DK1434789T3 - Forbedret proteindisaggregering og refoldning under tryk - Google Patents

Forbedret proteindisaggregering og refoldning under tryk

Info

Publication number
DK1434789T3
DK1434789T3 DK01270119T DK01270119T DK1434789T3 DK 1434789 T3 DK1434789 T3 DK 1434789T3 DK 01270119 T DK01270119 T DK 01270119T DK 01270119 T DK01270119 T DK 01270119T DK 1434789 T3 DK1434789 T3 DK 1434789T3
Authority
DK
Denmark
Prior art keywords
under pressure
refolding
improved protein
refolding under
disassembly
Prior art date
Application number
DK01270119T
Other languages
Danish (da)
English (en)
Inventor
John F Carpenter
Theodore W Randolph
John Richard J St
Jonathan N Webb
Original Assignee
Barofold Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Barofold Inc filed Critical Barofold Inc
Application granted granted Critical
Publication of DK1434789T3 publication Critical patent/DK1434789T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Disintegrating Or Milling (AREA)
  • Processing Of Solid Wastes (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK01270119T 2000-10-31 2001-10-31 Forbedret proteindisaggregering og refoldning under tryk DK1434789T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24480800P 2000-10-31 2000-10-31
PCT/US2001/045728 WO2002062827A2 (en) 2000-10-31 2001-10-31 Improved protein disaggregation and refolding using high pressure

Publications (1)

Publication Number Publication Date
DK1434789T3 true DK1434789T3 (da) 2008-07-07

Family

ID=22924182

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01270119T DK1434789T3 (da) 2000-10-31 2001-10-31 Forbedret proteindisaggregering og refoldning under tryk

Country Status (9)

Country Link
US (2) US7538198B2 (de)
EP (1) EP1434789B1 (de)
JP (3) JP2004530651A (de)
AT (1) ATE390436T1 (de)
CA (1) CA2434045A1 (de)
DE (1) DE60133426T2 (de)
DK (1) DK1434789T3 (de)
MX (1) MXPA03003867A (de)
WO (1) WO2002062827A2 (de)

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MXPA03003867A (es) 2000-10-31 2004-10-15 Univ Colorado Regents Desagregacion mejorada de proteina y replegamiento utilizando alta presion.
US7045297B2 (en) * 2001-11-14 2006-05-16 Prion Developmental Laboratories, Inc. Rapid prion-detection assay
US7614958B2 (en) * 2001-11-16 2009-11-10 Creative Kingdoms, Llc Interactive quest game
CA2587487A1 (en) * 2004-11-12 2006-05-18 Pfizer, Inc. Method of measuring amyloid-beta peptides
CN101511858A (zh) * 2005-07-25 2009-08-19 特鲁比昂药品公司 用于蛋白质解聚的组合物和方法
CA2915270C (en) * 2005-08-05 2017-07-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
CN101568427A (zh) * 2005-11-21 2009-10-28 巴罗福德公司 用于蛋白质的高压重折叠的装置和方法
WO2008033556A2 (en) * 2006-09-15 2008-03-20 Barofold, Inc. High pressure treatment of proteins for reduced immunogenicity
US7829681B2 (en) * 2007-04-05 2010-11-09 Barofold Inc. High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins
JPWO2008133141A1 (ja) * 2007-04-24 2010-07-22 東洋紡績株式会社 オスモチン組換えタンパク質およびその製造方法、並びにその利用
CN106267902B (zh) * 2007-06-04 2019-08-20 高压生物科学公司 分子的压力提高的提取和分配
US20090076247A1 (en) * 2007-09-10 2009-03-19 Seefeldt Matthew B High pressure refolding of monoclonal antibody aggregates
WO2009045553A1 (en) * 2007-10-05 2009-04-09 Barofold, Inc. High pressure treatment of aggregated interferons
CA2708585A1 (en) * 2007-12-10 2009-06-18 Novartis Ag Analysis of mixtures including proteins
CA2727246A1 (en) * 2008-05-07 2009-11-12 Pressure Biosciences Inc. Extraction of biomolecular complexes assisted by alternating hydrostatic pressure
WO2010065775A2 (en) * 2008-12-03 2010-06-10 The United States Government As Represented By The Department Of Veterans Affairs Pressure-assisted molecular recovery (pamr) of biomolecules, pressure-assisted antigen retrieval (paar), and pressure-assisted tissue histology (path)
EP2600843B9 (de) 2010-07-19 2020-03-11 Pressure BioSciences, Inc. Therapeutische proteinzusammensetzungen mit reduzierter immunogenität und/oder verbesserter wirksamkeit
US9797871B2 (en) 2010-08-05 2017-10-24 Ge Healthcare Bio-Sciences Ab Method for storage and stabilization of a target substance
US9995661B2 (en) 2010-08-18 2018-06-12 Pressure Biosciences, Inc. Flow-through high hydrostatic pressure microfluidic sample preparation device and related methods therefor
US10105704B2 (en) 2010-10-28 2018-10-23 Pressure Biosciences, Inc. System and method for microplate pressurization
JP6377527B2 (ja) * 2011-12-01 2018-08-22 バロフォールド，インコーポレイテッド 高圧タンパク質リフォールディングのための方法およびシステム
KR102208844B1 (ko) * 2012-08-30 2021-01-27 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 고압 디바이스 및 불활성화된 백신을 생산하고 재조합 단백질을 리폴딩/가용화하는 방법
ZA201501696B (en) 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
JP2014113108A (ja) * 2012-12-11 2014-06-26 Tokyo Medical Univ タンパク質の可溶化活性を有する多量体タンパク質およびその用途
US9982012B2 (en) 2013-03-29 2018-05-29 Dr. Reddy's Laboratories Limited Refolding of granulocyte colony stimulating factor
WO2015034915A1 (en) * 2013-09-04 2015-03-12 The Regents Of The University Of California Method for improving protein functionality using vortexing fluid shear forces
EP2975120A1 (de) * 2014-07-17 2016-01-20 Institut Pasteur Monomeres und funktionelles Adenylatcyclase-CyaA-Toxin
MX2017001022A (es) 2014-07-24 2017-12-20 Genentech Inc Metodos para conjugar un agente a un resto tiol en una proteina que contiene al menos un enlace trisulfuro.
WO2017094722A1 (ja) * 2015-12-01 2017-06-08 Ｓｐｉｂｅｒ株式会社 タンパク質溶液を製造する方法
JP2020152644A (ja) * 2019-03-18 2020-09-24 国立大学法人愛媛大学 Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法
KR20220079572A (ko) 2019-09-20 2022-06-13 플라즈마 테크놀로지스, 엘엘씨 치료 단백질 조성물 및 방법(therapeutic protein compositions and methods)
CN114015758B (zh) * 2021-10-15 2022-06-24 无锡百泰克生物技术有限公司 一种冻干保护剂、荧光pcr检测试剂盒及冻干工艺
WO2024030679A1 (en) * 2022-08-05 2024-02-08 University Of Delaware System and apparatus for measuring scattered light signals from pressurized solutions and method of assembly

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WO2000002901A1 (en) * 1998-07-09 2000-01-20 University Technology Corporation High pressure refolding of protein aggregates and inclusion bodies
US7615617B2 (en) 1999-10-25 2009-11-10 University Of Delaware Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
MXPA03003867A (es) 2000-10-31 2004-10-15 Univ Colorado Regents Desagregacion mejorada de proteina y replegamiento utilizando alta presion.
CN101568427A (zh) 2005-11-21 2009-10-28 巴罗福德公司 用于蛋白质的高压重折叠的装置和方法
WO2008033556A2 (en) 2006-09-15 2008-03-20 Barofold, Inc. High pressure treatment of proteins for reduced immunogenicity
WO2008033555A2 (en) 2006-09-15 2008-03-20 Barofold, Inc. High-pressure refolding of difficult-to-fold proteins
US7829681B2 (en) * 2007-04-05 2010-11-09 Barofold Inc. High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins

Also Published As

Publication number Publication date
CA2434045A1 (en) 2002-08-15
US20040038333A1 (en) 2004-02-26
US8329878B2 (en) 2012-12-11
JP2008031182A (ja) 2008-02-14
DE60133426T2 (de) 2008-11-13
DE60133426D1 (de) 2008-05-08
JP2004530651A (ja) 2004-10-07
EP1434789B1 (de) 2008-03-26
ATE390436T1 (de) 2008-04-15
EP1434789A2 (de) 2004-07-07
WO2002062827A2 (en) 2002-08-15
US20100075399A1 (en) 2010-03-25
JP2009102352A (ja) 2009-05-14
US7538198B2 (en) 2009-05-26
MXPA03003867A (es) 2004-10-15
WO2002062827A3 (en) 2004-05-06

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