CN1890376B - 使用改进量的氯和钾在微藻类中产生高水平的dha - Google Patents

使用改进量的氯和钾在微藻类中产生高水平的dha Download PDF

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CN1890376B
CN1890376B CN2004800356858A CN200480035685A CN1890376B CN 1890376 B CN1890376 B CN 1890376B CN 2004800356858 A CN2004800356858 A CN 2004800356858A CN 200480035685 A CN200480035685 A CN 200480035685A CN 1890376 B CN1890376 B CN 1890376B
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dha
ions
potassium
sodium
concentration
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CN1890376A (zh
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保罗·W·贝伦斯
约翰·M·汤普森
柯克·阿普特
约瑟夫·W·法伊弗第三
詹姆斯·P·温
詹姆斯·C·利普迈耶
贾奥亚德·菲克塔里
乔恩·汉森
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Dsmip Asset Co
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Martek Biosciences Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium

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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
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  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2004800356858A 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha Expired - Lifetime CN1890376B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50850503P 2003-10-02 2003-10-02
US60/508,505 2003-10-02
PCT/US2004/032383 WO2005035775A1 (en) 2003-10-02 2004-10-01 Production of high levels of dha in microalgae using modified amounts of chloride and potassium

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201410126418.7A Division CN103834699A (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha
CN200810166137.9A Division CN101386873B (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha

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CN1890376A CN1890376A (zh) 2007-01-03
CN1890376B true CN1890376B (zh) 2012-06-13

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CN2004800356858A Expired - Lifetime CN1890376B (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha
CN200810166137.9A Expired - Lifetime CN101386873B (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha
CN201410126418.7A Pending CN103834699A (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha

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CN201410126418.7A Pending CN103834699A (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha

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US (17) US7163811B2 (enExample)
EP (2) EP1702073B1 (enExample)
JP (4) JP4733043B2 (enExample)
KR (6) KR20150125731A (enExample)
CN (3) CN1890376B (enExample)
AU (2) AU2004280575B8 (enExample)
CA (2) CA2540617A1 (enExample)
DK (1) DK1702073T3 (enExample)
ES (1) ES2454196T3 (enExample)
HK (1) HK1199289A1 (enExample)
MX (4) MX271416B (enExample)
NO (1) NO20061916L (enExample)
WO (1) WO2005035775A1 (enExample)

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KR20140119198A (ko) 2014-10-08
US8663953B2 (en) 2014-03-04
CA2801065C (en) 2020-04-28
US20120071677A1 (en) 2012-03-22
US7163811B2 (en) 2007-01-16
US20080032357A1 (en) 2008-02-07
JP4733043B2 (ja) 2011-07-27
US9834799B2 (en) 2017-12-05
US20080032352A1 (en) 2008-02-07
DK1702073T3 (da) 2014-04-07
HK1089482A1 (en) 2006-12-01
KR20110033283A (ko) 2011-03-30
MX271416B (es) 2009-10-30
US20160108443A1 (en) 2016-04-21
CA2801065A1 (en) 2005-04-21
JP2013212126A (ja) 2013-10-17
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