Dsm Ip Assets B.V. Fatty acid compositions
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
CN103773687B (zh) * 2012-10-23 2019-07-12 中国石油化工股份有限公司 一种微藻的培养方法
US9534261B2 (en) 2012-10-24 2017-01-03 Pond Biofuels Inc. Recovering off-gas from photobioreactor
JP2014223024A (ja) * 2013-05-15 2014-12-04 日本電信電話株式会社 微細藻類の培養方法および培養装置
CN103627640B (zh) * 2013-08-10 2018-03-02 青岛海智源生命科技有限公司 一种培养裂殖壶菌的低氯培养基及用该培养基产生dha的方法
CN103468575B (zh) * 2013-09-18 2015-05-06 武汉轻工大学 一株高产dha的寇氏隐甲藻突变株及发酵方法和应用
KR101494649B1 (ko) * 2013-12-03 2015-02-23 한국에너지기술연구원 미생물로부터 차아염소산을 이용한 바이오오일 추출 방법
AU2014369045B2 (en) 2013-12-20 2020-02-27 Dsm Ip Assets B.V. Processes for obtaining microbial oil from microbial cells
AR098896A1 (es) 2013-12-20 2016-06-22 Dsm Ip Assets Bv Proceso para obtener aceite microbiano a partir de células microbianas
NZ721417A (en) 2013-12-20 2022-07-01 Dsm Ip Assets Bv Processes for obtaining microbial oil from microbial cells
TWI646189B (zh) 2013-12-20 2019-01-01 荷蘭商Ｄｓｍ智慧財產有限公司 用於從微生物細胞獲得微生物油之方法（五）
CN106029624B (zh) 2013-12-20 2021-12-07 帝斯曼知识产权资产管理有限公司 用于从微生物细胞获得微生物油的方法
FR3019559B1 (fr) * 2014-04-03 2018-01-05 Fermentalg Procede de culture des microalgues du genre aurantiochytrium dans un milieu de culture a teneur reduite en sodium et en chlorure pour la production de dha
KR102236782B1 (ko) 2014-05-22 2021-04-05 마라 리뉴어블즈 코퍼레이션 미생물에서 오일 생산 방법
WO2015191449A2 (en) 2014-06-08 2015-12-17 Solazyme, Inc. Personal care products containing microalgae or extracts thereof
FR3025215A1 (fr) * 2014-08-27 2016-03-04 Fermentalg Nouveau procede de culture de microalgues
WO2016100681A1 (en) 2014-12-17 2016-06-23 Solazyme, Inc. Microalgal derived cleaners and surfactants
US9181523B1 (en) 2014-12-29 2015-11-10 Heliae Development Llc Method of treating bacterial contamination in a microalgae culture with pH shock
SG11201707876YA (en) 2015-03-24 2017-10-30 Terravia Holdings Inc Microalgal compositions and uses thereof
WO2017183990A1 (en) * 2016-04-18 2017-10-26 Planktonic As Cryopreservation of juvenile stages of barnacles
JP6998935B2 (ja) 2016-07-13 2022-01-18 エボニック オペレーションズ ゲーエムベーハー 溶解された脂質含有バイオマスから脂質を分離する方法
CA3034122A1 (en) 2016-08-19 2018-02-22 Noblegen Inc. Methods and uses of dissolved organic material fractions for binding metal ions
DK3562925T3 (da) 2016-12-27 2021-05-25 Evonik Operations Gmbh Fremgangsmåde til isolering af lipider fra en lipidholdig biomasse
JP2020516768A (ja) 2017-04-07 2020-06-11 ノーブルジェン・インコーポレーテッド 金属を結合するための方法並びにカプセル化された滲出物及び乾燥ユーグレナ（ｅｕｇｌｅｎａ）バイオマスの使用
EP3470502A1 (en) 2017-10-13 2019-04-17 Evonik Degussa GmbH Method of separating lipids from a lysed lipids containing biomass
EP3527664A1 (en) 2018-02-15 2019-08-21 Evonik Degussa GmbH Method of isolating lipids from a lipids containing biomass
DK3794097T3 (da) 2018-05-15 2024-12-16 Evonik Operations Gmbh Fremgangsmåde til isolering af lipider fra en lipid-indeholdende biomasse ved hjælp af hydrofob silica
WO2019219396A1 (en) 2018-05-15 2019-11-21 Evonik Operations Gmbh Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion
KR102455795B1 (ko) * 2020-01-17 2022-10-17 고려대학교 산학협력단 지질 및 오메가-3 함량 증진을 위한 미세조류 배양 방법
US20250129395A1 (en) * 2022-01-25 2025-04-24 Dsm Ip Assets B.V. Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5407957A (en) 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
US6410281B1 (en) * 1992-07-10 2002-06-25 Omegatech, Inc. Reducing corrosion in a fermentor by providing sodium with a non-chloride sodium salt
JPH0775556A (ja) * 1993-09-09 1995-03-20 Nisshin Oil Mills Ltd:The ドコサヘキサエン酸含有藻類の培養法
JP3506740B2 (ja) * 1993-09-09 2004-03-15 日清オイリオ株式会社 ドコサヘキサエン酸含有藻類の培養方法
JPH0787959A (ja) * 1993-09-24 1995-04-04 Kawasaki Steel Corp 海洋性微細藻類の培養方法
JPH08294384A (ja) * 1995-04-27 1996-11-12 Kawasaki Steel Corp 海洋性微細藻類のシード培養方法
CA2261231C (en) 1996-07-23 2012-11-27 Nagase Biochemicals, Ltd. Process using ulkenia sp. to prepare docosahexaenoic acid and docosapentaenoic acid
WO1998029558A1 (en) * 1996-12-27 1998-07-09 Suntory Limited Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same
JP4283351B2 (ja) * 1998-08-27 2009-06-24 サントリー酒類株式会社 新規な油脂組成物の製造方法および用途
KR19990046733A (ko) * 1999-04-20 1999-07-05 류성구 미생물슈도모나스에의한도코사핵사노인산(ｄｈａ)의제조방법
GB9916537D0 (en) * 1999-07-14 1999-09-15 Univ Hull Culture of microorganisms for the synthesis of a polyunsaturated fatty acid
ES2352001T3 (es) 2000-01-19 2011-02-14 Martek Biosciences Corporation Procedimiento de extracción sin disolvente.
CN105112463A (zh) 2000-01-28 2015-12-02 Dsmip资产公司 通过在发酵罐中高密度培养真核微生物来增加含有多烯脂肪酸的脂质的产生
DE60134128D1 (de) 2000-04-12 2008-07-03 Westfalia Separator Gmbh Verfahren zur fraktionierung von öl- und polar lipid-enthaltenden rohstoffen
KR101295390B1 (ko) 2003-10-02 2013-09-17 마텍 바이오싸이언스스 코포레이션 변형량의 염소 및 칼륨을 사용하는 미세조류 중에 고농도 디에치에이의 생산

Also Published As

Publication number Publication date
US20080032358A1 (en) 2008-02-07
US9834799B2 (en) 2017-12-05
US20080032359A1 (en) 2008-02-07
KR20130041366A (ko) 2013-04-24
ES2454196T3 (es) 2014-04-09
EP1702073A4 (en) 2011-08-24
JP2013212126A (ja) 2013-10-17
WO2005035775A1 (en) 2005-04-21
KR101180594B1 (ko) 2012-09-06
US7829129B2 (en) 2010-11-09
HK1199289A1 (en) 2015-06-26
US20080032353A1 (en) 2008-02-07
MX351381B (es) 2017-10-12
US20080044866A1 (en) 2008-02-21
US20130150604A1 (en) 2013-06-13
US20160108443A1 (en) 2016-04-21
KR20060097009A (ko) 2006-09-13
US20080032357A1 (en) 2008-02-07
JP2007527233A (ja) 2007-09-27
HK1089482A1 (en) 2006-12-01
AU2004280575B8 (en) 2010-05-13
KR101761164B1 (ko) 2017-07-25
US20060100279A1 (en) 2006-05-11
US9249434B2 (en) 2016-02-02
US8669090B2 (en) 2014-03-11
CN1890376A (zh) 2007-01-03
US7252979B2 (en) 2007-08-07
JP4733043B2 (ja) 2011-07-27
EP1702073B1 (en) 2014-01-01
US20130158280A1 (en) 2013-06-20
US20050112736A1 (en) 2005-05-26
US8663953B2 (en) 2014-03-04
AU2010202691B2 (en) 2013-09-12
AU2004280575B2 (en) 2010-04-22
JP5466120B2 (ja) 2014-04-09
MX304474B (enExample) 2012-10-22
CN103834699A (zh) 2014-06-04
US20140142331A1 (en) 2014-05-22
US20120071677A1 (en) 2012-03-22
US7163811B2 (en) 2007-01-16
US20080032355A1 (en) 2008-02-07
NO20061916L (no) 2006-06-12
EP1702073A1 (en) 2006-09-20
JP5813061B2 (ja) 2015-11-17
MXPA06003467A (es) 2006-06-20
KR20150125731A (ko) 2015-11-09
US20080032354A1 (en) 2008-02-07
EP2759599A2 (en) 2014-07-30
US20080044865A1 (en) 2008-02-21
AU2004280575A1 (en) 2005-04-21
US7824892B2 (en) 2010-11-02
KR20110033283A (ko) 2011-03-30
MX271416B (es) 2009-10-30
US20080032352A1 (en) 2008-02-07
US8008050B2 (en) 2011-08-30
US20080032356A1 (en) 2008-02-07
CN1890376B (zh) 2012-06-13
CN101386873B (zh) 2014-05-07
KR101295390B1 (ko) 2013-09-17
US7745183B2 (en) 2010-06-29
AU2010202691A1 (en) 2010-07-15
EP2759599A3 (en) 2014-12-10
JP2011036261A (ja) 2011-02-24
KR20140119198A (ko) 2014-10-08
KR20140006109A (ko) 2014-01-15
US7871809B2 (en) 2011-01-18
MX338455B (es) 2016-04-18
CA2540617A1 (en) 2005-04-21
JP5940194B2 (ja) 2016-06-29
CA2801065A1 (en) 2005-04-21
JP2015130886A (ja) 2015-07-23
CA2801065C (en) 2020-04-28
CN101386873A (zh) 2009-03-18

Similar Documents

Publication Publication Date Title
DK2578685T3 (da) Rna indeholende modificerede nukleosider og fremgangsmåder til anvendelse deraf
EP1896634A4 (en) IMPROVED TRANSPARENT CONDUCTIVE COATINGS AND METHOD FOR THE PRODUCTION THEREOF
DK1628749T3 (da) Anordninger og fremgangsmåder til biomateriel produktion
DK2339016T3 (da) Øget produktion af subtilisiner
EP1702073A4 (en) PRODUCTION OF HIGH DHA LEVELS IN MICRO ALGAE USING MODIFIED AMOUNTS OF CHLORIDE AND CALIUM
EP1835915A4 (en) FORMULATIONS AND METHOD FOR MODIFYING THE IMMUNE RESPONSE
DK1524710T3 (da) Tynd batteristruktur, batterienhed og fremgangsmåde til fremstilling af batterienhed
EP1678449A4 (en) FLEXIBLE NGL PROCESSES AND METHODS
DK1687329T3 (da) Optimeret eksperession af HPV58 L1 i gær
EP1940787A4 (en) NEW IDO HEMMER AND APPLICATION METHOD THEREFOR
DK1483247T3 (da) Arylsubstituerede pyrimidiner og anvendelsen deraf
DK1824855T3 (da) Hidtil ukendte pyrrolo (3,2-d)pyrimidin-4-onderivater og anvendelser af disse til behandling
DK2137304T3 (da) Delta-9-elongaser og anvendelser heri i fremstillingen af flerumættedefedtsyrer
DK1473072T3 (da) Fremgangsmåde og anlæg til genvinding af carbondioxid
IS8316A (is) Notkun kalsítóníns við slitgigt
EP1784268A4 (en) SWITCHABLE CUTTING INSERTS AND MANUFACTURING METHOD THEREFOR
DK1542714T3 (da) Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
DK1694604T3 (da) Elektrolysecelle og behandling af forurenet vand
DK1937276T3 (da) Forbedret testosterongel og fremgangsmåde til anvendelse deraf
DK1765376T3 (da) Topiske sammensætninger og anvendelse deraf til behandling af epitel-relaterede tilstande
DK2305689T3 (da) Syntese af naturligt forekommende ecteinascidiner og relateredeforbindelser
FR2853424B1 (fr) Architecture de multiplicateurs polynomial et naturel combines
FR2835457B1 (fr) Melange gazeux ternaire utilisable en soudo-brasage de pieces galvanisees
ATE357245T1 (de) Biologisch stabile flüssige zusammensetzung von fviii, vwf oder fviii/vwf-komplex menschlichen ursprungs
IS8090A (is) Samsetning til að bæta vitsmuni og minni