DK168030B1 - Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader. - Google Patents

Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader. Download PDF

Info

Publication number
DK168030B1
DK168030B1 DK342684A DK342684A DK168030B1 DK 168030 B1 DK168030 B1 DK 168030B1 DK 342684 A DK342684 A DK 342684A DK 342684 A DK342684 A DK 342684A DK 168030 B1 DK168030 B1 DK 168030B1
Authority
DK
Denmark
Prior art keywords
atoms
proteins
aqueous
solution
formula
Prior art date
Application number
DK342684A
Other languages
Danish (da)
English (en)
Other versions
DK342684D0 (da
DK342684A (da
Inventor
Horst Thurow
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK342684D0 publication Critical patent/DK342684D0/da
Publication of DK342684A publication Critical patent/DK342684A/da
Application granted granted Critical
Publication of DK168030B1 publication Critical patent/DK168030B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK342684A 1983-07-13 1984-07-12 Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader. DK168030B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833325223 DE3325223A1 (de) 1983-07-13 1983-07-13 Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung
DE3325223 1983-07-13

Publications (3)

Publication Number Publication Date
DK342684D0 DK342684D0 (da) 1984-07-12
DK342684A DK342684A (da) 1985-01-14
DK168030B1 true DK168030B1 (da) 1994-01-24

Family

ID=6203842

Family Applications (1)

Application Number Title Priority Date Filing Date
DK342684A DK168030B1 (da) 1983-07-13 1984-07-12 Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader.

Country Status (15)

Country Link
US (1) US4637834A (nl)
EP (1) EP0131864B1 (nl)
JP (1) JPS6038398A (nl)
KR (1) KR920002934B1 (nl)
AT (1) ATE56876T1 (nl)
AU (1) AU579106B2 (nl)
DE (2) DE3325223A1 (nl)
DK (1) DK168030B1 (nl)
ES (2) ES8600319A1 (nl)
FI (1) FI80276C (nl)
GR (1) GR81504B (nl)
IE (1) IE57694B1 (nl)
IL (1) IL72389A (nl)
PT (1) PT78892A (nl)
ZA (1) ZA845384B (nl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
JPS61277633A (ja) * 1985-05-31 1986-12-08 Toray Ind Inc インタ−フエロン組成物
US5183746A (en) * 1986-10-27 1993-02-02 Schering Aktiengesellschaft Formulation processes for pharmaceutical compositions of recombinant β-
US4956274A (en) * 1987-04-06 1990-09-11 Microgenics Corporation Reagent stabilization in enzyme-donor and acceptor assay
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
US5981485A (en) * 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
EP0639984A1 (en) * 1992-04-07 1995-03-01 Mallinckrodt Veterinary, Inc. Lyophilized somatotropin formulations
CA2489978A1 (en) * 1992-07-31 1994-02-17 Genentech, Inc. Human growth hormone aqueous formulation
US6790439B1 (en) 1995-06-07 2004-09-14 Zymogenetics, Inc. Thrombopoietin compositions
PT1602667E (pt) * 1995-06-07 2007-07-13 Searle Llc Formulação aquosa que compreende tfpi e agentes de solubilização
MX9602398A (es) * 1995-06-23 1997-02-28 Kimberly Clark Co Material polimerico modificado teniendo humectabilidad mejorada.
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
CA2378949C (en) * 1999-07-12 2015-03-31 Grandis Biotech Gmbh Growth hormone formulations
CN1668332A (zh) * 2002-07-09 2005-09-14 桑多斯股份公司 包含苯酚的含高浓度人生长激素的液体制剂
ATE516306T1 (de) * 2003-08-13 2011-07-15 Novartis Vaccines & Diagnostic Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen
UA89781C2 (uk) 2004-04-07 2010-03-10 Арес Трейдінг С.А. Рідкий склад гормона росту
EP1847830A1 (en) * 2006-04-20 2007-10-24 TF Instruments, Inc. Determining optimal concentrations of protective additives for biomolecules
WO2024133849A1 (en) * 2022-12-22 2024-06-27 The Protein Brewery B.V. Ovalbumin fermentation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439355A (en) * 1976-12-02 1984-03-27 Colgate-Palmolive Company Elastic detergent product of improved foaming power after use
DE2917535C2 (de) * 1979-04-30 1986-10-30 Hoechst Ag, 6230 Frankfurt Gegen Denaturierung beständige Insulinlösungen
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
EP0083619A1 (en) * 1981-07-17 1983-07-20 Nordisk Insulinlaboratorium A stable aqueous, therapeutic insulin preparation and a process for preparing it

Also Published As

Publication number Publication date
FI842798A0 (fi) 1984-07-11
EP0131864A2 (de) 1985-01-23
ES535482A0 (es) 1986-09-01
DE3325223A1 (de) 1985-01-24
FI80276C (fi) 1990-05-10
KR920002934B1 (ko) 1992-04-10
ZA845384B (en) 1985-02-27
KR850000971A (ko) 1985-03-14
AU579106B2 (en) 1988-11-17
US4637834A (en) 1987-01-20
ES534195A0 (es) 1985-10-01
AU3053784A (en) 1985-01-17
IE57694B1 (en) 1993-03-10
JPH0582397B2 (nl) 1993-11-18
DK342684D0 (da) 1984-07-12
JPS6038398A (ja) 1985-02-27
DE3483287D1 (de) 1990-10-31
ATE56876T1 (de) 1990-10-15
ES8609361A1 (es) 1986-09-01
EP0131864A3 (en) 1987-08-26
DK342684A (da) 1985-01-14
FI80276B (fi) 1990-01-31
IE841796L (en) 1985-01-13
FI842798A (fi) 1985-01-14
GR81504B (nl) 1984-12-11
IL72389A (en) 1988-11-30
ES8600319A1 (es) 1985-10-01
PT78892A (de) 1984-08-01
EP0131864B1 (de) 1990-09-26
IL72389A0 (en) 1984-11-30

Similar Documents

Publication Publication Date Title
DK168030B1 (da) Vandige proteinoploesninger, som er bestandige over for denaturering, fremgangsmaade til deres fremstilling og deres anvendelse samt fremgangsmaade til behandling af hydrophobe overflader.
US4885164A (en) Aqueous protein solutions stable to denaturation
US4783441A (en) Aqueous protein solutions stable to denaturation
US20220023424A1 (en) Peroxide removal from drug delivery vehicle
CA1339440C (en) Process for stabilizing human albumin solutions and the solution obtained
US4216205A (en) Process of preparing a serum protein composition for intravenous application
JPH0694421B2 (ja) 静注可能な免疫グロブリン
CN86101708A (zh) γ-球蛋白的病毒灭活热处理方法以及经过热处理的含有这种蛋白的水溶液
WO1997002832A1 (fr) Preparations lyophilisees de hgf
RU2112522C1 (ru) Состав для стабилизации плазмы крови, способ пастеризации плазмы и использование стабилизированной плазмы в терапии
CA1293941C (en) Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product
IL44008A (en) Production of antisera
JPH09124507A (ja) ウイルスを不活化した静脈内注射可能な免疫血清グロブリンの調製
CN112672734B (zh) 包含蛋白质和聚烷氧基脂肪酰基表面活性剂的组合物
KR20220140487A (ko) 단백질 생물 공정
CZ2002264A3 (cs) Vícedávkové kompozice na bázi erythropoietinu
JPH0525862B2 (nl)
JP2000044600A (ja) タンパク質溶液の調製法
Østergaard Alsøe et al. Pasteurisation of a factor I (C3b inactivator) concentrate from human plasma
UA58727A (uk) Спосіб очистки сироватки крові великої рогатої худоби
Moore Production of complement: cellular studies.
Grangeorge et al. Process for stabilizing human albumin solutions and the solution obtained
TW201811815A (zh) 製備免疫球蛋白溶液的方法及其用途

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired