DK1566453T3 - Kvalitativ differentiel splejsning - Google Patents
Kvalitativ differentiel splejsning Download PDFInfo
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- DK1566453T3 DK1566453T3 DK05003839.7T DK05003839T DK1566453T3 DK 1566453 T3 DK1566453 T3 DK 1566453T3 DK 05003839 T DK05003839 T DK 05003839T DK 1566453 T3 DK1566453 T3 DK 1566453T3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Paper (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Medicines Containing Plant Substances (AREA)
- Sanitary Device For Flush Toilet (AREA)
- Threshing Machine Elements (AREA)
- Lock And Its Accessories (AREA)
Claims (3)
1. Sammensætning omfattende en bærer og oligonukleotider, kendetegnet ved, at oligonukleotiderne er enkeltstrengede, har en længde på mellem 5 og 50 nukleotider, og er specifikke for variationer i splejsningsformerne og/eller -mønstrene i flere forskellige gener, og hvor oligonukleotiderne kan opnås ved en fremgangsmåde omfattende: (a) identificering en splejsningsbegivenhed, som er karakteristisk for en fysiopathologisk situation og det splejsede domænes sekvens; (b) kunstig syntese af et eller flere oligonukleotider svarende til et eller flere områder af dette domæne, og at tillade identificering af den usplejsede form i RNA'erne afen testprøve ved hybridisering; (c) kunstig syntese af et eller flere oligonukleotider svarende til et eller flere forbindelsesområder mellem to domæner, der er adskilt af det splejsede domæne, og at tillade identificering af den splejsede form i RNA'erne af en testprøve ved hybridisering; (d) gentagelse af trinnene (a) til (c) ovenfor med andre splejsningsbegivenheder, som er karakteristiske for den fysiopathologiske situation; og (e) overførsel af oligonukleotiderne til en egnet bærer.
2. Sammensætning ifølge krav 1, hvor oligonukleotiderne har en længde på omkring 25 nukleotider.
3. Sammensætning ifølge krav 1 eller 2, hvor bæreren består af et filter, en membran eller en chip.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| FR9802997A FR2775984B1 (fr) | 1998-03-11 | 1998-03-11 | Criblage differentiel qualitatif |
| EP99909002A EP1062364B1 (fr) | 1998-03-11 | 1999-03-11 | Criblage differentiel qualitatif |
Publications (1)
| Publication Number | Publication Date |
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| DK1566453T3 true DK1566453T3 (da) | 2015-11-09 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| DK99909002T DK1062364T3 (da) | 1998-03-11 | 1999-03-11 | Kvalitativ differentiel screening |
| DK05003839.7T DK1566453T3 (da) | 1998-03-11 | 1999-03-11 | Kvalitativ differentiel splejsning |
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| Application Number | Title | Priority Date | Filing Date |
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| DK99909002T DK1062364T3 (da) | 1998-03-11 | 1999-03-11 | Kvalitativ differentiel screening |
Country Status (13)
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| EP (2) | EP1062364B1 (da) |
| JP (1) | JP4527280B2 (da) |
| AT (1) | ATE295426T1 (da) |
| AU (1) | AU760656B2 (da) |
| CA (1) | CA2323231C (da) |
| DE (1) | DE69925253T2 (da) |
| DK (2) | DK1062364T3 (da) |
| ES (2) | ES2243047T3 (da) |
| FR (1) | FR2775984B1 (da) |
| IL (1) | IL138249A0 (da) |
| PT (2) | PT1062364E (da) |
| WO (1) | WO1999046403A1 (da) |
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| US20030165931A1 (en) * | 1998-03-11 | 2003-09-04 | Bruno Tocque | Qualitative differential screening |
| US6881571B1 (en) * | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
| US20040248169A1 (en) * | 1999-01-06 | 2004-12-09 | Chondrogene Limited | Method for the detection of obesity related gene transcripts in blood |
| US20040248170A1 (en) * | 1999-01-06 | 2004-12-09 | Chondrogene Limited | Method for the detection of hyperlipidemia related gene transcripts in blood |
| US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| US20040241726A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of allergies related gene transcripts in blood |
| US20040241728A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of lung disease related gene transcripts in blood |
| US20050003394A1 (en) * | 1999-01-06 | 2005-01-06 | Chondrogene Limited | Method for the detection of rheumatoid arthritis related gene transcripts in blood |
| US20040265868A1 (en) * | 1999-01-06 | 2004-12-30 | Chondrogene Limited | Method for the detection of depression related gene transcripts in blood |
| WO2000040749A2 (en) | 1999-01-06 | 2000-07-13 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| US20060134635A1 (en) * | 2001-02-28 | 2006-06-22 | Chondrogene Limited | Method for the detection of coronary artery disease related gene transcripts in blood |
| US7473528B2 (en) * | 1999-01-06 | 2009-01-06 | Genenews Inc. | Method for the detection of Chagas disease related gene transcripts in blood |
| US20070105121A1 (en) * | 1999-01-06 | 2007-05-10 | Chondrogene Limited | Method for the detection of schizophrenia related gene transcripts in blood |
| US6960439B2 (en) | 1999-06-28 | 2005-11-01 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| US6692916B2 (en) | 1999-06-28 | 2004-02-17 | Source Precision Medicine, Inc. | Systems and methods for characterizing a biological condition or agent using precision gene expression profiles |
| FR2798392B1 (fr) | 1999-09-13 | 2005-07-15 | Exonhit Therapeutics Sa | Marqueurs genetiques de la toxicite, preparation et utilisations |
| FR2798673B1 (fr) * | 1999-09-16 | 2004-05-28 | Exonhit Therapeutics Sa | Methodes et compositions pour la detection d'evenements pathologiques |
| US7361488B2 (en) * | 2000-02-07 | 2008-04-22 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| JP2002065259A (ja) * | 2000-08-24 | 2002-03-05 | Shinya Watanabe | 核酸標識方法および核酸標識用キット |
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| JP2005519606A (ja) * | 2002-03-14 | 2005-07-07 | エグゾニ・テラピューティック・ソシエテ・アノニム | ヒトカリクレイン−２及びカリクレイン−３のバリアント並びにそれらの使用 |
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| FR2844713A1 (fr) * | 2002-09-25 | 2004-03-26 | Exonhit Therapeutics Sa | Nouvelle cible de l'angiogenese et utilisations |
| GB0228557D0 (en) * | 2002-12-06 | 2003-01-15 | Pharma Gen S A | Method to analyze polymeric nucleic acid sequence variations |
| FR2848573B1 (fr) * | 2002-12-13 | 2005-04-08 | Exonhit Therapeutics Sa | Compositions et methodes pour la detection et le traitement de pathologies neurodegeneratives |
| FR2848569A1 (fr) * | 2002-12-17 | 2004-06-18 | Exonhit Therapeutics Sa | Variants de kallikrein-2 et kallikrein-3 humaines et leurs utilisations |
| FR2851247B1 (fr) | 2003-02-19 | 2007-06-29 | Exonhit Therapeutics Sa | Methodes et compositions pour le traitement de pathologies degeneratives oculaires |
| EP1636379A2 (en) * | 2003-06-26 | 2006-03-22 | Exonhit Therapeutics S.A. | Prostate specific genes and the use thereof as targets for prostate cancer therapy and diagnosis |
| WO2005017186A2 (en) * | 2003-08-08 | 2005-02-24 | Thomas Jefferson University | Method for rapid identification of alternative splicing |
| FR2867485B1 (fr) * | 2003-12-10 | 2008-02-22 | Exonhit Therapeutics Sa | Identification de marqueurs diagnostics pour les encephalopathies subaigues spongiformes transmissibles |
| BRPI0416552A (pt) * | 2003-11-13 | 2007-01-23 | Exonhit Therapeutics Sa | método para detectar a presença ou risco de desenvolver uma encefalopatia em um mamìfero, utilização de uma sonda nucleica, de um iniciador nucleico e de um ácido nucleico, produto e kit |
| FR2862314A1 (fr) * | 2003-11-13 | 2005-05-20 | Exonhit Therapeutics Sa | Identification de marqueurs diagnostic pour les encephalopathies subaigues spongiformes transmissibles |
| EP1586587A1 (en) * | 2004-04-16 | 2005-10-19 | Exonhit Therapeutics SA | Compositions and methods for detecting angiogenesis |
| US7569367B2 (en) | 2005-09-07 | 2009-08-04 | Roche Diagnostics Operations, Inc. | Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy |
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| EP2287336A1 (fr) | 2009-07-31 | 2011-02-23 | Exhonit Therapeutics SA | Procédés et méthodes de diagnostic de la maladie d'Alzheimer |
| EP3034620A1 (en) | 2014-12-17 | 2016-06-22 | Diaxonhit | Compositions and methods for diagnosing thyroid cancer |
| FR3036287A1 (fr) | 2015-05-19 | 2016-11-25 | Univ Bordeaux | Traitement et detection des trypanosomes |
| EP3211096A1 (fr) | 2016-02-26 | 2017-08-30 | Prestizia | Combinaison de miarns permettant la prediction de l'evolution clinique du cancer du rectum |
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-
1998
- 1998-03-11 FR FR9802997A patent/FR2775984B1/fr not_active Expired - Fee Related
- 1998-03-24 US US09/046,920 patent/US6251590B1/en not_active Expired - Lifetime
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1999
- 1999-03-11 EP EP99909002A patent/EP1062364B1/fr not_active Expired - Lifetime
- 1999-03-11 PT PT99909002T patent/PT1062364E/pt unknown
- 1999-03-11 EP EP05003839.7A patent/EP1566453B1/fr not_active Expired - Lifetime
- 1999-03-11 AT AT99909002T patent/ATE295426T1/de active
- 1999-03-11 IL IL13824999A patent/IL138249A0/xx not_active IP Right Cessation
- 1999-03-11 ES ES99909002T patent/ES2243047T3/es not_active Expired - Lifetime
- 1999-03-11 DE DE69925253T patent/DE69925253T2/de not_active Expired - Lifetime
- 1999-03-11 DK DK99909002T patent/DK1062364T3/da active
- 1999-03-11 JP JP2000535770A patent/JP4527280B2/ja not_active Expired - Fee Related
- 1999-03-11 ES ES05003839.7T patent/ES2551441T3/es not_active Expired - Lifetime
- 1999-03-11 PT PT50038397T patent/PT1566453E/pt unknown
- 1999-03-11 WO PCT/FR1999/000547 patent/WO1999046403A1/fr active IP Right Grant
- 1999-03-11 CA CA2323231A patent/CA2323231C/fr not_active Expired - Fee Related
- 1999-03-11 AU AU28399/99A patent/AU760656B2/en not_active Ceased
- 1999-03-11 DK DK05003839.7T patent/DK1566453T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69925253T2 (de) | 2006-02-09 |
| FR2775984B1 (fr) | 2006-09-15 |
| ES2243047T3 (es) | 2005-11-16 |
| DE69925253D1 (en) | 2005-06-16 |
| PT1062364E (pt) | 2005-09-30 |
| CA2323231A1 (fr) | 1999-09-16 |
| EP1062364A1 (fr) | 2000-12-27 |
| FR2775984A1 (fr) | 1999-09-17 |
| IL138249A0 (en) | 2001-10-31 |
| EP1566453A3 (fr) | 2009-11-18 |
| US6251590B1 (en) | 2001-06-26 |
| JP4527280B2 (ja) | 2010-08-18 |
| WO1999046403A1 (fr) | 1999-09-16 |
| EP1062364B1 (fr) | 2005-05-11 |
| CA2323231C (fr) | 2011-06-21 |
| AU760656B2 (en) | 2003-05-22 |
| ES2551441T3 (es) | 2015-11-19 |
| DK1062364T3 (da) | 2005-09-05 |
| JP2002505887A (ja) | 2002-02-26 |
| PT1566453E (pt) | 2015-11-13 |
| EP1566453A2 (fr) | 2005-08-24 |
| EP1566453B1 (fr) | 2015-09-09 |
| AU2839999A (en) | 1999-09-27 |
| ATE295426T1 (de) | 2005-05-15 |
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