DK157292C - Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf - Google Patents

Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf

Info

Publication number
DK157292C
DK157292C DK046181A DK46181A DK157292C DK 157292 C DK157292 C DK 157292C DK 046181 A DK046181 A DK 046181A DK 46181 A DK46181 A DK 46181A DK 157292 C DK157292 C DK 157292C
Authority
DK
Denmark
Prior art keywords
methyl
hydroxy
hydroxy acid
phenylylethylethylethylethylethylethyl
polyhydronaphthyl
Prior art date
Application number
DK046181A
Other languages
Danish (da)
English (en)
Other versions
DK46181A (da
DK157292B (da
Inventor
Alvin K Willard
Robert L Smith
William F Hoffman
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK157292(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK46181A publication Critical patent/DK46181A/da
Publication of DK157292B publication Critical patent/DK157292B/da
Application granted granted Critical
Publication of DK157292C publication Critical patent/DK157292C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DK046181A 1980-02-04 1981-02-03 Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf DK157292C (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11805180A 1980-02-04 1980-02-04
US11804980A 1980-02-04 1980-02-04
US11804980 1980-02-04
US11805180 1980-02-04
US17546080A 1980-08-05 1980-08-05
US17523280 1980-08-05
US17546080 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (3)

Publication Number Publication Date
DK46181A DK46181A (da) 1981-08-05
DK157292B DK157292B (da) 1989-12-04
DK157292C true DK157292C (da) 1990-05-07

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
DK046181A DK157292C (da) 1980-02-04 1981-02-03 Fremgangsmaade til fremstilling af 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl-(eller hydrogen)-polyhydronaphthyl-1')-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-oner eller tilsvarende hydroxysyrer eller farmaceutisk acceptable salte af hydroxysyrerne eller c1-4alkylestere deraf eller phenyl-, dimethylamino- eller acetylaminosubstituerede alkylestere deraf

Country Status (22)

Country Link
EP (1) EP0033538B1 (cs)
AU (1) AU548996B2 (cs)
CA (1) CA1199322A (cs)
CY (1) CY1404A (cs)
DD (1) DD155989A5 (cs)
DE (1) DE3173042D1 (cs)
DK (1) DK157292C (cs)
ES (1) ES499079A0 (cs)
FI (1) FI78082C (cs)
GR (1) GR74798B (cs)
HK (1) HK16488A (cs)
IE (1) IE51478B1 (cs)
IL (1) IL62044A (cs)
MA (1) MA19054A1 (cs)
MY (1) MY8700745A (cs)
NL (1) NL930009I2 (cs)
NO (2) NO154229C (cs)
NZ (1) NZ196172A (cs)
PT (1) PT72441B (cs)
RO (1) RO82367B (cs)
SG (1) SG61087G (cs)
YU (1) YU28181A (cs)

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US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
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ATE241386T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und cholesteryl ester transfer protein inhibitoren
EP1340508A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
PT1140190E (pt) 1998-12-23 2003-02-28 Searle Llc Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
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ES2203239T3 (es) 1998-12-23 2004-04-01 G.D. Searle Llc Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de agentes secuestrantes de acidos biliares para indicaciones cardiovasculares.
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
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WO2001068637A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
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BR0213501A (pt) 2001-11-02 2004-08-24 Searle Llc Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
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KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
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WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
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WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2216016A1 (en) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
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Also Published As

Publication number Publication date
GR74798B (cs) 1984-07-12
AU6657381A (en) 1981-08-13
HK16488A (en) 1988-03-11
PT72441B (pt) 1984-08-01
RO82367A (ro) 1984-02-21
EP0033538A3 (en) 1982-02-24
NO1994001I1 (no) 1994-07-01
NL930009I1 (nl) 1993-04-01
NZ196172A (en) 1985-01-31
MA19054A1 (fr) 1981-10-01
FI810287L (fi) 1981-08-05
NL930009I2 (nl) 1993-09-16
RO82367B (ro) 1984-02-28
IE810204L (en) 1981-08-04
DK46181A (da) 1981-08-05
EP0033538B1 (en) 1985-11-27
NO154229B (no) 1986-05-05
DE3173042D1 (en) 1986-01-09
EP0033538A2 (en) 1981-08-12
NO810358L (no) 1981-08-05
AU548996B2 (en) 1986-01-09
IL62044A0 (en) 1981-03-31
CY1404A (en) 1988-04-22
MY8700745A (en) 1987-12-31
ES8609296A1 (es) 1985-10-16
DD155989A5 (de) 1982-07-21
PT72441A (pt) 1981-03-01
IE51478B1 (en) 1987-01-07
FI78082B (fi) 1989-02-28
DK157292B (da) 1989-12-04
NO154229C (no) 1986-08-13
IL62044A (en) 1987-03-31
CA1199322A (en) 1986-01-14
YU28181A (en) 1983-10-31
ES499079A0 (es) 1985-10-16
SG61087G (en) 1987-10-23
FI78082C (fi) 1989-06-12

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