DK1483264T3 - 1-allyl-ergotalkaloid-derivater, fremgangsmåde til disses fremstilling og disses anvendelse til profylakse og behandling af migræne - Google Patents

1-allyl-ergotalkaloid-derivater, fremgangsmåde til disses fremstilling og disses anvendelse til profylakse og behandling af migræne

Info

Publication number
DK1483264T3
DK1483264T3 DK02798301T DK02798301T DK1483264T3 DK 1483264 T3 DK1483264 T3 DK 1483264T3 DK 02798301 T DK02798301 T DK 02798301T DK 02798301 T DK02798301 T DK 02798301T DK 1483264 T3 DK1483264 T3 DK 1483264T3
Authority
DK
Denmark
Prior art keywords
migraine
prophylaxis
preparation
treatment
methods
Prior art date
Application number
DK02798301T
Other languages
English (en)
Inventor
Miroslav Flieger
Heinz Pertz
Karel Kranda
Jan Cvak
Erika Glusa
Sven Jaehnichen
Original Assignee
Axxonis Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axxonis Pharma Ag filed Critical Axxonis Pharma Ag
Application granted granted Critical
Publication of DK1483264T3 publication Critical patent/DK1483264T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
DK02798301T 2002-03-12 2002-12-21 1-allyl-ergotalkaloid-derivater, fremgangsmåde til disses fremstilling og disses anvendelse til profylakse og behandling af migræne DK1483264T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212564A DE10212564B4 (de) 2002-03-12 2002-03-12 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
PCT/DE2002/004759 WO2003076439A2 (de) 2002-03-12 2002-12-21 1-allyl-ergotalkaloid-derivate, verfahren zu ihrer herstellung und ihre verwendung zur prophylaxe und therapie von migräne

Publications (1)

Publication Number Publication Date
DK1483264T3 true DK1483264T3 (da) 2007-04-10

Family

ID=27798009

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02798301T DK1483264T3 (da) 2002-03-12 2002-12-21 1-allyl-ergotalkaloid-derivater, fremgangsmåde til disses fremstilling og disses anvendelse til profylakse og behandling af migræne

Country Status (10)

Country Link
US (1) US7622476B2 (da)
EP (1) EP1483264B1 (da)
AT (1) ATE349445T1 (da)
CA (1) CA2478393C (da)
DE (2) DE10212564B4 (da)
DK (1) DK1483264T3 (da)
ES (1) ES2277622T3 (da)
PT (1) PT1483264E (da)
SI (1) SI1483264T1 (da)
WO (1) WO2003076439A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006013307B3 (de) * 2006-03-21 2007-10-04 Ergonex Pharma Gmbh Tergurid/Protergurid zur Behandlung von chronischen Schmerzen
MX2009008582A (es) * 2007-02-11 2009-10-30 Map Pharmaceuticals Inc Metodo para la administracion terapeutica de dihidroergotamina para permitir un rapido alivio de la migraña mientras se minimiza el perfil de efectos secundarios.
EP2067780A1 (en) * 2007-12-07 2009-06-10 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
US20110082150A1 (en) * 2008-02-11 2011-04-07 Robert Owen Cook Headache pre-emption by dihydroergotamine treatment during headache Precursor events
DE102009018216A1 (de) * 2009-04-21 2010-10-28 Basf Coatings Ag Mehrschichtlackierung, ein Verfahren zu ihrer Herstellung und ihre Verwendung
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
EP2793583A4 (en) * 2011-12-21 2015-08-12 Map Pharmaceuticals Inc NOVEL NEUROMODULATORY CONNECTIONS
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH344731A (de) * 1956-05-18 1960-02-29 Sandoz Ag Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
DE1076137B (de) * 1956-05-18 1960-02-25 Sandoz Ag Verfahren zur Herstellung von am Indolstickstoff substituierten Derivaten der Lysergsaeure
CH392537A (de) * 1960-12-23 1965-05-31 Sandoz Ag Verfahren zur Herstellung von neuen heterocyclischen Alkoholen
US3232942A (en) * 1964-06-02 1966-02-01 Sandoz Ltd 1-substituted (+)-lysergol
CS231214B1 (en) * 1982-03-12 1984-10-15 Antonin Cerny Processing method of 1-substituted n+l8alpha-ergoline+p-n,diethyl urea
CH649998A5 (de) * 1982-08-09 1985-06-28 Sandoz Ag Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff.
US4563461A (en) * 1983-03-10 1986-01-07 Eli Lilly And Company Selective method for blocking 5HT2 receptors
CH657366A5 (en) * 1983-08-05 1986-08-29 Sandoz Ag Ergot alkaloids, their preparation and use
DE3403067A1 (de) * 1984-01-30 1985-08-14 Eckart Prof. Dr. 6500 Mainz Eich Ergolin-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
EP0228876A3 (en) * 1985-12-20 1989-03-22 Eli Lilly And Company Esters of dihydrolysergic acid and related compounds
US4898587A (en) 1988-11-15 1990-02-06 Mera Csaba L Intravenous line stabilizing device
US5043341A (en) * 1990-04-11 1991-08-27 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US5925672A (en) 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
GB9718712D0 (en) 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents
SE9801516D0 (sv) 1998-04-30 1998-04-30 Maria Carlsson M100907/4-Piperidinemethanol derivatives for autism
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
DE19934433A1 (de) 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate

Also Published As

Publication number Publication date
DE50209113D1 (de) 2007-02-08
DE10212564A1 (de) 2003-10-02
US20060014774A1 (en) 2006-01-19
ES2277622T3 (es) 2007-07-16
PT1483264E (pt) 2007-04-30
CA2478393A1 (en) 2003-09-18
US7622476B2 (en) 2009-11-24
WO2003076439A2 (de) 2003-09-18
DE10212564B4 (de) 2007-04-19
EP1483264A2 (de) 2004-12-08
AU2002363847A1 (en) 2003-09-22
WO2003076439A3 (de) 2004-01-29
CA2478393C (en) 2009-07-21
EP1483264B1 (de) 2006-12-27
ATE349445T1 (de) 2007-01-15
SI1483264T1 (sl) 2007-06-30

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