DE602004017438D1 - Biarylsubstituierte triazole als natriumkanalblocker - Google Patents
Biarylsubstituierte triazole als natriumkanalblockerInfo
- Publication number
- DE602004017438D1 DE602004017438D1 DE602004017438T DE602004017438T DE602004017438D1 DE 602004017438 D1 DE602004017438 D1 DE 602004017438D1 DE 602004017438 T DE602004017438 T DE 602004017438T DE 602004017438 T DE602004017438 T DE 602004017438T DE 602004017438 D1 DE602004017438 D1 DE 602004017438D1
- Authority
- DE
- Germany
- Prior art keywords
- biarylsubstituted
- triazole
- sodium channel
- channel blocker
- blocker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940125794 sodium channel blocker Drugs 0.000 title 1
- 239000003195 sodium channel blocking agent Substances 0.000 title 1
- 150000003852 triazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45595203P | 2003-03-18 | 2003-03-18 | |
PCT/US2004/007597 WO2004083189A1 (en) | 2003-03-18 | 2004-03-12 | Biaryl substituted triazoles as sodium channel blockers |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004017438D1 true DE602004017438D1 (de) | 2008-12-11 |
Family
ID=33030073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004017438T Expired - Lifetime DE602004017438D1 (de) | 2003-03-18 | 2004-03-12 | Biarylsubstituierte triazole als natriumkanalblocker |
Country Status (34)
Country | Link |
---|---|
US (2) | US7326726B2 (de) |
EP (1) | EP1606269B1 (de) |
JP (1) | JP4482554B2 (de) |
KR (1) | KR100737721B1 (de) |
CN (2) | CN101289428A (de) |
AR (1) | AR044503A1 (de) |
AT (1) | ATE412639T1 (de) |
AU (1) | AU2004221885C1 (de) |
BR (1) | BRPI0408407A (de) |
CA (1) | CA2519252C (de) |
CL (1) | CL2004000551A1 (de) |
CY (1) | CY1108720T1 (de) |
DE (1) | DE602004017438D1 (de) |
DK (1) | DK1606269T3 (de) |
EC (1) | ECSP056018A (de) |
EG (1) | EG25994A (de) |
ES (1) | ES2314387T3 (de) |
HR (1) | HRP20050816A2 (de) |
IS (1) | IS8001A (de) |
JO (1) | JO2480B1 (de) |
MA (1) | MA27665A1 (de) |
MX (1) | MXPA05009847A (de) |
MY (1) | MY142651A (de) |
NO (1) | NO20054775L (de) |
NZ (1) | NZ542205A (de) |
PE (1) | PE20041066A1 (de) |
PL (1) | PL1606269T3 (de) |
PT (1) | PT1606269E (de) |
RU (1) | RU2356897C2 (de) |
SI (1) | SI1606269T1 (de) |
TW (1) | TWI337605B (de) |
UA (1) | UA81660C2 (de) |
WO (2) | WO2004083190A1 (de) |
ZA (1) | ZA200506906B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1587821T1 (sl) | 2002-12-19 | 2009-02-28 | Scripps Research Inst | Sestavki in postopki za stabiliziranje transtiretina in zaviranje napaäśnega zvijanja transtiretina |
MY142651A (en) * | 2003-03-18 | 2010-12-15 | Merck Sharp & Dohme | Biaryl substituted triazoles as sodium channel blockers |
BRPI0416319A (pt) * | 2003-11-10 | 2007-01-09 | Merck & Co Inc | composto, composição farmacêutica, métodos de tratamento ou prevenção da dor, das sìndromes, e de doença, e, métodos de administrar anestesia local, e para a neuroproteção sob condições isquêmicas |
WO2005112913A1 (en) | 2004-05-20 | 2005-12-01 | The Scripps Research Institute | Transthyretin stabilization |
TW200728258A (en) | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
WO2007042250A1 (en) | 2005-10-10 | 2007-04-19 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
CN101641099A (zh) * | 2007-01-24 | 2010-02-03 | 葛兰素集团有限公司 | 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物 |
DK2118077T3 (en) | 2007-02-08 | 2015-03-09 | Synta Pharmaceuticals Corp | Triazole compounds that modulate HSP90 ACTIVITY |
EP2520561B1 (de) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1a-Inhibitoren |
ME02847B (de) | 2009-07-27 | 2018-01-20 | Gilead Sciences Inc | Kondensierte heterocyclische verbindungen als ionenkanalmodulatoren |
CA2802288C (en) | 2010-07-02 | 2018-08-21 | Gilead Sciences, Inc. | Triazolopyridinone compounds as ion channel modulators |
NZ617987A (en) | 2011-05-10 | 2016-02-26 | Gilead Sciences Inc | Fused heterocyclic compounds as sodium channel modulators |
TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
CN103781770B (zh) | 2011-09-16 | 2016-04-13 | 辉瑞公司 | 转甲状腺素蛋白解离抑制剂的固体形式 |
WO2013131018A1 (en) * | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲mPGES-1抑制劑之三唑酮化合物 |
CN105188380B (zh) | 2013-03-15 | 2017-08-15 | 百时美施贵宝公司 | Lxr调节剂 |
WO2016102967A1 (en) | 2014-12-23 | 2016-06-30 | Convergence Pharmaceuticals Limited | Process for preparing alpha-carboxamide pyrrolidine derivatives |
JP6616244B2 (ja) * | 2015-05-29 | 2019-12-04 | 北興化学工業株式会社 | 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法 |
KR20200061381A (ko) | 2017-10-05 | 2020-06-02 | 바이오젠 인크. | 알파-카르복스아미드 피롤리딘 유도체를 제조하기 위한 공정 |
KR102512548B1 (ko) | 2017-12-22 | 2023-03-22 | 삼성디스플레이 주식회사 | 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물 |
US20210002232A1 (en) * | 2018-03-09 | 2021-01-07 | Pi Industries Ltd. | Heterocyclic compounds as fungicides |
CN108794413A (zh) * | 2018-06-25 | 2018-11-13 | 青岛科技大学 | 一种1,2,4-三氮唑-3-甲酰胺的合成方法 |
CN108863965A (zh) * | 2018-06-25 | 2018-11-23 | 青岛科技大学 | 一锅法制备1,2,4-三氮唑-3-甲酰胺的方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US875782A (en) * | 1907-04-29 | 1908-01-07 | Walter H Cook | Fast-nut. |
TW226993B (de) * | 1992-05-29 | 1994-07-21 | Kumiai Chemical Industry Co | |
US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
IT1292091B1 (it) * | 1997-06-05 | 1999-01-25 | Geange Ltd | Derivati eterociclici aromatici azotati,procedimento per la loro preparazione e loro impiego come antigestativi,immunosoppressori e |
GB9726987D0 (en) | 1997-12-22 | 1998-02-18 | Glaxo Group Ltd | Compounds |
WO2000057877A1 (en) | 1999-03-26 | 2000-10-05 | Euro-Celtique S.A. | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
MXPA03009846A (es) * | 2001-04-27 | 2004-05-05 | Vertex Pharma | Derivados de triazol inhibidores de cinasa y usos de los mismos. |
US6797722B2 (en) * | 2002-05-03 | 2004-09-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases |
EP1531810B1 (de) * | 2002-07-09 | 2012-02-01 | Bristol-Myers Squibb Company | Substituierte heterozyklische derivate als mittel gegen diabetes und adipositas und verfahren |
KR100467668B1 (ko) * | 2002-08-07 | 2005-01-24 | 씨제이 주식회사 | 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물 |
KR100470075B1 (ko) * | 2002-11-21 | 2005-02-05 | 씨제이 주식회사 | 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물 |
JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
MY142651A (en) * | 2003-03-18 | 2010-12-15 | Merck Sharp & Dohme | Biaryl substituted triazoles as sodium channel blockers |
BRPI0416319A (pt) * | 2003-11-10 | 2007-01-09 | Merck & Co Inc | composto, composição farmacêutica, métodos de tratamento ou prevenção da dor, das sìndromes, e de doença, e, métodos de administrar anestesia local, e para a neuroproteção sob condições isquêmicas |
-
2004
- 2004-03-11 MY MYPI20040842A patent/MY142651A/en unknown
- 2004-03-11 AR ARP040100789A patent/AR044503A1/es unknown
- 2004-03-12 WO PCT/US2004/007830 patent/WO2004083190A1/en active Application Filing
- 2004-03-12 NZ NZ542205A patent/NZ542205A/en not_active IP Right Cessation
- 2004-03-12 SI SI200430959T patent/SI1606269T1/sl unknown
- 2004-03-12 UA UAA200509759A patent/UA81660C2/ru unknown
- 2004-03-12 RU RU2005132168/04A patent/RU2356897C2/ru not_active IP Right Cessation
- 2004-03-12 WO PCT/US2004/007597 patent/WO2004083189A1/en active Application Filing
- 2004-03-12 KR KR1020057017327A patent/KR100737721B1/ko not_active IP Right Cessation
- 2004-03-12 CA CA002519252A patent/CA2519252C/en not_active Expired - Fee Related
- 2004-03-12 BR BRPI0408407-1A patent/BRPI0408407A/pt not_active IP Right Cessation
- 2004-03-12 EP EP04720360A patent/EP1606269B1/de not_active Expired - Lifetime
- 2004-03-12 DE DE602004017438T patent/DE602004017438D1/de not_active Expired - Lifetime
- 2004-03-12 AT AT04720360T patent/ATE412639T1/de active
- 2004-03-12 CN CNA2008101000997A patent/CN101289428A/zh active Pending
- 2004-03-12 JP JP2006507122A patent/JP4482554B2/ja not_active Expired - Fee Related
- 2004-03-12 ES ES04720360T patent/ES2314387T3/es not_active Expired - Lifetime
- 2004-03-12 DK DK04720360T patent/DK1606269T3/da active
- 2004-03-12 AU AU2004221885A patent/AU2004221885C1/en not_active Ceased
- 2004-03-12 CN CNA200480013089XA patent/CN1788002A/zh active Pending
- 2004-03-12 US US10/799,230 patent/US7326726B2/en active Active
- 2004-03-12 PT PT04720360T patent/PT1606269E/pt unknown
- 2004-03-12 MX MXPA05009847A patent/MXPA05009847A/es active IP Right Grant
- 2004-03-12 PL PL04720360T patent/PL1606269T3/pl unknown
- 2004-03-14 JO JO200430A patent/JO2480B1/en active
- 2004-03-16 PE PE2004000280A patent/PE20041066A1/es not_active Application Discontinuation
- 2004-03-17 CL CL200400551A patent/CL2004000551A1/es unknown
- 2004-03-17 TW TW093107083A patent/TWI337605B/zh not_active IP Right Cessation
-
2005
- 2005-08-29 IS IS8001A patent/IS8001A/is unknown
- 2005-08-29 ZA ZA200506906A patent/ZA200506906B/xx unknown
- 2005-09-06 MA MA28481A patent/MA27665A1/fr unknown
- 2005-09-14 EC EC2005006018A patent/ECSP056018A/es unknown
- 2005-09-16 HR HR20050816A patent/HRP20050816A2/hr not_active Application Discontinuation
- 2005-09-18 EG EGNA2005000548 patent/EG25994A/xx active
- 2005-10-17 NO NO20054775A patent/NO20054775L/no not_active Application Discontinuation
-
2008
- 2008-01-30 US US12/011,967 patent/US7572822B2/en not_active Expired - Lifetime
-
2009
- 2009-01-15 CY CY20091100054T patent/CY1108720T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US |
|
R081 | Change of applicant/patentee |
Ref document number: 1606269 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., 07065-0900 RAHWAY, US Effective date: 20121213 |
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Ref document number: 1606269 Country of ref document: EP Representative=s name: ABITZ & PARTNER, DE Effective date: 20121213 |