DK158517C - 1-alkylsubstituerede 1,4-dihydropyridinlactoner og deres anvendelse i laegemidler - Google Patents

1-alkylsubstituerede 1,4-dihydropyridinlactoner og deres anvendelse i laegemidler

Info

Publication number
DK158517C
DK158517C DK131685A DK131685A DK158517C DK 158517 C DK158517 C DK 158517C DK 131685 A DK131685 A DK 131685A DK 131685 A DK131685 A DK 131685A DK 158517 C DK158517 C DK 158517C
Authority
DK
Denmark
Prior art keywords
alkyl
atoms
chain
optionally
substituted
Prior art date
Application number
DK131685A
Other languages
English (en)
Other versions
DK158517B (da
DK131685D0 (da
DK131685A (da
Inventor
Siegfried Goldmann
Friedrich Bossert
Hilmar Bischoff
Dieter Petzinna
Walter Puls
Klaus Schlossmann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK131685D0 publication Critical patent/DK131685D0/da
Publication of DK131685A publication Critical patent/DK131685A/da
Publication of DK158517B publication Critical patent/DK158517B/da
Application granted granted Critical
Publication of DK158517C publication Critical patent/DK158517C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Endoscopes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK131685A 1984-03-23 1985-03-22 1-alkylsubstituerede 1,4-dihydropyridinlactoner og deres anvendelse i laegemidler DK158517C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3410645 1984-03-23
DE19843410645 DE3410645A1 (de) 1984-03-23 1984-03-23 L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (4)

Publication Number Publication Date
DK131685D0 DK131685D0 (da) 1985-03-22
DK131685A DK131685A (da) 1985-09-24
DK158517B DK158517B (da) 1990-05-28
DK158517C true DK158517C (da) 1990-11-05

Family

ID=6231357

Family Applications (1)

Application Number Title Priority Date Filing Date
DK131685A DK158517C (da) 1984-03-23 1985-03-22 1-alkylsubstituerede 1,4-dihydropyridinlactoner og deres anvendelse i laegemidler

Country Status (24)

Country Link
US (1) US5026714A (da)
EP (1) EP0158138B1 (da)
JP (1) JPS60209584A (da)
KR (1) KR850006439A (da)
AT (1) ATE37880T1 (da)
AU (1) AU569783B2 (da)
CA (1) CA1249270A (da)
CS (1) CS250681B2 (da)
DD (1) DD234424A5 (da)
DE (2) DE3410645A1 (da)
DK (1) DK158517C (da)
EG (1) EG16785A (da)
ES (9) ES8607309A1 (da)
FI (1) FI83651C (da)
GR (1) GR850719B (da)
HU (1) HU191167B (da)
IL (1) IL74659A (da)
NO (1) NO161259C (da)
NZ (1) NZ211512A (da)
PH (3) PH23826A (da)
PL (1) PL143884B1 (da)
PT (1) PT80146B (da)
SU (1) SU1319785A3 (da)
ZA (1) ZA852172B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3521761A1 (de) * 1985-06-19 1987-01-02 Bayer Ag Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3600596A1 (de) * 1986-01-11 1987-07-16 Bayer Ag 4-aminoaryldihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5162338A (en) * 1986-01-11 1992-11-10 Bayer Aktiengesellschaft Circulation active 4-aminoaryldihydropryidine lactones
DE3629545A1 (de) * 1986-08-30 1988-03-10 Bayer Ag Dihydropyridinverbindungen, verfahren zu ihrer herstellung und ihre verwendung
DE3706204A1 (de) * 1987-02-26 1988-09-08 Bayer Ag Benzylaminoaryl-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
GB8716971D0 (en) * 1987-07-17 1987-08-26 Pfizer Ltd Therapeutic agents
DE4430092A1 (de) * 1994-08-25 1996-02-29 Bayer Ag 2,3-Cyclisch kondensierte 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2005025507A2 (en) * 2003-09-10 2005-03-24 Synta Phamaceuticals Corp. Dihydropyridine compounds for treating or preventing metabolic disorders
WO2021253180A1 (en) 2020-06-15 2021-12-23 Novartis Ag Methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-4, 5, 6, 7-tetrahydro-1h-cyclopenta [b] pyridine-3-carboxylate and methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-1, 4, 5, 7-tetrahydrofuro [3, 4-b] pyridine-3-carboxylate as cav1.2 activators
JP2023531399A (ja) 2020-06-16 2023-07-24 ノバルティス アーゲー ＣＡＶ１．２活性化物質としてのメチル２－メチル－５－オキソ－１，４，５，７－テトラヒドロフロ［３，４－ｂ］ピリジン－３－カルボキシレート化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2005116C3 (de) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
US4284634A (en) * 1975-07-02 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
US4253248A (en) 1979-04-16 1981-03-03 Cornish Judson E Teaching machine apparatus
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3130041A1 (de) * 1981-07-30 1983-02-17 Bayer Ag, 5090 Leverkusen Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
DE3206671A1 (de) * 1982-02-25 1983-09-01 Bayer Ag, 5090 Leverkusen Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
US4497808A (en) * 1981-12-30 1985-02-05 Ciba-Geigy Corporation N-Oxide compounds useful in the treatment of cardiovascular ailments
DE3209274A1 (de) * 1982-03-13 1983-09-15 Bayer Ag, 5090 Leverkusen Pyridincarbonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3209276A1 (de) * 1982-03-13 1983-09-15 Bayer Ag, 5090 Leverkusen Arzneimittel mit antihypoxischer und ischaemie-protektiver wirkung
EP0111455A3 (de) * 1982-12-10 1984-07-25 Ciba-Geigy Ag Ungesättigte Lactone
DE3521761A1 (de) * 1985-06-19 1987-01-02 Bayer Ag Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3601226A1 (de) * 1986-01-17 1987-07-23 Bayer Ag Dihydropyridinlactole, verfahren zur herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
ES551548A0 (es) 1986-12-16
ES8702417A1 (es) 1986-12-16
DK158517B (da) 1990-05-28
PL252522A1 (en) 1986-04-08
IL74659A (en) 1988-11-30
ES8702413A1 (es) 1987-01-01
CS250681B2 (en) 1987-05-14
JPS60209584A (ja) 1985-10-22
ES8702414A1 (es) 1986-12-16
HU191167B (en) 1987-01-28
FI851143L (fi) 1985-09-24
ES551544A0 (es) 1987-01-01
ES8702418A1 (es) 1986-12-16
ES8607309A1 (es) 1986-06-16
EP0158138B1 (de) 1988-10-12
FI83651B (fi) 1991-04-30
ES8702416A1 (es) 1987-01-01
AU4044985A (en) 1985-09-26
PL143884B1 (en) 1988-03-31
PH23455A (en) 1989-08-07
DK131685D0 (da) 1985-03-22
DE3565541D1 (en) 1988-11-17
SU1319785A3 (ru) 1987-06-23
PH23826A (en) 1989-11-23
ES551541A0 (es) 1987-01-01
CA1249270A (en) 1989-01-24
US5026714A (en) 1991-06-25
PT80146B (en) 1987-03-23
NZ211512A (en) 1988-07-28
FI851143A0 (fi) 1985-03-21
ES551543A0 (es) 1986-12-16
DE3410645A1 (de) 1985-09-26
HUT37795A (en) 1986-02-28
DD234424A5 (de) 1986-04-02
ES541309A0 (es) 1986-06-16
ES8704174A1 (es) 1987-03-16
IL74659A0 (en) 1985-06-30
ATE37880T1 (de) 1988-10-15
ES551542A0 (es) 1986-12-16
EG16785A (en) 1990-10-30
FI83651C (fi) 1991-08-12
KR850006439A (ko) 1985-10-05
ES551545A0 (es) 1986-12-16
GR850719B (da) 1985-07-19
EP0158138A1 (de) 1985-10-16
ES8704173A1 (es) 1987-03-16
ZA852172B (en) 1985-12-24
ES551547A0 (es) 1987-03-16
NO161259B (no) 1989-04-17
PT80146A (en) 1985-04-01
DK131685A (da) 1985-09-24
AU569783B2 (en) 1988-02-18
NO850891L (no) 1985-09-24
PH24347A (en) 1990-06-13
ES551546A0 (es) 1987-03-16
ES8702415A1 (es) 1986-12-16
NO161259C (no) 1989-07-26

Similar Documents

Publication Publication Date Title
DK158517C (da) 1-alkylsubstituerede 1,4-dihydropyridinlactoner og deres anvendelse i laegemidler
FI860107A (fi) Aminofenolderivat.
BR0207831A (pt) Compostos carbamato para uso na prevenção ou tratamento de distúrbios do movimento
BR0207829A (pt) Composto de carbamato para uso na prevenção ou tratamento de distúrbios psicóticos
GR3002267T3 (en) Dissymmetrical 1,4-dihydropyridine-3,5-dicarboxylic-acid derivatives, preparation processes and therapeutical use
AR005545A1 (es) Un procedimiento para la preparacion de derivados de imidazodiacepina.
ES2074430T3 (es) Compuesto opticamente activo, procedimiento para su fabricacion y composicion de cristal liquido que lo contiene.
TH3536A (th) สารประกอบชนิดใหม่ของเบนโซอิลเฟนนิลยุเรีย
TH3536EX (th) สารประกอบชนิดใหม่ของเบนโซอิลเฟนนิลยุเรีย

Legal Events

Date Code Title Description
PBP Patent lapsed