DK1458393T3 - Substituerede diketopiperaziner som oxytocinantagonister - Google Patents
Substituerede diketopiperaziner som oxytocinantagonisterInfo
- Publication number
- DK1458393T3 DK1458393T3 DK02799077T DK02799077T DK1458393T3 DK 1458393 T3 DK1458393 T3 DK 1458393T3 DK 02799077 T DK02799077 T DK 02799077T DK 02799077 T DK02799077 T DK 02799077T DK 1458393 T3 DK1458393 T3 DK 1458393T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxytocin antagonists
- substituted diketopiperazines
- oxytocin
- diketopiperazines
- substituted
- Prior art date
Links
- 239000003336 oxytocin antagonist Substances 0.000 title 1
- 229940121361 oxytocin antagonists Drugs 0.000 title 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
- 101800000989 Oxytocin Proteins 0.000 abstract 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
- 229960001723 oxytocin Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130677.8A GB0130677D0 (en) | 2001-12-21 | 2001-12-21 | Medicaments and novel compounds |
| PCT/EP2002/014823 WO2003053443A1 (en) | 2001-12-21 | 2002-12-20 | Substituted diketopiperazines as oxytocin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1458393T3 true DK1458393T3 (da) | 2008-10-13 |
Family
ID=9928187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02799077T DK1458393T3 (da) | 2001-12-21 | 2002-12-20 | Substituerede diketopiperaziner som oxytocinantagonister |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7514437B2 (sl) |
| EP (1) | EP1458393B1 (sl) |
| JP (1) | JP4638149B2 (sl) |
| KR (2) | KR100997856B1 (sl) |
| CN (1) | CN100374115C (sl) |
| AT (1) | ATE399011T1 (sl) |
| AU (1) | AU2002364304B2 (sl) |
| BR (1) | BRPI0215277B1 (sl) |
| CA (1) | CA2471355C (sl) |
| CO (1) | CO5590916A2 (sl) |
| CY (1) | CY1108334T1 (sl) |
| DE (1) | DE60227283D1 (sl) |
| DK (1) | DK1458393T3 (sl) |
| ES (1) | ES2307827T3 (sl) |
| GB (1) | GB0130677D0 (sl) |
| HK (1) | HK1069339A1 (sl) |
| HU (1) | HU229708B1 (sl) |
| IL (2) | IL162515A0 (sl) |
| IS (1) | IS2613B (sl) |
| MX (1) | MXPA04006033A (sl) |
| NO (1) | NO329543B1 (sl) |
| NZ (1) | NZ533218A (sl) |
| PL (1) | PL215826B1 (sl) |
| PT (1) | PT1458393E (sl) |
| RU (1) | RU2303032C2 (sl) |
| SI (1) | SI1458393T1 (sl) |
| WO (1) | WO2003053443A1 (sl) |
| ZA (1) | ZA200404326B (sl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0314738D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| GB0314733D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Medicaments |
| GB0414092D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0428235D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Novel compounds |
| AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| WO2009105774A2 (en) * | 2008-02-21 | 2009-08-27 | Sequoia Pharmaceuticals, Inc. | Amino acid inhibitors of cytochrome p450 |
| RU2519948C2 (ru) * | 2008-08-22 | 2014-06-20 | Бритиш Коламбиа Кэнсер Эйдженси Бранч | Низкомолекулярные ингибиторы n-концевой активации рецептора андрогенов |
| JP2013509391A (ja) | 2009-10-30 | 2013-03-14 | グラクソ グループ リミテッド | （３ｒ，６ｒ）−３−（２，３−ジヒドロ−１ｈ−インデン−２−イル）−１−［（１ｒ）−１−（２，６−ジメチル−３−ピリジニル）−２−（４−モルホリニル）−２−オキソエチル］−６−［（１ｓ）−１−メチルプロピル］−２，５−ピペラジンジオンの新規結晶性形態 |
| JP5579939B2 (ja) * | 2010-10-29 | 2014-08-27 | ロンザ リミテッド | ジケトピペラジン形成ジペプチジルリンカー |
| CN103242246A (zh) * | 2013-05-21 | 2013-08-14 | 苏州科捷生物医药有限公司 | 3-位取代的n-甲基哌嗪的合成方法 |
| CN105061317B (zh) * | 2015-08-26 | 2017-08-25 | 浙江大果生物医药科技有限公司 | 一类吲唑盐类化合物及其制备方法和应用 |
| JP6933322B2 (ja) | 2016-01-04 | 2021-09-08 | メルク セローノ エス．エー． | ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形 |
| CA3031252A1 (en) | 2016-07-21 | 2018-01-25 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| CN109305969B (zh) * | 2017-07-27 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 哌嗪-2,5-二酮类衍生物、其制备方法及其在医药上的应用 |
| CN109485598A (zh) * | 2018-11-29 | 2019-03-19 | 河南师范大学 | 一种去除氨基上喹啉保护基的新方法 |
| WO2021043726A1 (en) | 2019-09-03 | 2021-03-11 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| US20230102503A1 (en) | 2020-02-10 | 2023-03-30 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4596819A (en) * | 1984-01-23 | 1986-06-24 | Warner-Lambert Company | Modified tripeptides |
| HUT67287A (en) * | 1991-09-13 | 1995-03-28 | Merck & Co Inc | Piperazynil camphor derivatives and pharmaceutical compositions containing them |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5817751A (en) * | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| GB2326639A (en) | 1997-06-18 | 1998-12-30 | Merck & Co Inc | Piperazine Oxytocin Receptor Antagonists |
| GB9713748D0 (en) * | 1997-06-27 | 1997-09-03 | Unilever Plc | Production of detergent granulates |
| ATE346050T1 (de) * | 1998-01-27 | 2006-12-15 | Aventis Pharma Inc | Substituierte oxoazaheterocyclyl faktor xa hemmer |
| IL137571A0 (en) | 1998-01-29 | 2001-07-24 | Aventis Pharm Prod Inc | Method for preparing an n-[(aliphatic or aromatic)carboxyl]-2-aminoacetamide compound and a cyclyzed compound |
| CA2289621A1 (en) * | 1998-03-16 | 1999-09-23 | Ontogen Corporation | Piperazines as inhibitors of fructose-1,6-bisphosphatase (fbpase) |
| GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| GB0314733D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Medicaments |
| GB0414100D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414092D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0428235D0 (en) | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Novel compounds |
-
2001
- 2001-12-21 GB GBGB0130677.8A patent/GB0130677D0/en not_active Ceased
-
2002
- 2002-12-20 PT PT02799077T patent/PT1458393E/pt unknown
- 2002-12-20 SI SI200230719T patent/SI1458393T1/sl unknown
- 2002-12-20 WO PCT/EP2002/014823 patent/WO2003053443A1/en active Application Filing
- 2002-12-20 BR BRPI0215277A patent/BRPI0215277B1/pt not_active IP Right Cessation
- 2002-12-20 KR KR1020047009415A patent/KR100997856B1/ko not_active IP Right Cessation
- 2002-12-20 EP EP02799077A patent/EP1458393B1/en not_active Expired - Lifetime
- 2002-12-20 DE DE60227283T patent/DE60227283D1/de not_active Expired - Lifetime
- 2002-12-20 MX MXPA04006033A patent/MXPA04006033A/es active IP Right Grant
- 2002-12-20 AU AU2002364304A patent/AU2002364304B2/en not_active Ceased
- 2002-12-20 KR KR1020107009110A patent/KR20100060012A/ko not_active Application Discontinuation
- 2002-12-20 HU HU0500136A patent/HU229708B1/hu not_active IP Right Cessation
- 2002-12-20 DK DK02799077T patent/DK1458393T3/da active
- 2002-12-20 IL IL16251502A patent/IL162515A0/xx unknown
- 2002-12-20 ES ES02799077T patent/ES2307827T3/es not_active Expired - Lifetime
- 2002-12-20 CA CA2471355A patent/CA2471355C/en not_active Expired - Fee Related
- 2002-12-20 PL PL370981A patent/PL215826B1/pl unknown
- 2002-12-20 JP JP2003554200A patent/JP4638149B2/ja not_active Expired - Fee Related
- 2002-12-20 NZ NZ533218A patent/NZ533218A/en not_active IP Right Cessation
- 2002-12-20 CN CNB028257618A patent/CN100374115C/zh not_active Expired - Fee Related
- 2002-12-20 US US10/499,177 patent/US7514437B2/en not_active Expired - Fee Related
- 2002-12-20 RU RU2004122392/04A patent/RU2303032C2/ru not_active IP Right Cessation
- 2002-12-20 AT AT02799077T patent/ATE399011T1/de active
-
2004
- 2004-06-02 ZA ZA2004/04326A patent/ZA200404326B/en unknown
- 2004-06-14 IL IL162515A patent/IL162515A/en not_active IP Right Cessation
- 2004-06-16 IS IS7315A patent/IS2613B/is unknown
- 2004-06-17 CO CO04056454A patent/CO5590916A2/es active IP Right Grant
- 2004-07-20 NO NO20043115A patent/NO329543B1/no not_active IP Right Cessation
-
2005
- 2005-03-08 HK HK05102009A patent/HK1069339A1/xx not_active IP Right Cessation
-
2008
- 2008-09-11 CY CY20081100980T patent/CY1108334T1/el unknown
-
2009
- 2009-03-27 US US12/412,837 patent/US8367673B2/en not_active Expired - Fee Related
-
2012
- 2012-12-14 US US13/715,522 patent/US8541579B2/en not_active Expired - Fee Related
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