DK1425586T3 - Massemarkörer - Google Patents

Massemarkörer

Info

Publication number
DK1425586T3
DK1425586T3 DK02767650T DK02767650T DK1425586T3 DK 1425586 T3 DK1425586 T3 DK 1425586T3 DK 02767650 T DK02767650 T DK 02767650T DK 02767650 T DK02767650 T DK 02767650T DK 1425586 T3 DK1425586 T3 DK 1425586T3
Authority
DK
Denmark
Prior art keywords
mass markers
markers
mass
Prior art date
Application number
DK02767650T
Other languages
Danish (da)
English (en)
Inventor
Andrew Hugin Thompson
Christian Hamon
Jurgen Schafer
Karsten Kuhn
Josef Schwarz
Thomas Neumann
Original Assignee
Electrophoretics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Electrophoretics Ltd filed Critical Electrophoretics Ltd
Application granted granted Critical
Publication of DK1425586T3 publication Critical patent/DK1425586T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK02767650T 2001-09-14 2002-09-16 Massemarkörer DK1425586T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01307830 2001-09-14
PCT/GB2002/004240 WO2003025576A2 (en) 2001-09-14 2002-09-16 Mass labels

Publications (1)

Publication Number Publication Date
DK1425586T3 true DK1425586T3 (da) 2008-02-11

Family

ID=8182269

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02767650T DK1425586T3 (da) 2001-09-14 2002-09-16 Massemarkörer

Country Status (9)

Country Link
US (1) US7732378B2 (de)
EP (1) EP1425586B1 (de)
JP (1) JP4290003B2 (de)
CA (1) CA2460131C (de)
DE (1) DE60223696T2 (de)
DK (1) DK1425586T3 (de)
ES (1) ES2296996T3 (de)
PT (1) PT1425586E (de)
WO (1) WO2003025576A2 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004506900A (ja) * 2000-08-11 2004-03-04 アジリックス・コーポレイション 超高感度検出システム
US20030124595A1 (en) * 2001-11-06 2003-07-03 Lizardi Paul M. Sensitive coded detection systems
US7556969B2 (en) 2002-12-19 2009-07-07 Northeastern University Intensified neutral loss tags and use thereof in mass spectrometry
WO2004070352A2 (en) 2003-01-30 2004-08-19 Applera Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
GB0306756D0 (en) 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
JP2005140755A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency 質量分析用プローブ及びそれを用いた質量分析方法
JP4838725B2 (ja) * 2003-11-26 2011-12-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド クワイエットゾーン中の質量スペクトルデータの分析
EP1916527A1 (de) * 2003-11-26 2008-04-30 Applera Corporation Analyse von Massenspektraldaten in ruhigen Bereichen
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
US20050148771A1 (en) 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
EP1714157A2 (de) 2004-01-28 2006-10-25 Immatics Biotechnologies GmbH Verfahren zur identifizierung und quantifizierung tumorassoziierter peptide
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
EP1756307A1 (de) * 2004-05-20 2007-02-28 Trillion Genomics Limited Verwendung massenmarkierter sonden zum nachweis von zielnukleinsäuren mittels massenspektrometrie
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
EP1776588A1 (de) * 2004-07-12 2007-04-25 Applera Corporation Massen-tags für quantitative analysen
WO2006023398A2 (en) * 2004-08-16 2006-03-02 Ludwig Institute For Cancer Research Modular isotope labelled mass spectrometry reagents and methods for quantitation of amino acids, peptides and proteins
US20060134710A1 (en) * 2004-10-30 2006-06-22 Viorica Lopez-Avila WDR11 protein assay
WO2006084130A2 (en) * 2005-02-03 2006-08-10 Perkinelmer Las, Inc. Ultra-sensitive detection systems using multidimension signals
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US20070134802A1 (en) * 2005-06-30 2007-06-14 Heinz Doebeli Ionization modifier for mass spectrometry
GB0515323D0 (en) * 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
US8889423B2 (en) 2005-07-29 2014-11-18 Eisai R & D Management Co., Ltd. Method for analysis of compound-binding ability of protein
GB0518585D0 (en) * 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
EP1921081A1 (de) * 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Verwendung von Arylboronsäuren zur Proteinmarkierung
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
WO2008142579A2 (en) * 2007-05-23 2008-11-27 Williamson Nicholas A Method of mass analysis of target molecules in complex mixtures
GB0809488D0 (en) 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
GB0811574D0 (en) * 2008-06-24 2008-07-30 Trillion Genomics Ltd Characterising planar samples by mass spectrometry
KR101081053B1 (ko) * 2008-07-18 2011-11-07 포항공과대학교 산학협력단 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
GB0921665D0 (en) 2009-12-10 2010-01-27 Trillion Genomics Ltd Phobes
US8617898B2 (en) * 2010-01-25 2013-12-31 Dh Technologies Development Pte. Ltd. Quantitative analysis of vitamin D3, vitamin D2, and metabolites thereof
DE102011017084B4 (de) 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
GB201006360D0 (en) 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
ES2676183T3 (es) 2010-07-02 2018-07-17 Ventana Medical Systems, Inc. Detección de dianas usando marcas de masa y espectrometría de masas
US8589084B2 (en) * 2010-10-08 2013-11-19 Massachusetts Institute Of Technology Detection of ethanol emission from a spark ignition engine operating on gasohols
EP2651961A1 (de) * 2010-12-13 2013-10-23 De Staat Der Nederlanden, Vert. Door De Minister Van VWS Protein-affinitätsetikett und deren verwendung
US9040903B2 (en) 2011-04-04 2015-05-26 Wisconsin Alumni Research Foundation Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility
US9388132B2 (en) 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
US10436790B2 (en) 2011-09-28 2019-10-08 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
WO2013170067A1 (en) 2012-05-10 2013-11-14 Thermo Finnigan Llc Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor
US9581605B2 (en) 2012-05-22 2017-02-28 Biogen Ma Inc. Trapping reagents for reactive metabolites screening
GB201322567D0 (en) 2013-12-19 2014-02-05 Electrophoretics Ltd Mass labels
WO2015126595A1 (en) * 2014-02-21 2015-08-27 Purdue Research Foundation Analyzing an extracted sample using an immiscible extraction solvent
US11495448B2 (en) 2014-02-21 2022-11-08 Purdue Research Foundation Systems and methods for quantifying an analyte extracted from a sample
US10269550B2 (en) 2014-02-21 2019-04-23 Purdue Research Foundation Systems and methods for quantifying an analyte extracted from a sample
DK3213056T3 (da) 2014-10-30 2020-09-28 Waters Technologies Corp Fremgangsmåder til hurtig forberedelse af mærkede glycosylaminer og til analyse af glykosylerede biomolekyler, som giver samme baggrund
CN115536714A (zh) 2014-11-13 2022-12-30 沃特世科技公司 快速标记的n-聚糖的液相色谱校准方法
GB201423361D0 (en) 2014-12-30 2015-02-11 Immatics Biotechnologies Gmbh Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides
EP3472621A4 (de) 2016-06-21 2020-03-04 Waters Technologies Corporation Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen
CN109641846A (zh) 2016-06-21 2019-04-16 沃特世科技公司 通过用于增强的ms信号的还原胺化的聚糖和其他生物分子的荧光标记
US11150248B2 (en) 2016-07-01 2021-10-19 Waters Technologies Corporation Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation
CN110609103A (zh) * 2018-06-15 2019-12-24 中国科学院大连化学物理研究所 基于化学标记和质谱的蛋白与材料相互作用结构分析方法
KR102362170B1 (ko) * 2019-04-08 2022-02-11 주식회사 엘지화학 Maldi 질량분석을 이용한 고분자의 상대적 정량분석방법
WO2021163467A1 (en) * 2020-02-14 2021-08-19 Temple University-Of The Commonwealth System Of Higher Education Linking amino acid sequences, manufacturing method thereof, and use thereof
WO2023019148A1 (en) * 2021-08-10 2023-02-16 PrognomIQ, Inc. Macromolecule enrichment

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258498A (en) * 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
EP0868535B9 (de) 1996-01-23 2007-05-09 Qiagen Genomics, Inc. Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekulen
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
ES2213823T3 (es) 1996-04-08 2004-09-01 Glaxo Group Limited Codificacion y analisis cualitativo de bibliotecas combinatorias basadas en masa.
ATE319855T1 (de) * 1996-12-10 2006-03-15 Sequenom Inc Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
DE69836013T2 (de) * 1997-01-15 2007-05-24 Xzillion Gmbh & Co. Kg Massenmarkierte hybridisierungssonden
AU734636B2 (en) * 1997-07-11 2001-06-21 Xzillion Gmbh & Co. Kg Characterising nucleic acids
WO1999014362A1 (en) 1997-09-15 1999-03-25 Brax Group Limited Characterising nucleic acid by mass spectrometry
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
GB0006141D0 (en) * 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
JP2004506900A (ja) 2000-08-11 2004-03-04 アジリックス・コーポレイション 超高感度検出システム

Also Published As

Publication number Publication date
PT1425586E (pt) 2007-12-31
JP4290003B2 (ja) 2009-07-01
WO2003025576A3 (en) 2003-07-31
CA2460131A1 (en) 2003-03-27
DE60223696D1 (de) 2008-01-03
CA2460131C (en) 2006-11-21
DE60223696T2 (de) 2009-01-29
JP2005503557A (ja) 2005-02-03
US20050048489A1 (en) 2005-03-03
EP1425586B1 (de) 2007-11-21
ES2296996T3 (es) 2008-05-01
WO2003025576A2 (en) 2003-03-27
US7732378B2 (en) 2010-06-08
EP1425586A2 (de) 2004-06-09

Similar Documents

Publication Publication Date Title
DK1425586T3 (da) Massemarkörer
DE60227853D1 (de) Substituierte Pyridinylamine
IS7291A (is) Merkt kirni
DE50204184D1 (de) Espressobrüheinrichtung
ATE524462T1 (de) C5-modifizierte indazolylpyrrolotriazine
DE50206021D1 (de) Schlauchklemme
DE50103741D1 (de) Welle-Nabe-Verbindung
DE50204386D1 (de) Kreuztransducer
DE50206892D1 (de) Substituierte imidazotriazinone
DE60218081D1 (de) Markierungsteilchen
ATE335486T1 (de) Hydrazono-malonitrile
DE1319930T1 (de) Coriolismassendurchflussmesser
DE50204551D1 (de) Kugelgelenk
DK1373228T3 (da) Substituerede fluoralkoxyphenylsulfonylurinstoffer
DE50203984D1 (de) Kugelgelenk
DE50203412D1 (de) Schwenkkolbenverdränger
DE50204794D1 (de) Kugelgelenk
ATE355059T1 (de) Isoxazolopyridinone
ATE435197T1 (de) Substituierte 4-aminocyclohexanole
DE50201862D1 (de) Messwandler
DE50203093D1 (de) Losradlager
DE60204406D1 (de) Pleuelstangenvorrichtung
ATE319694T1 (de) Phenylalkyne
ATA18372001A (de) Gelenksbolzenbaueinheit
DE50202088D1 (de) Garmodulsystem