DK1606269T3 - Biaryl-substituerede triazoler som natriumkanalblokkere - Google Patents

Biaryl-substituerede triazoler som natriumkanalblokkere

Info

Publication number
DK1606269T3
DK1606269T3 DK04720360T DK04720360T DK1606269T3 DK 1606269 T3 DK1606269 T3 DK 1606269T3 DK 04720360 T DK04720360 T DK 04720360T DK 04720360 T DK04720360 T DK 04720360T DK 1606269 T3 DK1606269 T3 DK 1606269T3
Authority
DK
Denmark
Prior art keywords
biaryl
sodium channel
channel blockers
substituted triazoles
triazoles
Prior art date
Application number
DK04720360T
Other languages
Danish (da)
English (en)
Inventor
Prasun K Chakravarty
Michael H Fisher
Brenda Palucki
Min K Park
William H Parsons
Bishan Zhou
James P Carey
Douglas E Frantz
Michael H Kress
Damian Weaver
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK1606269T3 publication Critical patent/DK1606269T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04720360T 2003-03-18 2004-03-12 Biaryl-substituerede triazoler som natriumkanalblokkere DK1606269T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45595203P 2003-03-18 2003-03-18
PCT/US2004/007597 WO2004083189A1 (fr) 2003-03-18 2004-03-12 Triazoles substitues par biaryle utilises comme inhibiteurs des canaux sodiques

Publications (1)

Publication Number Publication Date
DK1606269T3 true DK1606269T3 (da) 2009-02-09

Family

ID=33030073

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04720360T DK1606269T3 (da) 2003-03-18 2004-03-12 Biaryl-substituerede triazoler som natriumkanalblokkere

Country Status (34)

Country Link
US (2) US7326726B2 (fr)
EP (1) EP1606269B1 (fr)
JP (1) JP4482554B2 (fr)
KR (1) KR100737721B1 (fr)
CN (2) CN1788002A (fr)
AR (1) AR044503A1 (fr)
AT (1) ATE412639T1 (fr)
AU (1) AU2004221885C1 (fr)
BR (1) BRPI0408407A (fr)
CA (1) CA2519252C (fr)
CL (1) CL2004000551A1 (fr)
CY (1) CY1108720T1 (fr)
DE (1) DE602004017438D1 (fr)
DK (1) DK1606269T3 (fr)
EC (1) ECSP056018A (fr)
EG (1) EG25994A (fr)
ES (1) ES2314387T3 (fr)
HR (1) HRP20050816A2 (fr)
IS (1) IS8001A (fr)
JO (1) JO2480B1 (fr)
MA (1) MA27665A1 (fr)
MX (1) MXPA05009847A (fr)
MY (1) MY142651A (fr)
NO (1) NO20054775L (fr)
NZ (1) NZ542205A (fr)
PE (1) PE20041066A1 (fr)
PL (1) PL1606269T3 (fr)
PT (1) PT1606269E (fr)
RU (1) RU2356897C2 (fr)
SI (1) SI1606269T1 (fr)
TW (1) TWI337605B (fr)
UA (1) UA81660C2 (fr)
WO (2) WO2004083189A1 (fr)
ZA (1) ZA200506906B (fr)

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BRPI0317463B8 (pt) 2002-12-19 2021-05-25 Scripps Research Inst composto, composição farmacêutica compreendendo o mesmo e uso do referido composto no preparo de um medicamento para tratar uma doença amilóide de transtiretina
AR044503A1 (es) * 2003-03-18 2005-09-14 Merck & Co Inc Triazoles sustituidos con biarilo como bloqueantes del canal de sodio
CA2545254A1 (fr) * 2003-11-10 2005-05-26 Merck & Co., Inc. Triazoles substitues utilises en tant que bloqueurs du canal sodique
CA2566923A1 (fr) 2004-05-20 2005-12-01 Foldrx Pharmaceuticals, Inc. Composes 2-(heteroaryl)benzoxazoles et derives, compositions et procedes servant a stabiliser la transthyretine et a inhiber le mauvais repliement de la transthyretine
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
WO2007042250A1 (fr) 2005-10-10 2007-04-19 Glaxo Group Limited Dérivés de prolinamide en tant que modulateurs des canaux sodiques
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
EA200970706A1 (ru) * 2007-01-24 2010-02-26 Глэксо Груп Лимитед Новые фармацевтические композиции
BRPI0807219A2 (pt) * 2007-02-08 2015-05-26 Synta Pharmaceuticals Corp Composto de tiazol que modulam a atividade de hsp90
MX2009013332A (es) 2007-06-08 2010-01-25 Mannkind Corp Inhibidores de ire-1 alfa.
CN102725290B (zh) 2009-07-27 2016-03-09 吉利德科学股份有限公司 作为离子通道调节剂的稠合杂环化合物
PT2588197E (pt) 2010-07-02 2015-02-09 Gilead Sciences Inc Compostos heterocíclicos fundidos como moduladores do canal de iões
CN105693645B (zh) 2011-05-10 2018-10-09 吉利德科学公司 作为离子通道调节剂的稠合杂环化合物
TWI478908B (zh) 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (fr) 2011-07-01 2018-04-28
EP2755961A1 (fr) 2011-09-16 2014-07-23 Pfizer Inc Formes solides d'un inhibiteur de la dissociation de dérivés de transthyrétine
WO2013131018A1 (fr) * 2012-03-02 2013-09-06 Zalicus Pharmaceuticals Ltd. Inhibiteurs biaryle du canal sodique
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
WO2014152738A1 (fr) 2013-03-15 2014-09-25 Bristol-Myers Squibb Company Modulateurs de lxr
EP3237379B1 (fr) 2014-12-23 2022-04-06 Convergence Pharmaceuticals Limited Procédé pour la préparation de dérivés de pyrrolidine alpha-carboxamide
JP6616244B2 (ja) * 2015-05-29 2019-12-04 北興化学工業株式会社 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法
SG10202112966SA (en) 2017-10-05 2021-12-30 Biogen Inc Process for preparing αlpha-carboxamide pyrrolidine derivatives
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
BR112020018403A2 (pt) * 2018-03-09 2020-12-22 Pi Industries Ltd. Compostos heterocíclicoscomo fungicidas
CN108794413A (zh) * 2018-06-25 2018-11-13 青岛科技大学 一种1,2,4-三氮唑-3-甲酰胺的合成方法
CN108863965A (zh) * 2018-06-25 2018-11-23 青岛科技大学 一锅法制备1,2,4-三氮唑-3-甲酰胺的方法

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US875782A (en) * 1907-04-29 1908-01-07 Walter H Cook Fast-nut.
TW226993B (fr) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
US5455252A (en) 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
IT1292091B1 (it) * 1997-06-05 1999-01-25 Geange Ltd Derivati eterociclici aromatici azotati,procedimento per la loro preparazione e loro impiego come antigestativi,immunosoppressori e
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6414011B1 (en) 1999-03-26 2002-07-02 Euro-Celtique S.A. Aryl substituted pyrazoles, and pyrroles, and the use thereof
AR029489A1 (es) 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
US6962936B2 (en) * 2001-04-27 2005-11-08 Vertex Pharmaceuticals Incorporated Triazole-derived kinase inhibitors and uses thereof
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
CA2490972C (fr) * 2002-07-09 2012-05-29 Bristol-Myers Squibb Company Derives heterocycliques substitues utiles comme agents antidiabetique et anti-obesite et procede correspondant
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
JO2397B1 (en) * 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
AR044503A1 (es) * 2003-03-18 2005-09-14 Merck & Co Inc Triazoles sustituidos con biarilo como bloqueantes del canal de sodio
CA2545254A1 (fr) * 2003-11-10 2005-05-26 Merck & Co., Inc. Triazoles substitues utilises en tant que bloqueurs du canal sodique

Also Published As

Publication number Publication date
DE602004017438D1 (de) 2008-12-11
NO20054775L (no) 2005-12-16
JO2480B1 (en) 2009-01-20
CY1108720T1 (el) 2013-09-04
IS8001A (is) 2005-08-29
EP1606269B1 (fr) 2008-10-29
AU2004221885B2 (en) 2010-04-22
AU2004221885A1 (en) 2004-09-30
PL1606269T3 (pl) 2009-04-30
MY142651A (en) 2010-12-15
BRPI0408407A (pt) 2006-03-21
HRP20050816A2 (hr) 2006-04-30
MXPA05009847A (es) 2005-12-05
SI1606269T1 (sl) 2009-02-28
AR044503A1 (es) 2005-09-14
US20050119261A1 (en) 2005-06-02
KR100737721B1 (ko) 2007-07-11
RU2005132168A (ru) 2006-04-27
PE20041066A1 (es) 2005-01-22
ECSP056018A (es) 2006-01-27
JP4482554B2 (ja) 2010-06-16
US7326726B2 (en) 2008-02-05
ZA200506906B (en) 2007-02-28
EP1606269A1 (fr) 2005-12-21
CL2004000551A1 (es) 2005-01-21
MA27665A1 (fr) 2005-12-01
AU2004221885C1 (en) 2010-09-23
CA2519252A1 (fr) 2004-09-30
JP2006520782A (ja) 2006-09-14
CN101289428A (zh) 2008-10-22
US20080171777A1 (en) 2008-07-17
CA2519252C (fr) 2008-11-18
WO2004083189A1 (fr) 2004-09-30
US7572822B2 (en) 2009-08-11
PT1606269E (pt) 2008-12-16
UA81660C2 (ru) 2008-01-25
ATE412639T1 (de) 2008-11-15
KR20050109583A (ko) 2005-11-21
NO20054775D0 (no) 2005-10-17
RU2356897C2 (ru) 2009-05-27
CN1788002A (zh) 2006-06-14
NZ542205A (en) 2008-11-28
ES2314387T3 (es) 2009-03-16
EG25994A (en) 2012-11-28
TWI337605B (en) 2011-02-21
WO2004083190A1 (fr) 2004-09-30
TW200505876A (en) 2005-02-16

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