DK1546119T3 - Fremgangsmåde til fremstilling af 4-(3'chlor-4'-fluoranilin)-7-methoxy-6-(3-morpholinpropoxy) quinazoline - Google Patents

Fremgangsmåde til fremstilling af 4-(3'chlor-4'-fluoranilin)-7-methoxy-6-(3-morpholinpropoxy) quinazoline

Info

Publication number
DK1546119T3
DK1546119T3 DK03795077T DK03795077T DK1546119T3 DK 1546119 T3 DK1546119 T3 DK 1546119T3 DK 03795077 T DK03795077 T DK 03795077T DK 03795077 T DK03795077 T DK 03795077T DK 1546119 T3 DK1546119 T3 DK 1546119T3
Authority
DK
Denmark
Prior art keywords
methoxy
quinazoline
chloro
fluoroaniline
preparation
Prior art date
Application number
DK03795077T
Other languages
Danish (da)
English (en)
Inventor
John Peter Gilday
David Moody
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1546119T3 publication Critical patent/DK1546119T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
DK03795077T 2002-09-13 2003-09-09 Fremgangsmåde til fremstilling af 4-(3'chlor-4'-fluoranilin)-7-methoxy-6-(3-morpholinpropoxy) quinazoline DK1546119T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221245.4A GB0221245D0 (en) 2002-09-13 2002-09-13 Chemical process
PCT/GB2003/003923 WO2004024703A1 (fr) 2002-09-13 2003-09-09 Procede de preparation de 4- (3'-chloro-4'-fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline

Publications (1)

Publication Number Publication Date
DK1546119T3 true DK1546119T3 (da) 2009-11-16

Family

ID=9943998

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03795077T DK1546119T3 (da) 2002-09-13 2003-09-09 Fremgangsmåde til fremstilling af 4-(3'chlor-4'-fluoranilin)-7-methoxy-6-(3-morpholinpropoxy) quinazoline

Country Status (23)

Country Link
US (1) US7705145B2 (fr)
EP (1) EP1546119B1 (fr)
JP (2) JP4527534B2 (fr)
KR (1) KR101114134B1 (fr)
CN (3) CN101348471B (fr)
AT (1) ATE440088T1 (fr)
AU (1) AU2003263348B2 (fr)
BR (1) BRPI0314238B8 (fr)
CA (1) CA2498122C (fr)
CY (1) CY1110511T1 (fr)
DE (1) DE60328901D1 (fr)
DK (1) DK1546119T3 (fr)
ES (1) ES2329567T3 (fr)
GB (1) GB0221245D0 (fr)
HK (1) HK1077809A1 (fr)
IL (1) IL167209A (fr)
MX (1) MXPA05002601A (fr)
NO (1) NO330009B1 (fr)
NZ (1) NZ538552A (fr)
PT (1) PT1546119E (fr)
SI (1) SI1546119T1 (fr)
WO (1) WO2004024703A1 (fr)
ZA (1) ZA200501892B (fr)

Families Citing this family (18)

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Publication number Priority date Publication date Assignee Title
WO2005070909A1 (fr) * 2004-01-22 2005-08-04 Natco Pharma Limited Procede ameliore de preparation de gefitinib
JP2010524909A (ja) * 2007-04-16 2010-07-22 シプラ・リミテッド ゲフィチニブの製造方法
CN101463012B (zh) * 2007-12-18 2011-06-08 上海百灵医药科技有限公司 一种吉非替尼的制备方法
CN101215274B (zh) * 2007-12-27 2011-05-04 上海北卡医药技术有限公司 N取代吗啉类有机化合物的制备工艺
CN101570516B (zh) * 2009-04-14 2011-01-05 重庆威尔德·浩瑞医药化工有限公司 一种制备4-(3-氯-4-氟苯基胺基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉的方法
CN101863844B (zh) * 2009-04-16 2012-10-03 欧美嘉股份有限公司 6,7-取代基-4-苯胺类喹唑啉的合成方法
CN102120731B (zh) * 2010-01-09 2015-01-07 浙江华海药业股份有限公司 一种制备4-(3-氯-4-氟苯基胺基)-7-甲氧基-6-(3-吗啉丙氧基)喹唑啉的新方法
CN102659716B (zh) * 2012-05-02 2014-09-10 北京国联诚辉医药技术有限公司 4-甲氧基-2-胺基-3-[3-(4-吗啉基)丙氧基]苯腈的制备方法及吉非替尼的制备工艺
KR101457453B1 (ko) * 2012-05-31 2014-11-04 주식회사 종근당 게피티닙의 제조방법 및 이의 제조에 사용되는 중간체
CN103073509A (zh) * 2012-12-31 2013-05-01 广东先强药业有限公司 一类喹唑啉衍生物的制备方法
CN103910690A (zh) * 2013-01-06 2014-07-09 上海科胜药物研发有限公司 一种吉非替尼新晶型及其制备方法
JP6020191B2 (ja) * 2013-01-21 2016-11-02 富士ゼロックス株式会社 表示制御装置及びプログラム
CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
CN103304491A (zh) * 2013-06-17 2013-09-18 连云港盛和生物科技有限公司 一种吉非替尼的制备方法
CN104130199A (zh) * 2013-08-07 2014-11-05 安徽安腾药业有限责任公司 制备7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3h)-酮的方法
CN105254614B (zh) * 2015-11-16 2017-08-15 山东罗欣药业集团股份有限公司 一种凡德他尼化合物的合成方法
CN109384747A (zh) * 2018-10-26 2019-02-26 苏州立新制药有限公司 吉非替尼相关物质及其制备和检测方法
CN112300082B (zh) * 2019-07-26 2022-04-26 暨南大学 一种苯基哌嗪喹唑啉类化合物或其药学上可接受的盐、制法与用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
AU8816298A (en) 1997-08-22 1999-03-16 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
JP3505991B2 (ja) 1998-02-13 2004-03-15 宇部興産株式会社 ４，５−ジ置換アントラニルアミドの製造法
JP3740835B2 (ja) * 1998-04-03 2006-02-01 宇部興産株式会社 ６，７−ジ置換−２，４−ジオキソキナゾリンの製造法
WO2001004102A1 (fr) * 1999-07-07 2001-01-18 Astrazeneca Uk Limited Derives de quinazoline
PL360439A1 (en) * 2000-06-28 2004-09-06 Astrazeneca Ab Substituted quinazoline derivatives and their use as inhibitors
WO2002048089A1 (fr) 2000-12-12 2002-06-20 Ube Industries, Ltd. Procede de production de compose d'ether aromatique au mononitrate
EP1466907B1 (fr) 2001-12-19 2011-08-10 Ube Industries, Ltd. Procede de production de quinazoline-4-one et derive de celle-ci
WO2003064377A1 (fr) 2002-01-29 2003-08-07 Ube Industries, Ltd. 2-formylaminobenzamides-4,5 substitues et methodes de production et de conversion desdits composes
JP4389205B2 (ja) 2002-02-06 2009-12-24 宇部興産株式会社 ４−アミノキナゾリン化合物の製法

Also Published As

Publication number Publication date
WO2004024703A1 (fr) 2004-03-25
NO20051104L (no) 2005-06-01
HK1077809A1 (en) 2006-02-24
GB0221245D0 (en) 2002-10-23
ZA200501892B (en) 2005-11-30
CA2498122A1 (fr) 2004-03-25
JP2010209071A (ja) 2010-09-24
NO330009B1 (no) 2011-02-07
ES2329567T3 (es) 2009-11-27
EP1546119A1 (fr) 2005-06-29
SI1546119T1 (sl) 2009-12-31
IL167209A (en) 2011-08-31
CN101348471B (zh) 2011-01-26
ATE440088T1 (de) 2009-09-15
JP4527534B2 (ja) 2010-08-18
MXPA05002601A (es) 2005-05-05
JP2006508922A (ja) 2006-03-16
BRPI0314238B8 (pt) 2021-05-25
EP1546119B1 (fr) 2009-08-19
CN100429204C (zh) 2008-10-29
DE60328901D1 (de) 2009-10-01
KR101114134B1 (ko) 2012-02-20
CN101348471A (zh) 2009-01-21
NZ538552A (en) 2007-02-23
KR20050042502A (ko) 2005-05-09
BRPI0314238B1 (pt) 2019-03-19
CN102030722B (zh) 2012-09-05
BR0314238A (pt) 2005-07-26
CY1110511T1 (el) 2015-04-29
AU2003263348B2 (en) 2007-10-11
CA2498122C (fr) 2010-11-09
AU2003263348A1 (en) 2004-04-30
US20060003999A1 (en) 2006-01-05
PT1546119E (pt) 2009-10-08
CN102030722A (zh) 2011-04-27
CN1681796A (zh) 2005-10-12
US7705145B2 (en) 2010-04-27

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