DK1565451T3 - Halogenthienoylcyclopropan-1-carboxylsyre-derivater - Google Patents
Halogenthienoylcyclopropan-1-carboxylsyre-derivaterInfo
- Publication number
- DK1565451T3 DK1565451T3 DK03811772T DK03811772T DK1565451T3 DK 1565451 T3 DK1565451 T3 DK 1565451T3 DK 03811772 T DK03811772 T DK 03811772T DK 03811772 T DK03811772 T DK 03811772T DK 1565451 T3 DK1565451 T3 DK 1565451T3
- Authority
- DK
- Denmark
- Prior art keywords
- branched
- linear
- alkyl
- halogenthienoylcyclopropan
- carboxylic acid
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 102100037652 Kynurenine 3-monooxygenase Human genes 0.000 abstract 2
- 108010033242 Kynurenine 3-monooxygenase Proteins 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 229930195712 glutamate Natural products 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003563 glycoside group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- -1 phenoxy, benzyloxy Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026597A EP1424333A1 (en) | 2002-11-28 | 2002-11-28 | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
| PCT/EP2003/013244 WO2004048361A1 (en) | 2002-11-28 | 2003-11-25 | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1565451T3 true DK1565451T3 (da) | 2007-09-10 |
Family
ID=32241303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03811772T DK1565451T3 (da) | 2002-11-28 | 2003-11-25 | Halogenthienoylcyclopropan-1-carboxylsyre-derivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060116329A1 (OSRAM) |
| EP (2) | EP1424333A1 (OSRAM) |
| JP (1) | JP4522864B2 (OSRAM) |
| AT (1) | ATE361921T1 (OSRAM) |
| AU (1) | AU2003296596B2 (OSRAM) |
| CA (1) | CA2507597A1 (OSRAM) |
| CY (1) | CY1106692T1 (OSRAM) |
| DE (1) | DE60313798T2 (OSRAM) |
| DK (1) | DK1565451T3 (OSRAM) |
| ES (1) | ES2286509T3 (OSRAM) |
| PT (1) | PT1565451E (OSRAM) |
| SI (1) | SI1565451T1 (OSRAM) |
| WO (1) | WO2004048361A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1475088A1 (en) * | 2003-05-05 | 2004-11-10 | Newron Pharmaceuticals S.p.A. | Use of kynurenine-3-hydroxylase inhibitors for the preparation of medicaments for the treatment of l-dopa induced movement disorders, dyskinesias, drug addiction, pain and cataract |
| GB2402940A (en) * | 2004-08-19 | 2004-12-22 | Pfizer Ltd | Biomarkers of inflammation and/or macrophage activation |
| JP2008535892A (ja) * | 2005-04-11 | 2008-09-04 | プロビオドルグ エージー | プロリルエンドペプチダーゼの阻害剤 |
| AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
| ES2972419T3 (es) | 2012-04-05 | 2024-06-12 | Chdi Foundation Inc | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmacéuticas y métodos de uso de los mismos |
| US9938252B2 (en) | 2013-09-26 | 2018-04-10 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| WO2015047982A2 (en) * | 2013-09-26 | 2015-04-02 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| GB201322512D0 (en) | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201508857D0 (en) | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
| GB201508864D0 (en) | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1278435B (de) * | 1965-01-19 | 1968-09-26 | Merck Ag E | Verfahren zur Herstellung von 1, 2-disubstituierten Cyclopropanderivaten |
| US4022903A (en) * | 1975-06-05 | 1977-05-10 | Abbott Laboratories | α-Thienyl and α-substituted thienyl, phenyl and substituted phenyl cyclopropylomethanols useful as biodegradable insecticides and mollusicides |
| US6274590B1 (en) * | 1993-01-15 | 2001-08-14 | G. D. Searle & Co. | Method of treating skin related conditions |
| JP4176150B2 (ja) * | 1996-10-30 | 2008-11-05 | 塩野義製薬株式会社 | グルタミン酸放出阻害剤および新規化合物 |
| GB9705031D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | 2-substituted benzoyl-cycloalkyl-1-carboxylic acid derivatives |
-
2002
- 2002-11-28 EP EP02026597A patent/EP1424333A1/en not_active Withdrawn
-
2003
- 2003-11-25 US US10/536,307 patent/US20060116329A1/en not_active Abandoned
- 2003-11-25 AU AU2003296596A patent/AU2003296596B2/en not_active Ceased
- 2003-11-25 CA CA002507597A patent/CA2507597A1/en not_active Abandoned
- 2003-11-25 EP EP03811772A patent/EP1565451B1/en not_active Expired - Lifetime
- 2003-11-25 ES ES03811772T patent/ES2286509T3/es not_active Expired - Lifetime
- 2003-11-25 PT PT03811772T patent/PT1565451E/pt unknown
- 2003-11-25 DK DK03811772T patent/DK1565451T3/da active
- 2003-11-25 AT AT03811772T patent/ATE361921T1/de not_active IP Right Cessation
- 2003-11-25 WO PCT/EP2003/013244 patent/WO2004048361A1/en not_active Ceased
- 2003-11-25 DE DE60313798T patent/DE60313798T2/de not_active Expired - Lifetime
- 2003-11-25 JP JP2004554463A patent/JP4522864B2/ja not_active Expired - Fee Related
- 2003-11-25 SI SI200330828T patent/SI1565451T1/sl unknown
-
2007
- 2007-07-02 CY CY20071100873T patent/CY1106692T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60313798D1 (en) | 2007-06-21 |
| EP1424333A1 (en) | 2004-06-02 |
| SI1565451T1 (sl) | 2007-08-31 |
| CA2507597A1 (en) | 2004-06-10 |
| DE60313798T2 (de) | 2008-01-24 |
| US20060116329A1 (en) | 2006-06-01 |
| CY1106692T1 (el) | 2012-05-23 |
| ATE361921T1 (de) | 2007-06-15 |
| AU2003296596B2 (en) | 2010-03-04 |
| JP2006509753A (ja) | 2006-03-23 |
| JP4522864B2 (ja) | 2010-08-11 |
| ES2286509T3 (es) | 2007-12-01 |
| WO2004048361A1 (en) | 2004-06-10 |
| EP1565451A1 (en) | 2005-08-24 |
| AU2003296596A1 (en) | 2004-06-18 |
| PT1565451E (pt) | 2007-08-03 |
| EP1565451B1 (en) | 2007-05-09 |
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