DK166390C - Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner - Google Patents

Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner

Info

Publication number
DK166390C
DK166390C DK196185A DK196185A DK166390C DK 166390 C DK166390 C DK 166390C DK 196185 A DK196185 A DK 196185A DK 196185 A DK196185 A DK 196185A DK 166390 C DK166390 C DK 166390C
Authority
DK
Denmark
Prior art keywords
adduct
preparing
halo
lincomycines
desoxy
Prior art date
Application number
DK196185A
Other languages
Danish (da)
English (en)
Other versions
DK196185A (da
DK196185D0 (da
DK166390B (da
Inventor
Douglas Alan Livingston
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK196185D0 publication Critical patent/DK196185D0/da
Publication of DK196185A publication Critical patent/DK196185A/da
Publication of DK166390B publication Critical patent/DK166390B/da
Application granted granted Critical
Publication of DK166390C publication Critical patent/DK166390C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK196185A 1984-05-15 1985-05-01 Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner DK166390C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/610,364 US4568741A (en) 1984-05-15 1984-05-15 Synthesis of 7-halo-7-deoxylincomycins
US61036484 1984-05-15

Publications (4)

Publication Number Publication Date
DK196185D0 DK196185D0 (da) 1985-05-01
DK196185A DK196185A (da) 1985-11-16
DK166390B DK166390B (da) 1993-05-10
DK166390C true DK166390C (da) 1993-09-27

Family

ID=24444721

Family Applications (1)

Application Number Title Priority Date Filing Date
DK196185A DK166390C (da) 1984-05-15 1985-05-01 Fremgangsmaade til fremstilling af 7-halogen-7-desoxy-lincomyciner

Country Status (18)

Country Link
US (1) US4568741A (hu)
EP (1) EP0161794B1 (hu)
JP (1) JPS60260591A (hu)
KR (1) KR910002224B1 (hu)
AT (1) ATE54150T1 (hu)
AU (1) AU574453B2 (hu)
CA (1) CA1229592A (hu)
DE (1) DE3578425D1 (hu)
DK (1) DK166390C (hu)
ES (1) ES8606877A1 (hu)
FI (1) FI78108C (hu)
GR (1) GR851150B (hu)
HK (1) HK59293A (hu)
HU (1) HU196820B (hu)
IL (2) IL74971A (hu)
MX (1) MX163480B (hu)
PT (1) PT80463B (hu)
ZA (1) ZA852592B (hu)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
TW282399B (hu) * 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
DE4039750A1 (de) * 1990-12-13 1992-06-17 Basf Ag Verfahren zur entfernung von phosgen aus abgasen
JP3202960B2 (ja) 1998-02-17 2001-08-27 大塚化学株式会社 ハロゲン化剤及び水酸基のハロゲン化方法
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
DE60204897T2 (de) * 2001-08-28 2006-05-11 Pharmacia Corp. Kristalline freie base von clindamycin
AU2003265475B2 (en) * 2002-08-15 2009-08-27 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199105B2 (en) * 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
AR042906A1 (es) 2003-01-24 2005-07-06 Connetics Australia Pty Ltd Espuma de fosfato de clindamicina sensible a la temperatura y metodo de tratamiento de acne que la utiliza
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
AU2004258953B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
US8425936B2 (en) * 2003-07-21 2013-04-23 Shionogi Inc. Antibiotic product, use and formulation thereof
JP2006528189A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
CA2535177A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
AU2004264356B2 (en) * 2003-08-12 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005023184A2 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
CA2538064C (en) * 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1701705A4 (en) * 2003-12-24 2007-08-08 Advancis Pharmaceutical Corp IMPROVED ABSORPTION OF MODIFIED RELEASE DOSAGE FORMS
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
EP1771158A4 (en) * 2004-07-02 2008-03-12 Advancis Pharmaceutical Corp TABLET FOR PULSED DELIVERY
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
ES2582654T3 (es) 2006-03-31 2016-09-14 Stiefel Research Australia Pty Ltd Gel en suspensión espumable
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN101205245B (zh) * 2007-12-06 2011-04-06 河南天方药业股份有限公司 盐酸克林霉素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3475407A (en) * 1967-12-22 1969-10-28 Upjohn Co Process for preparing 7(r)- and 7(s)-halolincomycins
US3509127A (en) * 1968-04-30 1970-04-28 Upjohn Co Isologs of lincomycins and process for preparing the same
US3574186A (en) * 1969-10-08 1971-04-06 Upjohn Co Process for making 7-chloro-7-deoxylincomycin and related compounds and novel intermediates produced therein
US3714141A (en) * 1970-05-26 1973-01-30 Upjohn Co Process for making 7-halolincomycins
US4324888A (en) * 1979-03-09 1982-04-13 Talres Development (N.A.) N.V. Process for the preparation of chlorodeoxysugars
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Also Published As

Publication number Publication date
FI851941L (fi) 1985-11-16
IL75175A0 (en) 1985-09-29
DK196185A (da) 1985-11-16
DK196185D0 (da) 1985-05-01
HU196820B (en) 1989-01-30
DK166390B (da) 1993-05-10
ATE54150T1 (de) 1990-07-15
AU574453B2 (en) 1988-07-07
ES542940A0 (es) 1986-05-16
GR851150B (hu) 1985-11-25
FI78108C (fi) 1989-06-12
HUT40805A (en) 1987-02-27
HK59293A (en) 1993-06-25
KR850008349A (ko) 1985-12-16
EP0161794A2 (en) 1985-11-21
AU4095085A (en) 1985-11-21
PT80463A (en) 1985-06-01
IL74971A (en) 1991-07-18
CA1229592A (en) 1987-11-24
EP0161794A3 (en) 1987-07-29
ZA852592B (en) 1985-11-27
ES8606877A1 (es) 1986-05-16
FI851941A0 (fi) 1985-05-15
EP0161794B1 (en) 1990-06-27
PT80463B (pt) 1987-08-19
KR910002224B1 (ko) 1991-04-08
FI78108B (fi) 1989-02-28
US4568741A (en) 1986-02-04
MX163480B (es) 1992-05-19
JPS60260591A (ja) 1985-12-23
DE3578425D1 (de) 1990-08-02
IL74971A0 (en) 1985-08-30
JPH0533711B2 (hu) 1993-05-20

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