DK165247C - 2,3,4,5-substituerede 1,6-naphthyridinderivater, deres fremstilling samt anvendelse af disse til fremstilling af laegemidler til bekaempelse af cardiale, cerebrale og perifere karlidelser, myocardial iskaemi, cerebral infarkt, lungethrombose, stenoser, arterioscleroser og hjerte-kredsloebslidelser og laegemiddel indeholdende disse derivater - Google Patents

2,3,4,5-substituerede 1,6-naphthyridinderivater, deres fremstilling samt anvendelse af disse til fremstilling af laegemidler til bekaempelse af cardiale, cerebrale og perifere karlidelser, myocardial iskaemi, cerebral infarkt, lungethrombose, stenoser, arterioscleroser og hjerte-kredsloebslidelser og laegemiddel indeholdende disse derivater

Info

Publication number
DK165247C
DK165247C DK384485A DK384485A DK165247C DK 165247 C DK165247 C DK 165247C DK 384485 A DK384485 A DK 384485A DK 384485 A DK384485 A DK 384485A DK 165247 C DK165247 C DK 165247C
Authority
DK
Denmark
Prior art keywords
chained
straight
carbon atoms
branched alkyl
alkyl radical
Prior art date
Application number
DK384485A
Other languages
Danish (da)
English (en)
Other versions
DK384485D0 (da
DK165247B (da
DK384485A (da
Inventor
Gerhard Satzinger
Johannes Hartenstein
Karl Mannhardt
Juergen Kleinschroth
Hartmut Osswald
Guenter Weinheimer
Edgar Fritschi
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843431303 external-priority patent/DE3431303A1/de
Priority claimed from DE19853502790 external-priority patent/DE3502790A1/de
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of DK384485D0 publication Critical patent/DK384485D0/da
Publication of DK384485A publication Critical patent/DK384485A/da
Publication of DK165247B publication Critical patent/DK165247B/da
Application granted granted Critical
Publication of DK165247C publication Critical patent/DK165247C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Liquid Crystal Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK384485A 1984-08-25 1985-08-23 2,3,4,5-substituerede 1,6-naphthyridinderivater, deres fremstilling samt anvendelse af disse til fremstilling af laegemidler til bekaempelse af cardiale, cerebrale og perifere karlidelser, myocardial iskaemi, cerebral infarkt, lungethrombose, stenoser, arterioscleroser og hjerte-kredsloebslidelser og laegemiddel indeholdende disse derivater DK165247C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3431303 1984-08-25
DE19843431303 DE3431303A1 (de) 1984-08-25 1984-08-25 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE19853502790 DE3502790A1 (de) 1985-01-29 1985-01-29 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE3502790 1985-01-29

Publications (4)

Publication Number Publication Date
DK384485D0 DK384485D0 (da) 1985-08-23
DK384485A DK384485A (da) 1986-02-26
DK165247B DK165247B (da) 1992-10-26
DK165247C true DK165247C (da) 1993-04-26

Family

ID=25824189

Family Applications (1)

Application Number Title Priority Date Filing Date
DK384485A DK165247C (da) 1984-08-25 1985-08-23 2,3,4,5-substituerede 1,6-naphthyridinderivater, deres fremstilling samt anvendelse af disse til fremstilling af laegemidler til bekaempelse af cardiale, cerebrale og perifere karlidelser, myocardial iskaemi, cerebral infarkt, lungethrombose, stenoser, arterioscleroser og hjerte-kredsloebslidelser og laegemiddel indeholdende disse derivater

Country Status (22)

Country Link
US (1) US4711901A (fr)
EP (1) EP0173933B1 (fr)
KR (1) KR890000706B1 (fr)
AT (1) ATE48276T1 (fr)
AU (1) AU576887B2 (fr)
BG (1) BG43691A3 (fr)
CA (1) CA1263118A (fr)
DE (1) DE3574471D1 (fr)
DK (1) DK165247C (fr)
ES (1) ES8604960A1 (fr)
FI (1) FI80697C (fr)
GR (1) GR852040B (fr)
HU (1) HU194879B (fr)
IE (1) IE58364B1 (fr)
IL (2) IL75987A (fr)
NO (1) NO161493C (fr)
NZ (1) NZ213218A (fr)
PH (4) PH21177A (fr)
PL (1) PL146668B1 (fr)
RO (1) RO92245B (fr)
SU (1) SU1395143A3 (fr)
YU (2) YU45000B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE3906406C1 (fr) * 1989-03-01 1990-10-25 Goedecke Ag, 1000 Berlin, De
DE3906460C1 (fr) * 1989-03-01 1990-11-15 Goedecke Ag, 1000 Berlin, De
DE102006026585A1 (de) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung
DE102006026583A1 (de) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
CN106795155B (zh) * 2014-08-01 2023-06-16 拜耳医药股份有限公司 一种化合物的制备方法及其纯化以用作活性药物成分
PE20180555A1 (es) * 2015-08-21 2018-04-02 Bayer Pharma AG Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridina-3-carboxamida y para la recuperacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridina-3-carboxamida por medio de metodos electroquimicos
ES2739904T3 (es) * 2015-08-21 2020-02-04 Bayer Pharma AG Procedimiento para la preparación de (4S)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificación para el uso como principio activo farmacéutico

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304914A (en) * 1980-07-07 1981-12-08 Usv Pharmaceutical Corporation Naphthyridone derivatives
DE3327650A1 (de) * 1983-07-30 1985-02-14 Gödecke AG, 1000 Berlin 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen

Also Published As

Publication number Publication date
HU194879B (en) 1988-03-28
IE852085L (en) 1986-02-25
US4711901A (en) 1987-12-08
YU14588A (en) 1991-02-28
ES546366A0 (es) 1986-03-01
IL75987A (en) 1991-07-18
IL75987A0 (en) 1985-12-31
SU1395143A3 (ru) 1988-05-07
YU47010B (sh) 1994-11-15
ES8604960A1 (es) 1986-03-01
GR852040B (fr) 1985-12-19
NO161493C (no) 1989-08-23
DE3574471D1 (de) 1990-01-04
HUT39448A (en) 1986-09-29
RO92245A (fr) 1987-07-30
DK384485D0 (da) 1985-08-23
NO853329L (no) 1986-02-26
RO92245B (ro) 1987-07-31
CA1263118A (fr) 1989-11-21
EP0173933A1 (fr) 1986-03-12
ATE48276T1 (de) 1989-12-15
YU134885A (en) 1988-10-31
AU576887B2 (en) 1988-09-08
PL255118A1 (en) 1986-07-29
AU4662685A (en) 1986-02-27
BG43691A3 (en) 1988-07-15
EP0173933B1 (fr) 1989-11-29
IE58364B1 (en) 1993-09-08
PL146668B1 (en) 1989-02-28
PH21177A (en) 1987-08-07
FI80697C (fi) 1990-07-10
FI853233A0 (fi) 1985-08-22
PH23411A (en) 1989-07-26
FI853233L (fi) 1986-02-26
KR890000706B1 (ko) 1989-03-27
NZ213218A (en) 1990-01-29
PH24762A (en) 1990-10-01
YU45000B (en) 1991-06-30
DK165247B (da) 1992-10-26
KR860001810A (ko) 1986-03-22
NO161493B (no) 1989-05-16
DK384485A (da) 1986-02-26
FI80697B (fi) 1990-03-30
PH23379A (en) 1989-07-26

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