ATE475675T1 - Verwendung prokariotischer pest-ähnlicher peptide zur verstärkung der immunogenität von antigenen - Google Patents

Verwendung prokariotischer pest-ähnlicher peptide zur verstärkung der immunogenität von antigenen

Info

Publication number
ATE475675T1
ATE475675T1 AT01928324T AT01928324T ATE475675T1 AT E475675 T1 ATE475675 T1 AT E475675T1 AT 01928324 T AT01928324 T AT 01928324T AT 01928324 T AT01928324 T AT 01928324T AT E475675 T1 ATE475675 T1 AT E475675T1
Authority
AT
Austria
Prior art keywords
immunogenicity
procariotic
plague
antigens
peptides
Prior art date
Application number
AT01928324T
Other languages
English (en)
Inventor
Yvonne Paterson
George Raymond Gunn Iii
Christian Peters
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Priority claimed from PCT/US2001/009736 external-priority patent/WO2001072329A1/en
Application granted granted Critical
Publication of ATE475675T1 publication Critical patent/ATE475675T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT01928324T 2000-03-29 2001-03-26 Verwendung prokariotischer pest-ähnlicher peptide zur verstärkung der immunogenität von antigenen ATE475675T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/537,642 US6855320B2 (en) 2000-03-29 2000-03-29 Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity
US09/735,450 US6767542B2 (en) 2000-03-29 2000-12-13 Compositions and methods for enhancing immunogenicity of antigens
PCT/US2001/009736 WO2001072329A1 (en) 2000-03-29 2001-03-26 Compositions and methods for enhancing immunogenicity of antigens

Publications (1)

Publication Number Publication Date
ATE475675T1 true ATE475675T1 (de) 2010-08-15

Family

ID=24143505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01928324T ATE475675T1 (de) 2000-03-29 2001-03-26 Verwendung prokariotischer pest-ähnlicher peptide zur verstärkung der immunogenität von antigenen

Country Status (4)

Country Link
US (2) US6855320B2 (de)
AT (1) ATE475675T1 (de)
DE (1) DE60142689D1 (de)
IL (1) IL151942A (de)

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US8114414B2 (en) * 1994-11-08 2012-02-14 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical cancer
US7820180B2 (en) * 2004-09-24 2010-10-26 The Trustees Of The University Of Pennsylvania Listeria-based and LLO-based vaccines
US8791237B2 (en) 1994-11-08 2014-07-29 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of non-hodgkins lymphoma
US8956621B2 (en) 1994-11-08 2015-02-17 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical dysplasia
US7662396B2 (en) * 2001-03-26 2010-02-16 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing the immunogenicity of antigens
WO2001072329A1 (en) * 2000-03-29 2001-10-04 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing immunogenicity of antigens
US20070264279A1 (en) * 1994-11-08 2007-11-15 Claudia Gravekamp Compositions and methods comprising a MAGE-b antigen
US6051237A (en) * 1994-11-08 2000-04-18 The Trustees Of The University Of Pennsylvania Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector
US9012141B2 (en) * 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
US7700344B2 (en) * 2001-03-26 2010-04-20 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing the immunogenicity of antigens
US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
US7794728B2 (en) * 2002-05-29 2010-09-14 The Regents Of The University Of California Attenuated Listeria spp. and methods for using the same
AU2004204751A1 (en) * 2003-01-09 2004-07-29 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector
EP1592442A2 (de) * 2003-02-06 2005-11-09 Cerus Corporation Modifizierte freilebende mikroben, impfstoffzusammensetzungen und deren verwendungen
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
WO2004110481A2 (en) * 2003-02-06 2004-12-23 Cerus Corporation Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof
US7842289B2 (en) * 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
US8906664B2 (en) 2004-08-13 2014-12-09 The Trustees Of The University Of Pennsylvania Methods for constructing antibiotic resistance free vaccines
US7855064B2 (en) * 2004-08-13 2010-12-21 The Trustees Of The University Of Pennsylvania Antibiotic resistance free vaccines and methods for constructing and using same
AU2005271247A1 (en) * 2004-08-13 2006-02-16 The Trustees Of The University Of Pennsylvania Antibiotic resistance free DNA vaccines
US7858097B2 (en) * 2004-08-13 2010-12-28 The Trustees Of The University Of Pennsylvania Antibiotic resistance free Listeria strains and methods for constructing and using same
US20070207171A1 (en) * 2006-03-01 2007-09-06 Cerus Corporation Engineered listeria and methods of use thereof
US7935804B2 (en) * 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
PT1991263E (pt) * 2006-03-01 2015-03-03 Aduro Biotech Listeria geneticamente modificada e métodos de uso da mesma
EP2032158A2 (de) * 2006-06-15 2009-03-11 Timothy John Mitchell Adjuvante zusammensetzungen
WO2008019131A2 (en) * 2006-08-04 2008-02-14 The Trustees Of The University Of Pennsylvania Methods and compositions for treating ige-mediated diseases
US8268326B2 (en) * 2006-08-15 2012-09-18 The Trustees Of The University Of Pennsylvania Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
DK2977456T3 (en) 2006-08-15 2018-01-22 Univ Pennsylvania Compositions comprising HMW-MAA and fragments thereof for the treatment of cancer
US8277797B2 (en) 2006-11-22 2012-10-02 The Regents Of The University Of California Interferon-β production modulating Listeria strains and methods for using same
JP5757863B2 (ja) 2008-05-19 2015-08-05 アドバクシス インコーポレイテッド 異種抗原のための二重送達システム
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
JP5539411B2 (ja) 2009-03-04 2014-07-02 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 血管新生因子を含む組成物およびその使用方法
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
EP2498808A4 (de) * 2009-11-11 2014-01-08 Advaxis Zusammensetzungen und verfahren zur verhinderung von fluchtmutationen bei der behandlung von tumoren mit her2/neu-überexpression
WO2011100754A1 (en) * 2010-02-15 2011-08-18 The Trustees Of The University Of Pennsylvania Live listeria-based vaccines for central nervous system therapy
US20110305724A1 (en) * 2010-04-19 2011-12-15 Yvonne Paterson Immunotherapeutic, anti-tumorigenic compositions and methods of use thereof
US9226958B2 (en) 2010-10-01 2016-01-05 University Of Georgia Research Foundation, Inc. Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
US10702614B2 (en) 2011-02-15 2020-07-07 Albert Einstein College Of Medicine Radiobacteria for therapy of cancer
CN103687611A (zh) 2011-03-11 2014-03-26 阿德瓦希斯公司 基于李斯特菌属的佐剂
BR112014022662A2 (pt) * 2012-03-12 2017-10-03 Advaxis Inc Inibição da função de célula supressora seguindo tratamento de vacina de listeria
KR102160322B1 (ko) 2012-12-27 2020-09-25 아두로 바이오테크, 인코포레이티드 항원 서열의 리스테리아 발현을 용이하게 하는 신호 펩타이드 융합 상대 및 이의 제조방법 및 용도
EP3107566A4 (de) 2014-02-18 2017-10-11 Advaxis, Inc. Auf biomarker gerichtete multi-target-immuntherapie
KR20160122829A (ko) * 2014-02-25 2016-10-24 어드박시스, 인크. Ｈｅｒ2/ｎｅｕ 과발현 종양의 치료를 위한 조성물 및 방법
MA39849A (fr) 2014-04-24 2017-03-01 Advaxis Inc Souches de listeria utilisées comme vaccin recombinant et procédé de production
JP2017514904A (ja) 2014-05-02 2017-06-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｈｅｒ２陽性ガンの治療のための免疫療法および放射線療法の併用
SG10201913696YA (en) 2014-07-18 2020-03-30 Advaxis Inc Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
SG11201702611YA (en) 2014-10-14 2017-04-27 Univ Pennsylvania Combination therapy for use in cancer therapy
MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
WO2018102584A1 (en) 2016-11-30 2018-06-07 Advaxis, Inc. Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof
CN111356760A (zh) 2017-09-19 2020-06-30 阿德瓦希斯公司 细菌或李斯特菌菌株的冻干组合物和方法
JP2021516972A (ja) 2018-03-09 2021-07-15 アドバクシス， インコーポレイテッド Ｌｉｓｔｅｒｉａ株の弱毒化および感染性を評価するための組成物および方法
WO2019210034A1 (en) 2018-04-27 2019-10-31 Advaxis, Inc. Compositions and methods for evaluating potency of listeria-based immunotherapeutics

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Publication number Priority date Publication date Assignee Title
US5262177A (en) * 1986-02-07 1993-11-16 Oncogen Recombinant viruses encoding the human melanoma-associated antigen
US5830702A (en) 1990-10-31 1998-11-03 The Trustees Of The University Of Pennsylvania Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response
US6051237A (en) * 1994-11-08 2000-04-18 The Trustees Of The University Of Pennsylvania Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector
EP0902086A1 (de) 1997-08-22 1999-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Tuberkolose Impfstoff

Also Published As

Publication number Publication date
DE60142689D1 (de) 2010-09-09
US20020028206A1 (en) 2002-03-07
US6767542B2 (en) 2004-07-27
US20020025323A1 (en) 2002-02-28
IL151942A (en) 2009-07-20
US6855320B2 (en) 2005-02-15

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