DK15490A - Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning - Google Patents

Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning Download PDF

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Publication number
DK15490A
DK15490A DK015490A DK15490A DK15490A DK 15490 A DK15490 A DK 15490A DK 015490 A DK015490 A DK 015490A DK 15490 A DK15490 A DK 15490A DK 15490 A DK15490 A DK 15490A
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DK
Denmark
Prior art keywords
phenylthiomethylindol
dimethylaminomethyl
antiviral
interferon
bromo
Prior art date
Application number
DK015490A
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Danish (da)
English (en)
Other versions
DK15490D0 (da
Inventor
Alexei Nikolaevich Grinev
Fedor Alexandrovich Trofimov
Nina Gavrilovna Tsyshkova
Grigory Nikolaevich Pershin
Nadezhda Sergeevna Bogdanova
Irina Sergeevna Nikolaeva
Svetlana Alexeevna Zotova
Zinaida Mikhailovna Sakhaschik
Evgenia Alexandrovna Svirina
Alla Nikolaevna Fomina
Elena Nikolaevna Padeiskaya
Dmitry Mikhailovich Zlydnikov
Olga Iosifovna Kubar
Evgenia Georgievna Shvetsova
Elena Alexeevna Bryantseva
Valentina Vasilievna Peters
Svetlana Nikolaevna Kutchak
Anatoly Georgie Konoplyannikov
M Fl Boris Pavlovich Surinov
Original Assignee
Vni Khim Farma Tsevtiches
Nii Med Radiologii Ak
Le Nii Epedimiologii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vni Khim Farma Tsevtiches, Nii Med Radiologii Ak, Le Nii Epedimiologii filed Critical Vni Khim Farma Tsevtiches
Priority to DK015490A priority Critical patent/DK15490A/da
Publication of DK15490D0 publication Critical patent/DK15490D0/da
Publication of DK15490A publication Critical patent/DK15490A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK015490A 1989-01-12 1990-01-19 Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning DK15490A (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK015490A DK15490A (da) 1989-01-12 1990-01-19 Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/SU1988/000272 WO1990008135A1 (en) 1989-01-12 1989-01-12 Ethyl ester 6-bromine-5-hydroxy-4-dimethyl-aminomethyl-1-methyl-2-phenylthiomethyl indole-3-carboxylic acid hydrochloride monohydrate, method of obtaining it and a pharmaceutical preparation of antiviral, interferon inducing and immunomodulating action based on it
DK015490A DK15490A (da) 1989-01-12 1990-01-19 Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning

Publications (2)

Publication Number Publication Date
DK15490D0 DK15490D0 (da) 1990-01-19
DK15490A true DK15490A (da) 1991-07-20

Family

ID=21617367

Family Applications (1)

Application Number Title Priority Date Filing Date
DK015490A DK15490A (da) 1989-01-12 1990-01-19 Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning

Country Status (10)

Country Link
US (1) US5198552A (es)
BE (1) BE1003341A4 (es)
CH (1) CH678726A5 (es)
DE (2) DE3891468C2 (es)
DK (1) DK15490A (es)
FR (1) FR2650504B1 (es)
GB (1) GB2234510B (es)
NL (1) NL9000265A (es)
SE (1) SE465462B (es)
WO (1) WO1990008135A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH678726A5 (es) * 1989-01-12 1991-10-31 Vni Khim Farmatsevtichesky I I
WO1995029897A1 (en) * 1994-04-29 1995-11-09 G.D. Searle & Co. METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS
CN100361975C (zh) * 2003-01-04 2008-01-16 沈阳药科大学 5－羟基－3－羧酸酯吲哚类衍生物及其制备方法
CN100519523C (zh) * 2004-03-12 2009-07-29 沈阳药科大学 5-羟基吲哚-3-羧酸酯类衍生物及其用途
CN1560035A (zh) * 2004-03-12 2005-01-05 沈阳药科大学 5－羟基吲哚－3－羧酸脂类衍生物
CN100364975C (zh) * 2005-04-26 2008-01-30 武汉大学 一种抗呼吸道病毒的药物及用途
CN1316968C (zh) * 2005-09-30 2007-05-23 青岛大学 吲哚－2,3－二酮在制备抗病毒或免疫增强剂药物中的应用
EP2036889A4 (en) 2006-05-23 2009-11-04 Alla Chem Llc SUBSTITUTED INDOLES AND PROCESS FOR PRODUCTION AND USE THEREOF
CN101070319B (zh) * 2007-05-29 2012-04-18 沈阳中海生物技术开发有限公司 一种抗乙肝病毒化合物的结晶形态以及它的制备方法和用途
US20130131126A1 (en) 2010-07-16 2013-05-23 Jsc Grindeks Derivatives of 1,4-dihydropyridine possessing antiviral efficacy
CN102786462B (zh) * 2011-05-18 2016-08-31 中国医学科学院药物研究所 阿比朵尔盐酸盐晶b型及制法与在药品和保健品中应用
CN102786461B (zh) * 2011-05-18 2016-08-31 中国医学科学院药物研究所 阿比朵尔盐酸盐晶e型及制法与在药品和保健品中应用
CN102351778A (zh) * 2011-08-17 2012-02-15 湖北华龙生物制药有限公司 一种盐酸阿比朵尔的制备方法
EP2578218A1 (en) 2011-10-06 2013-04-10 Grindeks, A Joint Stock Company Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives
CN104193669B (zh) * 2014-08-01 2016-12-07 大连理工大学 一类阿比朵尔类似物或其盐、其制备方法及应用
CN106083691B (zh) * 2016-08-22 2018-11-27 山东罗欣药业集团恒欣药业有限公司 一种盐酸阿比朵尔一水合物的制备方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN111533677A (zh) * 2020-05-13 2020-08-14 大连万福制药有限公司 一种合成盐酸阿比朵尔中间体的方法
CN116003308B (zh) * 2022-12-27 2023-09-29 石家庄中硕制药有限公司 阿比多尔结晶方法
CN117586173B (zh) * 2023-11-29 2024-07-12 石家庄中硕制药有限公司 一种阿比多尔的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124702A (en) * 1971-07-06 1978-11-07 Merck & Co., Inc. Polynucleotides active as inducers of interferon production in living animal cells
US4215137A (en) * 1978-06-26 1980-07-29 Sterling Drug Inc. Method of alleviating diseases by cell-mediated immune modulation
US4619942A (en) * 1982-04-08 1986-10-28 University Of North Carolina Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds
ATE82961T1 (de) * 1986-04-17 1992-12-15 Willem Nico Speckamp Indochinon-verbindungen.
WO1988005432A1 (en) * 1987-01-23 1988-07-28 Yoshitomi Pharmaceutical Industries, Ltd. 5-hydroxyindole-3-carboxamide compound and medicinal use thereof
JPS63188665A (ja) * 1987-01-30 1988-08-04 Yoshitomi Pharmaceut Ind Ltd ５−ヒドロキシインド−ル−３−カルボン酸エステル化合物
CH678726A5 (es) * 1989-01-12 1991-10-31 Vni Khim Farmatsevtichesky I I

Also Published As

Publication number Publication date
DE3891468C2 (de) 1994-02-24
SE465462B (sv) 1991-09-16
GB2234510B (en) 1992-03-25
GB9020370D0 (en) 1990-11-21
DK15490D0 (da) 1990-01-19
FR2650504B1 (fr) 1993-12-24
DE3891468T1 (de) 1991-02-21
CH678726A5 (es) 1991-10-31
NL9000265A (nl) 1991-09-02
FR2650504A1 (fr) 1991-02-08
SE9000282L (sv) 1991-07-27
GB2234510A (en) 1991-02-06
SE9000282D0 (sv) 1990-01-26
US5198552A (en) 1993-03-30
WO1990008135A1 (en) 1990-07-26
BE1003341A4 (fr) 1992-03-03

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