DK150483C - Analogifremgangsmaade til fremstilling af trans-3-(4-oxo-4h-quinazolin-3-yl)-2-propensyrederivater eller salte deraf med farmaceutisk acceptablesyrer - Google Patents

Analogifremgangsmaade til fremstilling af trans-3-(4-oxo-4h-quinazolin-3-yl)-2-propensyrederivater eller salte deraf med farmaceutisk acceptablesyrer

Info

Publication number
DK150483C
DK150483C DK294780A DK294780A DK150483C DK 150483 C DK150483 C DK 150483C DK 294780 A DK294780 A DK 294780A DK 294780 A DK294780 A DK 294780A DK 150483 C DK150483 C DK 150483C
Authority
DK
Denmark
Prior art keywords
quinazolin
analogue
oxo
trans
salts
Prior art date
Application number
DK294780A
Other languages
Danish (da)
English (en)
Other versions
DK150483B (da
DK294780A (da
Inventor
Ronald Andrew Lemahieu
William Chester Nason
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK294780A publication Critical patent/DK294780A/da
Publication of DK150483B publication Critical patent/DK150483B/da
Application granted granted Critical
Publication of DK150483C publication Critical patent/DK150483C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK294780A 1979-07-09 1980-07-08 Analogifremgangsmaade til fremstilling af trans-3-(4-oxo-4h-quinazolin-3-yl)-2-propensyrederivater eller salte deraf med farmaceutisk acceptablesyrer DK150483C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5572879A 1979-07-09 1979-07-09
US5572879 1979-07-09
US06/142,903 US4281127A (en) 1979-07-09 1980-04-23 Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives
US14290380 1980-04-23

Publications (3)

Publication Number Publication Date
DK294780A DK294780A (da) 1981-01-10
DK150483B DK150483B (da) 1987-03-09
DK150483C true DK150483C (da) 1987-11-09

Family

ID=26734565

Family Applications (1)

Application Number Title Priority Date Filing Date
DK294780A DK150483C (da) 1979-07-09 1980-07-08 Analogifremgangsmaade til fremstilling af trans-3-(4-oxo-4h-quinazolin-3-yl)-2-propensyrederivater eller salte deraf med farmaceutisk acceptablesyrer

Country Status (21)

Country Link
US (1) US4281127A (no)
EP (1) EP0023594B1 (no)
AR (1) AR226854A1 (no)
AU (1) AU521014B2 (no)
CA (1) CA1134825A (no)
DE (1) DE3067830D1 (no)
DK (1) DK150483C (no)
ES (2) ES493203A0 (no)
FI (1) FI74279C (no)
GR (1) GR65952B (no)
HK (1) HK52187A (no)
HU (1) HU184797B (no)
IE (1) IE49938B1 (no)
IL (1) IL60514A (no)
MC (1) MC1333A1 (no)
NO (1) NO154426C (no)
NZ (1) NZ194259A (no)
PH (1) PH16413A (no)
PT (1) PT71512B (no)
SG (1) SG20887G (no)
YU (1) YU42348B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599336A (en) * 1983-08-08 1986-07-08 Hoffmann-La Roche Inc. Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US6706721B1 (en) * 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
AU2003213092A1 (en) * 2002-02-15 2003-09-09 Smithkline Beecham Corporation Syntheses of quinazolinones
BR0309892A2 (pt) * 2002-05-09 2011-04-05 Cytokinetics Inc composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto
JP2005530785A (ja) * 2002-05-09 2005-10-13 サイトキネティクス・インコーポレーテッド 化合物、組成物、及び方法
US7038048B2 (en) * 2002-05-23 2006-05-02 Cytokinetics, Inc. 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
EP1556357A4 (en) * 2002-06-14 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
AU2003256805A1 (en) * 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
EP1558083A4 (en) * 2002-09-30 2008-04-16 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
JP2007510652A (ja) * 2003-11-03 2007-04-26 サイトキネティクス・インコーポレーテッド ピリミジン−４−オン化合物、組成物、および方法
EP1680420A4 (en) * 2003-11-07 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
JP2007513154A (ja) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
UY29198A1 (es) * 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786055A (en) * 1955-02-10 1957-03-19 Mallinckrodt Chemical Works Carboxyalkyl-iodoquinazolones
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3696102A (en) * 1970-03-09 1972-10-03 Pfizer & Co C Process for the synthesis of substituted quinazolin-4-ones

Also Published As

Publication number Publication date
NO154426C (no) 1986-09-17
FI74279B (fi) 1987-09-30
PT71512A (en) 1980-08-01
IE801412L (en) 1981-01-09
FI74279C (fi) 1988-01-11
DK150483B (da) 1987-03-09
ES8106302A1 (es) 1981-05-16
CA1134825A (en) 1982-11-02
NZ194259A (en) 1984-09-28
AU6024480A (en) 1981-03-12
IL60514A0 (en) 1980-09-16
NO802056L (no) 1981-01-12
IL60514A (en) 1985-03-31
DE3067830D1 (en) 1984-06-20
EP0023594B1 (de) 1984-05-16
YU176680A (en) 1984-12-31
PT71512B (en) 1981-12-11
ES499035A0 (es) 1982-09-16
AR226854A1 (es) 1982-08-31
DK294780A (da) 1981-01-10
US4281127A (en) 1981-07-28
IE49938B1 (en) 1986-01-08
ES8207155A1 (es) 1982-09-16
SG20887G (en) 1988-09-16
YU42348B (en) 1988-08-31
FI802195A (fi) 1981-01-10
GR65952B (no) 1981-01-09
HU184797B (en) 1984-10-29
ES493203A0 (es) 1981-05-16
AU521014B2 (en) 1982-03-11
PH16413A (en) 1983-09-29
NO154426B (no) 1986-06-09
EP0023594A1 (de) 1981-02-11
MC1333A1 (fr) 1981-04-21
HK52187A (en) 1987-07-17

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