DK15490A - Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning - Google Patents
Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning Download PDFInfo
- Publication number
- DK15490A DK15490A DK015490A DK15490A DK15490A DK 15490 A DK15490 A DK 15490A DK 015490 A DK015490 A DK 015490A DK 15490 A DK15490 A DK 15490A DK 15490 A DK15490 A DK 15490A
- Authority
- DK
- Denmark
- Prior art keywords
- phenylthiomethylindol
- dimethylaminomethyl
- antiviral
- interferon
- bromo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK015490A DK15490A (da) | 1989-01-12 | 1990-01-19 | Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SU1988/000272 WO1990008135A1 (en) | 1989-01-12 | 1989-01-12 | Ethyl ester 6-bromine-5-hydroxy-4-dimethyl-aminomethyl-1-methyl-2-phenylthiomethyl indole-3-carboxylic acid hydrochloride monohydrate, method of obtaining it and a pharmaceutical preparation of antiviral, interferon inducing and immunomodulating action based on it |
DK015490A DK15490A (da) | 1989-01-12 | 1990-01-19 | Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning |
Publications (2)
Publication Number | Publication Date |
---|---|
DK15490D0 DK15490D0 (da) | 1990-01-19 |
DK15490A true DK15490A (da) | 1991-07-20 |
Family
ID=21617367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK015490A DK15490A (da) | 1989-01-12 | 1990-01-19 | Forbindelsen ethyl 6-brom-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindol-3-carboxylat, hydrochlorid, monohydrat, fremgangsmaade til fremstilling af denne, og farmaceutiske praeparater indeholdende denne med antiviral, interferoninducerende og immunmodulerende virkning |
Country Status (10)
Country | Link |
---|---|
US (1) | US5198552A (de) |
BE (1) | BE1003341A4 (de) |
CH (1) | CH678726A5 (de) |
DE (2) | DE3891468T1 (de) |
DK (1) | DK15490A (de) |
FR (1) | FR2650504B1 (de) |
GB (1) | GB2234510B (de) |
NL (1) | NL9000265A (de) |
SE (1) | SE465462B (de) |
WO (1) | WO1990008135A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990008135A1 (en) * | 1989-01-12 | 1990-07-26 | Vsesojuzny Nauchno-Issledovatelsky Khimiko-Farmatsevtichesky Institut Imeni S.Ordzhonikidze (Vnikhfi) | Ethyl ester 6-bromine-5-hydroxy-4-dimethyl-aminomethyl-1-methyl-2-phenylthiomethyl indole-3-carboxylic acid hydrochloride monohydrate, method of obtaining it and a pharmaceutical preparation of antiviral, interferon inducing and immunomodulating action based on it |
AU2395095A (en) * | 1994-04-29 | 1995-11-29 | G.D. Searle & Co. | Method of using (h+/k+) atpase inhibitors as antiviral agents |
CN100361975C (zh) * | 2003-01-04 | 2008-01-16 | 沈阳药科大学 | 5-羟基-3-羧酸酯吲哚类衍生物及其制备方法 |
CN100519523C (zh) * | 2004-03-12 | 2009-07-29 | 沈阳药科大学 | 5-羟基吲哚-3-羧酸酯类衍生物及其用途 |
CN1560035A (zh) * | 2004-03-12 | 2005-01-05 | 沈阳药科大学 | 5-羟基吲哚-3-羧酸脂类衍生物 |
CN100364975C (zh) * | 2005-04-26 | 2008-01-30 | 武汉大学 | 一种抗呼吸道病毒的药物及用途 |
CN1316968C (zh) * | 2005-09-30 | 2007-05-23 | 青岛大学 | 吲哚-2,3-二酮在制备抗病毒或免疫增强剂药物中的应用 |
US8329689B2 (en) | 2006-05-23 | 2012-12-11 | Alexandre Vasilievich Ivachtchenko | Substituted indoles and a method for the production and use thereof |
CN101070319B (zh) * | 2007-05-29 | 2012-04-18 | 沈阳中海生物技术开发有限公司 | 一种抗乙肝病毒化合物的结晶形态以及它的制备方法和用途 |
CN103189354A (zh) | 2010-07-16 | 2013-07-03 | 格林代克斯联合股份公司 | 具有抗病毒功效的1,4-二氢吡啶衍生物 |
CN102786461B (zh) * | 2011-05-18 | 2016-08-31 | 中国医学科学院药物研究所 | 阿比朵尔盐酸盐晶e型及制法与在药品和保健品中应用 |
CN102786462B (zh) * | 2011-05-18 | 2016-08-31 | 中国医学科学院药物研究所 | 阿比朵尔盐酸盐晶b型及制法与在药品和保健品中应用 |
CN102351778A (zh) * | 2011-08-17 | 2012-02-15 | 湖北华龙生物制药有限公司 | 一种盐酸阿比朵尔的制备方法 |
EP2578218A1 (de) | 2011-10-06 | 2013-04-10 | Grindeks, A Joint Stock Company | Antivirale Wirksamkeit von Dinatrium-2,6-Dimethyl-1,4-Dihydropyridin-3,5-Bis(carbonyloxyacetat) und Derivate davon |
CN104193669B (zh) * | 2014-08-01 | 2016-12-07 | 大连理工大学 | 一类阿比朵尔类似物或其盐、其制备方法及应用 |
CN106083691B (zh) * | 2016-08-22 | 2018-11-27 | 山东罗欣药业集团恒欣药业有限公司 | 一种盐酸阿比朵尔一水合物的制备方法 |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
CN111533677A (zh) * | 2020-05-13 | 2020-08-14 | 大连万福制药有限公司 | 一种合成盐酸阿比朵尔中间体的方法 |
CN116003308B (zh) * | 2022-12-27 | 2023-09-29 | 石家庄中硕制药有限公司 | 阿比多尔结晶方法 |
CN117586173B (zh) * | 2023-11-29 | 2024-07-12 | 石家庄中硕制药有限公司 | 一种阿比多尔的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4124702A (en) * | 1971-07-06 | 1978-11-07 | Merck & Co., Inc. | Polynucleotides active as inducers of interferon production in living animal cells |
US4215137A (en) * | 1978-06-26 | 1980-07-29 | Sterling Drug Inc. | Method of alleviating diseases by cell-mediated immune modulation |
US4619942A (en) * | 1982-04-08 | 1986-10-28 | University Of North Carolina | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds |
EP0302874B1 (de) * | 1986-04-17 | 1992-12-02 | SPECKAMP, Willem Nico | Indochinon-verbindungen |
US4874759A (en) * | 1987-01-23 | 1989-10-17 | Yoshitomi Pharmaceutical Industries, Ltd. | 5-Hydroxyindole-3-carboxylic acid amide compounds, pharmaceutical compositions and use |
JPS63188665A (ja) * | 1987-01-30 | 1988-08-04 | Yoshitomi Pharmaceut Ind Ltd | 5−ヒドロキシインド−ル−3−カルボン酸エステル化合物 |
WO1990008135A1 (en) * | 1989-01-12 | 1990-07-26 | Vsesojuzny Nauchno-Issledovatelsky Khimiko-Farmatsevtichesky Institut Imeni S.Ordzhonikidze (Vnikhfi) | Ethyl ester 6-bromine-5-hydroxy-4-dimethyl-aminomethyl-1-methyl-2-phenylthiomethyl indole-3-carboxylic acid hydrochloride monohydrate, method of obtaining it and a pharmaceutical preparation of antiviral, interferon inducing and immunomodulating action based on it |
-
1989
- 1989-01-12 WO PCT/SU1988/000272 patent/WO1990008135A1/ru active Application Filing
- 1989-01-12 DE DE883891468T patent/DE3891468T1/de active Pending
- 1989-01-12 DE DE3891468A patent/DE3891468C2/de not_active Expired - Fee Related
- 1989-01-12 CH CH3071/90A patent/CH678726A5/de not_active IP Right Cessation
- 1989-01-12 US US07/576,444 patent/US5198552A/en not_active Expired - Fee Related
- 1989-08-04 FR FR8910558A patent/FR2650504B1/fr not_active Expired - Fee Related
-
1990
- 1990-01-19 DK DK015490A patent/DK15490A/da not_active Application Discontinuation
- 1990-01-23 BE BE9000076A patent/BE1003341A4/fr not_active IP Right Cessation
- 1990-01-26 SE SE9000282A patent/SE465462B/sv unknown
- 1990-02-02 NL NL9000265A patent/NL9000265A/nl not_active Application Discontinuation
- 1990-09-11 GB GB9020370A patent/GB2234510B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK15490D0 (da) | 1990-01-19 |
NL9000265A (nl) | 1991-09-02 |
GB2234510B (en) | 1992-03-25 |
FR2650504B1 (fr) | 1993-12-24 |
US5198552A (en) | 1993-03-30 |
FR2650504A1 (fr) | 1991-02-08 |
SE465462B (sv) | 1991-09-16 |
DE3891468C2 (de) | 1994-02-24 |
BE1003341A4 (fr) | 1992-03-03 |
WO1990008135A1 (en) | 1990-07-26 |
GB9020370D0 (en) | 1990-11-21 |
SE9000282L (sv) | 1991-07-27 |
SE9000282D0 (sv) | 1990-01-26 |
CH678726A5 (de) | 1991-10-31 |
GB2234510A (en) | 1991-02-06 |
DE3891468T1 (de) | 1991-02-21 |
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Legal Events
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A0 | Application filed | ||
AHS | Application shelved for other reasons than non-payment |