DK152670C - Analogifremgangsmaade til fremstilling af 1-(4-aryl-4-cyano-cyclohexyl)-4-aryl-4-piperidincarboxylsyre-derivater eller farmaceutisk acceptable syreadditionssalte og stereokemiske isomere deraf - Google Patents
Analogifremgangsmaade til fremstilling af 1-(4-aryl-4-cyano-cyclohexyl)-4-aryl-4-piperidincarboxylsyre-derivater eller farmaceutisk acceptable syreadditionssalte og stereokemiske isomere derafInfo
- Publication number
- DK152670C DK152670C DK029381A DK29381A DK152670C DK 152670 C DK152670 C DK 152670C DK 029381 A DK029381 A DK 029381A DK 29381 A DK29381 A DK 29381A DK 152670 C DK152670 C DK 152670C
- Authority
- DK
- Denmark
- Prior art keywords
- aryl
- stereochemists
- analogue
- cyclohexyl
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11492480A | 1980-01-24 | 1980-01-24 | |
| US11492480 | 1980-01-24 | ||
| US06/191,631 US4369184A (en) | 1980-01-24 | 1980-09-29 | 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives |
| US19163180 | 1980-09-29 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK29381A DK29381A (da) | 1981-07-25 |
| DK152670B DK152670B (da) | 1988-04-11 |
| DK152670C true DK152670C (da) | 1988-08-22 |
Family
ID=26812674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK029381A DK152670C (da) | 1980-01-24 | 1981-01-22 | Analogifremgangsmaade til fremstilling af 1-(4-aryl-4-cyano-cyclohexyl)-4-aryl-4-piperidincarboxylsyre-derivater eller farmaceutisk acceptable syreadditionssalte og stereokemiske isomere deraf |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4369184A (xx) |
| EP (1) | EP0034415B1 (xx) |
| AU (1) | AU538130B2 (xx) |
| BG (2) | BG35465A3 (xx) |
| CA (1) | CA1187080A (xx) |
| CS (1) | CS221818B2 (xx) |
| DE (1) | DE3163787D1 (xx) |
| DK (1) | DK152670C (xx) |
| ES (2) | ES8204421A1 (xx) |
| FI (1) | FI76562C (xx) |
| GR (1) | GR71898B (xx) |
| HK (1) | HK81088A (xx) |
| HU (1) | HU183293B (xx) |
| IE (1) | IE50706B1 (xx) |
| IL (1) | IL61968A (xx) |
| LU (1) | LU88220I2 (xx) |
| MA (1) | MA19046A1 (xx) |
| MY (1) | MY8700593A (xx) |
| NL (1) | NL930017I2 (xx) |
| NO (1) | NO1994012I1 (xx) |
| NZ (1) | NZ196117A (xx) |
| PH (1) | PH16611A (xx) |
| PL (2) | PL127679B1 (xx) |
| SU (1) | SU1230467A3 (xx) |
| YU (1) | YU48446B (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6322584A (ja) * | 1986-07-15 | 1988-01-30 | Senjiyu Seiyaku Kk | １−ハイドロキシ−５−オキソ−５Ｈ−ピリド〔３，２−ａ〕フエノキサジン−３−カルボン酸エステル類 |
| DE4108527A1 (de) * | 1991-03-15 | 1992-09-17 | Basf Ag | Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung |
| WO1995025518A1 (en) * | 1994-03-18 | 1995-09-28 | Ciba-Geigy Ag | Aqueous solution of levocabastine for ophthalmic use |
| US5661163A (en) * | 1995-06-07 | 1997-08-26 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| CA2252374C (en) | 1996-04-19 | 2007-08-07 | Alpha Therapeutic Corporation | A process for viral inactivation of lyophilized blood proteins |
| US6267986B1 (en) | 1999-09-24 | 2001-07-31 | Ranbaxy Laboratories Limited | Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine |
| US20020146409A1 (en) * | 2001-01-30 | 2002-10-10 | Herring Steven W. | Methods for stabilizing lyophilized blood proteins |
| CN1674916A (zh) | 2002-08-30 | 2005-09-28 | 奥坦纳医药公司 | 环缩松与抗组胺药的组合用于治疗变应性鼻炎的用途 |
| AU2007205114B2 (en) | 2006-01-06 | 2012-11-08 | Sunovion Pharmaceuticals Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| NZ573174A (en) | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
| EP2366381A1 (en) | 2006-06-01 | 2011-09-21 | MSD Consumer Care, Inc. | Phenylephrine pharmaceutical formulations and compositions for colonic absorption |
| CA2710271A1 (en) * | 2007-12-21 | 2009-07-09 | Schering-Plough Healthcare Products, Inc. | Enhancing photostabilization of oxymetazoline |
| CN106831541B (zh) | 2011-11-18 | 2019-09-06 | 赫普泰雅治疗有限公司 | 毒蕈碱性m1受体激动剂 |
| GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| US10259787B2 (en) | 2016-10-14 | 2019-04-16 | Heptares Therapeutics Limited | Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1206436B (de) * | 1957-07-05 | 1965-12-09 | Janssen Pharmaceutica Nv | Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen |
| NL127792C (xx) * | 1965-06-29 |
-
1980
- 1980-09-29 US US06/191,631 patent/US4369184A/en not_active Expired - Lifetime
-
1981
- 1981-01-08 GR GR63814A patent/GR71898B/el unknown
- 1981-01-16 AU AU66255/81A patent/AU538130B2/en not_active Expired
- 1981-01-21 CS CS81435A patent/CS221818B2/cs unknown
- 1981-01-22 DK DK029381A patent/DK152670C/da not_active IP Right Cessation
- 1981-01-22 MA MA19247A patent/MA19046A1/fr unknown
- 1981-01-22 PH PH25120A patent/PH16611A/en unknown
- 1981-01-23 CA CA000369180A patent/CA1187080A/en not_active Expired
- 1981-01-23 EP EP81300313A patent/EP0034415B1/en not_active Expired
- 1981-01-23 ES ES498793A patent/ES8204421A1/es not_active Expired
- 1981-01-23 IE IE125/81A patent/IE50706B1/en not_active IP Right Cessation
- 1981-01-23 PL PL1981229365A patent/PL127679B1/pl unknown
- 1981-01-23 BG BG8150518A patent/BG35465A3/xx unknown
- 1981-01-23 FI FI810193A patent/FI76562C/fi not_active IP Right Cessation
- 1981-01-23 YU YU18381A patent/YU48446B/sh unknown
- 1981-01-23 IL IL61968A patent/IL61968A/xx not_active IP Right Cessation
- 1981-01-23 HU HU81148A patent/HU183293B/hu unknown
- 1981-01-23 LU LU88220C patent/LU88220I2/xx unknown
- 1981-01-23 PL PL1981233921A patent/PL127483B1/pl unknown
- 1981-01-23 SU SU813233002A patent/SU1230467A3/ru active
- 1981-01-23 DE DE8181300313T patent/DE3163787D1/de not_active Expired
- 1981-01-26 NZ NZ196117A patent/NZ196117A/en unknown
- 1981-12-30 ES ES508441A patent/ES8307219A1/es not_active Expired
-
1987
- 1987-12-30 MY MY593/87A patent/MY8700593A/xx unknown
-
1988
- 1988-10-06 HK HK810/88A patent/HK81088A/xx not_active IP Right Cessation
-
1993
- 1993-03-02 NL NL930017C patent/NL930017I2/nl unknown
- 1993-06-16 BG BG97872A patent/BG60472B2/bg unknown
-
1994
- 1994-08-30 NO NO1994012C patent/NO1994012I1/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CTFF | Application for supplementary protection certificate (spc) filed |
Free format text: CA 1993 00010, 930205 |
|
| CTFF | Application for supplementary protection certificate (spc) filed |
Free format text: CA 1993 00010, 930205 |
|
| PUP | Patent expired |