ZA845384B - Aqueous protein solutions which are stable towards denaturing,processes for their preparation and their use - Google Patents

Aqueous protein solutions which are stable towards denaturing,processes for their preparation and their use

Info

Publication number
ZA845384B
ZA845384B ZA845384A ZA845384A ZA845384B ZA 845384 B ZA845384 B ZA 845384B ZA 845384 A ZA845384 A ZA 845384A ZA 845384 A ZA845384 A ZA 845384A ZA 845384 B ZA845384 B ZA 845384B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
formula
protein solutions
aqueous protein
Prior art date
Application number
ZA845384A
Other languages
English (en)
Inventor
Horst Thurow
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA845384B publication Critical patent/ZA845384B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
ZA845384A 1983-07-13 1984-07-12 Aqueous protein solutions which are stable towards denaturing,processes for their preparation and their use ZA845384B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833325223 DE3325223A1 (de) 1983-07-13 1983-07-13 Gegen denaturierung bestaendige, waessrige proteinloesungen, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA845384B true ZA845384B (en) 1985-02-27

Family

ID=6203842

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA845384A ZA845384B (en) 1983-07-13 1984-07-12 Aqueous protein solutions which are stable towards denaturing,processes for their preparation and their use

Country Status (15)

Country Link
US (1) US4637834A (nl)
EP (1) EP0131864B1 (nl)
JP (1) JPS6038398A (nl)
KR (1) KR920002934B1 (nl)
AT (1) ATE56876T1 (nl)
AU (1) AU579106B2 (nl)
DE (2) DE3325223A1 (nl)
DK (1) DK168030B1 (nl)
ES (2) ES8600319A1 (nl)
FI (1) FI80276C (nl)
GR (1) GR81504B (nl)
IE (1) IE57694B1 (nl)
IL (1) IL72389A (nl)
PT (1) PT78892A (nl)
ZA (1) ZA845384B (nl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
JPS61277633A (ja) * 1985-05-31 1986-12-08 Toray Ind Inc インタ−フエロン組成物
US5183746A (en) * 1986-10-27 1993-02-02 Schering Aktiengesellschaft Formulation processes for pharmaceutical compositions of recombinant β-
US4956274A (en) * 1987-04-06 1990-09-11 Microgenics Corporation Reagent stabilization in enzyme-donor and acceptor assay
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
US5763394A (en) * 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
US5981485A (en) * 1997-07-14 1999-11-09 Genentech, Inc. Human growth hormone aqueous formulation
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
JPH08502021A (ja) * 1992-04-07 1996-03-05 マリンクロッド・ヴェタラネリィ・インコーポレイテッド 生体相容性ソマトトロピン溶液
DK0955062T3 (da) * 1992-07-31 2007-09-17 Genentech Inc Vandig formulering indeholdende humant væksthormon
US6790439B1 (en) 1995-06-07 2004-09-14 Zymogenetics, Inc. Thrombopoietin compositions
PT1602667E (pt) * 1995-06-07 2007-07-13 Searle Llc Formulação aquosa que compreende tfpi e agentes de solubilização
MX9602398A (es) * 1995-06-23 1997-02-28 Kimberly Clark Co Material polimerico modificado teniendo humectabilidad mejorada.
AUPN801296A0 (en) * 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
BR0013162A (pt) * 1999-07-12 2002-05-28 Grandis Biotech Gmbh Formulações de hormÈnio de crescimento
CN1668332A (zh) * 2002-07-09 2005-09-14 桑多斯股份公司 包含苯酚的含高浓度人生长激素的液体制剂
EP1654283B1 (en) * 2003-08-13 2011-07-13 Novartis Vaccines and Diagnostics, Inc. Improved method of purifying tfpi and tfpi analogs
AU2005237775B2 (en) 2004-04-07 2010-03-04 Ares Trading S.A. Liquid growth hormone formulation
EP1847830A1 (en) * 2006-04-20 2007-10-24 TF Instruments, Inc. Determining optimal concentrations of protective additives for biomolecules
WO2024133849A1 (en) * 2022-12-22 2024-06-27 The Protein Brewery B.V. Ovalbumin fermentation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439355A (en) * 1976-12-02 1984-03-27 Colgate-Palmolive Company Elastic detergent product of improved foaming power after use
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
DE2917535C2 (de) * 1979-04-30 1986-10-30 Hoechst Ag, 6230 Frankfurt Gegen Denaturierung beständige Insulinlösungen
JPS58501125A (ja) * 1981-07-17 1983-07-14 ノルデイスク・インスリンラボラトリウム 安定な水性治療性インシユリン製剤及びその製造方法

Also Published As

Publication number Publication date
DE3483287D1 (de) 1990-10-31
ES534195A0 (es) 1985-10-01
DE3325223A1 (de) 1985-01-24
AU579106B2 (en) 1988-11-17
FI842798A (fi) 1985-01-14
FI842798A0 (fi) 1984-07-11
IE841796L (en) 1985-01-13
JPH0582397B2 (nl) 1993-11-18
ES8609361A1 (es) 1986-09-01
AU3053784A (en) 1985-01-17
EP0131864A2 (de) 1985-01-23
US4637834A (en) 1987-01-20
FI80276B (fi) 1990-01-31
KR850000971A (ko) 1985-03-14
FI80276C (fi) 1990-05-10
KR920002934B1 (ko) 1992-04-10
JPS6038398A (ja) 1985-02-27
DK342684D0 (da) 1984-07-12
IE57694B1 (en) 1993-03-10
DK168030B1 (da) 1994-01-24
DK342684A (da) 1985-01-14
ATE56876T1 (de) 1990-10-15
EP0131864B1 (de) 1990-09-26
EP0131864A3 (en) 1987-08-26
PT78892A (de) 1984-08-01
GR81504B (nl) 1984-12-11
IL72389A0 (en) 1984-11-30
ES8600319A1 (es) 1985-10-01
ES535482A0 (es) 1986-09-01
IL72389A (en) 1988-11-30

Similar Documents

Publication Publication Date Title
IL72389A0 (en) Aqueous protein solutions which are stable towards denaturing,processes for their preparation and their use
NZ220546A (en) Benzothiophene- and benzofuran- amides and compositions
EP0886648A4 (en) COMPOUNDS AND PEPTIDES BINDING THE ERYTHROPOIETIN RECEPTOR
GR3002618T3 (en) Solutions of oxazaphosphorins with enhanced stability and process for their preparation
EP0373549A3 (de) Enzym-hemmende Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung
ES2045485T3 (es) Metodo de preparacion de derivados de fenil-6 piperazinilalquil-3 1h, 3h-pirimidinediona-2,4, y su aplicacion en terapeutica.
AU555418B2 (en) Muramyl peptides
AU1779188A (en) Guanidine-related compounds comprising a substituted tetraphenylborate ion, process for obtaining these compounds, and use of the compounds
PT90814A (pt) Processo de preparacao de derivados da fenotiazina
DE3664634D1 (en) Substituted o-sulfonyl-glycosyl amides, method for their preparation and their use as mediacments
DE59007216D1 (de) Verfahren zur Herstellung von Clausenamid und Neoclausenamid und deren Derivate.
ES2043784T3 (es) Procedimiento de preparacion de compuestos guanidinicos.
ATE111087T1 (de) Verfahren zur herstellung von 2-aryl-2h-1,2,3- triazolen.
IT1240323B (it) Processo per indurre la secrezione di proteine da cellule eucariote