DE60232577D1 - Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential - Google Patents
Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potentialInfo
- Publication number
- DE60232577D1 DE60232577D1 DE60232577T DE60232577T DE60232577D1 DE 60232577 D1 DE60232577 D1 DE 60232577D1 DE 60232577 T DE60232577 T DE 60232577T DE 60232577 T DE60232577 T DE 60232577T DE 60232577 D1 DE60232577 D1 DE 60232577D1
- Authority
- DE
- Germany
- Prior art keywords
- chimeric proteins
- immunogenic potential
- oligomeric complexes
- improved immunogenic
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title 1
- 102000007474 Multiprotein Complexes Human genes 0.000 abstract 1
- 108010085220 Multiprotein Complexes Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01200193 | 2001-01-18 | ||
PCT/EP2002/000628 WO2002074795A2 (en) | 2001-01-18 | 2002-01-18 | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60232577D1 true DE60232577D1 (de) | 2009-07-23 |
Family
ID=8179773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60232577T Expired - Lifetime DE60232577D1 (de) | 2001-01-18 | 2002-01-18 | Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential |
Country Status (9)
Country | Link |
---|---|
US (1) | US7449188B2 (de) |
EP (1) | EP1362109B1 (de) |
AT (1) | ATE433491T1 (de) |
AU (1) | AU2002252978B9 (de) |
CA (1) | CA2435000C (de) |
DE (1) | DE60232577D1 (de) |
DK (1) | DK1362109T3 (de) |
ES (1) | ES2327719T3 (de) |
WO (1) | WO2002074795A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104147597A (zh) | 2002-12-16 | 2014-11-19 | 全球免疫股份有限公司 | 用于免疫治疗的基于酵母的疫苗 |
ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
CA2638760A1 (en) | 2006-03-07 | 2007-09-13 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
CA2659592C (en) | 2006-07-14 | 2016-10-04 | Konstantin V. Pugachev | Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins |
US20100239605A1 (en) * | 2006-09-29 | 2010-09-23 | Sanofi Pasteur Biologics Co. | Recombinant Rhinovirus Vectors |
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
EP2610345B1 (de) | 2007-11-27 | 2015-08-19 | Medicago Inc. | In transgenen Hämagglutinin exprimierenden Pflanzen produzierte rekombinante Influenza-Virus-ähnliche Partikel (VLPS) |
JP2011519828A (ja) | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
WO2009133463A1 (en) * | 2008-04-30 | 2009-11-05 | University Of Copenhagen | Soluble influenza vaccine |
EP2294202B1 (de) * | 2008-07-08 | 2015-05-20 | Medicago Inc. | Lösliche rekombinante influenza-antigene |
US10272148B2 (en) | 2009-06-24 | 2019-04-30 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
WO2011014794A1 (en) | 2009-07-31 | 2011-02-03 | Paxvax, Inc. | Adenoviral-based vectors |
PT3354657T (pt) | 2009-09-22 | 2022-05-06 | Medicago Inc | Método de preparação de proteínas derivadas de plantas |
HUE030724T2 (en) * | 2010-04-09 | 2017-06-28 | Univ Utrecht Holding Bv | Recombinant multimer influenza proteins |
BR112013001514A2 (pt) * | 2010-07-23 | 2016-06-07 | Erasmus University Rotterdam Medical Ct | vacina para influenza |
BR112013024157A2 (pt) * | 2011-03-22 | 2016-12-06 | Mucosis Bv | composições imunogênicas em forma particulada e métodos para produção destas |
TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
CA2878427A1 (en) | 2012-07-26 | 2014-01-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Multimeric fusion protein vaccine and immunotherapeutic |
US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
EP2914283B1 (de) * | 2012-11-05 | 2020-05-20 | Georgia State University Research Foundation, Inc. | Universeller influenzaimpfstoff auf basis mehrerer heterologer m2e-proteine |
WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
EP3512874A2 (de) | 2017-11-30 | 2019-07-24 | Grifols Diagnostic Solutions Inc. | Immunoassays und manipulierte proteine zur überwachung von antikörperbehandlungen gegen die immun-checkpoint-inhibitoren pd-1 und pd-l1 |
US11851648B2 (en) | 2019-02-08 | 2023-12-26 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
EP4022046A2 (de) | 2019-08-27 | 2022-07-06 | Wisconsin Alumni Research Foundation (WARF) | Rekombinante influenzaviren mit stabilisiertem ha zur replikation in eiern |
WO2021150874A1 (en) * | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
US20240075152A1 (en) * | 2021-01-13 | 2024-03-07 | Purdue Research Foundation | Supramolecular assemblies, compositions and methods for producing and using the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041385A (en) * | 1986-11-01 | 1991-08-20 | Oxford Gene Systems Limited | Vector expressing fusion proteins and particles |
ES2198414T3 (es) * | 1992-10-23 | 2004-02-01 | Immunex Corporation | Procedimientos para preparar proteinas oligomericas solubles. |
US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
WO1999062953A1 (en) * | 1998-06-04 | 1999-12-09 | Shanghai Second Medical University | A human leucine zipper protein gene (bmh) (cblayd06) |
BR9915771A (pt) | 1998-11-30 | 2001-12-26 | Cytos Biotechnology Ag | Apresentação molecular ordenada de antìgenos,processo de preparação e utilização |
EP1179013A1 (de) * | 1999-05-14 | 2002-02-13 | Medical Research Council | Proteingerüst und seine verwendung zur multimerisierung von monomeren peptiden |
CA2377731A1 (en) | 1999-07-02 | 2001-01-11 | Genentech, Inc. | Fusion peptides comprising a peptide ligand domain and a multimerization domain |
DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
US20020015951A1 (en) | 2000-01-06 | 2002-02-07 | Bader Joel S. | Method of analyzing a nucleic acid |
-
2002
- 2002-01-18 AU AU2002252978A patent/AU2002252978B9/en not_active Expired
- 2002-01-18 WO PCT/EP2002/000628 patent/WO2002074795A2/en not_active Application Discontinuation
- 2002-01-18 DE DE60232577T patent/DE60232577D1/de not_active Expired - Lifetime
- 2002-01-18 CA CA2435000A patent/CA2435000C/en not_active Expired - Lifetime
- 2002-01-18 US US10/466,655 patent/US7449188B2/en not_active Expired - Lifetime
- 2002-01-18 AT AT02722030T patent/ATE433491T1/de active
- 2002-01-18 ES ES02722030T patent/ES2327719T3/es not_active Expired - Lifetime
- 2002-01-18 EP EP02722030A patent/EP1362109B1/de not_active Expired - Lifetime
- 2002-01-18 DK DK02722030T patent/DK1362109T3/da active
Also Published As
Publication number | Publication date |
---|---|
DK1362109T3 (da) | 2009-07-27 |
ATE433491T1 (de) | 2009-06-15 |
CA2435000A1 (en) | 2002-09-26 |
EP1362109B1 (de) | 2009-06-10 |
ES2327719T3 (es) | 2009-11-03 |
AU2002252978A1 (en) | 2002-10-03 |
EP1362109A2 (de) | 2003-11-19 |
US7449188B2 (en) | 2008-11-11 |
WO2002074795A3 (en) | 2003-09-04 |
CA2435000C (en) | 2014-03-25 |
AU2002252978B9 (en) | 2007-02-01 |
AU2002252978B2 (en) | 2006-12-07 |
US20040116664A1 (en) | 2004-06-17 |
WO2002074795A2 (en) | 2002-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |