DK1604016T3 - In vitro-fremgangsmåde til differentiering af monocytiske dendritiske precursorceller i umodne dendritiske celler - Google Patents
In vitro-fremgangsmåde til differentiering af monocytiske dendritiske precursorceller i umodne dendritiske cellerInfo
- Publication number
- DK1604016T3 DK1604016T3 DK04715780T DK04715780T DK1604016T3 DK 1604016 T3 DK1604016 T3 DK 1604016T3 DK 04715780 T DK04715780 T DK 04715780T DK 04715780 T DK04715780 T DK 04715780T DK 1604016 T3 DK1604016 T3 DK 1604016T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- monocytes
- dendritic
- csf
- dendritic cells
- Prior art date
Links
- 210000004443 dendritic cell Anatomy 0.000 title abstract 6
- 210000004027 cell Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000000338 in vitro Methods 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 210000001616 monocyte Anatomy 0.000 abstract 4
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 3
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 3
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 108090000978 Interleukin-4 Proteins 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/72—Undefined extracts from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/70—Non-animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/10—Mineral substrates
- C12N2533/12—Glass
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45101503P | 2003-02-27 | 2003-02-27 | |
| PCT/US2004/006119 WO2004076651A2 (en) | 2003-02-27 | 2004-02-27 | Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1604016T3 true DK1604016T3 (da) | 2009-05-18 |
Family
ID=32927693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04715780T DK1604016T3 (da) | 2003-02-27 | 2004-02-27 | In vitro-fremgangsmåde til differentiering af monocytiske dendritiske precursorceller i umodne dendritiske celler |
Country Status (20)
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040057935A1 (en) * | 2002-09-20 | 2004-03-25 | Cedars-Sinai Medical Center | Intratumoral delivery of dendritic cells |
| CN102600461B (zh) * | 2002-12-06 | 2017-07-14 | 西北生物治疗药物公司 | 给予体外部分成熟的树突细胞治疗肿瘤 |
| WO2005037995A2 (en) * | 2003-10-06 | 2005-04-28 | Cedars-Sinai Medical Center | Use of cox-2 inhibitor to prevent t-cell anergy induced by dendritic cell therapy |
| EP1676132B1 (en) * | 2003-10-21 | 2014-01-22 | Cedars-Sinai Medical Center | Combination of chemotherapy and administration of glioma-antigen-pulsed dendritic cells in the treatment of glioma |
| US7790039B2 (en) * | 2003-11-24 | 2010-09-07 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for stem cell enrichment |
| AU2006249640C1 (en) | 2005-04-08 | 2016-10-13 | Coimmune, Inc. | Dendritic cell compositions and methods |
| EP1957634A4 (en) * | 2005-12-08 | 2010-01-27 | Northwest Biotherapeutics Inc | COMPOSITIONS AND METHODS OF INDUCING THE ACTIVATION OF UNREFERENCE MONOCYTIC DENDRITE CELLS |
| EP1806395A1 (en) * | 2006-01-06 | 2007-07-11 | Stichting Sanquin Bloedvoorziening | Maturation of dendritic cells |
| CA2700573C (en) | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
| WO2008039969A2 (en) | 2006-09-28 | 2008-04-03 | Cedars-Sinai Medical Center | Cancer vaccines and vaccination methods |
| PL1920781T3 (pl) * | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
| KR100896747B1 (ko) | 2007-05-30 | 2009-05-11 | 동아대학교 산학협력단 | 후코이단 또는 그 유사체를 함유하는 수지상 세포의 성숙화유도용 조성물 |
| US8728465B2 (en) * | 2008-06-17 | 2014-05-20 | Cedars-Sinai Medical Center | Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors |
| PL2328923T3 (pl) | 2008-09-02 | 2016-06-30 | Cedars Sinai Medical Center | Epitopy CD133 |
| JP2010063404A (ja) * | 2008-09-10 | 2010-03-25 | Olympus Corp | 幹細胞の分離方法 |
| FR2940451B1 (fr) * | 2008-12-18 | 2014-09-12 | Proteus | Procede d'evaluation de l'immunogenicite des proteines |
| PL2427485T3 (pl) | 2009-05-07 | 2017-10-31 | Immunocellular Therapeutics Ltd | Epitopy CD133 |
| NZ597724A (en) * | 2009-07-24 | 2013-10-25 | Rhode Island Hospital | Dendritic cell vaccines for asparaginyl-beta-hydroxylase expressing tumors |
| AU2010307075B2 (en) * | 2009-10-12 | 2014-12-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Granulysin in immunotherapy |
| JP2013522309A (ja) * | 2010-03-15 | 2013-06-13 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 活性化した成熟樹状細胞を調製し保存するシステムおよび方法 |
| RU2458985C1 (ru) * | 2011-03-18 | 2012-08-20 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт клинической иммунологии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИКИ" СО РАМН) | Способ генерации антиген-специфических цитотоксических клеток с противоопухолевой активностью |
| SG11201404570WA (en) * | 2012-02-10 | 2014-11-27 | Hakushinkouseikai Foundation | Proliferating agent for monocyte, culture medium for proliferating monocyte, method for producing monocyte, method for producing dendritic cell, and method for producing dendritic cell vaccine |
| WO2014127296A1 (en) | 2013-02-14 | 2014-08-21 | Immunocellular Therapeutics, Ltd | Cancer vaccines and vaccination methods |
| CN104098652B (zh) * | 2014-07-23 | 2016-11-09 | 国家纳米科学中心 | 一种抑制肿瘤转移的多肽和多肽复合物、其制备方法及其应用 |
| DK3173420T3 (da) * | 2014-07-23 | 2021-10-18 | Nat Ct Nanoscience & Technology China | Polypeptid og polypeptidkompleks til undertrykkelse af tumormetastase og behandling af leukæmi samt fremgangsmåde til fremstilling deraf og anvendelse deraf |
| MX2018000056A (es) * | 2015-06-30 | 2018-05-28 | Northwest Biotherapeutics Inc | Celulas dendriticas optimamente activadas que inducen una respuesta inmunologica antitumoral mayor o mejorada. |
| CA2998614A1 (en) | 2015-09-15 | 2017-03-23 | Northwest Biotherapeutics, Inc. | Methods relating to activated dendritic cell compositions and immunotherapeutic treatments for subjects with advanced cancers |
| CN105483084A (zh) * | 2016-01-04 | 2016-04-13 | 英普乐孚生物技术(上海)有限公司 | 肿瘤抗原靶向性dc细胞的制备方法 |
| WO2019246111A1 (en) | 2018-06-19 | 2019-12-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Oncolytic virus or antigen presenting cell mediated cancer therapy using type i interferon and cd40-ligand |
| KR102159766B1 (ko) * | 2018-11-12 | 2020-09-24 | 조선대학교산학협력단 | 홍조류추출물을 이용한 미성숙수지상세포 분화유도용 배지조성물 및 미성숙수지상세포 분화유도방법 |
| CA3135852A1 (en) * | 2019-04-03 | 2020-10-08 | Akron Biotechnology, Llc | Cryopreservation and cell culture media |
| EP3984597A4 (en) * | 2019-07-12 | 2023-07-12 | Kyushu University, National University Corporation | DEVELOPMENT OF A THERAPY TO IMPROVE MYOCARDIAL CONTRACTION AND A METHOD OF INHIBITION OF CARDIOMYOCYTE DEATH |
| EP4061423A4 (en) * | 2019-11-18 | 2023-12-06 | Children's Medical Center Corporation | HYPERACTIVE DENDRITIC CELLS FOR PERMANENT ANTITUMOR EFFECT ON ADOPTIONAL CELL TRANSFER BASIS |
| KR102904431B1 (ko) * | 2021-05-07 | 2025-12-26 | (주)나노팬텍 | 수지상 세포의 배양 방법 |
| JP7652461B2 (ja) * | 2021-05-07 | 2025-03-27 | ナノファエンテック カンパニー リミテッド | 樹状細胞の培養方法 |
| CN113881632B (zh) * | 2021-09-29 | 2023-09-29 | 四川省医学科学院·四川省人民医院 | 一种提高dc细胞活性的细胞培养基及培养方法 |
| US12584107B2 (en) * | 2022-01-20 | 2026-03-24 | 3T Biosciences, Inc. | T cell receptor (TCR) compositions and methods for optimizing antigen reactive T-cells |
| US20230287448A1 (en) * | 2022-01-20 | 2023-09-14 | 3T Biosciences, Inc. | T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells |
| GB2624871A (en) * | 2022-11-29 | 2024-06-05 | Alv B As | Process for preparing a population of dendritic cells and immunotherapy using the same |
| CN118389430A (zh) * | 2024-04-12 | 2024-07-26 | 广东壹加再生医学研究院有限公司 | 一种高抗肿瘤特异性dc-cik细胞的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0205387B1 (en) * | 1985-06-11 | 1992-02-26 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Human monocytes cultured in suspension in serum-free medium |
| US5162504A (en) | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
| PT633929E (pt) | 1992-04-01 | 2004-07-30 | Merix Bioscience Inc | Metodo para proliferacao (in vitro) de precursores de celulas dentifricas e sua utilizacao para produzir imunogenios |
| US6010905A (en) * | 1995-01-27 | 2000-01-04 | The United States Of America As Represented By The Department Of Health & Human Services | Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells |
| US5788963A (en) | 1995-07-31 | 1998-08-04 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| US7659119B2 (en) * | 1996-02-12 | 2010-02-09 | Argos Therapeutics, Inc. | Method and compositions for obtaining mature dendritic cells |
| US20020094545A1 (en) | 2000-11-30 | 2002-07-18 | Harris Paul E. | Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads |
| WO2003010292A2 (en) * | 2001-07-25 | 2003-02-06 | Northwest Biotherapeutics, Inc. | Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors |
| BRPI0212545B8 (pt) * | 2001-09-06 | 2021-05-25 | Northwest Biotherapeutics Inc | método ex vivo ou in vitro para produzir uma população de célula dendrítica madura e método para produzir células t |
| JP4567446B2 (ja) | 2002-06-19 | 2010-10-20 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 白血球富化のための平行流濾過デバイスおよび方法 |
| JP2006517108A (ja) * | 2003-02-10 | 2006-07-20 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 培養されたｃｄ１４＋抗原提示細胞 |
-
2004
- 2004-02-27 AT AT04715780T patent/ATE420946T1/de not_active IP Right Cessation
- 2004-02-27 TW TW093105079A patent/TW200506061A/zh unknown
- 2004-02-27 BR BRPI0407900-0A patent/BRPI0407900A/pt not_active Application Discontinuation
- 2004-02-27 KR KR1020117021421A patent/KR20110106474A/ko not_active Ceased
- 2004-02-27 MX MXPA05009178A patent/MXPA05009178A/es active IP Right Grant
- 2004-02-27 CN CN2004800105421A patent/CN1784488B/zh not_active Expired - Fee Related
- 2004-02-27 KR KR1020057016059A patent/KR101201875B1/ko not_active Expired - Fee Related
- 2004-02-27 ES ES04715780T patent/ES2321939T3/es not_active Expired - Lifetime
- 2004-02-27 PL PL378291A patent/PL209998B1/pl unknown
- 2004-02-27 EP EP04715780A patent/EP1604016B1/en not_active Expired - Lifetime
- 2004-02-27 JP JP2006503922A patent/JP4762887B2/ja not_active Expired - Fee Related
- 2004-02-27 CA CA2517295A patent/CA2517295C/en not_active Expired - Lifetime
- 2004-02-27 RU RU2005129561/13A patent/RU2364625C2/ru active
- 2004-02-27 US US10/789,807 patent/US8389278B2/en not_active Expired - Fee Related
- 2004-02-27 NZ NZ542071A patent/NZ542071A/en not_active IP Right Cessation
- 2004-02-27 DK DK04715780T patent/DK1604016T3/da active
- 2004-02-27 AU AU2004214896A patent/AU2004214896A1/en not_active Abandoned
- 2004-02-27 WO PCT/US2004/006119 patent/WO2004076651A2/en not_active Ceased
- 2004-02-27 DE DE602004019057T patent/DE602004019057D1/de not_active Expired - Lifetime
-
2005
- 2005-08-25 IL IL170512A patent/IL170512A/en active IP Right Grant
-
2009
- 2009-04-14 CY CY20091100437T patent/CY1109099T1/el unknown
-
2010
- 2010-04-01 AU AU2010201319A patent/AU2010201319B2/en not_active Ceased
-
2013
- 2013-03-05 US US13/786,208 patent/US9102917B2/en not_active Expired - Lifetime
-
2015
- 2015-07-30 US US14/814,315 patent/US10731130B2/en not_active Expired - Fee Related
-
2020
- 2020-08-03 US US16/983,300 patent/US11827903B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL378291A1 (pl) | Wytwarzanie komórek dendrytycznych z monocytarnych prekursorów komórek dendrytycznych z zastosowaniem GM-CSF w nieobecności dodatkowych cytokin | |
| Khosravi et al. | Induction of CD4+ CD25+ FOXP3+ regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation | |
| Đokić et al. | Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte‐derived dendritic cells | |
| WO2006065495A3 (en) | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens | |
| Jongmans et al. | Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: the importance of maturation cocktails | |
| EP2722387A3 (en) | Definitive endoderm | |
| ATE407138T1 (de) | Verfahren zur herstellung interferierender rna- moleküle in säugetierzellen und therapeutische anwendungen solcher moleküle | |
| BRPI0212545B8 (pt) | método ex vivo ou in vitro para produzir uma população de célula dendrítica madura e método para produzir células t | |
| NZ598657A (en) | Anti-il-6 antibodies, compositions, methods and uses | |
| RU2008122550A (ru) | Композиции и способы индуцирования активации незрелых моноцитарных дендритных клеток | |
| UA81398C2 (en) | Keratinocytes which may be used as biologically active substances for the treatment of wounds | |
| PH12020551151A1 (en) | Method of producing natural killer cells and composition for treating cancer | |
| NZ600075A (en) | Means and methods for influencing the stability of antibody producing cells | |
| WO2003083089A3 (en) | Tolerogenic antigen-presenting cells | |
| CN116004533A (zh) | iNKT细胞的激活扩增方法及其培养基组合 | |
| WO2012118349A3 (ko) | 제대혈 ｃｄ14 양성 단핵세포로부터 자연살해세포 분화 및 증식 방법 | |
| EP1572989B1 (fr) | Lignee de cellules dendritiques gen2.2 | |
| WO2004072262A3 (en) | Cultured cd14+ antigen presenting cells | |
| EP2377922A3 (en) | PDX1 expressing endoderm | |
| AU2001259744A1 (en) | Compositions and methods for producing antigen-presenting cells | |
| O'Connell et al. | Type‐1 polarized nature of mouse liver CD8α–and CD8α+ dendritic cells: tissue‐dependent differences offset CD8α‐related dendritic cell heterogeneity | |
| EP2484759A3 (en) | Methods of refolding mammalian glycosyltransferases | |
| WO2003100010A3 (en) | Cytokine-free growth and maintenance of progenitor cells | |
| CA2442300A1 (en) | Cd8.alpha. + lymphoid dendritic cell differentiated from human hematopoietic stem cell and a method for differentiation | |
| WO2005023982A3 (en) | Methods for enhancing engraftment of purified hematopoietic stem cells in allogenic recipients |