DK1581174T3 - Gærbaserede vacciner som immunterapi - Google Patents
Gærbaserede vacciner som immunterapi Download PDFInfo
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- DK1581174T3 DK1581174T3 DK03814130.5T DK03814130T DK1581174T3 DK 1581174 T3 DK1581174 T3 DK 1581174T3 DK 03814130 T DK03814130 T DK 03814130T DK 1581174 T3 DK1581174 T3 DK 1581174T3
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Claims (14)
1. Terapeutisk sammensaetning, der omfatter: (a) et gaervehikel, der er en fuldgaer; og (b) et fusionsprotein udtrykt af gaervehiklet, hvor fusionsproteinet i en hvilken som helst raekkefolge omfatter: (i) et polypeptid, der omfatter et immunogent domaene, der omfatter positionerne 2-165 af etvildtype-Ras-protein, hvor aminosyren ved position 12 ermuteretved substitution afglycin med valin, cystein eller asparaginsyre, og hvor aminosyren ved position 61 er muteret ved substitution af glutamin med arginin; og (ii) et polypeptid, der omfatter et immunogent domaene, der omfatter positionerne 56 - 67 af etvildtype-Ras-protein, hvor aminosyren ved position 61 er muteret ved substitution af glutamin med leucin.
2. Terapeutisk sammensaetning ifolge krav 1, hvor polypeptidet, der omfatter Q61L-domaenet er kondenseret til N-terminus af polypeptidet, der omfatter G12V-, G12C- eller G12D- og Q61 R-domaenet.
3. Terapeutisk sammensaetning ifolge krav 1, hvor fusionsproteinet omfatter et polypeptid, der omfatter SEQ ID NO: 1 efterfulgt af polypeptiddomaenerne (i) til (iv) defineret som: (i) et polypeptid, der omfatter positionerne 3 - 30 af N-terminus af vildtype-Ras-proteinet, hvor aminosyren ved position 12 er muteret ved substitutionen af glycin med valin; (ii) et polypeptid, der omfatter positionerne 3 - 39 af vildtype-Ras-proteinet, hvor aminosyren ved position 12 er muteret ved substitutionen af glycin med cystein; (iii) et polypeptid, der omfatter positions 3 - 165 af vildtype-Ras-proteinet, hvor aminosyren ved position 12 er muteret ved substitutionen af glycin med asparaginsyre og aminosyren ved position 61 er muteret ved substitutionen af glutamin med arginin; (iv) et polypeptid, der omfatter positionerne 56 - 69 af vildtype-Ras-proteinet, hvor aminosyren ved position 61 er muteret ved substitutionen af glutamin med leucin; og hvor fusionsproteinet er konstrueret med polypeptiddomaener (i) til (iv) i sekventiel raekkefolge fra (i) til (iv), eller i en hvilken som helst anden raekkefolge.
4. Terapeutisk sammensaetning ifolge et hvilket som helst af kravene 1 til 3, hvor vildtype-Ras-proteinet bestar af aminosyresekvensen ifolge SEQ ID NO: 3.
5. Terapeutisk sammensaetning ifolge et hvilket som helst af kravene 1 til 3, hvor vildtype-Ras-proteinet bestar af aminosyresekvensen ifolge SEQ ID NO: 5.
6. Terapeutisk sammensaetning ifolge krav 2, hvor fusionsproteinet omfatter SEQ ID NO: 15.
7. Terapeutisk sammensaetning ifolge et hvilket som helst af kravene 1 til 6, hvor gaervehiklet er et draebt fuldgaer.
8. Terapeutisk sammensaetning ifolge et hvilket som helst af kravene 1 til 7, hvor gaervehiklet er udvalgtfra Saccharomyces, Schizosaccharomyces, Kluveromyces, Hansenula, Candida og Pichia.
9. Terapeutisk sammensaetning ifolge krav 8, hvor gaervehiklet er fra S. cerevisiae.
10. Terapeutisk sammensaetning ifolge et hvilket som helst af kravene 1 til 9, hvor sammensaetningen er formuleret til parenteral administration.
11. Terapeutisk sammensaetning ifolge et hvilket som helst af kravene 1 til 10, hvor sammensaetningen endvidere omfatter en biologisk responsmodifikator.
12. Terapeutisk sammensaetning ifolge et hvilket som helst af kravene 1 til 11 til anvendelse i behandling af cancer.
13. Terapeutisk sammensaetning til anvendelse if0lge krav 12, hvor anvendelsen er til behandling af pankreascancer.
14. Terapeutisk sammensaetning til anvendelse ifolge krav 12, hvor anvendelsen er til behandling af lungecancer eller gastrointestinal cancer.
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