ATE390436T1 - Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks - Google Patents

Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks

Info

Publication number
ATE390436T1
ATE390436T1 AT01270119T AT01270119T ATE390436T1 AT E390436 T1 ATE390436 T1 AT E390436T1 AT 01270119 T AT01270119 T AT 01270119T AT 01270119 T AT01270119 T AT 01270119T AT E390436 T1 ATE390436 T1 AT E390436T1
Authority
AT
Austria
Prior art keywords
refolding
high pressure
proteins
improved decay
present
Prior art date
Application number
AT01270119T
Other languages
English (en)
Inventor
Theodore Randolph
John Carpenter
John Richard St
Jonathan Webb
Original Assignee
Barofold Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Barofold Inc filed Critical Barofold Inc
Application granted granted Critical
Publication of ATE390436T1 publication Critical patent/ATE390436T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Disintegrating Or Milling (AREA)
  • Processing Of Solid Wastes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
AT01270119T 2000-10-31 2001-10-31 Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks ATE390436T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24480800P 2000-10-31 2000-10-31

Publications (1)

Publication Number Publication Date
ATE390436T1 true ATE390436T1 (de) 2008-04-15

Family

ID=22924182

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01270119T ATE390436T1 (de) 2000-10-31 2001-10-31 Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks

Country Status (9)

Country Link
US (2) US7538198B2 (de)
EP (1) EP1434789B1 (de)
JP (3) JP2004530651A (de)
AT (1) ATE390436T1 (de)
CA (1) CA2434045A1 (de)
DE (1) DE60133426T2 (de)
DK (1) DK1434789T3 (de)
MX (1) MXPA03003867A (de)
WO (1) WO2002062827A2 (de)

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ATE349460T1 (de) 1998-07-09 2007-01-15 Barofold Inc Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck
US7615617B2 (en) 1999-10-25 2009-11-10 University Of Delaware Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
ATE390436T1 (de) 2000-10-31 2008-04-15 Barofold Inc Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks
US7045297B2 (en) * 2001-11-14 2006-05-16 Prion Developmental Laboratories, Inc. Rapid prion-detection assay
US7614958B2 (en) * 2001-11-16 2009-11-10 Creative Kingdoms, Llc Interactive quest game
EP1820019A4 (de) * 2004-11-12 2008-05-14 Pfizer Verfahren zur messung von amyloid-beta-peptiden
EP1910415A4 (de) * 2005-07-25 2010-08-11 Trubion Pharmaceuticals Inc Zusammensetzungen und verfahren zur proteindeaggregation
CA2915270C (en) * 2005-08-05 2017-07-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
WO2007062174A2 (en) * 2005-11-21 2007-05-31 Barofold, Inc. Devices and methods for high-pressure refolding of proteins
EP2059523A2 (de) * 2006-09-15 2009-05-20 Barofold, Inc. Hochdruckbehandlung von proteinen für reduzierte immunogenizität
WO2008124139A1 (en) * 2007-04-05 2008-10-16 Barofold, Inc. High pressure inclusion body solubilization in the presence of a protease
JPWO2008133141A1 (ja) * 2007-04-24 2010-07-22 東洋紡績株式会社 オスモチン組換えタンパク質およびその製造方法、並びにその利用
CN106267902B (zh) * 2007-06-04 2019-08-20 高压生物科学公司 分子的压力提高的提取和分配
EP2205622A1 (de) * 2007-09-10 2010-07-14 BaroFold, Inc. Umfaltung monoklonaler antikörperaggregate unter hohem druck
WO2009045553A1 (en) * 2007-10-05 2009-04-09 Barofold, Inc. High pressure treatment of aggregated interferons
US8547536B2 (en) * 2007-12-10 2013-10-01 Novartis Ag Analysis of mixtures including proteins
EP2288696A4 (de) * 2008-05-07 2012-02-15 Pressure Biosciences Inc Extraktion biomolekularer komplexe mit alternierendem hydrostatischem druck
CA2745431A1 (en) * 2008-12-03 2010-06-10 Timothy J. O'leary Pressure-assisted molecular recovery (pamr) of biomolecules, pressure-assisted antigen retrieval (paar), and pressure-assisted tissue histology (path)
ES2749977T3 (es) 2010-07-19 2020-03-24 Pressure Biosciences Inc Composiciones de proteínas terapéuticas que tienen inmunogenia reducida y/o eficacia mejorada
WO2012018294A1 (en) * 2010-08-05 2012-02-09 Ge Healthcare Bio-Sciences Ab Method for storage and stabilization of a target substance
CN111426533A (zh) 2010-08-18 2020-07-17 压力生物科技公司 流通式高静压的微流样本的预处理设备及其相关方法
WO2012058412A1 (en) 2010-10-28 2012-05-03 Ting Edmund Y System and method for microplate pressurization
EP2785196B1 (de) * 2011-12-01 2020-08-05 Pressure BioSciences, Inc. Verfahren und systeme zur proteinrückfaltung
ZA201501696B (en) 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
EA031988B1 (ru) * 2012-08-30 2019-03-29 Мериал, Инк. Гипербарическое устройство и способы получения инактивированных вакцин и повторно свернутых/солюбилизированных рекомбинантных белков
JP2014113108A (ja) * 2012-12-11 2014-06-26 Tokyo Medical Univ タンパク質の可溶化活性を有する多量体タンパク質およびその用途
WO2014155349A2 (en) 2013-03-29 2014-10-02 Dr. Reddy's Laboratories Refolding of proteins
WO2015034915A1 (en) * 2013-09-04 2015-03-12 The Regents Of The University Of California Method for improving protein functionality using vortexing fluid shear forces
EP2975120A1 (de) * 2014-07-17 2016-01-20 Institut Pasteur Monomeres und funktionelles Adenylatcyclase-CyaA-Toxin
JP6956630B2 (ja) 2014-07-24 2021-11-02 ジェネンテック， インコーポレイテッド 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法
WO2017094722A1 (ja) * 2015-12-01 2017-06-08 Ｓｐｉｂｅｒ株式会社 タンパク質溶液を製造する方法
JP2020152644A (ja) * 2019-03-18 2020-09-24 国立大学法人愛媛大学 Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法
US10836790B1 (en) 2019-09-20 2020-11-17 Plasma Technologies, Llc Therapeutic protein compositions and methods
CN114015758B (zh) * 2021-10-15 2022-06-24 无锡百泰克生物技术有限公司 一种冻干保护剂、荧光pcr检测试剂盒及冻干工艺
WO2024030679A1 (en) * 2022-08-05 2024-02-08 University Of Delaware System and apparatus for measuring scattered light signals from pressurized solutions and method of assembly

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US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
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US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
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US5605691A (en) * 1992-09-17 1997-02-25 Ophidian Pharmaceuticals, Inc. Immunologically active proteins from inclusion bodies
US5714371A (en) * 1995-05-12 1998-02-03 Schering Corporation Method for refolding insoluble aggregates of hepatitis C virus protease
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ATE349460T1 (de) * 1998-07-09 2007-01-15 Barofold Inc Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck
US7615617B2 (en) * 1999-10-25 2009-11-10 University Of Delaware Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
ATE390436T1 (de) * 2000-10-31 2008-04-15 Barofold Inc Verbesserter zerfall und rückfaltung von proteinen mittels hohen drucks
WO2007062174A2 (en) 2005-11-21 2007-05-31 Barofold, Inc. Devices and methods for high-pressure refolding of proteins
WO2008033555A2 (en) 2006-09-15 2008-03-20 Barofold, Inc. High-pressure refolding of difficult-to-fold proteins
EP2059523A2 (de) 2006-09-15 2009-05-20 Barofold, Inc. Hochdruckbehandlung von proteinen für reduzierte immunogenizität
WO2008124139A1 (en) * 2007-04-05 2008-10-16 Barofold, Inc. High pressure inclusion body solubilization in the presence of a protease

Also Published As

Publication number Publication date
US20040038333A1 (en) 2004-02-26
DE60133426T2 (de) 2008-11-13
JP2004530651A (ja) 2004-10-07
US8329878B2 (en) 2012-12-11
WO2002062827A2 (en) 2002-08-15
JP2009102352A (ja) 2009-05-14
US20100075399A1 (en) 2010-03-25
EP1434789A2 (de) 2004-07-07
JP2008031182A (ja) 2008-02-14
DK1434789T3 (da) 2008-07-07
WO2002062827A3 (en) 2004-05-06
MXPA03003867A (es) 2004-10-15
DE60133426D1 (de) 2008-05-08
EP1434789B1 (de) 2008-03-26
CA2434045A1 (en) 2002-08-15
US7538198B2 (en) 2009-05-26

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