DK168190B1 - Præparat på basis af pyrimidinderivater til fremkaldelse og stimulering af hårvækst og reduktion af hårfald, fremgangsmåde til kosmetisk behandling med præparat og anvendelse af præparatet til fremstilling af lægemidler - Google Patents
Præparat på basis af pyrimidinderivater til fremkaldelse og stimulering af hårvækst og reduktion af hårfald, fremgangsmåde til kosmetisk behandling med præparat og anvendelse af præparatet til fremstilling af lægemidler Download PDFInfo
- Publication number
- DK168190B1 DK168190B1 DK413687A DK413687A DK168190B1 DK 168190 B1 DK168190 B1 DK 168190B1 DK 413687 A DK413687 A DK 413687A DK 413687 A DK413687 A DK 413687A DK 168190 B1 DK168190 B1 DK 168190B1
- Authority
- DK
- Denmark
- Prior art keywords
- composition according
- preparation
- hair
- alkyl
- composition
- Prior art date
Links
- 201000004384 Alopecia Diseases 0.000 title claims description 12
- 230000003676 hair loss Effects 0.000 title claims description 12
- 230000003779 hair growth Effects 0.000 title claims description 11
- 208000024963 hair loss Diseases 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 10
- 239000002537 cosmetic Substances 0.000 title claims description 8
- 150000003230 pyrimidines Chemical class 0.000 title claims description 6
- 230000001939 inductive effect Effects 0.000 title claims description 5
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title claims description 5
- 230000004936 stimulating effect Effects 0.000 title claims description 5
- 239000003814 drug Substances 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 238000002360 preparation method Methods 0.000 title description 23
- 229940079593 drug Drugs 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims description 48
- 210000004209 hair Anatomy 0.000 claims description 29
- 150000001875 compounds Chemical class 0.000 claims description 25
- 239000002609 medium Substances 0.000 claims description 18
- 239000002245 particle Substances 0.000 claims description 18
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims description 15
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
- 229960003632 minoxidil Drugs 0.000 claims description 15
- 239000002562 thickening agent Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 229920001577 copolymer Polymers 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- ZIMGGGWCDYVHOY-UHFFFAOYSA-N 3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine Chemical compound N=C1N(O)C(N)=CC(N2CCCCC2)=N1 ZIMGGGWCDYVHOY-UHFFFAOYSA-N 0.000 claims description 8
- 239000013543 active substance Substances 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 210000004761 scalp Anatomy 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 239000012736 aqueous medium Substances 0.000 claims description 6
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
- -1 alkylene glycols Chemical class 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
- 125000000129 anionic group Chemical group 0.000 claims description 4
- 229920006317 cationic polymer Polymers 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- 239000000178 monomer Substances 0.000 claims description 3
- 125000003386 piperidinyl group Chemical group 0.000 claims description 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000003926 acrylamides Chemical class 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims description 2
- 125000004948 alkyl aryl alkyl group Chemical group 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 2
- 125000004069 aziridinyl group Chemical group 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 125000004634 hexahydroazepinyl group Chemical group N1(CCCCCC1)* 0.000 claims description 2
- 229920001519 homopolymer Polymers 0.000 claims description 2
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims description 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- DGXNWWJYEMQHED-UHFFFAOYSA-N trimethyl-(4-methyl-3-oxopent-4-enyl)azanium Chemical class CC(=C)C(=O)CC[N+](C)(C)C DGXNWWJYEMQHED-UHFFFAOYSA-N 0.000 claims description 2
- 150000003863 ammonium salts Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 9
- 239000000725 suspension Substances 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 5
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 description 3
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 3
- 230000003698 anagen phase Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000031774 hair cycle Effects 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 239000004584 polyacrylic acid Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- NJSSICCENMLTKO-HRCBOCMUSA-N [(1r,2s,4r,5r)-3-hydroxy-4-(4-methylphenyl)sulfonyloxy-6,8-dioxabicyclo[3.2.1]octan-2-yl] 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)O[C@H]1C(O)[C@@H](OS(=O)(=O)C=2C=CC(C)=CC=2)[C@@H]2OC[C@H]1O2 NJSSICCENMLTKO-HRCBOCMUSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 229920006318 anionic polymer Polymers 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 1
- IAGROJPXACRRDT-UHFFFAOYSA-N 2-piperidin-1-ylpyrimidine Chemical compound C1CCCCN1C1=NC=CC=N1 IAGROJPXACRRDT-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- XLYMOEINVGRTEX-ARJAWSKDSA-N Ethyl hydrogen fumarate Chemical compound CCOC(=O)\C=C/C(O)=O XLYMOEINVGRTEX-ARJAWSKDSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- BAVYZALUXZFZLV-UHFFFAOYSA-O Methylammonium ion Chemical class [NH3+]C BAVYZALUXZFZLV-UHFFFAOYSA-O 0.000 description 1
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000002535 acidifier Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000003113 alkalizing effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- NRHDCQLCSOWVTF-UHFFFAOYSA-N azonane Chemical compound C1CCCCNCCC1 NRHDCQLCSOWVTF-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- MJEMIOXXNCZZFK-UHFFFAOYSA-N ethylone Chemical compound CCNC(C)C(=O)C1=CC=C2OCOC2=C1 MJEMIOXXNCZZFK-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- VZTGWJFIMGVKSN-UHFFFAOYSA-O trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium Chemical class CC(=C)C(=O)NCCC[N+](C)(C)C VZTGWJFIMGVKSN-UHFFFAOYSA-O 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU86547 | 1986-08-07 | ||
| LU86547A LU86547A1 (fr) | 1986-08-07 | 1986-08-07 | Suspension pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de la pyrimidine |
| AT269387 | 1987-10-12 | ||
| AT269387A AT400515B (de) | 1986-08-07 | 1987-10-12 | Pharmazeutisches mittel zur förderung und stimulierung des haarwachstums und zur verringerung von haarausfall auf basis von pyrimidinderivaten, sowie verwendung des mittels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK413687D0 DK413687D0 (da) | 1987-08-07 |
| DK413687A DK413687A (da) | 1988-02-08 |
| DK168190B1 true DK168190B1 (da) | 1994-02-28 |
Family
ID=25598930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK413687A DK168190B1 (da) | 1986-08-07 | 1987-08-07 | Præparat på basis af pyrimidinderivater til fremkaldelse og stimulering af hårvækst og reduktion af hårfald, fremgangsmåde til kosmetisk behandling med præparat og anvendelse af præparatet til fremstilling af lægemidler |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS6344512A (enExample) |
| AT (1) | AT400515B (enExample) |
| AU (1) | AU608763B2 (enExample) |
| BE (1) | BE1001044A5 (enExample) |
| CA (1) | CA1294882C (enExample) |
| CH (1) | CH675965A5 (enExample) |
| DE (1) | DE3726177A1 (enExample) |
| DK (1) | DK168190B1 (enExample) |
| FR (1) | FR2602424B1 (enExample) |
| GB (1) | GB2194887B (enExample) |
| LU (1) | LU86547A1 (enExample) |
| NL (1) | NL8701853A (enExample) |
| SE (1) | SE503269C2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU86574A1 (fr) * | 1986-09-08 | 1988-04-05 | Oreal | Composition pour induire et stimuler la croissance des cheveux et freiner leur chute,a base d'esters nicotiniques et de derives de pyrimidine |
| JP2675111B2 (ja) * | 1988-02-18 | 1997-11-12 | ジ・アップジョン・カンパニー | ミノキシジルゲル |
| US5225189A (en) * | 1988-02-18 | 1993-07-06 | The Upjohn Company | Minoxidil gel |
| ATE90195T1 (de) * | 1988-02-18 | 1993-06-15 | Upjohn Co | Minoxidil-gel. |
| US7442369B1 (en) * | 2000-08-09 | 2008-10-28 | Mcneil Ab | Compositions of minoxidil |
| JP2023031353A (ja) * | 2021-08-25 | 2023-03-09 | 学校法人近畿大学 | 毛包上皮幹細胞活性化剤及び外用組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3461461A (en) * | 1965-11-01 | 1969-08-12 | Upjohn Co | 6-amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines |
| CA1020558A (en) * | 1971-04-07 | 1977-11-08 | Richard C. Thomas (Jr.) | 6-amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines |
| US4076711A (en) * | 1976-04-05 | 1978-02-28 | Schering Corporation | Triazolo [4,5-d]-pyrimidines |
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| CH638216A5 (de) * | 1977-02-04 | 1983-09-15 | Hoffmann La Roche | Oxadiazolopyrimidin-deriate. |
| LU84708A1 (fr) * | 1983-03-23 | 1984-11-14 | Oreal | Composition epaissie ou gelifiee de conditionnement des cheveux contenant au moins un polymere cationique,au moins un polymere anionique et au moins une gomme de xanthane |
| DE3584595D1 (de) * | 1984-08-29 | 1991-12-12 | Kao Corp | Antimikrobische suspensionen und antimikrobische haarbehandlungsmittel. |
| NZ214397A (en) * | 1984-12-21 | 1989-04-26 | Richardson Vicks Inc | Minoxidil and acrylate polymer topical compositions |
| IT1201436B (it) * | 1985-07-19 | 1989-02-02 | Vincenzo Zappia | Formulazioni topiche a lento rilascio |
| FR2590897B1 (fr) * | 1985-12-06 | 1988-02-19 | Kemyos Bio Medical Research Sr | Nouveaux derives de 6 amino 1,2-dihydro-1-hydroxy-2-imino-pyrimidine, leur procede de preparation et compositions cosmetiques les renfermant |
| DE3615396A1 (de) * | 1986-05-07 | 1987-11-12 | Wella Ag | Mittel zur behandlung der haare und der kopfhaut |
-
1986
- 1986-08-07 LU LU86547A patent/LU86547A1/fr unknown
-
1987
- 1987-08-05 CH CH3010/87A patent/CH675965A5/fr not_active IP Right Cessation
- 1987-08-06 FR FR878711207A patent/FR2602424B1/fr not_active Expired - Lifetime
- 1987-08-06 AU AU76619/87A patent/AU608763B2/en not_active Ceased
- 1987-08-06 SE SE8703068A patent/SE503269C2/sv not_active IP Right Cessation
- 1987-08-06 GB GB8718612A patent/GB2194887B/en not_active Expired - Lifetime
- 1987-08-06 DE DE19873726177 patent/DE3726177A1/de active Granted
- 1987-08-06 NL NL8701853A patent/NL8701853A/nl not_active Application Discontinuation
- 1987-08-06 CA CA000543885A patent/CA1294882C/fr not_active Expired - Lifetime
- 1987-08-06 BE BE8700870A patent/BE1001044A5/fr not_active IP Right Cessation
- 1987-08-07 JP JP62198011A patent/JPS6344512A/ja active Pending
- 1987-08-07 DK DK413687A patent/DK168190B1/da not_active IP Right Cessation
- 1987-10-12 AT AT269387A patent/AT400515B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE8703068D0 (sv) | 1987-08-06 |
| AU608763B2 (en) | 1991-04-18 |
| CA1294882C (fr) | 1992-01-28 |
| NL8701853A (nl) | 1988-03-01 |
| DE3726177C2 (enExample) | 1992-04-09 |
| DK413687A (da) | 1988-02-08 |
| FR2602424B1 (fr) | 1991-08-16 |
| CH675965A5 (enExample) | 1990-11-30 |
| SE8703068L (sv) | 1988-02-08 |
| AU7661987A (en) | 1988-02-11 |
| GB2194887A (en) | 1988-03-23 |
| GB2194887B (en) | 1991-01-30 |
| FR2602424A1 (fr) | 1988-02-12 |
| ATA269387A (de) | 1995-06-15 |
| BE1001044A5 (fr) | 1989-06-20 |
| JPS6344512A (ja) | 1988-02-25 |
| DE3726177A1 (de) | 1988-02-11 |
| AT400515B (de) | 1996-01-25 |
| GB8718612D0 (en) | 1987-09-09 |
| DK413687D0 (da) | 1987-08-07 |
| SE503269C2 (sv) | 1996-04-29 |
| LU86547A1 (fr) | 1988-03-02 |
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