EG25994A - Biaryl substituted triazoles as sodium channel blockers - Google Patents
Biaryl substituted triazoles as sodium channel blockersInfo
- Publication number
- EG25994A EG25994A EGNA2005000548A EG25994A EG 25994 A EG25994 A EG 25994A EG NA2005000548 A EGNA2005000548 A EG NA2005000548A EG 25994 A EG25994 A EG 25994A
- Authority
- EG
- Egypt
- Prior art keywords
- sodium channel
- channel blockers
- substituted triazoles
- biaryl substituted
- biaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45595203P | 2003-03-18 | 2003-03-18 | |
PCT/US2004/007830 WO2004083190A1 (fr) | 2003-03-18 | 2004-03-12 | Triazoles substitues par du biaryle, utilises comme inhibiteurs des canaux sodiques |
Publications (1)
Publication Number | Publication Date |
---|---|
EG25994A true EG25994A (en) | 2012-11-28 |
Family
ID=33030073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EGNA2005000548 EG25994A (en) | 2003-03-18 | 2005-09-18 | Biaryl substituted triazoles as sodium channel blockers |
Country Status (34)
Country | Link |
---|---|
US (2) | US7326726B2 (fr) |
EP (1) | EP1606269B1 (fr) |
JP (1) | JP4482554B2 (fr) |
KR (1) | KR100737721B1 (fr) |
CN (2) | CN101289428A (fr) |
AR (1) | AR044503A1 (fr) |
AT (1) | ATE412639T1 (fr) |
AU (1) | AU2004221885C1 (fr) |
BR (1) | BRPI0408407A (fr) |
CA (1) | CA2519252C (fr) |
CL (1) | CL2004000551A1 (fr) |
CY (1) | CY1108720T1 (fr) |
DE (1) | DE602004017438D1 (fr) |
DK (1) | DK1606269T3 (fr) |
EC (1) | ECSP056018A (fr) |
EG (1) | EG25994A (fr) |
ES (1) | ES2314387T3 (fr) |
HR (1) | HRP20050816A2 (fr) |
IS (1) | IS8001A (fr) |
JO (1) | JO2480B1 (fr) |
MA (1) | MA27665A1 (fr) |
MX (1) | MXPA05009847A (fr) |
MY (1) | MY142651A (fr) |
NO (1) | NO20054775L (fr) |
NZ (1) | NZ542205A (fr) |
PE (1) | PE20041066A1 (fr) |
PL (1) | PL1606269T3 (fr) |
PT (1) | PT1606269E (fr) |
RU (1) | RU2356897C2 (fr) |
SI (1) | SI1606269T1 (fr) |
TW (1) | TWI337605B (fr) |
UA (1) | UA81660C2 (fr) |
WO (2) | WO2004083190A1 (fr) |
ZA (1) | ZA200506906B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60323155D1 (de) | 2002-12-19 | 2008-10-02 | Scripps Research Inst | Von transthyretin und zur hemmung von transthyretin-fehlfaltung |
AR044503A1 (es) * | 2003-03-18 | 2005-09-14 | Merck & Co Inc | Triazoles sustituidos con biarilo como bloqueantes del canal de sodio |
CN1922156A (zh) * | 2003-11-10 | 2007-02-28 | 默克公司 | 作为钠通道阻断剂的取代的三唑 |
US20050272704A1 (en) | 2004-05-20 | 2005-12-08 | Kelly Jeffery W | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
TW200728258A (en) | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
EP1943216B1 (fr) | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Dérivés de prolinamide en tant que modulateurs des canaux sodiques |
EP2117538A1 (fr) * | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Compositions pharmaceutiques contenant du 2-méthoxy-5- (5-trifluorométhyl-tétrazol-i-yl-benzyl) - (2s-phényl-pipéridin-3s-yl-) |
BRPI0807219A2 (pt) | 2007-02-08 | 2015-05-26 | Synta Pharmaceuticals Corp | Composto de tiazol que modulam a atividade de hsp90 |
ES2601856T3 (es) | 2007-06-08 | 2017-02-16 | Mannkind Corporation | Inhibidores de la IRE-1A |
CN102725290B (zh) | 2009-07-27 | 2016-03-09 | 吉利德科学股份有限公司 | 作为离子通道调节剂的稠合杂环化合物 |
BR112012033402A2 (pt) | 2010-07-02 | 2017-01-24 | Gilead Sciences Inc | moduladores de canais de íons conforme os compostos heterocíclicos fundidos |
BR112013028886A2 (pt) | 2011-05-10 | 2016-08-09 | Gilead Sciences Inc | compostos heterocíclicos fundidos como moduladores dde canal de sódio |
NO3175985T3 (fr) | 2011-07-01 | 2018-04-28 | ||
TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
EP2755961A1 (fr) | 2011-09-16 | 2014-07-23 | Pfizer Inc | Formes solides d'un inhibiteur de la dissociation de dérivés de transthyrétine |
WO2013131018A1 (fr) * | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Inhibiteurs biaryle du canal sodique |
TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲mPGES-1抑制劑之三唑酮化合物 |
CN105188380B (zh) | 2013-03-15 | 2017-08-15 | 百时美施贵宝公司 | Lxr调节剂 |
WO2016102967A1 (fr) | 2014-12-23 | 2016-06-30 | Convergence Pharmaceuticals Limited | Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine |
JP6616244B2 (ja) * | 2015-05-29 | 2019-12-04 | 北興化学工業株式会社 | 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法 |
SG10202112966SA (en) | 2017-10-05 | 2021-12-30 | Biogen Inc | Process for preparing αlpha-carboxamide pyrrolidine derivatives |
KR102512548B1 (ko) | 2017-12-22 | 2023-03-22 | 삼성디스플레이 주식회사 | 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물 |
EP3762367A1 (fr) * | 2018-03-09 | 2021-01-13 | PI Industries Ltd. | Composés hétérocycliques en tant que fongicides |
CN108863965A (zh) * | 2018-06-25 | 2018-11-23 | 青岛科技大学 | 一锅法制备1,2,4-三氮唑-3-甲酰胺的方法 |
CN108794413A (zh) * | 2018-06-25 | 2018-11-13 | 青岛科技大学 | 一种1,2,4-三氮唑-3-甲酰胺的合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US875782A (en) * | 1907-04-29 | 1908-01-07 | Walter H Cook | Fast-nut. |
TW226993B (fr) | 1992-05-29 | 1994-07-21 | Kumiai Chemical Industry Co | |
US5455252A (en) | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
IT1292091B1 (it) * | 1997-06-05 | 1999-01-25 | Geange Ltd | Derivati eterociclici aromatici azotati,procedimento per la loro preparazione e loro impiego come antigestativi,immunosoppressori e |
GB9726987D0 (en) | 1997-12-22 | 1998-02-18 | Glaxo Group Ltd | Compounds |
MXPA01009655A (es) | 1999-03-26 | 2003-06-24 | Eruo Celtique S A | Pirazoles, imidazoles, oxazoles, tiazoles y pirroles substituidos con arilo y uso de los mismos. |
AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
WO2002088097A1 (fr) * | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Derives triazole inhibiteurs des kinases et leurs utilisations |
US6797722B2 (en) * | 2002-05-03 | 2004-09-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases |
GEP20084475B (en) * | 2002-07-09 | 2008-09-10 | Bristol Myers Squibb Co | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method for their production |
KR100467668B1 (ko) * | 2002-08-07 | 2005-01-24 | 씨제이 주식회사 | 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물 |
KR100470075B1 (ko) * | 2002-11-21 | 2005-02-05 | 씨제이 주식회사 | 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물 |
JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
AR044503A1 (es) * | 2003-03-18 | 2005-09-14 | Merck & Co Inc | Triazoles sustituidos con biarilo como bloqueantes del canal de sodio |
CN1922156A (zh) * | 2003-11-10 | 2007-02-28 | 默克公司 | 作为钠通道阻断剂的取代的三唑 |
-
2004
- 2004-03-11 AR ARP040100789A patent/AR044503A1/es unknown
- 2004-03-11 MY MYPI20040842A patent/MY142651A/en unknown
- 2004-03-12 UA UAA200509759A patent/UA81660C2/ru unknown
- 2004-03-12 WO PCT/US2004/007830 patent/WO2004083190A1/fr active Application Filing
- 2004-03-12 AU AU2004221885A patent/AU2004221885C1/en not_active Ceased
- 2004-03-12 CN CNA2008101000997A patent/CN101289428A/zh active Pending
- 2004-03-12 CA CA002519252A patent/CA2519252C/fr not_active Expired - Fee Related
- 2004-03-12 CN CNA200480013089XA patent/CN1788002A/zh active Pending
- 2004-03-12 NZ NZ542205A patent/NZ542205A/en not_active IP Right Cessation
- 2004-03-12 AT AT04720360T patent/ATE412639T1/de active
- 2004-03-12 DE DE602004017438T patent/DE602004017438D1/de not_active Expired - Lifetime
- 2004-03-12 WO PCT/US2004/007597 patent/WO2004083189A1/fr active Application Filing
- 2004-03-12 BR BRPI0408407-1A patent/BRPI0408407A/pt not_active IP Right Cessation
- 2004-03-12 ES ES04720360T patent/ES2314387T3/es not_active Expired - Lifetime
- 2004-03-12 US US10/799,230 patent/US7326726B2/en active Active
- 2004-03-12 KR KR1020057017327A patent/KR100737721B1/ko not_active IP Right Cessation
- 2004-03-12 JP JP2006507122A patent/JP4482554B2/ja not_active Expired - Fee Related
- 2004-03-12 DK DK04720360T patent/DK1606269T3/da active
- 2004-03-12 PT PT04720360T patent/PT1606269E/pt unknown
- 2004-03-12 RU RU2005132168/04A patent/RU2356897C2/ru not_active IP Right Cessation
- 2004-03-12 SI SI200430959T patent/SI1606269T1/sl unknown
- 2004-03-12 EP EP04720360A patent/EP1606269B1/fr not_active Expired - Lifetime
- 2004-03-12 PL PL04720360T patent/PL1606269T3/pl unknown
- 2004-03-12 MX MXPA05009847A patent/MXPA05009847A/es active IP Right Grant
- 2004-03-14 JO JO200430A patent/JO2480B1/en active
- 2004-03-16 PE PE2004000280A patent/PE20041066A1/es not_active Application Discontinuation
- 2004-03-17 CL CL200400551A patent/CL2004000551A1/es unknown
- 2004-03-17 TW TW093107083A patent/TWI337605B/zh not_active IP Right Cessation
-
2005
- 2005-08-29 IS IS8001A patent/IS8001A/is unknown
- 2005-08-29 ZA ZA200506906A patent/ZA200506906B/xx unknown
- 2005-09-06 MA MA28481A patent/MA27665A1/fr unknown
- 2005-09-14 EC EC2005006018A patent/ECSP056018A/es unknown
- 2005-09-16 HR HR20050816A patent/HRP20050816A2/hr not_active Application Discontinuation
- 2005-09-18 EG EGNA2005000548 patent/EG25994A/xx active
- 2005-10-17 NO NO20054775A patent/NO20054775L/no not_active Application Discontinuation
-
2008
- 2008-01-30 US US12/011,967 patent/US7572822B2/en not_active Expired - Lifetime
-
2009
- 2009-01-15 CY CY20091100054T patent/CY1108720T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EG25994A (en) | Biaryl substituted triazoles as sodium channel blockers | |
EP1615895A4 (fr) | Pyrazoles biaryle substitue utilises en tant que bloqueurs de canaux sodiques | |
EP1608622A4 (fr) | Heterocycles a 6 elements a substitution biaryle en tant que bloqueurs des canaux sodiques | |
EP1670475A4 (fr) | Bloqueurs du canal sodique a base de pyrazinoylguanidine alaphatique | |
EP1670474A4 (fr) | Bloqueurs du canal sodique a pyrazinoyl-guanidine cyclique | |
DK1663235T3 (da) | Beskyttede pyrazinoylguanidin-natriumkanal-blokkere | |
EP1542686A4 (fr) | Composes hydantoine aryle substitues et utilisation de ces composes comme bloqueurs de canal sodium | |
AU2003248122A8 (en) | Sodium channel inhibitor | |
EP1534259A4 (fr) | Sulfonamides utilises comme agents de blocage des canaux a potassium | |
EP1501509A4 (fr) | Thiazolidine-dione et oxazolidine-dione a substitution aryle-liaison-aryle utiles en tant que bloqueurs des canaux sodiques | |
EP1610759A4 (fr) | Analogues de quinobenzoxazine substitues | |
EP1596860A4 (fr) | Nouveaux composes | |
EP1648885A4 (fr) | Nouveaux composes | |
EP1501790A4 (fr) | Nouveaux bloqueurs de canaux sodiques | |
TWI319322B (en) | Frozen-dried preperation containing prostaglandin | |
GB0302546D0 (en) | Novel compounds | |
GB0302431D0 (en) | Novel compounds | |
SI1485359T1 (sl) | Blokatorji natrijevega kanala | |
EP1635834A4 (fr) | Nouveaux composes | |
GB0323098D0 (en) | Improvements relating to communications | |
GB0216212D0 (en) | Sodium channel inhibitors | |
GB0406002D0 (en) | Sodium channels | |
GB0406004D0 (en) | Sodium channels | |
GB0406001D0 (en) | Sodium channels | |
GB0406006D0 (en) | Sodium channels |